Article
Neurosciences
Fan-Pei Gloria Yang, Tzu-Yu Liu, Chih-Hsuan Liu, Shumei Murakami, Toshiharu Nakai
Summary: This study used fMRI to examine the neural basis of the response to cognitive training in healthy older adults. The findings revealed that cognitive training increased connectivity in frontotemporal regions related to language and memory functions. There were also significant correlations between the behavioral changes in a linguistic task and connectivity in regions associated with goal-oriented persistence and lexical processing. The increased hippocampal connectivity was consistent with previous research on memory improvement. The study suggests that cognitive training can promote neural changes in the right direction and potentially mitigate age-associated cognitive decline.
FRONTIERS IN HUMAN NEUROSCIENCE
(2022)
Article
Neurosciences
S. Duke Han, Debra A. Fleischman, Lei Yu, Victoria Poole, Melissa Lamar, Namhee Kim, Sue E. Leurgans, David A. Bennett, Konstantinos Arfanakis, Lisa L. Barnes
Summary: This study investigated neuroimaging correlates of cognitive decline in older Black adults and found that global cognitive decline was associated with functional connectivity of the hippocampus to the dorsolateral prefrontal cortex. Decline in semantic memory was associated with connectivity of the hippocampus to the precentral gyrus, and decline in perceptual speed was inversely associated with connectivity of the hippocampus to the intracalcarine cortex and the fusiform gyrus.
HUMAN BRAIN MAPPING
(2022)
Article
Neurosciences
Xiang Liu, Liting Chen, Wenfeng Duan, Haijun Li, Linghong Kong, Yongqiang Shu, Panmei Li, Kunyao Li, Wei Xie, Yaping Zeng, Dechang Peng
Summary: This study aimed to investigate the changes in functional connectivity between hippocampal subdivisions and their relationship with neurocognitive function in male patients with untreated severe obstructive sleep apnoea (OSA). The results revealed functional connectivity abnormalities predominantly in the sensorimotor network, fronto-parietal network, and semantic/default mode network, which are closely related to the neurocognitive impairment observed in OSA patients.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Neurosciences
Leonie Borne, Ye Tian, Michelle K. Lupton, Johan N. van der Meer, Jayson Jeganathan, Bryan Paton, Nikitas Koussis, Christine C. Guo, Gail A. Robinson, Jurgen Fripp, Andrew Zalesky, Michael Breakspear
Summary: The functional organization of the hippocampus changes smoothly along connectivity gradients and abruptly at inter-areal boundaries, similar to the cortex. This organization allows for flexible integration of hippocampal gradients into cortical networks. By studying fMRI data, researchers found that the functional connectivity gradients of the hippocampus map onto connectivity gradients in the default mode network. The presence of familiar cues accentuates a stepwise transition across the boundary from the anterior to the posterior hippocampus, which is shifted in individuals with mild cognitive impairment or Alzheimer's disease.
Article
Psychiatry
Shalaila S. Haas, Alison Myoraku, Kathleen Watson, Thalia Robakis, Sophia Frangou, Fahim Abbasi, Natalie Rasgon
Summary: This study investigates the influence of metabolic drivers on hippocampal functional connectivity in healthy adults and finds a link between metabolic abnormality and hippocampal function. The results indicate that individuals with increased metabolic deviance exhibit lower functional connectivity and integration of the hippocampus with the resting-state networks.
EUROPEAN PSYCHIATRY
(2022)
Article
Neurosciences
Wenxian Huang, Ahmed Ameen Fateh, Yilin Zhao, Hongwu Zeng, Binrang Yang, Diangang Fang, Linlin Zhang, Xianlei Meng, Muhammad Hassan, Feiqiu Wen
Summary: This study aimed to investigate the association between the synaptosomal-associated protein 25 (SNAP-25) gene and hippocampal functional connectivity in attention-deficit/hyperactivity disorder (ADHD). The results revealed that variations in the SNAP-25 gene were related to different patterns of hippocampal functional connectivity in ADHD patients, providing new insights for ADHD imaging biomarkers.
FRONTIERS IN HUMAN NEUROSCIENCE
(2023)
Article
Neurosciences
Paul F. Hill, Sarah E. Seger, Hye Bin Yoo, Danielle R. King, Bradley C. Lega, Michael D. Rugg, David X. Wang
Summary: The study found that the neurophysiological correlates of the BOLD signal differ between different brain regions, with a negative correlation between BOLD signal and high gamma SMEs in the hippocampus, and a positive correlation in the neocortex.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Zhenglong Lin, Gangqiang Hou, Youli Yao, Zhifeng Zhou, Feiqi Zhu, Linjing Liu, Lingwu Zeng, Yatao Yang, Junxian Ma
Summary: The study found that 40-Hz light can significantly alter the activity and functional connectivity of core brain areas related to memory, while 0-Hz light mainly affects brain areas in the prefrontal cortex. The results suggest that the frequency characteristics of light are important in regulating cognitive functions.
FRONTIERS IN HUMAN NEUROSCIENCE
(2021)
Article
Neurosciences
Sarah Daviddi, Tiziana Pedale, Laura Serra, Simone Macri, Patrizia Campolongo, Valerio Santangelo
Summary: Individuals with Highly Superior Autobiographical Memory (HSAM) show altered hippocampal resting-state functional connectivity, potentially leading to a reduced ability to discern and select salient information and an increased probability of encoding and consolidating sensory information.
Article
Neurosciences
Luigi Caputi, Anna Pidnebesna, Jaroslav Hlinka
Summary: Persistent homology shows potential in analyzing disease-related brain connectivity alterations, performing well in seizure discrimination but less effectively in schizophrenia classification, potentially due to technical challenges in effective connectivity estimation. Standard homology outperformed directed homology, which may be attributed to the accuracy issues in effective connectivity estimation.
Article
Behavioral Sciences
Michael Freedberg
Summary: The relationship between hippocampal and caudate connectivity strength and episodic memory is unclear. Lower caudate network dominance in bilateral thalamic regions is associated with worse episodic memory. Age-related differences in caudate network dominance in the pallidum and putamen are also associated with worse episodic memory performance, but through their shared variance with age. There is no evidence that hippocampal network dominance is related to episodic memory performance.
Review
Clinical Neurology
Camille K. Milton, Christen M. O'Neal, Andrew K. Conner
Summary: A systematic review of resting-state fMRI studies on hippocampal network connectivity laterality in patients with temporal lobe epilepsy revealed consistent patterns, suggesting potential non-invasive diagnostic utility in preoperative evaluations.
JOURNAL OF NEUROLOGY
(2022)
Article
Psychiatry
S. Parker Singleton, Julie B. B. Wang, Michael Mithoefer, Colleen Hanlon, Mark S. S. George, Annie Mithoefer, Oliver Mithoefer, Allison R. R. Coker, Berra Yazar-Klosinski, Amy Emerson, Rick Doblin, Amy Kuceyeski
Summary: 3,4-methylenedioxymethamphetamine-assisted therapy (MDMA-AT) has shown promise in treating post-traumatic stress disorder (PTSD). However, there have been no neuroimaging studies investigating the neural impact of MDMA-AT in PTSD patients.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Neurosciences
Jiayi Liu, Guangyuan Zuo, Jing Xu, Shuqin Zhou, Lang Qin, Hongqiang Sun, Qihong Zou, Jia-Hong Gao
Summary: Sleep regulation and functioning may rely on coordinated interactions between the cerebellum and other brain regions. This study used EEG-fMRI recordings to examine cerebellar connectivity during wakefulness and non-rapid eye movement (NREM) sleep. The results showed sleep-dependent alterations in cerebellar connectivity, with greater changes in deep N3 sleep compared to other states. Furthermore, specific changes in cerebellar connectivity between N2 sleep and N3 sleep were observed, highlighting the potential role of the cerebellum in sleep regulation and functioning.
Article
Immunology
Irene Esteban-Cornejo, Chelsea M. Stillman, Maria Rodriguez-Ayllon, Arthur F. Kramer, Charles H. Hillman, Andres Catena, Kirk I. Erickson, Francisco B. Ortega
Summary: This study found that physical fitness is associated with functional connectivity between hippocampal subregions and frontal regions in children with overweight/obesity. Specifically, cardiorespiratory fitness may enhance anterior hippocampal functional connectivity while motor fitness may diminish posterior hippocampal functional connectivity. Additionally, resting state hippocampal functional connectivity may relate to better written expression.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Dario R. Quinones, Luis Miguel Fernandez-Molla, Jesus Pacheco-Torres, Jose M. Carames, Santiago Canals, David Moratal
MAGNETIC RESONANCE IMAGING
(2019)
Editorial Material
Biochemistry & Molecular Biology
Silvia De Santis, Wolfgang H. Sommer, Santiago Canals
ACS CHEMICAL NEUROSCIENCE
(2019)
Article
Geriatrics & Gerontology
Nicola Toschi, Rebeca Arrais Gisbert, Luca Passamonti, Santiago Canals, Silvia De Santis
NEUROBIOLOGY OF AGING
(2020)
Article
Biology
Victor J. Lopez-Madrona, Elena Perez-Montoyo, Efren Alvarez-Salvado, David Moratal, Oscar Herreras, Ernesto Pereda, Claudio R. Mirasso, Santiago Canals
Article
Multidisciplinary Sciences
Silvia De Santis, Alejandro Cosa-Linan, Raquel Garcia-Hernandez, Lesia Dmytrenko, Lydia Vargova, Ivan Vorisek, Serena Stopponi, Patrick Bach, Peter Kirsch, Falk Kiefer, Roberto Ciccocioppo, Eva Sykova, David Moratal, Wolfgang H. Sommer, Santiago Canals
Article
Behavioral Sciences
Vicente Pallares, Mateusz Dudek, Andrea Moreno, Ursula Perez-Ramirez, David Moratal, Mia Haaranen, Roberto Ciccocioppo, Wolfgang H. Sommer, Santiago Canals, Petri Hyytia
Summary: The study used brain imaging techniques to reveal distinctly different neural activity patterns in two genetically different rat lines during alcohol drinking, indicating varied motivational and behavioral processes driving alcohol consumption.
BEHAVIOURAL PHARMACOLOGY
(2021)
Article
Neurosciences
Jaime Sanchez-Claros, Aref Pariz, Alireza Valizadeh, Santiago Canals, Claudio R. Mirasso
Summary: Synchronization between neuronal populations is crucial for communication between brain networks, with the thalamus playing a key role in coordinating this process. The delay in connections and detuning of oscillation frequencies determine the amount of information transferred between populations, with relay transmission from the thalamus to cortex supporting robust bottom-up and top-down interactions. Adding a cortico-cortical connection expands the system dynamics, with varying operation modes depending on synaptic strength.
FRONTIERS IN SYSTEMS NEUROSCIENCE
(2021)
Article
Neurosciences
Ursula Perez-Ramirez, Victor J. Lopez-Madrona, Andres Perez-Segura, Vicente Pallares, Andrea Moreno, Roberto Ciccocioppo, Petri Hyytia, Wolfgang H. Sommer, David Moratal, Santiago Canals
Summary: Chronic alcohol drinking in rats induces changes in brain functional connectivity, leading to network reorganization characterized by functional dedifferentiation and functional narrowing. These alterations persist after alcohol discontinuation, suggesting persistent network states.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Wolfgang H. Sommer, Santiago Canals, Angelo Bifone, Markus Heilig, Petri Hyytia
Summary: Excessive alcohol use can lead to alcohol addiction, but the understanding of how alcohol-induced brain changes lead to addiction is limited. An unbiased discovery strategy based on systems medicine identified specific brain regions, with the insula emerging as a consistent finding. While initial translation failed, proof-of-concept experiments have shown the potential to guide network dynamics in animal models.
Article
Chemistry, Analytical
Aaron Cuevas-Lopez, Elena Perez-Montoyo, Victor J. Lopez-Madrona, Santiago Canals, David Moratal
Summary: This study introduces a digital compression algorithm capable of compressing electrophysiological data to a smaller size without distorting signals, tested in experimental animals. The algorithm is based on signal optimization techniques, able to run on low-power FPGAs with minimal hardware requirements.
Article
Multidisciplinary Sciences
Raquel Garcia-Hernandez, Antonio Cerdan Cerda, Alejandro Trouve Carpena, Mark Drakesmith, Kristin Koller, Derek K. Jones, Santiago Canals, Silvia De Santis
Summary: This study presents a noninvasive diffusion-weighted magnetic resonance imaging method to image changes in glia morphology. Using animal models, the researchers demonstrate that this method can quantify specific markers of glial cell activation and is sensitive to changes in morphology and proliferation. The study also proves the translational value of this approach in human experiments.
Article
Cell Biology
E. Dominguez-Sala, L. Valdes-Sanchez, S. Canals, O. Reiner, A. Pombero, R. Garcia-Lopez, A. Estirado, D. Pastor, E. Geijo-Barrientos, S. Martinez
Summary: LIS1 (PAFAH1B1) plays a major role in the developing cerebral cortex and mutations in this gene can cause lissencephaly type 1. Research on mutant mice with a deletion in the first exon of the Lis1 gene revealed abnormal distribution and functional abnormalities in cortical GABAergic interneurons. Additionally, these mice exhibited altered oscillatory activity and abnormalities in the fast spiking inhibitory GABAergic interneurons. These findings suggest that certain mutations in the Lis1 gene can lead to phenotypes similar to those observed in patients with schizophrenia and autism.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Clinical Neurology
Mohamed Kotb Selim, Maayan Harel, Silvia De Santis, Irene Perini, Wolfgang H. Sommer, Markus Heilig, Abraham Zangen, Santiago Canals
Summary: This study investigates the effect of deep transcranial magnetic stimulation (Deep TMS) on the microstructure of white matter in patients with alcohol use disorder (AUD). The study found that Deep TMS can arrest the changes in white matter integrity in AUD patients and decrease craving and relapse scores. Additionally, specific brain regions were found to have persistently modulated functional connectivity.
PSYCHIATRY AND CLINICAL NEUROSCIENCES
(2023)
Meeting Abstract
Substance Abuse
L. Varga, B. Molnar, V. V. Moca, L. Perez-Cervera, A. Diaz-Parra, D. Moratal, W. H. Sommer, R. C. Muresan, S. Canals, M. Ercsey-Ravasz
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
(2022)
Meeting Abstract
Substance Abuse
S. Canals
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Slimane Tounekti, Mahdi Alizadeh, Devon Middleton, James S. Harrop, Bassem Hiba, Laura Krisa, Choukri Mekkaoui, Feroze B. Mohamed
Summary: This study proposes and demonstrates a new method combining reduced field-of-view strategy with phase segmented EPI to address geometric distortion in post-operative DTI scans of patients with metal implants. The results show that the new method outperforms traditional techniques in reducing distortion.
MAGNETIC RESONANCE IMAGING
(2024)
Article
Radiology, Nuclear Medicine & Medical Imaging
Silvia Minosse, Eliseo Picchi, Valentina Ferrazzoli, Noemi Pucci, Valerio Da Ros, Raffaella Giocondo, Roberto Floris, Francesco Garaci, Francesca Di Giuliano
Summary: The aim of this study was to investigate the variation of DCE-MRI-derived kinetic parameters in brain tumors as a function of acquisition time. The results showed that K-ep and V-e were time-dependent and required longer scan times to obtain reliable parameter values, while K-trans was time-independent and remained the same in all acquisition times, making it a reliable parameter for short acquisition times.
MAGNETIC RESONANCE IMAGING
(2024)
Article
Radiology, Nuclear Medicine & Medical Imaging
Xingmin Guan, Xinheng Zhang, Hsin-Jung Yang, Rohan Dharmakumar
Summary: This study aims to investigate why DIR-prepared dark-blood T2* weighted images have lower SNR, CNR, and diagnostic accuracy for intramyocardial hemorrhage (IMH) detection compared to non-DIR-prepared bright-blood T2* images. Through phantom and animal studies, it was confirmed that the signal loss on DIR-prepared T2* images mainly originates from spin-relaxation during the DIR preparation. Therefore, when used for IMH detection, extra attention should be paid to the SNR of DIR-prepared dark-blood T2* imaging protocols.
MAGNETIC RESONANCE IMAGING
(2024)
Article
Radiology, Nuclear Medicine & Medical Imaging
Beatriz Laureano, Hassna Irzan, Helen OReilly, Sebastian Ourselin, Neil Marlow, Andrew Melbourne
Summary: Prematurity and preterm stressors have significant effects on the development of infants, especially at earlier gestations. While neonatal care advances have reduced preterm mortality rates, disability rates continue to grow in middle-income settings. Imaging the preterm brain using MR technology has improved our understanding of its development and the affected regions and networks. This research aims to support interventions, improve neurodevelopment, and provide accurate prognoses for preterm infants. This study focuses on the fully developed brain of extremely preterm subjects and examines myelin-related biomarkers to assess long-term effects. The findings suggest altered connectivity and cognitive outcomes in the adult preterm brain.
MAGNETIC RESONANCE IMAGING
(2024)
Article
Radiology, Nuclear Medicine & Medical Imaging
Julian Rauch, Frederik B. Laun, Peter Bachert, Mark E. Ladd, Tristan A. Kuder
Summary: This study presents a method for reducing concomitant field effects in double diffusion encoding (DDE) sequences by adding oscillating gradient pulses. The modified sequences successfully reduced accumulated concomitant phase without significant changes in the original sequence characteristics. The proposed method led to an increase in signal-to-noise ratio (SNR) for phantom and in vivo experiments, supported by simulations.
MAGNETIC RESONANCE IMAGING
(2024)
Article
Radiology, Nuclear Medicine & Medical Imaging
Marlon Bran Lorenzana, Shekhar S. Chandra, Feng Liu
Summary: Sparse reconstruction is important in MRI for reducing acquisition time and improving spatial-temporal resolution. This paper introduces two decoupling techniques for explicit 1D regularization and a combined 1D + 2D reconstruction technique that improves image quality.
MAGNETIC RESONANCE IMAGING
(2024)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yifan Gou, W. Christopher Golden, Zixuan Lin, Jennifer Shepard, Aylin Tekes, Zhiyi Hu, Xin Li, Kumiko Oishi, Marilyn Albert, Hanzhang Lu, Peiying Liu, Dengrong Jiang
Summary: ARTS algorithm improves the reliability of Y-v estimation in noncompliant subjects, enhancing the utility of Y-v as a biomarker for brain diseases.
MAGNETIC RESONANCE IMAGING
(2024)
