Article
Medicine, General & Internal
Tingting Zhang, Haijun Niu, Yawen Liu, Linkun Cai, Dong Liu, Erwei Zhao, Min Li, Wenjuan Liu, Jing Li, PengGang Qiao, Wei Zheng, Pengling Ren, Zhenchang Wang
Summary: This study investigated the effects of dobutamine on cerebral hemodynamics and found that dobutamine stress significantly decreased cerebral blood flow in the frontal lobe anterior circulation. Additionally, body mass index, resting systolic blood pressure, and basilar artery diameter were significantly associated with changes in frontal lobe cerebral blood flow.
Article
Neurosciences
Xiao-Hui Wang, Xiao-Fan Liu, Min Ao, Ting Wang, Jinglan He, Yue-Wen Gu, Jing-Wen Fan, Li Yang, Renqiang Yu, Shuliang Guo
Summary: This study aims to explore the cerebral perfusion pattern and blood flow status of anxiety in patients with pulmonary nodules, and found significant differences between the anxiety group and the non-anxiety group. By detecting the cerebral blood flow in specific brain regions, the anxiety group can be accurately distinguished from the non-anxiety group.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Shiori Amemiya, Yusuke Watanabe, Naoyuki Takei, Tsuyoshi Ueyama, Satoru Miyawaki, Satoshi Koizumi, Seiji Kato, Hidemasa Takao, Osamu Abe, Nobuhito Saito
Summary: The study found that in severe steno-occlusive diseases, the Combo strategy using ATT correction can improve CBF measurement accuracy, and VS significantly enhances CBF measurement accuracy in standard protocol and in moyamoya patients for the Combo.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Xinyu Wang, Weiqiang Dou, Dong Dong, Xinyi Wang, Xueyu Chen, Kunjian Chen, Huimin Mao, Yu Guo, Chao Zhang
Summary: This study aimed to explore the feasibility of three-dimensional pseudo-continuous arterial-spin-labeling (tASL) in evaluating MCA recanalization. After recanalization, tASL provided good prognosis and was found to be an independent predictor of good clinical outcome.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2021)
Review
Oncology
Abir Troudi, Fatima Tensaouti, Eloise Baudou, Patrice Peran, Anne Laprie
Summary: This article introduces the magnetic resonance imaging techniques for pediatric brain tumors, especially the ASL MRI technique in evaluating treatment response and neurocognitive sequelae. ASL is a noninvasive technique for measuring cerebral blood flow, but it has some drawbacks and technical requirements.
Article
Radiology, Nuclear Medicine & Medical Imaging
James H. Holmes, Mu-Lan Jen, Laura B. Eisenmenger, Tilman Schubert, Patrick A. Turski, Kevin M. Johnson
Summary: This study introduces a mapping approach to investigate the relative tagging efficiency of VS-ASL, validated through numerical simulations and experiments. Unique efficiency patterns were observed in normal volunteers based on individual anatomy and physiology. While uniform tagging efficiency was generally seen in vivo, regions of high blood velocity and local susceptibility gradients showed reduced efficiency.
MAGNETIC RESONANCE IN MEDICINE
(2021)
Article
Multidisciplinary Sciences
Hossein Rahimzadeh, Hadi Kamkar, Narges Hoseini-Tabatabaei, Neda Mohammadi Mobarakeh, Jafar Mehvari Habibabadi, Seyed-Sohrab Hashemi-Fesharaki, Mohammad-Reza Nazem-Zadeh
Summary: Summary in English: This study aimed to investigate the differences in perfusion pattern changes in right and left mesial temporal lobe epilepsy (mTLE). By using pulsed arterial spin labeling, 42 mTLE patients (22 left and 20 right mTLE) and 14 controls were surveyed. The results showed that cerebral blood flow decreased in the ipsilateral sides in both epilepsy subcohorts, with right mTLE showing significant differences in most regions of interest (ROIs), while left mTLE did not exhibit significant changes. Compared to controls, left mTLE displayed significant drops in cerebral blood flow in the left middle temporal and left intermediate posterior cerebral artery ROIs, as well as in the asymmetry index analysis in the parahippocampus, distal anterior cerebral artery, distal middle cerebral artery, and intermediate anterior cerebral artery. Cerebral blood flow hypoperfusion was observed in the left intermediate anterior cerebral artery, left middle temporal, right middle temporal, and left superior temporal in right mTLE patients compared to controls. Left mTLE also differed significantly from right mTLE in cerebral blood flow in the right distal middle cerebral artery ROI and the asymmetry index of the proximal middle cerebral artery.
Article
Critical Care Medicine
Linda Xu, Jeffrey B. Ware, Junghoon J. Kim, Pashtun Shahim, Erika Silverman, Brigid Magdamo, Cian Dabrowski, Leroy Wesley, My Duyen Le, Justin Morrison, Hannah Zamore, Cillian E. Lynch, Dmitriy Petrov, H. Isaac Chen, James Schuster, Ramon Diaz-Arrastia, Danielle K. Sandsmark
Summary: Imaging detection of brain perfusion alterations after traumatic brain injury (TBI) may provide prognostic insights. The study found that TBI participants had globally elevated CBF in both acute and chronic phases, with focal hypo- and hyperperfusion present in brain tissue. Furthermore, acute elevation in CBF post-TBI may play a reparative role and be associated with better clinical outcomes in the long term.
JOURNAL OF NEUROTRAUMA
(2021)
Article
Neurosciences
Katja Neumann, Martin Schidlowski, Matthias Guenther, Tony Stoecker, Emrah Duezel
Summary: The study investigated the reliability and reproducibility of perfusion measures using an innovative Hadamard encoded pCASL sequence on healthy elderly individuals. The results demonstrated excellent reliability of CBF and ATT measures in different brain regions, with ATT appearing to be even more reliable than CBF. High intra-class correlation coefficients indicated substantial agreement of perfusion values acquired on two different MRI systems, suggesting potential improvements for future follow-up perfusion studies in aging and/or diseased brains.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Clinical Neurology
G. Pouliquen, L. Fillon, V. Dangouloff-Ros, M. Kuchenbuch, C. Bar, N. Chemaly, R. Levy, C. -J. Roux, A. Saitovitch, J. Boisgontier, R. Nabbout, N. Boddaert
Summary: This study aimed to evaluate the role of arterial spin-labeling perfusion imaging in the early diagnosis of Sturge-Weber syndrome. The results showed a significant decrease in CBF in the affected cortices of patients with Sturge-Weber syndrome. This finding was particularly evident in patients younger than 1 year of age, highlighting the high sensitivity of arterial spin-labeling in this age window.
AMERICAN JOURNAL OF NEURORADIOLOGY
(2022)
Article
Cell Biology
Joseph S. R. Alisch, Nikkita Khattar, Richard W. Kim, Luis E. Cortina, Abinand C. Rejimon, Wenshu Qian, Luigi Ferrucci, Susan M. Resnick, Richard G. Spencer, Mustapha Bouhrara
Summary: Cerebral blood flow varies with age in different brain regions, with white matter regions showing increased blood flow with age and women having higher blood flow than men. The study results provide a foundation for further investigation of CNS perfusion in various scenarios.
Article
Endocrinology & Metabolism
Manuel Taso, Fanny Munsch, Li Zhao, David C. Alsop
Summary: High-resolution imaging methods using ASL and T-1 mapping highlight the importance of spatial resolution and tissue heterogeneity in measuring cortical cerebral blood flow. Regional analysis reveals significant differences across cortical regions, with depth-dependent T-1 variation complicating interpretation of ASL signal. This has implications for accurate CBF quantification, especially at lower resolutions.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Article
Clinical Neurology
G. Pouliquen, L. Fillon, V. Dangouloff-Ros, M. Kuchenbuch, C. Bar, N. Chemaly, R. Levy, C. -J. Roux, A. Saitovitch, J. Boisgontier, R. Nabbout, N. Boddaert
Summary: Arterial spin-labeling perfusion imaging can help diagnose early-stage Sturge-Weber syndrome by revealing cortical hypoperfusion near the leptomeningeal vascular malformation, with significantly lower CBF values in affected cortices compared to controls, especially in children under 1 year old, highlighting the high sensitivity of arterial spin-labeling in this age group.
AMERICAN JOURNAL OF NEURORADIOLOGY
(2022)
Article
Neurosciences
Michael A. Chappell, Flora A. Kennedy McConnell, Xavier Golay, Matthias Gunther, Juan A. Hernandez-Tamames, Matthias J. van Osch, Iris Asllani
Summary: The mismatch in spatial resolution of ASL MRI perfusion images and brain tissues leads to a partial volume effect (PVE), which confounds perfusion estimation. PVE influences brain perfusion studies, particularly when changes in perfusion coincide with alterations in brain structure. The application of PVE correction (PVEc) is limited and methodologies are inconsistent.
Article
Radiology, Nuclear Medicine & Medical Imaging
Shiori Amemiya, Yusuke Watanabe, Naoyuki Takei, Tsuyoshi Ueyama, Satoru Miyawaki, Satoshi Koizumi, Seiji Kato, Hidemasa Takao, Osamu Abe, Nobuhito Saito
Summary: Noninvasive cerebral blood flow monitoring using ASL MRI is more reliable and sensitive than SPECT in evaluating perfusion changes in patients with steno-occlusive diseases. ASL test-retest reliability and sensitivity were higher with a postlabeling delay of 2333 milliseconds.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2022)
Article
Endocrinology & Metabolism
Daniel Milej, Lian He, Androu Abdalmalak, Wesley B. Baker, Udunna C. Anazodo, Mamadou Diop, Sudipto Dolui, Venkaiah C. Kavuri, William Pavlosky, Lin Wang, Ramani Balu, John A. Detre, Olivia Amendolia, Francis Quattrone, W. Andrew Kofke, Arjun G. Yodh, Keith St Lawrence
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2020)
Article
Biochemical Research Methods
Seva Ioussoufovitch, Laura B. Morrison, Lise Desjardins, Jennifer A. Hadway, Keith St Lawrence, Ting-Yim Lee, Frank Beier, Mamadou Diop
JOURNAL OF BIOMEDICAL OPTICS
(2020)
Article
Neurosciences
Androu Abdalmalak, Daniel Milej, David J. Cohen, Udunna Anazodo, Tracy Ssali, Mamadou Diop, Adrian M. Owen, Keith St Lawrence
NEUROSCIENCE LETTERS
(2020)
Article
Neurosciences
Androu Abdalmalak, Daniel Milej, Lawrence C. M. Yip, Ali R. Khan, Mamadou Diop, Adrian M. Owen, Keith St Lawrence
FRONTIERS IN NEUROSCIENCE
(2020)
Review
Oncology
Rachel M. Glicksman, Michael C. Tjong, Wellington F. P. Neves-Junior, Daniel E. Spratt, Kevin L. M. Chua, Alireza Mansouri, Melvin L. K. Chua, Alejandro Berlin, Jeff D. Winter, Max Dahele, Ben J. Slotman, Mark Bilsky, David B. Shultz, Marcos Maldaun, Nicholas Szerlip, Simon S. Lo, Yoshiya Yamada, Francisco Emilio Vera-Badillo, Gustavo N. Marta, Fabio Y. Moraes
Article
Oncology
Jeff D. Winter, Jenna Adleman, Thomas G. Purdie, Jacqueline Heaton, Andrea McNiven, Jennifer Croke
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2020)
Article
Biochemical Research Methods
Daniel Milej, Marwan Shahid, Androu Abdalmalak, Ajay Rajaram, Mamadou Diop, Keith St Lawrence
BIOMEDICAL OPTICS EXPRESS
(2020)
Article
Radiology, Nuclear Medicine & Medical Imaging
Neil Cockburn, Jeffrey Corsaut, Michael S. Kovacs, Keith St. Lawrence, Justin W. Hicks
NUCLEAR MEDICINE COMMUNICATIONS
(2020)
Article
Neurosciences
Ajay Rajaram, Lawrence C. M. Yip, Daniel Milej, Marianne Suwalski, Matthew Kewin, Marcus Lo, Jeffrey J. L. Carson, Victor Han, Soume Bhattacharya, Mamadou Diop, Sandrine de Ribaupierre, Keith St Lawrence
Article
Biochemical Research Methods
Ajay Rajaram, Daniel Milej, Marianne Suwalski, Lawrence C. M. Yip, Linrui R. Guo, Michael W. A. Chu, Jason Chui, Mamadou Diop, John M. Murkin, Keith St Lawrence
BIOMEDICAL OPTICS EXPRESS
(2020)
Article
Neurosciences
Daniel Milej, Androu Abdalmalak, Ajay Rajaram, Keith St Lawrencea
Article
Engineering, Biomedical
Lucas Narciso, Tracy Ssali, Hidehiro Iida, Keith St Lawrence
Summary: A non-invasive reference-based technique for imaging CMRO2 has been developed for PET/MRI, aiming to simplify the procedure without the need for invasive blood sampling. The approach utilizes whole-brain measurements of oxygen extraction fraction and cerebral blood flow to calibrate PET data, showing promising results in producing quantitative CMRO2 images. The study demonstrates the feasibility of this approach in quantifying CMRO2 without invasive procedures.
PHYSICS IN MEDICINE AND BIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Lucas Narciso, Tracy Ssali, Linshan Liu, Heather Biernaski, John Butler, Laura Morrison, Jennifer Hadway, Jeffrey Corsaut, Justin W. Hicks, Michael C. Langham, Felix W. Wehrli, Hidehiro Iida, Keith St Lawrence
Summary: A noninvasive PET/MRI technique for imaging cerebral metabolic rate of oxygen (CMRO2) was proposed and validated in an animal study. The technique uses functional MRI to calibrate PET data, potentially reducing the complexity of PET imaging. The results showed good agreement between regional CMRO2 measurements from the new technique and traditional PET-alone measurements.
JOURNAL OF NUCLEAR MEDICINE
(2021)
Article
Engineering, Biomedical
Aly Khalifa, Jeff Winter, Inmaculada Navarro, Chris McIntosh, Thomas G. Purdie
Summary: The objective of this study was to determine if a machine learning model trained on computed tomography (CT) imaging can be applied to magnetic resonance (MR) imaging through domain adaptation for radiation treatment planning. The results showed that highly acceptable MR-based treatment plans could be created using a CT-trained machine learning model, although there were clinically significant dose deviations from CT-based plans.
PHYSICS IN MEDICINE AND BIOLOGY
(2022)
Article
Oncology
Archya Dasgupta, Jayson Co, Jeff Winter, Barbara-Ann Millar, Normand Laperriere, Derek S. Tsang, Monique van Prooijen, Andrei Damyanovich, Robert Heaton, Catherine Coolens, Mark Bernstein, Paul Kongkham, Gelareh Zadeh, Alejandro Berlin, Tatiana Conrad, Fabio Y. Moraes, David B. Shultz
Summary: The study found that most long term survivors in brain metastasis patients were younger, with a single brain metastasis, and many received treatment with surgery or targeted, immune, or hormonal therapy.
Article
Radiology, Nuclear Medicine & Medical Imaging
Slimane Tounekti, Mahdi Alizadeh, Devon Middleton, James S. Harrop, Bassem Hiba, Laura Krisa, Choukri Mekkaoui, Feroze B. Mohamed
Summary: This study proposes and demonstrates a new method combining reduced field-of-view strategy with phase segmented EPI to address geometric distortion in post-operative DTI scans of patients with metal implants. The results show that the new method outperforms traditional techniques in reducing distortion.
MAGNETIC RESONANCE IMAGING
(2024)
Article
Radiology, Nuclear Medicine & Medical Imaging
Silvia Minosse, Eliseo Picchi, Valentina Ferrazzoli, Noemi Pucci, Valerio Da Ros, Raffaella Giocondo, Roberto Floris, Francesco Garaci, Francesca Di Giuliano
Summary: The aim of this study was to investigate the variation of DCE-MRI-derived kinetic parameters in brain tumors as a function of acquisition time. The results showed that K-ep and V-e were time-dependent and required longer scan times to obtain reliable parameter values, while K-trans was time-independent and remained the same in all acquisition times, making it a reliable parameter for short acquisition times.
MAGNETIC RESONANCE IMAGING
(2024)
Article
Radiology, Nuclear Medicine & Medical Imaging
Xingmin Guan, Xinheng Zhang, Hsin-Jung Yang, Rohan Dharmakumar
Summary: This study aims to investigate why DIR-prepared dark-blood T2* weighted images have lower SNR, CNR, and diagnostic accuracy for intramyocardial hemorrhage (IMH) detection compared to non-DIR-prepared bright-blood T2* images. Through phantom and animal studies, it was confirmed that the signal loss on DIR-prepared T2* images mainly originates from spin-relaxation during the DIR preparation. Therefore, when used for IMH detection, extra attention should be paid to the SNR of DIR-prepared dark-blood T2* imaging protocols.
MAGNETIC RESONANCE IMAGING
(2024)
Article
Radiology, Nuclear Medicine & Medical Imaging
Beatriz Laureano, Hassna Irzan, Helen OReilly, Sebastian Ourselin, Neil Marlow, Andrew Melbourne
Summary: Prematurity and preterm stressors have significant effects on the development of infants, especially at earlier gestations. While neonatal care advances have reduced preterm mortality rates, disability rates continue to grow in middle-income settings. Imaging the preterm brain using MR technology has improved our understanding of its development and the affected regions and networks. This research aims to support interventions, improve neurodevelopment, and provide accurate prognoses for preterm infants. This study focuses on the fully developed brain of extremely preterm subjects and examines myelin-related biomarkers to assess long-term effects. The findings suggest altered connectivity and cognitive outcomes in the adult preterm brain.
MAGNETIC RESONANCE IMAGING
(2024)
Article
Radiology, Nuclear Medicine & Medical Imaging
Julian Rauch, Frederik B. Laun, Peter Bachert, Mark E. Ladd, Tristan A. Kuder
Summary: This study presents a method for reducing concomitant field effects in double diffusion encoding (DDE) sequences by adding oscillating gradient pulses. The modified sequences successfully reduced accumulated concomitant phase without significant changes in the original sequence characteristics. The proposed method led to an increase in signal-to-noise ratio (SNR) for phantom and in vivo experiments, supported by simulations.
MAGNETIC RESONANCE IMAGING
(2024)
Article
Radiology, Nuclear Medicine & Medical Imaging
Marlon Bran Lorenzana, Shekhar S. Chandra, Feng Liu
Summary: Sparse reconstruction is important in MRI for reducing acquisition time and improving spatial-temporal resolution. This paper introduces two decoupling techniques for explicit 1D regularization and a combined 1D + 2D reconstruction technique that improves image quality.
MAGNETIC RESONANCE IMAGING
(2024)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yifan Gou, W. Christopher Golden, Zixuan Lin, Jennifer Shepard, Aylin Tekes, Zhiyi Hu, Xin Li, Kumiko Oishi, Marilyn Albert, Hanzhang Lu, Peiying Liu, Dengrong Jiang
Summary: ARTS algorithm improves the reliability of Y-v estimation in noncompliant subjects, enhancing the utility of Y-v as a biomarker for brain diseases.
MAGNETIC RESONANCE IMAGING
(2024)