Article
Chemistry, Multidisciplinary
Julien Mahin, Christoph O. Franck, Luise Fanslau, Hirak K. Patra, Michael D. Mantle, Ljiljana Fruk, Laura Torrente-Murciano
Summary: A novel method for synthesizing bare iron oxide nanoparticles using modular microreactor systems and functionalizing them with a custom heterobifunctional PEG stabilizer in a reproducible and efficient manner is presented. The nanoparticles can be easily conjugated with any molecule of interest through simple amide coupling, showcasing their potential for various biomedical applications. The produced iron oxide nanoparticles are fully biocompatible, stable in biologically relevant media, and suitable for T-2 MRI contrast applications, with a low total cost, demonstrating the feasibility of large-scale deployment in real world applications.
REACTION CHEMISTRY & ENGINEERING
(2021)
Article
Chemistry, Multidisciplinary
Liang Yue, Yong-Liang Su, Mingzhe Li, Luxia Yu, S. Macrae Montgomery, Xiaohao Sun, M. G. Finn, Will R. Gutekunst, Rampi Ramprasad, H. Jerry Qi
Summary: A depolymerizable vitrimer was synthesized through a simple and scalable one-pot two-step synthesis from cyclic lactones, allowing both reprocessability and monomer recovery. The solidification of the amorphous poly(delta-lactone) into an elastomer (delta-lactone vitrimer) with dynamic acetal linkages enables reprocessing and healing. The thermolysis of the bulk delta-lactone vitrimer at 200 degrees C can recover 85-90 wt% of the material, demonstrating its potential as a sustainable replacement for conventional soft elastomers in various applications.
ADVANCED MATERIALS
(2023)
Article
Crystallography
Jin Motoyanagi, Ayane Fujishima, Masahiko Minoda
Summary: This study investigates a new amphipathic poly(vinyl ether) with an SP moiety, exploring its photoresponsive properties and the control of self-assembly through photoirradiation.
Article
Biology
Stephen R. Piccolo, Zachary E. Ence, Elizabeth C. Anderson, Jeffrey T. Chang, Andrea H. Bild
Summary: Common Workflow Language (CWL) is a community standard that formalizes tool descriptions to allow for portable execution on diverse computers. It is widely used in biology research, especially in genomics, for batch processing of large datasets. CWL also supports workflows that describe tool dependencies and input-output relationships.
Article
Chemistry, Multidisciplinary
Sebastiano Mantovani, Sara Khaliha, Laura Favaretto, Cristian Bettini, Antonio Bianchi, Alessandro Kovtun, Massimo Zambianchi, Massimo Gazzano, Barbara Casentini, Vincenzo Palermo, Manuela Melucci
Summary: The study demonstrates that microwave accelerated synthesis combined with microfiltration enables fast and scalable preparation of highly pure modified graphene oxide nanosheets, which could be used for simultaneous removal of arsenic and lead from water.
CHEMICAL COMMUNICATIONS
(2021)
Article
Polymer Science
Xuemei Zhang, Xiaoli Chen, Xiaoqing Chen, Shuai Wang, Mengli Wang, Chao Geng, Guoxing Xu, Shixue Wang
Summary: A scalable and efficient method for synthesizing high-fidelity PEG(n)-NH(2)s has been developed using (Boc)(2)NH as an amination reagent. This method ensures high reaction efficiency and fidelity of the end-groups. The synthesis of various PEG(n)-NH(2)s with different functional groups or topological structures demonstrates the versatility of this novel approach. Furthermore, mPEG(114)-NH2 can be quantitatively converted to mPEG(114)-Mal, which can efficiently couple with GSH, providing a foundation for the synthesis of high-quality drugs and the development of novel therapeutics.
Article
Chemistry, Multidisciplinary
Clarisse Brossard, Manuel Vlach, Elise Vene, Catherine Ribault, Vincent Dorcet, Nicolas Noiret, Pascal Loyer, Nicolas Lepareur, Sandrine Cammas-Marion
Summary: This study successfully developed PMLABe derivatives end-functionalized with different peptides and their corresponding scrambled peptides, and formulated nanoparticles with different properties, indicating that these nanoparticles may be promising drug delivery systems for the theranostics of HCC.
Article
Biochemical Research Methods
Laura Wratten, Andreas Wilm, Jonathan Goke
Summary: The rapid growth of high-throughput technologies has made scalability and reproducibility essential in biomedical research. Workflow managers simplify pipeline development, optimize resource usage, handle software installation and versions, and enable workflow portability and sharing across different compute platforms. They contribute to making computational analysis in biomedical research shareable, scalable, and reproducible.
Article
Polymer Science
Hae-Nam Choi, In-Hwan Lee
Summary: This study presents a one-pot synthesis of P3HT-OH via Suzuki-Miyaura catalyst-transfer polycondensation, eliminating the laborious postpolymerization modifications and additional protecting group techniques. Mild reaction conditions with good functional group tolerance allow for the preparation of well-defined P3HT-OH without protective groups or postmodification processes. It is important to maintain a [Pd]/[alcohol initiator] ratio of <= 1 to suppress oxidation of the alcohol group and ensure high end-group fidelity.
Article
Chemistry, Physical
Masahiro Nishikawa, Ming Liu, Taro Yoshikawa, Hidekazu Takeuchi, Naoyoshi Matsuno, Naoki Komatsu
Summary: Poly(glycerol) is a promising platform for surface modification of nanomaterials, especially for in vivo applications. By grafting-from process, it can covalently functionalize the nanomaterial surface through ring-opening polymerization of glycidol. Nanodiamond is often used with Poly(glycerol) due to its fluorescence properties. However, the process lacks scalability and controllability, and the structural details of Poly(glycerol) chain on nanodiamond surface are still unclear. In this study, a more scalable and safer Poly(glycerol) functionalization of nanodiamonds is developed by dropwise-addition of glycidol to ethylene glycol suspension of nanodiamonds. The resulting Poly(glycerol) amount can be controlled or estimated by reaction conditions and nanodiamond properties. The structure of Poly(glycerol) chain is analyzed qualitatively and quantitatively, revealing its structure.
Article
Polymer Science
Jingyuan Deng, Sean Bailey, Ruiwen Ai, Anthony Delmonico, Gregory Denbeaux, Shaoyi Jiang, Christopher K. Ober
Summary: Conventional chemically amplified resists (CARs) face the trade-off between resolution, line edge roughness, and sensitivity (RLS) due to acid diffusion. This study proposes an end-cap enabled chain scissionable resist based on the self-immolative property of polyphthalaldehyde (PPA) derivatives for extreme ultraviolet (EUV) lithography, and demonstrates its feasibility through experimental validation.
Article
Chemistry, Inorganic & Nuclear
Xing-Wang Han, Olafs Daugulis, Maurice Brookhart
Summary: The end-functionalized poly(norbornenes) and poly(ethylidenenorbornenes) were prepared using the palladium catalyst B-t(3) PPdMeCl/NaBArf in combination with chain transfer agents (CTAs) 4-penten-l-ol and 10-undecenal, resulting in polymers end-capped with -OH and -CHO groups in high yields. These polymers with precise M-n values and narrow molecular weight distributions were accessed via living polymerizations with the monomer completely consumed, demonstrating the utility of aldehyde-functionalized polymers in applications like coupling to dye molecules and synthesizing ambiphilic diblock copolymers.
Article
Chemistry, Multidisciplinary
Yu Tokita, Tatsuya Uchida, Takeru Kamigawara, Kenta Hoka, Reo Nitto, Yoshihiro Ohta, Tsutomu Yokozawa
Summary: This study successfully introduced various functional groups at both ends of P3HT polymer through successive catalyst-transfer condensation polymerization and coupling reactions in one pot, and synthesized a polymer with a base-sensitive functional group.
CHEMICAL COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Yu Tokita, Tatsuya Uchida, Takeru Kamigawara, Kenta Hoka, Reo Nitto, Yoshihiro Ohta, Tsutomu Yokozawa
Summary: In this study, polymeric materials with functional groups at both ends were synthesized via successive Kumada catalyst-transfer polycondensation and Suzuki coupling reaction in one pot, expanding the synthetic methods for functionalized polymers.
CHEMICAL COMMUNICATIONS
(2023)
Article
Polymer Science
Tuemay Abadi Belay, Jupeng Chen, Huan Xu, Shaowen Zhang, Shilu Chen, Xiaofang Li
Summary: The study presents a method for the synthesis of silane-end-functionalized linear and star polymers through metal-free borates or borane mediated polymerization, with properties easily tunable by varying the type and concentration of hydrosilanes. H-1, Si-29, and H-1-Si-29 HMBC NMR, FT-IR, ESI-MS, and MALDI-TOF-MS analyses confirm the presence of silane-end-functional groups in these polymers, with hydrosilanes playing a dual role in the polymerization process.