期刊
REGULATORY TOXICOLOGY AND PHARMACOLOGY
卷 72, 期 3, 页码 683-693出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.yrtph.2015.03.001
关键词
Skin sensitisation; Dermal Sensitisation Threshold (DST); High Potency Category Chemicals (HPC); Sensitisation risk assessment; Structure alerts; Local Lymph Node Assay (LLNA); Non-animal methods
资金
- Research Institute for Fragrance Materials, Inc.
An essential step in ensuring the toxicological safety of chemicals used in consumer products is the evaluation of their skin sensitising potential. The sensitising potency, coupled with information on exposure levels, can be used in a Quantitative Risk Assessment (QRA) to determine an acceptable level of a given chemical in a given product. Where consumer skin exposure is low, a risk assessment can be conducted using the Dermal Sensitisation Threshold (DST) approach, avoiding the need to determine potency experimentally. Since skin sensitisation involves chemical reaction with skin proteins, the first step in the DST approach is to assess, on the basis of the chemical structure, whether the chemical is expected to be reactive or not. Our accompanying publication describes the probabilistic derivation of a DST of 64 mu g/cm(2) for chemicals assessed as reactive. This would protect against 95% of chemicals assessed as reactive, but the remaining 5% would include chemicals with very high potency. Here we discuss the chemical properties and structural features of high potency sensitisers, and derive an approach whereby they can be identified and consequently excluded from application of the DST. (C) 2015 Elsevier Inc. All rights reserved.
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