Article
Polymer Science
Yoshihisa Tokushita, Shogo Furuya, Shotaro Nobe, Kazuhiro Nakabayashi, Sadaki Samitsu, Hideharu Mori
Summary: Selenium-containing polymers with high refractive indices were prepared by radical polymerization, showing potential for improving refractive indices of (meth)acrylate-based copolymers. By adjusting the content of methyl methacrylate, the refractive indices of copolymers could be controlled, with higher transparency achieved in copolymers with more MMA content. The polymers exhibited good transmittances around 400 nm wavelength.
Article
Chemistry, Multidisciplinary
Hugo Fouilloux, Wei Qiang, Carine Robert, Vincent Placet, Christophe M. Thomas
Summary: The study introduces a one-pot catalytic system that can efficiently transform renewable materials into monomers suitable for polymer production, enabling the synthesis of a new library of unique poly(meth)acrylates under mild conditions.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Polymer Science
Alexander Schweigerdt, Daniel D. Stoebener, Andreas Schaefer, Selin Kara, Marie Weinhart
Summary: In this study, the thermoresponsive properties of two novel glycerol ether-based poly(meth)acrylates with beta-hydroxy-functional side chains were comprehensively investigated. The phase transition behavior and its dependence on intrinsic and extrinsic factors were analyzed in detail. The results provide a basis for the rational design of polymers with adjustable hydration and demonstrate the potential of these polymers as postfunctionalizable thermoresponsive polymer platforms.
Article
Polymer Science
Jing Wang, Jiaqi Si, Junwei Zhu, Yiqing Nie, Yan Lu, Yongming Chen
Summary: A series of crystalline-coil block copolymers with different block ratios were synthesized to explore the impact of polymer compositions on self-assembly morphologies. The copolymers were found to self-assemble into various morphologies including lozenges, quadrilaterals, elongated hexagons, hexagonal platelets, saw blade platelets, and spindle micelles. Adjusting block ratios of the copolymers is a facile way to construct diverse morphologies of polymer materials.
Article
Polymer Science
Tomohiro Shirai, Hiroki Fukumoto, Yasunori Kanno, Toshio Kubota, Tomohiro Agou
Summary: Novel polyacrylates with vinylene-bridged fluoroalkyl side chains were successfully synthesized to prevent the formation of bioaccumulative polyfluorinated compounds. These polymers exhibited excellent surface properties, making them promising alternatives to conventional analogues.
Article
Polymer Science
Piotr Cieciorski, Pawel W. Majewski, Elzbieta Megiel
Summary: A series of photoresponsive poly(meth)acrylates containing azobenzene groups were synthesized, showing reversible structural transformation under light illumination and high potential for energy storage applications. The enthalpy determined from DSC was relatively high, indicating liquid-crystalline behavior of the materials.
Article
Polymer Science
Zonghao Hong, Lukun Feng, Hiroshi Watanabe, Quan Chen, Hongxia Guo
Summary: The dynamic asymmetry between polyisoprene (PI3) and poly(4-tert-butyl)styrene (PtBS27) in a blend significantly affects its viscoelastic and dielectric properties. At low temperatures, PI3 showed a broad dielectric loss peak with a terminal relaxation frequency close to PtBS27, but this peak narrowed at higher temperatures. Molecular dynamics simulations confirmed the importance of dynamic concentration heterogeneity in PtBS27 for the relaxation of PI3.
Article
Polymer Science
Liuyong Zhu, Jingqing Li, Hongfei Li, Binyuan Liu, Jizhong Chen, Shichun Jiang
Summary: The topology of polymer chains, including entanglement loops, tie molecules, and end groups, plays a crucial role in polymer crystallization. In this study, low molecular weight poly(epsilon-caprolactone)s (PCL) with different end groups (phenyl, naphthyl, and anthracenyl) were synthesized to avoid entanglement. The crystallization behavior of these PCLs was investigated using various techniques, and the rheology property of the PCL melts was characterized. The results showed that the size of the end groups inversely influenced the spherulite growth rate and crystallization half-time, with the largest end group leading to the slowest growth rate and longest half-time. However, the effect of naphthyl and phenyl on the crystallization rate was similar. Rheology results revealed that naphthyl modified PCL had lower viscosity due to its compatibility with PCL. Interestingly, regardless of the end groups, the spherulite growth rate and crystallization half-time showed the same behavior when plotted against supercooling, suggesting that the conformation changes during crystallization were consistent for polymer chains with different end groups. Moreover, simultaneous SAXS/WAXS investigations on the heating samples with different end groups after isothermal crystallization showed doubled lamellar thickness during melting, possibly indicating a transition from folded chains to extended chains in the dynamic favored metastable structures.
Article
Pharmacology & Pharmacy
Meenal Agrawal, Anilkumar Yadav, Sonam Takkar, Ritu Kulshreshtha, Bhanu Nandan, Rajiv K. Srivastava
Summary: Nanocomposite poly (e-caprolactone) scaffolds were fabricated using modified silica nanoparticles as stabilizers. The concentration of nanoparticles and the size of dispersed phase particles were controlled to achieve tunable properties of the scaffolds. Clove oil was used to functionalize the scaffolds, improving their antibacterial effectiveness and inhibiting biofilm formation.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Polymer Science
Congkai Ma, Ting Han, Spyridon Efstathiou, Arkadios Marathianos, Hannes A. Houck, David M. Haddleton
Summary: A visible-light-regulated polymerization protocol was reported for the preparation of high-quality polymers with promising photopatterning capabilities. The method allows for the synthesis of complex copolymers and can be easily adapted for flow setups.
Article
Polymer Science
Paulina Bednarczyk, Karolina Mozelewska, Joanna Klebeko, Joanna Rokicka, Paula Ossowicz-Rupniewska
Summary: A series of UV-curable urethane (meth)acrylates with different (meth)acrylic groups were synthesized and their influence on UV-curing process and self-healing properties of cured coatings was studied. The chemical structure of prepolymers was characterized by FTIR and NMR spectroscopy, and the UV-curing process was monitored in real time using FTIR and photo-DSC. The self-healing properties were characterized using various methods. The results show that the self-healing of the coatings can be controlled by reducing the effective healing temperature, making the material attractive for a variety of applications.
Article
Polymer Science
Ying-Ying Li, Dong Xing, Xiang-Qiang Pan, Jian Zhu
Summary: A selenium-functionalized epsilon-caprolactone polymer was synthesized by introducing a phenyl selenide group, leading to controlled molecular weight and antibacterial properties. The polymerization process was achieved under mild conditions, resulting in copolymers with varying thermal degradation and glass transition temperatures. The modification of the phenyl selenide side group to a polyselenonium salt enhanced the antibacterial properties of the polymer, with a significant reduction in survival rate of E. coli and S. aureus.
CHINESE JOURNAL OF POLYMER SCIENCE
(2022)
Article
Multidisciplinary Sciences
Karolina Ptaszynska, Anna Malaika, Magdalena Kapska, Mieczyslaw Kozlowski
Summary: High quality carbon fibers (CFs) were produced from hydrocarbons using the catalytic chemical vapor deposition method (CCVD) with Ni catalyst. The CFs were functionalized with acidic groups using concentrated sulfuric acid or 4-benzenediazonium sulfonate (BDS). The BDS-modified CFs showed high glycerol conversions and substantial yields of mono- and di-glycerol ethers in the glycerol etherification reaction.
SCIENTIFIC REPORTS
(2023)
Article
Chemistry, Organic
Denisa Hidasova, Tomas Slanina
Summary: We present a mild OtBu deprotection catalytic protocol using two commercial reagents: magic blue (MB center dot+), also known as tris-4-bromophenylamminium radical cation, and triethylsilane. Magic blue catalytically facilitates the cleavage of the C-O bond in tert-butyl carbamates, carbonates, esters, and ethers, achieving a high isolated yield of up to 95%, while sacrificial triethylsilane accelerates the reaction. This method is suitable for an array of structurally diverse compounds without the need for high temperatures, transition metals, or strong acidic or basic catalysts.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Polymer Science
Monika Flejszar, Kinga Slusarczyk, Agata Hochol, Pawel Chmielarz, Kaja Spilarewicz, Pawel Bloniarz
Summary: This paper presents the possibility of synthesizing immiscible with water, well-defined poly(meth)acrylates using supplemental activation and reducing agent atom transfer radical polymerization (SARA ATRP) in a mini-emulsion environment with a copper wire (Cu0) as the reducing agent and supplemental activator. This study introduces interfacial and ion-pair catalysis in Cu0-mediated ATRP carried out in heterogeneous media for the first time. SEM and DLS were employed for further analysis and characterization of the occurring processes and mini-emulsion droplets. The selection of optimum reaction conditions and the applicability of the developed system for a wide range of monomers were emphasized. Moreover, the advantages of this polymerization technique in the context of sustainable development of the chemical industry were highlighted by calculating the green metrics (E-factors) for the synthesized polymers.
EUROPEAN POLYMER JOURNAL
(2023)
Article
Pharmacology & Pharmacy
Anna Mielanczyk, Katarzyna Mrowiec, Maria Kupczak, Lukasz Mielanczykc, Dorota Scieglinska, Agnieszka Gogler-Piglowska, Marek Michalski, Andrzej Gabriel, Dorota Neugebauer, Magdalena Skonieczna
EUROPEAN JOURNAL OF PHARMACOLOGY
(2020)
Article
Polymer Science
Aleksander Sinek, Maria Kupczak, Anna Mielanczyk, Marcin Lemanowicz, Shin-ichi Yusa, Dorota Neugebauer, Andrzej Gierczycki
Article
Polymer Science
Justyna Odrobinska, Lukasz Mielanczyk, Dorota Neugebauer
Article
Biochemistry & Molecular Biology
Katarzyna Niesyto, Dorota Neugebauer
Summary: Drug nanocarriers were designed using copolymers with cholinium-based ionic liquid units, and pharmaceutical anions were introduced through ionic exchange reactions. The resulting polymer-drug ionic conjugates showed potential medical applications, with slightly reduced hydrophilicity observed in the drug conjugates.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Justyna Odrobinska, Magdalena Skonieczna, Dorota Neugebauer
Summary: Amphiphilic copolymers containing PDMS and MPEG were synthesized via azide-alkyne cycloaddition reaction, showing efficient encapsulation of active substances and controlled release in vitro.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Physical
Maria Kupczak, Anna Mielanczyk, Dorota Neugebauer
Summary: This study reported the synthesis, physicochemical characterization, and enzymatic degradation of amphiphilic miktoarm star-shaped polymers. Star-shaped macroinitiators were synthesized, followed by the synthesis of polyesters using ring opening polymerization. Enzymatic degradation studies were conducted using a lipase, showing that polymers with lower molecular weight degraded faster. Amphiphilic miktopolymers have potential applications as biomaterials for drug-delivery systems.
Article
Biochemistry & Molecular Biology
Katarzyna Niesyto, Wiktoria Lyzniak, Magdalena Skonieczna, Dorota Neugebauer
Summary: In this study, the cytotoxicity of polymer carriers and drug conjugates on bronchial epithelial cells and cancer cells was evaluated, showing that the polymer systems have a supportive effect on normal cells and a cytostatic effect on cancer cells, which can be regulated by the polymer structure.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Physical
Maria Kupczak, Anna Mielanczyk, Dorota Neugebauer
Summary: Well-defined, semi-degradable polyester/polymethacrylate block copolymers were synthesized based on various monomers by ROP and ATRP. Comprehensive degradation studies indicated that the presence of PDMAEMA component increased hydrolysis rates, and enzymatic degradation primarily involved ester bonds in PDMAEMA side chains. Amphiphilic copolymers may have potential applications in nanoscale drug delivery systems with tunable degradation kinetics.
Article
Chemistry, Physical
Katarzyna Niesyto, Aleksy Mazur, Dorota Neugebauer
Summary: Graft copolymers based on a choline ionic liquid were synthesized and exhibited excellent drug carrier properties. These systems showed advantages in drug encapsulation and could be used for co-delivery of two drugs for combined therapy.
Article
Chemistry, Physical
Rafal Bielas, Justyna Wrobel-Marek, Ewa U. Kurczynska, Dorota Neugebauer
Summary: A rhodamine B (RhB)-based initiator was synthesized and applied for preparation of PChMA, PHEMA, and PHEMATMS. The fluorescence of the polymers was confirmed by quantum yield determination, and it was found that the emission intensity depended on the polymer chain hydrophilicity and solvent type. The RhB-functionalized polymers were tested in plant materials and showed different cellular localizations.
Article
Biochemistry & Molecular Biology
Aleksy Mazur, Katarzyna Niesyto, Dorota Neugebauer
Summary: In this study, polymerizable choline-based ionic liquid was functionalized with pharmaceutical anions to prepare drug delivery systems. The in vitro drug release was observed and low cytotoxicity was found for normal cell lines.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Physical
Marcin Lemanowicz, Justyna Chrzanowska, Milena Kotek, Anna Mielanczyk, Maria Kupczak, Daria Niewolik, Anna Korytkowska-Walach, Olesya Klymenko, Alicja Kocur, Dorota Neugebauer
Summary: This study proposed a new method using stimuli-responsive star polymer for crystallization to obtain hollow crystals. The importance of the polymer's phase transition occurrence in the crystal growth process was demonstrated and monitored through absorbance readings and nucleation energetic effects analysis. It was suggested that hydrophobic particles created from polymeric aggregates served as templates for hollow crystal formation.
Article
Engineering, Biomedical
Katarzyna Niesyto, Magdalena Skonieczna, Malgorzata Adamiec-Organisciok, Dorota Neugebauer
Summary: The cytotoxicity of a linear copolymer (LC) containing choline ionic liquid units and its conjugates with antibacterial drugs (p-aminosalicylate, clavulanate, or piperacillin) was evaluated in vitro. The systems were tested against normal and cancer cell lines, and the viability of cells was measured after 72 hours of exposure. The results showed higher cytotoxicity in cancer cell lines compared to normal cells, as well as pro-inflammatory activity towards cancer cells.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2023)
Article
Pharmacology & Pharmacy
Shadi Keihankhadiv, Dorota Neugebauer
Summary: Bioactive linear poly(ionic liquid)s (PIL) were designed as carriers in drug delivery systems (DDS). Their synthesis was based on a monomeric ionic liquid (MIL) with a relevant pharmaceutical anion to create therapeutically functionalized monomers, which further can be used in the controlled atom transfer radical polymerization (ATRP). The resulting copolymers showed efficient exchange of pharmaceutical anions, indicating their potential as drug delivery carriers.
Article
Polymer Science
Anna Mielanczyk, Maria Kupczak, Olesya Klymenko, Lukasz Mielanczyk, Sebastian Arabasz, Krystian Madej, Dorota Neugebauer
Summary: Well-defined miktoarm star-shaped polymers and linear block copolymers have been successfully synthesized based on a heterofunctional glucose derivative initiator, N,N'-dimethylaminoethyl methacrylate (DMAEMA), using a combination of atom transfer radical polymerization (ATRP) and ring-opening polymerization (ROP) techniques followed by click reactions. The presence of salts in polymer solutions affects the phase transformation and aggregate sizes, with the critical aggregation concentration (CAC) decreasing with decreasing DMAEMA unit content. TEM and AFM analysis reveal the microstructure changes in samples with different compositions of polyester arms.
