Review
Biotechnology & Applied Microbiology
Earnest P. Chen, Zeren Toksoy, Bruce A. Davis, John P. Geibel
Summary: The aim of tissue engineering with 3D bioprinting is to construct fully functional tissue and organ replacements for clinical applications. One of the main challenges is maintaining tissue viability through the inclusion of complex vascular networks. Recent advancements have made great strides in incorporating vascular networks in 3D printed tissue and organs, offering new possibilities for creating biologically functional tissues and organs.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Engineering, Manufacturing
Frederik Wulle, Oliver Gorke, Sarah Schmidt, Maximilian Nistler, Gunter E. Tover, Oliver Riedel, Alexanser Verl, Achim Weber, Alexanser Southan
Summary: This paper introduces the potential and advantages of multi-axis 3D printing of hydrogels, and demonstrates through experiments the relative flexibility and water absorbency of 3D printed hydrogels compared to conventional molded hydrogels. The research also highlights related research questions, such as cross-linking chemistry and formulation of hydrogel inks.
ADDITIVE MANUFACTURING
(2022)
Review
Engineering, Environmental
Arkodip Mandal, Kaushik Chatterjee
Summary: 4D bioprinting using water as a stimulus shows great potential in tissue engineering by addressing the challenges of smart hydrogels and cytocompatible stimuli.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Gabriel Grossbacher, Michael Bartolf-Kopp, Csaba Gergely, Paulina Nunez Bernal, Sammy Florczak, Mylene de Ruijter, Nuria Gines Rodriguez, Juergen Groll, Jos Malda, Tomasz Jungst, Riccardo Levato
Summary: The major challenge in biofabrication is capturing the complex composition of native tissues. Current 3D printing techniques have limited capacity to produce composite biomaterials. Volumetric bioprinting, a light-based technique, allows for the fabrication of 3D structures with enhanced design freedom, but the prints have low mechanical stability.
ADVANCED MATERIALS
(2023)
Article
Automation & Control Systems
Sagil James, Samir Mulgaonkar
Summary: Three-dimensional bioprinting is a promising field in medical science that has enormous potential for manufacturing operative tissue structures. The quality of bioprinting results depends heavily on printing parameters and the selection of biomaterials that closely match the target structure. This study aims to determine and optimize printing parameters for hybrid bio-inks, with a focus on the composition of hydrogels. The results indicate that parameters such as air pressure, nozzle speed and diameter, and hydrogel composition significantly affect printing quality. The study also provides a systematic framework to assess the properties of amino acids and derivatives, which can be applicable to other areas of 3D bioprinting. The findings of this study are crucial for establishing 3D bioprinting as a comprehensive manufacturing solution for biopharmaceutical industries.
INTERNATIONAL JOURNAL OF ADVANCED MANUFACTURING TECHNOLOGY
(2022)
Article
Engineering, Biomedical
Cyrus W. Beh, Dionis S. Yew, Ruth J. Chai, Sau Yin Chin, Yiqi Seow, Shawn S. Hoon
Summary: The study introduces a hydrogel 3D printer that can print complex structures quickly and continuously, and is capable of multi-material printing. This innovative approach helps address the nutrient supply issue in bioprinting.
Review
Engineering, Biomedical
Guy Decante, Joao B. Costa, Joana Silva-Correia, Maurice N. Collins, Rui L. Reis, J. Miguel Oliveira
Summary: Three-dimensional (3D) bioprinting technology has gained significant attention in biomedical engineering and clinical applications, with advancements in bioink development allowing for more precise mimicry of native tissue characteristics and support for biofunctionality.
Article
Materials Science, Multidisciplinary
Boris Chichkov
Summary: This paper presents a personal view on the potential development and applications of laser printing technologies based on laser-induced forward transfer of inorganic and biological materials, including micro- and nanoparticles, living cells, and microorganisms.
APPLIED PHYSICS A-MATERIALS SCIENCE & PROCESSING
(2022)
Article
Engineering, Biomedical
Erik Brodin, Melanie Boehmer, Alexandra Prentice, Emily Neff, Kathleen McCoy, Jens Mueller, Justin Saul, Jessica L. Sparks
Summary: Keratins, derived from sources such as human hair, offer desirable characteristics for tissue engineering scaffolds. This study aimed to leverage the rheological properties of keratin hydrogels to develop a strategy for 3D printing keratin bio-inks without the need for exogenous modifiers. By varying the keratose/kerateine ratio and total keratin weight percentage, the rheological properties of keratin hydrogels were tuned. The study found that adjusting these parameters influenced the flow resistance and degradation kinetics of the gels, allowing for enhanced printability and control of scaffold properties.
BIOMEDICAL MATERIALS
(2022)
Review
Engineering, Multidisciplinary
Zizhuo Zheng, David Eglin, Mauro Alini, Geoff R. Richards, Ling Qin, Yuxiao Lai
Summary: Three-dimensional (3D) bioprinting is an emerging technology that assembles biocompatible materials and cells to create tissue engineering solutions. Photopolymerized materials play a crucial role in the success of 3D bioprinting. Visible light is considered more biocompatible than UV light for bioprinting applications.
Review
Materials Science, Multidisciplinary
Yahya Bozkurt, Elif Karayel
Summary: 3D printing technology, a miracle manufacturing method widely used in the medical field in recent years, is applied in surgery, pharmaceutical industry, disease modeling, development of customized implants and prostheses, organ printing, vet medicine, and tissue engineering applications.
JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T
(2021)
Review
Polymer Science
Alireza Ghofrani, Lozaalsadat Taghavi, Bahareh Khalilivavdareh, Anahita Rohani Shirvan, Alireza Nouri
Summary: Cardiac patches made of polymer scaffolds and heart muscle cells have the potential to repair damaged heart tissue and improve its function. Traditional methods have limitations in controlling the structure and reproducibility of the patches, while 3D bioprinting technology allows for flexible design and precise placement based on individual patient needs. Recent research has focused on enhancing various functionalities of cardiac patches and addressing the challenge of adhesion to heart tissue.
EUROPEAN POLYMER JOURNAL
(2022)
Article
Engineering, Industrial
Mostafa Moussa, Hoda ElMaraghy
Summary: Industry 4.0 promotes the utilization of new technologies such as additive manufacturing to address manufacturing challenges. The integration of additive and subtractive manufacturing technologies, as well as the use of product platforms, can improve manufacturing efficiency and customization. A genetic algorithm-based model is developed to determine optimal multiple platforms for cost-effective manufacturing of product families.
JOURNAL OF MANUFACTURING SYSTEMS
(2021)
Review
Food Science & Technology
Rahul Soni, K. Ponappa, Puneet Tandon
Summary: This paper reviews the development of food 3D printing technologies, from theoretical models to commercialized printers. It explores the mechanisms and materials used in food 3D printing, as well as the role of different food constituents and additives. The study introduces food-layered manufacturing (FLM) as a combination of digital gastronomy and additive manufacturing technology. Despite challenges and limitations, FLM offers opportunities for customized nutrition and food waste reduction.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
Review
Engineering, Biomedical
Reza Noroozi, Zia Ullah Arif, Hadi Taghvaei, Muhammad Yasir Khalid, Hossein Sahbafar, Amin Hadi, Ali Sadeghianmaryan, Xiongbiao Chen
Summary: Bioprinting is a revolutionary technology in additive manufacturing that prints 3D cell-laden constructs for various clinical applications. It uses biomaterials and cells to regenerate tissues like heart, bone, cornea, cartilage, nerve, and skin, and also contributes to drug delivery, wound healing, bio-actuators, bio-robotics, and bio-sensors. The development of 4D bioprinting and stimuli-responsive materials has further enhanced its potential and led to a billion-dollar market. This study reviews the concepts, applications, and future research topics of 3D and 4D bioprinting, emphasizing the need for collaboration among clinicians, engineers, scientists, and regulatory bodies to translate this technology into biomedical systems.
ANNALS OF BIOMEDICAL ENGINEERING
(2023)
Article
Cell & Tissue Engineering
Mohamed Abou-El-Enein, Gerhard Bauer, Nicholas Medcalf, Hans-Dieter Volk, Petra Reinke
Article
Automation & Control Systems
Andrew Gleadall, Nikola Vladov, Joel Segal, Svetan Ratchev, Matthias Plasch, Daniel Kimmig, Markus Dickerhof
INTERNATIONAL JOURNAL OF ADVANCED MANUFACTURING TECHNOLOGY
(2016)
Article
Materials Science, Multidisciplinary
Fernando Barrera Betanzos, Miquel Gimeno-Fabra, Joel Segal, David Grant, Ifty Ahmed
MATERIALS & DESIGN
(2016)
Review
Biotechnology & Applied Microbiology
Richard P. Harrison, Steven Ruck, Qasim A. Rafiq, Nicholas Medcalf
BIOTECHNOLOGY ADVANCES
(2018)
Article
Medicine, Research & Experimental
Francesca Citossi, Thomas Smith, Jong Bong Lee, Joel Segal, Pavel Gershkovich, Michael J. Stocks, Tracey D. Bradshaw, Barrie Kellam, Maria Marlow
MOLECULAR PHARMACEUTICS
(2018)
Article
Engineering, Biomedical
D. O. Visscher, A. Gleadall, J. K. Buskermolen, F. Burla, J. Segal, G. H. Koenderink, M. N. Helder, P. P. M. van Zuijlen
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2019)
Editorial Material
Engineering, Industrial
Dharm Kapletia, Wendy Phillips, Nick Medcalf, Harris Makatsoris, Chris McMahon, Nick Rich
PRODUCTION PLANNING & CONTROL
(2019)
Review
Pharmacology & Pharmacy
Akmal H. Sabri, Jane Ogilvie, Khuriah Abdulhamid, Volha Shpadaruk, John McKenna, Joel Segal, David J. Scurr, Maria Marlow
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2019)
Article
Cell & Tissue Engineering
Nicholas Medcalf
Summary: This paper suggests considering the impact of institutional unreadiness on the cost of clinical adoption of advanced therapies, and recommends using business process engineering and activity-based cost analysis to quantify these costs. The relationship between regenerative medicine innovators and clinics is evolving, with Advanced Therapy Treatment Centres in the UK as an example. The various agents in the value chain are becoming collaborators in a shared innovation process.
REGENERATIVE MEDICINE
(2021)
Article
Engineering, Industrial
Peter H. Smith, James W. Murray, Alex Jackson-Crisp, Joel Segal, Adam T. Clare
Summary: Laser directed energy deposition is useful for aerospace component manufacture and repair, but its application for fine features is limited. This study demonstrated the use of a solenoid to manipulate track dimensions and powder behavior, leading to a 25% material efficiency improvement and examination of critical parameters.
JOURNAL OF MATERIALS PROCESSING TECHNOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Sandhya Moise, Luigi Dolcetti, Francesco Dazzi, Paul Roach, Lee Buttery, Sheila MacNeil, Nick Medcalf
Summary: This study evaluated the immunosuppressive effect of alginate-encapsulated MSCs on proliferating mouse splenocytes. The results showed that MSCs significantly suppressed splenocyte proliferation via both direct and indirect mechanisms. Additionally, the study demonstrated for the first time that MSCs can sustain immunosuppressive activity when physically isolated from splenocytes.
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
(2022)
Article
Engineering, Biomedical
F. A. A. Ruiter, C. Alexander, F. R. A. J. Rose, J. I. Segal
BIOMEDICAL MATERIALS
(2017)
Review
Cell & Tissue Engineering
Richard P. Harrison, Steven Ruck, Nicholas Medcalf, Qasim A. Rafiq
Article
Chemistry, Physical
Bryan W. Stuart, Miquel Gimeno-Fabra, Joel Segal, Ifty Ahmed, David M. Grant
APPLIED SURFACE SCIENCE
(2017)
Article
Engineering, Manufacturing
Andrew Gleadall, Ian Ashcroft, Joel Segal
ADDITIVE MANUFACTURING
(2018)