Review
Biochemistry & Molecular Biology
Yunwei Niu, Jiahe Wu, Yanxiang Kang, Pingli Sun, Zuobing Xiao, Di Zhao
Summary: Magnetic chitosan hydrogels are a type of organic-inorganic composite material that combines the characteristics of magnetic materials and natural polysaccharides. These hydrogels, which are made by adding magnetic nanoparticles to chitosan, have improved mechanical strength and exhibit magnetic thermal effects, targeting capabilities, magnetically-sensitive release characteristics, and easy separation and recovery. They have been used in various applications including drug delivery, magnetic resonance imaging, mag-netothermal therapy, and adsorption of heavy metals and dyes.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Haofeng Qiu, Junjie Deng, Rufang Wei, Xiang Wu, Shengjia Chen, Yanyu Yang, Chenyang Gong, Lingling Cui, Zhangyong Si, Yabin Zhu, Rong Wang, Dangsheng Xiong
Summary: Dually cross-linked hydrogels made of oxidized hyaluronic acid and HTCC methacrylate showed appropriate rheological properties, self-healing capability, and exhibited superior lubrication and tissue adhesion properties. The hydrogels also demonstrated good antibacterial ability, cell proliferation promotion, and robust regenerating ability for articular cartilage both in vitro and in vivo. This lubricant-adhesive hydrogel holds promise for joint injury treatment and regeneration.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Multidisciplinary Sciences
Wenjun Feng, Zhengke Wang
Summary: Chitosan (CS) and graphene oxide (GO) nanocomposites have great potential in biomedical applications. Nanocomposites based on CS and GO, with the synergistic effect between them, can be used in various forms for drug delivery, wound healing, bone tissue engineering, and biosensors.
Review
Biochemistry & Molecular Biology
Sara La Manna, Concetta Di Natale, Valentina Onesto, Daniela Marasco
Summary: Self-assembling peptides are a novel class of agents with versatile applications in the biomedical field. They exhibit biocompatibility and molecular recognition capabilities, making them suitable for drug delivery and tissue engineering purposes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Pharmacology & Pharmacy
Nimeet Desai, Dhwani Rana, Sagar Salave, Raghav Gupta, Pranav Patel, Bharathi Karunakaran, Amit Sharma, Jyotsnendu Giri, Derajram Benival, Nagavendra Kommineni
Summary: Chitosan, derived from chitin, is a promising material for drug delivery and biomedical applications. Different extraction techniques can produce chitosan with unique properties, which can be further modified to enhance bioactivities. Chitosan-based drug delivery systems have been developed for various administration routes, allowing for targeted and sustained release of drugs. It has also been used in biomedical applications such as tissue regeneration and gene delivery. Modified chitosan derivatives offer innovative materials with potential in biomedical applications. This article summarizes recent findings on chitosan and its applications in drug delivery and biomedical science.
Review
Biochemical Research Methods
Neeraj Kulkarni, Suchita Dattatray Shinde, Govinda Shivaji Jadhav, Diksha Ramesh Adsare, Kamya Rao, Mihir Kachhia, Mohit Maingle, Shubham Prakash Patil, Neha Arya, Bichismita Sahu
Summary: Peptides and chitosan are important biomolecules with potential for a wide range of biomedical applications. Hybridizing peptides and chitosan into new biomaterials can enhance their biosignaling properties and cell adhesion properties for use in drug delivery, tissue engineering, and other fields.
BIOCONJUGATE CHEMISTRY
(2021)
Article
Biotechnology & Applied Microbiology
Sandra Escalante, Gustavo Rico, Jose Becerra, Julio San Roman, Blanca Vazquez-Lasa, Maria Rosa Aguilar, Ivan Duran, Luis Garcia-Fernandez
Summary: Articular cartilage is an important avascular tissue that provides support, shock absorption, and facilitates joint motion. Current surgical treatments for cartilage damage have limitations in restoring fully functional cartilage. This study presents the development of hydrogels based on hyaluronic acid and chitosan loaded with chondroitin sulfate, which have the potential to improve the microfracture procedure and promote the colonization of articular cartilage by chondrocytes. These hydrogels act as delivery systems for chondroitin sulfate and have mucoadhesive properties, making them promising for next-generation therapies against articular cartilage damage.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Materials Science, Biomaterials
Yi Ou, Meng Tian
Summary: Chitosan, a natural polycationic polysaccharide, plays a vital role in the formation of self-healing hydrogels with multiple functionalities. The self-healing mechanisms involve various physical and chemical interactions, providing strategies for multifunctionalization. Additionally, chitosan-based self-healing hydrogels find wide applications in wound dressings, delivery vehicles, scaffolds, and biological sensors.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
Article
Materials Science, Characterization & Testing
Katarzyna Nawrotek, Jacek Grams, Robert Sobczyk, Monika Kubicka, Beata Czeladzinska, Piotr Jozwiak
Summary: Chitosan-hydroxyapatite tubular-shaped hydrogel structures have been obtained by electrophoretic deposition, showing great potential in peripheral nerve tissue engineering. The formation mechanism involves protonation of chitosan ions and their attraction to H2PO4- groups on hydroxy-apatite particles in an acidic environment, resulting in the deposition of an insoluble chitosan-hydroxyapatite-calcium carbonate deposit on the cathode surface. This understanding can provide insights for modeling desired deposit properties on an industrial scale.
Article
Multidisciplinary Sciences
Jiawei Li, Huiming Jiang, Zhongyang Lv, Ziying Sun, Chaoqun Cheng, Guihua Tan, Maochun Wang, Anlong Liu, Heng Sun, Hu Guo, Fufei Chen, Zizheng Liu, Yuxiang Fei, Yuan Liu, Rui Wu, Xingquan Xu, Wenjin Yan, Qing Jiang, Dongquan Shi
Summary: This study proposed a new strategy for cartilage regeneration by hyalinizing fibrocartilage through stabilizing the cytoskeleton. The use of docetaxel was found to inhibit cartilage fibrosis and promote the regeneration of hyaline cartilage.
Article
Biochemistry & Molecular Biology
Jon Andrade del Olmo, Leyre Perez-Alvarez, Virginia Saez Martinez, Sandra Benito Cid, Leire Ruiz-Rubio, Raul Perez Gonzalez, Jose Luis Vilas-Vilela, Jose Maria Alonso
Summary: In the biomedical community, there has been a focus on developing antibacterial coatings to prevent implant-associated infections. Traditional mono-functional antibacterial strategies have not been sufficient for long-term success. Researchers have recently turned their attention to novel bifunctional or multifunctional antibacterial coatings that combine multiple antibacterial mechanisms. In this study, chitosan-based hydrogel coatings with genipin and polyethylene glycol crosslinking agents were created on a Ti6Al4V surface. These hydrogel coatings demonstrated excellent biocompatibility, as well as the ability to promote cell proliferation and differentiation. Additionally, they showed outstanding bacteria-repelling and contact killing ability. The controlled release of drugs could further enhance their multifunctional antibacterial properties.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Engineering, Biomedical
Chanmi Cho, Hyeryeon Oh, Jin Sil Lee, Li-Jung Kang, Eun-Jeong Oh, Yiseul Hwang, Seok Jung Kim, Yong-Soo Bae, Eun-Jeong Kim, Ho Chul Kang, Won Il Choi, Siyoung Yang
Summary: This study describes the efficacy and mechanisms of action of Prussian blue nanozymes coated with Pluronic (PPBzymes) as a new therapy for osteoarthritis. PPBzymes are stable, promote cartilage generation, and reduce cartilage degradation. Intra-articular injections of PPBzymes in mice show long-term stability, effective uptake, and attenuated cartilage degradation without cytotoxic effects. Furthermore, PPBzymes specifically block JNK phosphorylation, suggesting their potential as a biocompatible nanotherapeutic for inflammatory osteoarthritis.
Article
Nanoscience & Nanotechnology
Chengqi Lyu, Chi Cheng, YuShi He, Ling Qiu, Zijun He, Derong Zou, Dan Li, Jiayu Lu
Summary: Porous scaffolds are commonly used for cartilage tissue regeneration, but understanding the impact of their hierarchical structure on the regeneration process can be challenging. In this study, a graphene hydrogel with stable and adjustable structure was used as a model scaffold to investigate the effect of porous structure on matrix remodeling and chondrocyte ingrowth. The results showed that the graphene scaffold with an open pore structure accelerated and balanced cartilage remodeling. Furthermore, this enhanced remodeling selectively promoted the expression of collagen type II fibrils, providing new insights into scaffold design for cartilage repair.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Review
Chemistry, Multidisciplinary
Adrija Ghosh, Jonathan Tersur Orasugh, Suprakas Sinha Ray, Dipankar Chattopadhyay
Summary: Efficient and adaptable electrospinning technology can produce porous structures with sizes between the submicrometer and nanometerscales. Combining electrospinning with 3D printing or additive manufacturing provides a flexible technique for digitally controlled shape-morphing fabrication. The integration of configurations allows for complex shapes and patterns on mesostructured, stimulus-responsive fabrics. This review discusses the synergy between 3D printing and electrospinning for advanced applications in biomedicine.
Review
Biochemistry & Molecular Biology
Sourav Mohanto, Soumya Narayana, Khushboo Paresh Merai, Jahanvee Ashok Kumar, Adrija Bhunia, Umme Hani, Adel Al Fatease, B. H. Jaswanth Gowda, Sagnik Nag, Mohammed Gulzar Ahmed, Karthika Paul, Lalitkumar K. Vora
Summary: A gelatin-based hydrogel system is a biocompatible and biodegradable polymer system that responds to stimuli and has solid-like rheology. It can entangle moisture and gradually assemble a hierarchical crosslinked structure, allowing for controlled release of encapsulated payloads and providing mechanical signals to adjacent cells. The use of functional tunable biopolymers in hydrogels has increased their porosity and mechanical ability, enabling higher loading of therapeutic molecules. This review presents gelatin-based hydrogel as a potential biomaterial for various biomedical applications, highlighting its sources, structural characteristics, challenges, and designs for drug delivery.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Nanoscience & Nanotechnology
Eugene Lih, Ki Wan Park, So Young Chun, Hyuncheol Kim, Tae Gyun Kwon, Yoon Ki Joung, Dong Keun Han
ACS APPLIED MATERIALS & INTERFACES
(2016)
Review
Pharmacology & Pharmacy
Mahmoud A. Elnaggar, Ramesh Subbiah, Dong Keun Han, Yoon Ki Joung
EXPERT OPINION ON DRUG DELIVERY
(2017)
Article
Polymer Science
Youngjin Cho, Si Yoong Seo, Bang Ju Park, Yoon Ki Joung, Dong Keun Han
MACROMOLECULAR RESEARCH
(2017)
Article
Materials Science, Biomaterials
Seong Min Kim, Sung-Bin Park, Tarek M. Bedair, Man-Ho Kim, Bang Ju Park, Yoon Ki Joung, Dong Keun Han
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2017)
Review
Polymer Science
Sung-Bin Park, Eugene Lih, Kwang-Sook Park, Yoon Ki Joung, Dong Keun Han
PROGRESS IN POLYMER SCIENCE
(2017)
Article
Chemistry, Multidisciplinary
Eugene Lih, Chang Hun Kum, Wooram Park, So Young Chun, Youngjin Cho, Yoon Ki Joung, Kwang-Sook Park, Young Joon Hong, Dong June Ahn, Byung-Soo Kim, Tae Gyun Kwon, Myung Ho Jeong, Jeffrey A. Hubbell, Dong Keun Han
Article
Engineering, Biomedical
Kwang-Sook Park, Byoung-Ju Kim, Eugene Lih, Wooram Park, Soo-Hong Lee, Yoon Ki Joung, Dong Keun Han
ACTA BIOMATERIALIA
(2018)
Article
Chemistry, Multidisciplinary
Hye Jung Jang, Sung-Bin Park, Tarek M. Bedair, Min-Kyu Oh, Dong-June Ahn, Wooram Park, Yoon Ki Joung, Dong Keun Han
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
(2018)
Article
Chemistry, Multidisciplinary
Eugene Lih, Wooram Park, Ki Wan Park, So Young Chun, Hyuncheol Kim, Yoon Ki Joung, Tae Gyun Kwon, Jeffrey A. Hubbell, Dong Keun Han
ACS CENTRAL SCIENCE
(2019)
Article
Chemistry, Multidisciplinary
Chungwon Park, Kwang-Sook Park, Mi Jin Jeong, Han Byul Kim, Inho Bae, Kyung Seob Lim, Mei-Xian Li, Young Joon Hong, Dong Keun Han, Yoon Ki Joung
Summary: A universal method of using cell-made extracellular matrices (ECMs) to coat substrates for therapeutic cell delivery is recommended to improve integration of implantable materials with surrounding tissues. ECM-coated substrates show promising results in supporting endothelial regeneration and inhibiting neointimal growth in in vivo experiments, making them more effective than traditional stents.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Chemistry, Physical
Su-Yeon Choi, Mei-Xian Li, Jong Hee Kang, Dae Hyeok Yang, Yoon Ki Joung
Summary: The study synthesized novel SMOs with zwitterion and fluorine for blending with PVC, enhancing anti-thrombotic performance through anti-fouling effect. Results showed successful migration of SMOs to the PVC surface, improving resistivity to adsorption and inhibiting platelet adhesion and activation for enhanced anti-thrombotic effect. The synergistic effect of sulfobetaine and fluorine in SMOs-blended PVCs demonstrated promising potential for anti-thrombotic surface modification in cardiovascular applications.
SURFACES AND INTERFACES
(2021)
Article
Cell & Tissue Engineering
Dong-Heon Ga, Chung-Man Lim, Yoonsun Jang, Tae Il Son, Dong Keun Han, Yoon Ki Joung
Summary: By combining zwitterionic polyurethane additives with metal ions, the hydrophilicity of polyurethanes was significantly improved, leading to enhanced anti-fouling effects. The introduction of metal ions decreased the effectiveness of the additives in protein adsorption tests.
TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2022)
Article
Chemistry, Multidisciplinary
Ju-Ro Lee, Woo-Sup Sim, Hun-Jun Park, Bong-Woo Park, Yoon Ki Joung
Summary: The modulation of inflammatory responses is important in the development of cardiac failure. In this study, apoptotic bodies-mimetic nanovesicles derived from apoptotic fibroblasts were developed as a therapeutic strategy for ischemia-reperfusion (IR)-injured hearts. These nanovesicles actively targeted the ischemic myocardium and polarized macrophages to alleviate inflammation. Injection of the nanovesicles attenuated cardiac remodeling and prevented cardiac function exacerbation in IR-injured hearts.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Review
Engineering, Biomedical
Mei-Xian Li, Qian-Qi Wei, Hui-Lin Mo, Yu Ren, Wei Zhang, Huan-Jun Lu, Yoon Ki Joung
Summary: Arterial occlusive disease is a common cause of cardiovascular diseases that often requires revascularization. However, current synthetic vascular grafts have limitations in small-diameter applications due to infection, thrombosis, and intimal hyperplasia. The development of tissue engineering and regenerative medicine technology has allowed the creation of biological tissue-engineered vascular grafts that can integrate, remodel, and repair host vessels. This paper evaluates advanced fabrication technologies for small-diameter vascular grafts and discusses future perspectives for their clinical application.
BIOMATERIALS RESEARCH
(2023)
Article
Nanoscience & Nanotechnology
Mahmoud Elnaggar, Md Lemon Hasan, Suk Ho Bhang, Yoon Ki Joung
Summary: The study aimed to engineer an endothelium-mimetic surface using lipid bilayers extracted from endothelial cells with embedded organoselenium catalyst for nitric oxide generation. The resulting bilayer demonstrated endothelium-similar properties and selective responses to different cell types. This innovative approach provides valuable insights for the rational design and development of vascular implantable devices and potentially nonvascular biointerfacing devices.
ACS APPLIED BIO MATERIALS
(2021)