期刊
MACROMOLECULAR CHEMISTRY AND PHYSICS
卷 219, 期 18, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/macp.201800266
关键词
gelatin methacrylamide; gelatin methacrylate; gelatin methacryloyl; hydrolysis; structural stability
资金
- Wenzhou Medical University [QTJ17012]
- Wenzhou Institute of Biomaterial and Engineering [WIBEZD2017010-03]
- Competitive Research Programme of the National Research Foundation of Singapore (NRF) [NRF-CRP10-2012-07]
Gelatin methacryloyl (GelMA; GM) is a promising nature-derived photocurable material that can mimic the extracellular matrix because GelMA features tailorable mechanical properties, proteolytic degradation, and good cell adhesion. GelMA contains not only methacrylamide but also methacrylate. However, the hydrolytic stability of methacrylamide and methacrylate groups of GelMA in aqueous solutions has not been scrutinized. Here, the structural change of GelMA through hydrolysis is investigated for the first time. The structural change of hydrolyzed GelMA is quantitatively identified using colorimetric and H-1 NMR methods. The methacrylate groups decompose markedly at high pH solutions, but the methacrylamide groups remain stable. Further, pure gelatin methacrylamide is successfully decoupled from GelMA for a better understanding of GelMA structure and future use for biomedical applications.
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