期刊
MACROMOLECULAR CHEMISTRY AND PHYSICS
卷 211, 期 17, 页码 1857-1867出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/macp.201000206
关键词
coumarin linkers; 5-fluorouracil; photoresponsive polymers; polymeric drug depots
资金
- BMBF
The synthesis of a polymeric, photoresponsive drug-delivery system on the basis of 4-methylcoumarin-side-chain-functionalized methacrylic copolymers with different degrees of functionalization is reported. Drug-release experiments in solution indicated a maximum release of 22 mu g of 5-fluorouracil per 1 mg of polymer. Polymer analogous photochemical drug immobilization does not lead to observable intermolecular cross-linking. Miscibility experiments with PMMA suggest that the bulk polymerization of homogeneous, transparent polymer sheets for intraocular lens fabrication, using MMA as the matrix monomer and incorporating the polymer-drug conjugates as a functional component, is possible.
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