Article
Chemistry, Analytical
Burcu Altiparmak Gulec, Fatma Yurt
Summary: This review discusses the potential of molecular imaging agents labeled with Zr-89 radionuclide for cancer tissue imaging, with a focus on nanoparticles showing greater potential than antibodies for radiopharmaceutical development.
JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
(2021)
Article
Chemistry, Analytical
Elif Tugce Sarcan, Stephen Paisey, Martin Ruthardt, Asuman Yekta Ozer, Christopher Marshall, Neil Hartman
Summary: This study optimized the Zr-89 labelling of Obinutuzumab and validated its binding to CD20(+) cells in an in-vitro model. This is important for the diagnosis and monitoring of CD20(+) tumors.
JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
(2022)
Article
Medicine, Research & Experimental
Ge Yan, Xinyu Wang, Yeli Fan, Jianhan Lin, Junjie Yan, Lizhen Wang, Donghui Pan, Yuping Xu, Min Yang
Summary: This study used immuno-positron emission tomography (PET) imaging to label TNF-alpha and discovered an increased level of TNF-alpha in the inflammatory colon of mice. The results showed a significantly higher uptake rate in the inflammatory colon compared to the control group, suggesting the potential for this method in diagnosing and predicting efficacy in IBD and other autoimmune diseases.
MOLECULAR PHARMACEUTICS
(2022)
Article
Biochemical Research Methods
Sai Kiran Sharma, Jonathan M. Glaser, Kimberly J. Edwards, Elaheh Khozeimeh Sarbisheh, Akam K. Salih, Jason S. Lewis, Eric W. Price
Summary: Synthesizing trastuzumab immunoconjugates with 1-3 DFOs per Ab (T5 and T10) and radiolabeling in low reaction volumes using Chelex treated PBS or HEPEs without a radioprotectant resulted in radioimmunoconjugates with high molar activity/specific activity (97 MBq/nmol; 17.5 +/- 2.2 mCi/mg), preserved immunoreactive fractions (86-93%), and favorable in vivo biodistribution profile with excellent tumor uptake.
BIOCONJUGATE CHEMISTRY
(2021)
Article
Oncology
Iris H. C. Miedema, Jessica E. Wijngaarden, Johanna E. E. Pouw, Gerben J. C. Zwezerijnen, Hylke J. Sebus, Egbert Smit, Adrianus J. de Langen, Idris Bahce, Andrea Thiele, Danielle J. Vugts, Ronald Boellaard, Marc C. Huisman, C. Willemien van der Houven van Oordt
Summary: This study utilized Zr-89 immuno-PET to investigate the uptake of five immune-checkpoint-targeting antibodies, revealing evidence of target engagement for some of the antibodies.
Article
Radiology, Nuclear Medicine & Medical Imaging
Guus A. M. S. van Dongen, Wissam Beaino, Albert D. Windhorst, Gerben J. C. Zwezerijnen, Daniela E. Oprea-Lager, N. Harry Hendrikse, Cornelis van Kuijk, Ronald Boellaard, Marc C. Huisman, Danielle J. Vugts
Summary: The identification of molecular drivers of disease and the rise of biotherapeutics have impacted clinical care, but also presented challenges. The application of Zr-89-immuno-PET in drug development shows promise in guiding the design, development, and application of biologic drugs, with increasing potential for understanding drug-target combinations in clinical studies.
JOURNAL OF NUCLEAR MEDICINE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Iris H. C. Miedema, Marc C. Huisman, Gerben J. C. Zwezerijnen, Rolf Grempler, Alejandro Perez Pitarch, Andrea Thiele, Raphael Hesse, Mabrouk Elgadi, Alexander Peltzer, Danielle J. Vugts, Guus A. M. S. van Dongen, Tanja D. de Gruijl, C. Willemien Menke-van der Houven van Oordt, Idris Bahce
Summary: This study explored the potential use of the anti-LAG-3 antibody tracer [Zr-89]Zr-BI 754111 as a predictive imaging biomarker and investigated its target specific uptake as well as the correlation of its tumor uptake and the tumor immune infiltration. The results showed that [Zr-89]Zr-BI 754111 PET imaging has favorable technical and biological characteristics for developing a potential predictive imaging biomarker for LAG-3-directed therapies.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Pharmacology & Pharmacy
Helen Damerow, Xia Cheng, Valeska von Kiedrowski, Ralf Schirrmacher, Bjoern Waengler, Gert Fricker, Carmen Waengler
Summary: Zr-89 is a highly favorable positron emitter for immuno-PET imaging. Complexation of the Zr-89(4+) ion with desferrioxamine B is commonly used to introduce the ion into antibodies, but the complexes have limited kinetic inertness. Therefore, new chelators, such as DFO* and 3,4,3-(LI-1,2-HOPO), have been developed. Comparisons between these chelators have shown that DFO* is the most suitable candidate for stable Zr-89 labeling of antibodies for clinical translation.
Article
Biology
Kikkie Poels, Maxime Schreurs, Matthijs Jansen, Danielle J. Vugts, Tom T. P. Seijkens, Guus A. M. S. van Dongen, Esther Lutgens, Wissam Beaino
Summary: This study investigates the feasibility of using PET/CT with an anti-CD40 monoclonal antibody to detect plaques in a mouse model of atherosclerosis. The results show that CD40 can be detected using a Zirconium-89 labeled antibody, making it a potential marker for plaque inflammation and vulnerability.
Article
Multidisciplinary Sciences
Jin Won Park, Kyung-Ho Jung, Jin Hee Lee, Seung Hwan Moon, Young Seok Cho, Kyung-Han Lee
Summary: This study utilized an antibody that cross-reacts with both human and mouse CD44 isoforms to demonstrate high-specific binding to colon cancer cells and monocytic cells. The research revealed that high splenic uptake of CD44 was attributable to myeloid cells and that CD44 immuno-PET has the potential to monitor CD44 regulation on splenic myeloid cells and be useful for imaging colon tumors.
SCIENTIFIC REPORTS
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Marc C. Huisman, C. Willemien Menke-van Der Houven Van Oordt, Josee M. Zijlstra, Otto S. Hoekstra, Ronald Boellaard, Guus A. M. S. van Dongen, Dhaval K. Shah, Yvonne W. S. Jauw
Summary: The study investigated the relationship between antibody tumor uptake and target concentration using mathematical modeling of Zr-89-labeled antibody disposition, with trastuzumab kinetics serving as an example. Results showed that Zr-89-trastuzumab uptake initially increases with increasing target concentration before leveling off, influenced by the total administered mass dose of the antibody. The findings suggest the potential of Zr-89-trastuzumab uptake in assessing target expression, while also highlighting the importance of defining clinical target positivity and considering the administered mass dose to avoid false-positive results.
Article
Medicine, Research & Experimental
Thomas E. Wuensche, Natascha Stergiou, Iris Mes, Mariska Verlaan, Maxime Schreurs, Esther J. M. Kooijman, Bart Janssen, Albert D. Windhorst, Allan Jensen, Ayodeji A. Asuni, Benny Bang-Andersen, Wissam Beaino, Guus A. M. S. Dongen, Danielle J. Vugts
Summary: This study demonstrated the effectiveness of 89Zr-immuno-PET in imaging and quantifying amyloid-beta specific brain uptake. The use of the novel chelator DFO* showed superior results compared to DFO.
Article
Immunology
Jin Hee Lee, Kyung-Ho Jung, Mina Kim, Kyung-Han Lee
Summary: This study successfully labeled Zr-89-anti-CD25 IgG to sulfhydryl moieties and verified its specific binding capacity in human T-cell lymphoma. Pharmacokinetic and biodistribution studies confirmed the specific uptake of Zr-89-CD25 IgG in lymphoma tumors. Furthermore, the uptake in non-tumor tissues was minimal and not influenced by circulating soluble CD25 protein.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
Saikat Ghosh, Nicholas L. Fletcher, Pie Huda, Zachary H. Houston, Christopher B. Howard, Maria E. Lund, Yanling Lu, Douglas H. Campbell, Bradley J. Walsh, Kristofer J. Thurecht
Summary: This study developed an antibody-based positron emission tomography (PET) tracer for noninvasive detection of glypican-1 (GPC-1) positive glioblastoma (GBM) tumors. The results show that 89Zr-DFO-Miltuximab is an effective immuno-PET imaging agent for detecting GPC-1positive tumors such as GBM.
MOLECULAR PHARMACEUTICS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jessica E. Wijngaarden, Marc C. Huisman, Yvonne W. S. Jauw, Guus A. M. S. van Dongen, Henri N. J. M. Greuter, Robert C. Schuit, Matthew Cleveland, Elske C. Gootjes, Danielle J. Vugts, C. Willemien Menke-van der Houven van Oordt, Ronald Boellaard
Summary: This study assesses the validity of three commonly used quantification parameters (SUV, TPR, and TBR) in quantifying reversible Zr-89-Immuno-PET uptake. The results showed that SUV, TPR, and TBR are valid quantification parameters for constant mass doses. However, for variable mass doses, only TPR and TBR provide reliable quantification values, while SUV does not consider patient and mass dose-specific plasma clearance.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Oncology
G. Gebhart, L. E. Lamberts, Z. Wimana, C. Garcia, P. Emonts, L. Ameye, S. Stroobants, M. Huizing, P. Aftimos, J. Tol, W. J. G. Oyen, D. J. Vugts, O. S. Hoekstra, C. P. Schroder, C. W. Menke-van der Houven van Oordt, T. Guiot, A. H. Brouwers, A. Awada, E. G. E. de Vries, P. Flamen
ANNALS OF ONCOLOGY
(2016)
Article
Radiology, Nuclear Medicine & Medical Imaging
Kristoff Muylle, Patrick Flamen, Danielle J. Vugts, Thomas Guiot, Ghanem Ghanem, Nathalie Meuleman, Pierre Bourgeois, Bruno Vanderlinden, Guus A. M. S. van Dongen, Hendrik Everaert, Melanie Vaes, Dominique Bron
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2015)
Article
Radiology, Nuclear Medicine & Medical Imaging
Samantha Y. A. Terry, Marije I. Koenders, Gerben M. Franssen, Tapan K. Nayak, Anne Freimoser-Grundschober, Christian Klein, Wim J. Oyen, Otto C. Boerman, Peter Laverman
JOURNAL OF NUCLEAR MEDICINE
(2016)
Article
Radiology, Nuclear Medicine & Medical Imaging
Peter Laverman, Tessa van der Geest, Samantha Y. A. Terry, Danny Gerrits, Birgitte Walgreen, Monique M. Helsen, Tapan K. Nayak, Anne Freimoser-Grundschober, Inja Waldhauer, Ralf J. Hosse, Ekkehard Moessner, Pablo Umana, Christian Klein, Wim J. G. Oyen, Marije I. Koenders, Otto C. Boerman
JOURNAL OF NUCLEAR MEDICINE
(2015)
Article
Oncology
Catharina Willemien Menke-van der Houven van Oordt, Elske C. Gootjes, Marc C. Huisman, Danielle J. Vugts, Chantal Roth, Anne Marije Luik, Emma R. Mulder, Robert C. Schuit, Ronald Boellaard, Otto S. Hoekstra, Guus A. M. S. van Dongen, Henk M. W. Verheul
Article
Cardiac & Cardiovascular Systems
Kang He Zheng, Fleur M. van der Valk, Loek P. Smits, Mara Sandberg, Jean-Louis Dasseux, Rudi Baron, Ronald Barbaras, Constance Keyserling, Bram F. Coolen, Aart J. Nederveen, Hein J. Verberne, Thijs E. Nell, Danielle J. Vugts, Raphael Duivenvoorden, Zahi A. Fayad, Willem J. M. Mulder, Guus A. M. S. van Dongen, Erik S. G. Stroes
Article
Biochemistry & Molecular Biology
Bieneke Janssen, Danielle J. Vugts, Uta Funke, Ger T. Molenaar, Perry S. Kruijer, Bart N. M. van Berckel, Adriaan A. Lammertsma, Albert D. Windhorst
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2016)
Article
Oncology
Lauren C. J. Baker, Jessica K. R. Boult, Markus Thomas, Astrid Koehler, Tapan Nayak, Jean Tessier, Chia-Huey Ooi, Fabian Birzele, Anton Belousov, Magdalena Zajac, Carsten Horn, Clare LeFave, Simon P. Robinson
BRITISH JOURNAL OF CANCER
(2016)
Article
Radiology, Nuclear Medicine & Medical Imaging
Danielle J. Vugts, Chris Klaver, Claudia Sewing, Alex J. Poot, Kevin Adamzek, Seraina Huegli, Cristina Mari, Gerard W. M. Visser, Ibai E. Valverde, Gilles Gasser, Thomas L. Mindt, Guus A. M. S. van Dongen
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2017)
Article
Oncology
Marc H. A. Jansen, Tonny Lagerweij, A. Charlotte P. Sewing, Danielle J. Vugts, Dannis G. van Vuurden, Carla F. M. Molthoff, Viola Caretti, Susanna J. E. Veringa, Naomi Petersen, Angel M. Carcaboso, David P. Noske, W. Peter Vandertop, Pieter Wesseling, Guus A. M. S. van Dongen, Gertjan J. L. Kaspers, Esther Hulleman
MOLECULAR CANCER THERAPEUTICS
(2016)
Article
Medicine, Research & Experimental
Gaurav Malviya, Tapan Nayak, Christian Gerdes, Rudi A. J. O. Dierckx, Alberto Signore, Erik F. J. de Vries
MOLECULAR PHARMACEUTICS
(2016)
Article
Multidisciplinary Sciences
Tapan Kumar Nayak, Srirupa Chakraborty, Wenjun Zheng, Anthony Auerbach
NATURE COMMUNICATIONS
(2016)
Review
Pharmacology & Pharmacy
Yvonne W. S. Jauw, C. Willemien Menke-van der Houven van Oordt, Otto S. Hoekstra, N. Harry Hendrikse, Danielle J. Vugts, Josee M. Zijlstra, Marc C. Huisman, Guus A. M. S. van Dongen
FRONTIERS IN PHARMACOLOGY
(2016)
Article
Radiology, Nuclear Medicine & Medical Imaging
Edwin J. W. Geven, Stefan Evers, Tapan K. Nayak, Mats Bergstroem, Fei Su, Danny Gerrits, Gerben M. Franssen, Otto C. Boerman
CONTRAST MEDIA & MOLECULAR IMAGING
(2015)
Review
Radiology, Nuclear Medicine & Medical Imaging
G. A. M. S. Van Dongen, M. C. Huisman, R. Boellaard, N. Harry Hendrikse, A. D. Windhorst, G. W. M. Visser, C. F. M. Molthoff, D. J. Vugts
QUARTERLY JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2015)