Article
Oncology
H. Winters, H. J. P. Tielemans, S. Hummelink, N. J. Slater, D. J. O. Ulrich
Summary: In this study, it was found that vascularized lymph node transfer in combination with DIEP flap breast reconstruction can significantly improve lymphedema-related quality of life. Even without a decrease in volume difference, it can reduce the usage of compression garments and the need for physiotherapy.
Article
Oncology
Yan-fei Liu, Jun-E Liu, Yi Zhu, Yim Wah Mak, Hui Qiu, Li-hui Liu, Shen-shen Yang, Shao-hua Chen
Summary: BCRL risk factors include factors such as modified radical mastectomy, radiotherapy, chemotherapy, and higher BMI. However, active physical activity behavior of patients appears to be a factor against lymphedema. The nomogram developed in this study incorporating both clinical and lifestyle factors could be useful for predicting lymphedema in breast cancer survivors.
SUPPORTIVE CARE IN CANCER
(2021)
Editorial Material
Oncology
Colby J. Hyland, Oscar J. Manrique, Anna Weiss, Justin M. Broyles
Summary: Complicated and resource-intensive surgeries are being developed and performed to prevent breast cancer-related lymphedema. Identifying risk factors for lymphedema development is crucial in optimizing patient selection for such procedures.
Article
Surgery
Maureen Beederman, Rebecca M. Garza, Shailesh Agarwal, David W. Chang
Summary: The long-term impact of VLNT and LVB surgeries on secondary lymphedema patients was examined in this study. The results showed that most UEL patients and some LEL patients experienced a reduction in affected limb volume after surgery. UEL patients had a more substantial reduction in limb volume differential compared to LEL patients.
Review
Oncology
Maureen P. McEvoy, Ameer Gomberawalla, Mark Smith, Francesco M. Boccardo, Dennis Holmes, Risal Djohan, Paul Thiruchelvam, Suzanne Klimberg, Jill Dietz, Sheldon Feldman
Summary: Breast cancer-related lymphedema affects millions of patients worldwide. Prevention and treatment require a multidisciplinary team, emphasizing early detection and awareness of risk factors to reduce the progression of lymphedema. Treatment can be costly, time-consuming, and not always effective, therefore prevention is the ultimate goal.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Anna R. Vang, Simona F. Shaitelman, John C. Rasmussen, Wenyaw Chan, Eva M. Sevick-Muraca, Melissa B. Aldrich
Summary: Breast cancer-related lymphedema (BCRL) occurs in approximately 40% of patients after axillary lymph node dissection (ALND), radiation therapy (RT), or chemotherapy. First-line palliative treatment involves the use of compression garments and specialized massage. Reparative microsurgeries are a second-line treatment, but both compression and surgical therapy are most effective in the early stages of LE development. Identifying patients at the highest risk for BCRL would allow for earlier and more effective treatment.
Article
Health Care Sciences & Services
Gabriela Duran-Aguilar, Alberto Rossa-Sierra, Rita Q. Fuentes-Aguilar
Summary: Breast cancer is a common malignant tumor in the United States, Europe, and Mexico, and its treatment can lead to secondary lymphedema. This complication has significant impacts on the health, social, and economic aspects, and physical therapy is important for improving the quality of life in survivors. The design of a lymphatic vessel is proposed as a solution to assist the mechanical failure of the damaged lymphatic system.
Article
Multidisciplinary Sciences
Bin Wang, Zhenxing Chen, Ru Zhao, Li Zhang, Ye Zhang
Summary: A nomogram model was developed to predict postoperative pulmonary complications (PPCs) in thoracoscopic surgery, using data from 905 patients. The model incorporated seven key variables related to PPCs and showed good predictive performance in distinguishing the risk of PPCs, aiding in making reasonable treatment choices. With high C-indices and well-fitted calibration curves, the nomogram offers a reliable tool for assessing and managing PPCs in thoracoscopic surgery.
Article
Acoustics
Colleen B. Kerrigan, Thomas P. Ahern, Sara K. Brennan, Kathryn C. Kurchena, Carl J. Nelson, Michelle M. Sowden
Summary: This study demonstrates that ultrasound-measured dermal thickness difference is an effective method for quantifying breast lymphedema, and is associated with surgical factors, radiotherapy factors, and patient-reported impacts on quality of life.
JOURNAL OF ULTRASOUND IN MEDICINE
(2022)
Article
Immunology
Yi Liu, Jiandong Wang, Mengxi Jiang
Summary: The relationship between copper homeostasis and breast cancer development is complex. Copper elimination and overload both have therapeutic potential in cancer treatment. This study analyzed the impact of copper-related genes on breast cancer prognosis, immune infiltration, drug sensitivity, and metabolic profile. Immunohistochemistry staining showed high expression of copper-related genes in breast cancer samples, and copper distribution was observed in breast cancer tissue.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Surgery
Harm Winters, Hanneke J. P. Tielemans, Vera Paulus, Stefan Hummelink, Nicholas J. Slater, Dietmar J. O. Ulrich
Summary: Vascularized lymph node transfer (VLNT) is an effective technique for treating lymphedema in breast cancer patients. The current evidence suggests that VLNT can improve the volume differences between the arms and have a positive effect on patients' quality of life, reducing skin infections and the need for compression garment usage. The complication rate is low.
JOURNAL OF VASCULAR SURGERY-VENOUS AND LYMPHATIC DISORDERS
(2022)
Review
Oncology
Cheryl L. Brunelle, John Boyages, Amanda W. Jung, Hiroo Suami, Brooke C. Juhel, Asha Heydon-White, Helen Mackie, Shinn-Huey Shirley Chou, Vincent S. Paramanandam, Louise Koelmeyer, Alphonse G. Taghian
Summary: The diagnosis and treatment of breast lymphedema (BL) after breast-conserving surgery lacks standardized criteria and high-quality studies. There is variability in the incidence, time course, and risk factors for BL. Tissue dielectric constant and ultrasound are emerging as promising assessment tools, but further validation and research are needed.
BREAST CANCER RESEARCH AND TREATMENT
(2023)
Article
Multidisciplinary Sciences
Zijun Zhou, Jiaxin Li, He Wang, Ze Luan, Yuan Li, Xin Peng
Summary: This study developed a virtual reality upper limb rehabilitation system for breast cancer patients post-surgery, with positive results in terms of usability and user experience. It lays the foundation for future research and application in this field.
Article
Medicine, General & Internal
Yixin Cheng, Pengkun Zhang, Yulin Huang, Zhihui Zhang, Ru Tang, Feng Chi, Jia-Yuan Sun, Zhenyu He
Summary: This study developed and validated nomograms to predict the survival of patients with breast invasive micropapillary carcinoma (IMPC) for objective decision-making. These nomograms showed excellent performance in predicting overall survival and breast cancer-specific survival, and could provide personalized treatment strategies for high-risk patients.
Article
Oncology
Alina A. Ghazaleh, Tristan M. Handschin, Julia Buckowiecki, Frederique S. Chammartin, Christoph Andree, Dirk J. Schaefer, Martin Haug, Elisabeth A. Kappos, Katrin Seidenstuecker
Summary: The study suggests that a one-stage combination of VLNT with WAL for treating chronic BCRL leads to significant outcomes with longer surgery time but fewer complications, and no significant difference in patient satisfaction.
BREAST CANCER RESEARCH AND TREATMENT
(2023)
Article
Nursing
Komal P. Murali, Gary Yu, John D. Merriman, Allison Vorderstrasse, Amy S. Kelley, Abraham A. Brody
Summary: This study used latent class analysis to identify subgroups of seriously ill older adults receiving palliative care based on comorbidity burden and mortality risk. The findings showed distinct subgroups with different combinations of chronic conditions.
WESTERN JOURNAL OF NURSING RESEARCH
(2023)
Article
Nursing
Lauren Ghazal, Sheila J. Santacroce, John D. Merriman, Victoria Vaughan Dickson
Summary: Young adult cancer survivors (YACS) diagnosed between ages 20 and 39 years have faced disruptions in their lives due to cancer before the COVID-19 pandemic. This study explored the experiences of working YACS during the pandemic, highlighting a shift in awareness and understanding, as well as the need to reimagine work environments. The consequences of COVID-19 on the overall quality of life for YACS are complex, and effective interventions to support them in the workplace are crucial.
Review
Anesthesiology
Katherine J. Holzer, Christin Veasley, Robert D. Kerns, Robert R. Edwards, Jennifer S. Gewandter, Dale J. Langford, Lauren H. Yaeger, Ewan McNicol, McKenzie Ferguson, Dennis C. Turk, Robert H. Dworkin, Simon Haroutounian
Summary: The interest and rationale for patient engagement in pain treatment clinical trials have been increasing. This review aims to provide a historical perspective and current evaluation, highlighting the benefits and challenges of patient engagement in clinical research. Factors that facilitate or hinder patient engagement and areas for future research are also summarized.
Article
Oncology
Lauren Ghazal, John D. Merriman, Sheila J. Santacroce, Jason Fletcher, Fay Wright, Victoria Vaughan Dickson
Summary: This study found that quality of life among young adult hematologic cancer survivors was associated with depressive symptoms, fatigue, impaired cognitive function, work ability and financial health. It suggests that future research should include larger and more diverse samples to further investigate the impact of these factors on survivors' quality of life.
JOURNAL OF ADOLESCENT AND YOUNG ADULT ONCOLOGY
(2022)
Article
Oncology
Dale J. Langford, Linda Eaton, Kord M. Kober, Steven M. Paul, Bruce A. Cooper, Marilyn J. Hammer, Yvette P. Conley, Fay Wright, Laura B. Dunn, Jon D. Levine, Christine Miaskowski
Summary: The purpose of this study was to evaluate differences in pain characteristics and mood disturbance among oncology patients with distinct stress profiles. The study found that patients with high stress profiles reported higher levels of pain intensity, pain interference, anxiety, and depressive symptoms. They also commonly described their pain as throbbing, shooting, burning, exhausting, tiring, penetrating, nagging, miserable, and unbearable. Compared to resilient patients, stressed patients reported higher mood-related pain interference scores and more severe anxiety and depressive symptoms.
EUROPEAN JOURNAL OF ONCOLOGY NURSING
(2022)
Article
Nursing
Carolyn S. Harris, Christine A. Miaskowski, Yvette P. Conley, Marilyn J. Hammer, Anand A. Dhruva, Jon D. Levine, Adam B. Olshen, Kord M. Kober
Summary: This study identified an association between epigenetic regulation of genes involved in gastrointestinal immune responses and the occurrence of gastrointestinal symptom cluster in patients receiving chemotherapy. The findings suggest a potential therapeutic target for this common symptom cluster.
BIOLOGICAL RESEARCH FOR NURSING
(2023)
Article
Nursing
Nadia D. Haas, Carol Viele, Steve M. Paul, Gary Abrams, Betty Smoot, Michelle Melisko, Jon D. Levine, Christine Miaskowski, Kord M. Kober
Summary: Little is known about the genetic characteristics associated with exercise in women undergoing breast cancer surgery. In this study, researchers evaluated the differences in demographic and clinical characteristics between breast cancer patients who did and did not exercise regularly. They also analyzed the associations between genetic polymorphisms in cytokine-related genes and exercise behavior. The study found that only 23.5% of the patients met the recommended exercise level and identified specific characteristics and genetic variations associated with not engaging in regular exercise. The findings suggest that genetic factors may play a role in exercise behavior and highlight the importance of assessing barriers to exercise and educating patients on its benefits.
BIOLOGICAL RESEARCH FOR NURSING
(2023)
Article
Nursing
Ying Sheng, Janet S. Carpenter, Brenda J. Smith, Steven M. Paul, Michelle Melisko, Javid Moslehi, Jon D. Levine, Yvette P. Conley, Kord M. Kober, Christine Miaskowski
Summary: This study identified SNP genes associated with palpitations in women prior to breast cancer surgery, suggesting a potential role of inflammatory mechanisms in the subjective sensation of palpitations.
BIOLOGICAL RESEARCH FOR NURSING
(2023)
Article
Clinical Neurology
Dale J. Langford, Raissa Lou, Soun Sheen, Dagmar Amtmann, Luana Colloca, Robert R. Edwards, John T. Farrar, Nathaniel P. Katz, Michael P. McDermott, Bryce B. Reeve, Ajay D. Wasan, Dennis C. Turk, Robert H. Dworkin, Jennifer S. Gewandter
Summary: Variability in pain outcomes can hinder the sensitivity of chronic pain clinical trials. Participants' expectations may contribute to this variability and impede the development of new pain treatments. Measurement and management of expectations in clinical trials need to be optimized and standardized. This article provides an overview of research findings on the relationship between baseline expectations and pain outcomes, emphasizing the potential benefit of adjusting for participants' expectations in trial analyses.
Article
Nursing
Lauren V. Ghazal, John D. Merriman, Sheila J. Santacroce, Jason Fletcher, Fay Wright, Victoria Vaughan Dickson
Summary: This study examines the relationship between work ability, work-related goals, and quality of life among young adult hematologic cancer survivors. The findings suggest that declines in work ability can lead to questioning of work-related goals and impact quality of life. Integrated analysis reveals four profiles, which enhance understanding of the influence of work on quality of life for young adult cancer survivors and identify factors considered when contemplating work-related goals after a cancer diagnosis.
WESTERN JOURNAL OF NURSING RESEARCH
(2023)
Article
Oncology
Kord M. Kober, Carolyn Harris, Yvette P. Conley, Anand Dhruva, Vasuda Dokiparthi, Marilyn J. Hammer, Jon D. Levine, Kate Oppegaard, Steven Paul, Joosun Shin, Anatol Sucher, Fay Wright, Brian Yuen, Adam B. Olshen, Christine Miaskowski
Summary: This study describes the common and distinct perturbed inflammatory pathways associated with morning and/or evening fatigue in cancer patients. The phosphatidylinositol 3-kinase (PI3K)-Akt pathway was identified as a bottleneck pathway. The findings suggest potential targets for therapeutic interventions for this common and devastating clinical problem.
Article
Computer Science, Software Engineering
Thomas J. Hoffmann, Christine Miaskowski, Kord M. Kober
Summary: A user-friendly open source tool, shinyGAStool, has been developed for performing candidate gene association analysis from large datasets. It allows users to identify and explore distributions of phenotype and covariates, select genes and variants for evaluation, and run an association analysis to link them.
Article
Nursing
Komal Patel Murali, John D. Merriman, Gary Yu, Allison Vorderstrasse, Amy S. Kelley, Abraham A. Brody
Summary: Understanding the complex care needs of seriously ill adults with multiple chronic conditions with and without cancer is critical for the delivery of high-quality serious illness and palliative care at the end of life.
JOURNAL OF HOSPICE & PALLIATIVE NURSING
(2023)
Article
Oncology
Kord M. Kober, Ritu Roy, Yvette Conley, Anand Dhruva, Marilyn J. Hammer, Jon Levine, Adam Olshen, Christine Miaskowski
Summary: This study used machine learning techniques to accurately predict the severity of morning fatigue in cancer patients in the week following chemotherapy administration, and found that two simple questions from the Lee Fatigue Scale could be used to predict fatigue severity.
SUPPORTIVE CARE IN CANCER
(2023)
Article
Endocrinology & Metabolism
Kesava Asam, Kimberly A. Lewis, Kord Kober, Xingyue Gong, Alka M. Kanaya, Bradley E. Aouizerat, Elena Flowers
Summary: This study investigates the pathogenesis of type 2 diabetes (T2D) using integrated transcriptome and microRNA differential gene expression analysis. The results validate previous findings and identify new potential mechanisms related to T2D risk factors, providing insights for potential therapeutic targets to decrease T2D risk.
DIABETES METABOLIC SYNDROME AND OBESITY
(2023)
