Article
Multidisciplinary Sciences
Bo Hyun Lee, Bertil Hille, Duk-Su Koh
Summary: The pineal gland secretes melatonin at night, regulated by sympathetic nerve terminals. The secretion of 5-HT is primarily through a specific transporter, and activation of receptors on pinealocytes affects melatonin release.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Agriculture, Multidisciplinary
Jing-Hui Ruan, Jun Li, Guliqire Adili, Guang-Ying Sun, Munire Abuduaini, Rahima Abdulla, Maitinuer Maiwulanjiang, Haji Akber Aisa
Summary: A study found that compounds extracted from pomegranate peels have potential biological activities, including antioxidant, antimicrobial, and antitumor activities. These findings provide further information on the utilization of pomegranate peels.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Review
Food Science & Technology
Alami Mehdi, Benchagra Lamiae, Boulbaroud Samira, Mhamed Ramchoun, Khalil Abdelouahed, Fulop Tamas, Berrougui Hicham
Summary: Polyphenols have neuroprotective benefits and could be valuable in treating neurodegenerative diseases like Alzheimer's and Parkinson's. However, inconsistent findings and variations in individuals and study designs need to be considered.
Article
Food Science & Technology
Francesco Cairone, Chiara Salvitti, Antonia Iazzetti, Giancarlo Fabrizi, Anna Troiani, Federico Pepi, Stefania Cesa
Summary: In this study, fruit seeds of pomegranate cultivar Granata were extracted and analyzed to obtain information about their composition. The oily phase extracted from the seeds showed the presence of conjugated isomers of linolenic acid (CLNA isomers), which adds value to this traditionally considered waste. Different extraction methods were used, and the resulting oils were evaluated for their chemical composition. The prevalence of punicic acid in the triacylglycerol mixture was observed, with a higher content in the extract obtained by supercritical CO2.
Review
Medicine, Research & Experimental
Amira Mohamed Taha, Abdelrahman Mohamed Mahmoud, Mohamed M. Ghonaim, Ateeba Kamran, Jehad Feras Alsamhori, Majd M. Albarakat, Abhigan Babu Shrestha, Vikash Jaiswal, Russel J. Reiter
Summary: Septic cardiomyopathy is a complication of sepsis with high mortality rates. Despite extensive research, there is currently no effective pharmacological agent for this condition. Melatonin, with its diverse functions in the body, has emerged as a potential treatment for sepsis-induced cardiomyopathy due to its anti-oxidant, anti-inflammatory, anti-apoptotic, and cardioprotective roles.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Endocrinology & Metabolism
Yan Meng, Zhengbo Tao, Siming Zhou, Wacili Da, Lin Tao
Summary: This study conducted a quantitative and qualitative analysis of melatonin research over the past 20 years using bibliometric methods, predicting future research trends. Findings showed that the United States had the highest number of publications in melatonin research, and future research hot spots are likely to focus on the structure and function of melatonin, clinical applications, and target-based drug design.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Plant Sciences
P. Roopa Sowjanya, Parashuram Shilpa, Goudappa Prakash Patil, Dhinesh Karuppannan Babu, Jyotsana Sharma, Vipul R. Sangnure, Dhananjay M. Mundewadikar, Purushothaman Natarajan, Arvind Rajiv Marathe, Umesh K. Reddy, Vikram Nripendra Singh
Summary: This study sequenced and assembled the genome of pomegranate using next-generation sequencing technologies and obtained a high-quality reference genome assembly for the 'Bhagawa' cultivar. The assembly covered a large portion of the estimated pomegranate genome size and identified numerous genes and miRNA copies, providing valuable genomic resources for future pomegranate improvement.
FRONTIERS IN PLANT SCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Simona Aleksandrova, Ralitza Alexova, Stela Dragomanova, Reni Kalfin, Ferdinando Nicoletti, Paolo Fagone, Maria Cristina Petralia, Katia Mangano, Lyubka Tancheva
Summary: Pomegranate is a polyphenol-rich food and medicinal plant that contains various beneficial compounds. Studies have shown that these compounds can target brain cells and support their functions by regulating redox balance, proliferation, and survival. The neuroprotective effects of pomegranate are mediated by its antioxidant and anti-inflammatory properties, ability to activate signaling pathways, and regulation of mitochondrial damage. In vitro and in vivo studies have demonstrated that pomegranate polyphenols can directly affect neuronal and glial cells, as well as influence blood-brain barrier function and increase blood flow to the brain.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Rehab T. Oshiba, Ehab Touson, Yasser M. Elsherbini, Mohamed E. Abdraboh
Summary: This study demonstrates the significant impact of melatonin in counteracting tumor growth through scavenging free radicals, regulating lipid peroxidation, and affecting cell cycle and apoptosis. The signaling pathways of melatonin in adenocarcinoma have been highlighted, emphasizing the novel role of M./P53/miR215/CD44 and M./miR96//foxO1 cascades in diminishing cancer cell growth, survival, and metastasis.
Article
Agriculture, Multidisciplinary
Chen Yan-hui, Gao Hui-fang, Wang Sa, Liu Xian-yan, Hu Qing-xia, Jian Zai-hai, Wan Ran, Song Jin-hui, Shi Jiang-li
Summary: Recent investigations on pomegranate products have increased and drawn consumers' attention, promoting the development of the pomegranate industry worldwide. Little information on Chinese pomegranates was available, leading to a study on morphological and chemical characterizations of fruits and arils from 20 pomegranate cultivars in six regions of China. Promising cultivars were identified, and the study also revealed the influence of cultivation locations on fruit traits.
JOURNAL OF INTEGRATIVE AGRICULTURE
(2022)
Article
Chemistry, Medicinal
Zahra Shekarriz, Asieh Jokar, Seyde Sedighe Yousefi
Summary: Pica is an eating disorder characterized by craving for nonfood items, and its exact etiology is still unknown. Treatment and prevalence of pica vary according to patients' behavior and characteristics. Punica granatum extract appears to be effective in controlling pica symptoms in a patient treated with Persian Traditional Medicine.
PHYTOTHERAPY RESEARCH
(2021)
Article
Food Science & Technology
Gabriela Rios-Corripio, Mariana Morales-de la Pena, Jorge Welti-Chanes, Jose Angel Guerrero-Beltran
Summary: This study evaluated the effects of pulsed electric field (PEF) and pasteurization on a pomegranate fermented beverage. PEF treatment significantly reduced microbial counts and had minimal impact on the beverage's physicochemical properties. However, the bioactive compounds slightly decreased during storage.
INNOVATIVE FOOD SCIENCE & EMERGING TECHNOLOGIES
(2022)
Article
Biochemistry & Molecular Biology
Virginia Brighenti, Ramona Iseppi, Luca Pinzi, Annamaria Mincuzzi, Antonio Ippolito, Patrizia Messi, Simona Marianna Sanzani, Giulio Rastelli, Federica Pellati
Summary: The study investigated the inhibition ability of pomegranate phenolic compounds on plant and human fungal pathogens, identifying topoisomerases I and II as potential biological targets of punicalagin. Results suggest that punicalagin is a valuable candidate for combating human fungal infections.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Kamila Martyniuk, Maria Hanuszewska-Dominiak, Bogdan Lewczuk
Summary: Research on age-dependent changes in pineal activity has mainly focused on melatonin. This study found significant alterations in the metabolic profile of indoles related to melatonin synthesis during post-embryonic development in birds, which could be categorized into four stages based on age.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Environmental Sciences
Wenbo Jiang, Huanyu Wu, Rui Guo, Xiaoqing Xu, Yue Wang, XiTao Jiang, Yu Wang, Xuemin Yan, Wenbo Gu, Xin Liu, Fengyu Cao, Ying Li, Tianshu Han, Changhao Sun
Summary: This study found that Dibromoacetic acid (DBA) can induce neurotoxicity in the pineal gland and disrupt melatonin rhythm by inhibiting the p-CREB1-AANAT signaling pathway.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Review
Biochemistry & Molecular Biology
Giuseppe Di Pede, Pedro Mena, Letizia Bresciani, Rosa M. Lamuela-Raventos, Mariem Achour, Ramon Estruch, Rikard Landberg, Sabine E. Kulling, David Wishart, Ana Rodriguez-Mateos, Alan Crozier, Claudine Manach, Daniele Del Rio
Summary: This systematic review summarizes human studies on the absorption, metabolism, distribution and excretion of dietary flavan-3-ols and their metabolites. Forty-nine intervention studies were included, and up to 180 metabolites were quantified in blood and urine samples after flavan-3-ol intake. The main compounds detected were phase 2 conjugates of microbial catabolites, with phenyl-gamma-valerolactones being the most representative ones. The bioavailability of flavan-3-ols was moderate, and it showed intra- and inter-source differences.
MOLECULAR ASPECTS OF MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Silvia Montoro-Garcia, Sara Martinez-Sanchez, Miguel Carmena-Bargueno, Horacio Perez-Sanchez, Maria Campillo, Camille Oger, Jean-Marie Galano, Thierry Durand, Angel Gil-Izquierdo, Jose Antonio Gabaldon
Summary: The effects of 9-D1t-PhytoP on platelet activation and vascular cells were tested, along with possible interactions with platelets and the endothelial EP3 receptor. The results showed that 9-D1t-PhytoP has prothrombotic and wound-healing properties, and mimics the migration stimulus of PGE(2) in endothelial cells. Computational analysis revealed its potential as an EP3 agonist by forming a stable complex with the EP3 receptor.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Paula Garcia-Ibanez, Maria A. Nunez-Sanchez, Alba Oliva-Bolarin, Maria A. Martinez-Sanchez, Bruno Ramos-Molina, Antonio J. Ruiz-Alcaraz, Diego A. Moreno
Summary: Digestates from red cabbage sprouts and red radish sprouts, which are derived from cruciferous vegetables, have anti-inflammatory effects and could be used as dietary coadjuvants in the treatment of chronic inflammation. These findings were observed in an in vitro model, where the bioaccessible compounds from the sprouts significantly decreased the production of pro-inflammatory cytokines in stimulated cells.
Article
Food Science & Technology
Catarina Andrade, David M. Pereira, Nelson G. M. Gomes, Federico Ferreres, Angel Gil-Izquierdo, Paula B. Andrade, Sutsawat Duangsrisai, Patricia Valenta
Summary: Kitul (Caryota urens L.) inflorescences are widely used for sweet sap production in Asian countries and have potential antidiabetic properties. In this study, the methanol extract of the inflorescences was shown to reduce reactive species in pancreatic cells and inflammatory markers in stimulated macrophages. The extract also inhibited 5-lipoxygenase activity. These findings suggest that Kitul inflorescences may have pleiotropic mechanisms as an antidiabetic agent.
FOOD RESEARCH INTERNATIONAL
(2023)
Article
Biochemistry & Molecular Biology
Mari Merce Cascant-Vilaplana, Eduardo Viteritti, Victor Sadras, Sonia Medina, Maria Puerto Sanchez-Iglesias, Camille Oger, Jean-Marie Galano, Thierry Durand, Jose Antonio Gabaldon, Julian Taylor, Federico Ferreres, Manuel Sergi, Angel Gil-Izquierdo
Summary: This study investigates the impact of aphids feeding on wheat plants and their role in triggering a defensive plant reaction to oxidative stress. The experiment involves different nitrogen and CO2 concentrations, as well as two types of aphids. The results show that aphids significantly affect the levels of certain oxylipins in wheat leaves, indicating their ability to manipulate plant defense mechanisms.
Article
Materials Science, Multidisciplinary
Erika Paulsen, Diego A. Moreno, Domingo Martinez-Romero, Cristina Garcia-Viguera
Summary: The impact of perforation-mediated modified atmosphere packaging (PM-MAP) on broccoli florets was studied at different temperature scenarios. PM-MAP slightly altered the composition of O-2 and CO2, preserving the external quality and bioactive compounds of florets for 21 days, even at 7 degrees C. The level of perforation affected the evolution of firmness and glucosinolate content, especially with increasing temperature. Therefore, the perforation level should be considered in the design of packaging for fresh-cut products.
Article
Agronomy
Maria Pinciroli, Raul Dominguez-Perles, Sonia Medina, Camille Oger, Alexandre Guy, Thierry Durand, Mari Merce Cascant-Vilaplana, Jose Antonio Gabaldon-Hernandez, Federico Ferreres, Angel Gil-Izquierdo
Summary: This study aimed to investigate the effects of exogenously foliar-applied salicylic acid (SA) on oxidative stress in rice. The concentrations of PhytoPs and PhytoFs in immature and mature grains of three different genotypes of rice were monitored, and their influence on grains per panicle and chalkiness was examined. The results showed that SA reduced oxylipin levels and increased rice yield.
Article
Agronomy
Angelo Signore, Fabio Amoruso, Victor M. Gallegos-Cedillo, Perla A. Gomez, Jesus Ochoa, Catalina Egea-Gilabert, Antonio Costa-Perez, Raul Dominguez-Perles, Diego A. Moreno, Jose Antonio Pascual, Juan A. Fernandez
Summary: By using agro-industrial compost as a substitute for peat, the growth of rocket salad can be improved without negatively affecting yield and dry weight percentage. This compost can also enhance the concentration of phytochemicals and vitamin C in the plants.
Article
Biochemistry & Molecular Biology
Raul Arcusa, Juan Angel Carillo, Begona Cerda, Thierry Durand, Angel Gil-Izquierdo, Sonia Medina, Jean-Marie Galano, Maria Pilar Zafrilla, Javier Marhuenda
Summary: This study aimed to evaluate the efficacy of long-term consumption of high polyphenolic content from fruits and vegetables (such as berries) as a nutraceutical against central nervous system lipid peroxidation, as assessed through urine biomarkers. The results showed significant reductions in AdA and DHA-derived metabolites after consumption of the nutraceutical, indicating its effectiveness in preventing CNS lipid peroxidation.
Review
Biochemistry & Molecular Biology
Giuseppe Di Pede, Pedro Mena, Letizia Bresciani, Mariem Achour, Rosa M. Lamuela-Raventos, Ramon Estruch, Rikard Landberg, Sabine E. Kulling, David Wishart, Ana Rodriguez-Mateos, Michael N. Clifford, Alan Crozier, Claudine Manach, Daniele Del Rio
Summary: This work systematically assessed the pharmacokinetics, urinary recovery, and bioavailability of hydroxycinnamic acids (HCAs) and their metabolites. It was found that C-6-C-3 cinnamic acids, such as caffeic and ferulic acid, had the highest blood concentrations, while their excretion in urine was lower than hydroxybenzene catabolites. A comprehensive study investigating the ADME of HCAs from different dietary sources is urgently required.
ANTIOXIDANTS & REDOX SIGNALING
(2023)
Article
Immunology
Omar Guadarrama-Enriquez, Gabriel Fernando Moreno-Perez, Maria Eva Gonzalez-Trujano, Guadalupe Esther Angeles-Lopez, Rosa Ventura-Martinez, Irene Diaz-Reval, Agustina Cano-Martinez, Francisco Pellicer, Nieves Baenas, Diego A. Moreno, Cristina Garcia-Viguera
Summary: This study investigates the analgesic and anti-inflammatory activities of an aqueous extract of Brassica oleracea var. italica sprouts (AEBS) and its active metabolite sulforaphane (SFN). The results demonstrate the potential of AEBS and SFN as natural products for the treatment of pain and inflammation.
INFLAMMOPHARMACOLOGY
(2023)
Review
Nutrition & Dietetics
Antonio Costa-Perez, Vanesa Nunez-Gomez, Nieves Baenas, Giuseppe Di Pede, Mariem Achour, Claudine Manach, Pedro Mena, Daniele Del Rio, Cristina Garcia-Viguera, Diego A. Moreno, Raul Dominguez-Perles
Summary: This systematic review summarizes the findings of human studies on the metabolism and bioavailability of glucosinolates (GSL) and isothiocyanates (ITC), providing a comprehensive analysis for future research and consultation on this less studied area of GSL for food and health.
Article
Biochemistry & Molecular Biology
Jananee Muralidharan, Cindy Romain, Letizia Bresciani, Pedro Mena, Donato Angelino, Daniele Del Rio, Linda H. Chung, Pedro E. Alcaraz, Julien Cases
Summary: This study evaluated the nutrikinetics and bioavailability of a flavanone-rich product, Sinetrol (R) Xpur, in overweight and obese individuals. The results showed that while urinary excretion of metabolites decreased significantly over 16 weeks, there was no significant decrease in circulating metabolites. This suggests that chronic intake may not offer the same bioavailability as acute intake.
Review
Nutrition & Dietetics
Irene Rossi, Cristiana Mignogna, Daniele Del Rio, Pedro Mena
Summary: This review evaluates the impact of different types of 100% fruit and vegetable juices on human health, emphasizing the differences in bioactive compounds. While some juices have beneficial effects on cardiometabolic health outcomes, cognition, and exercise performance, they have no significant impact on anthropometric parameters and body composition. Further research is needed to better understand the effects of 100% fruit and vegetable juices on human health.
NUTRITION RESEARCH REVIEWS
(2023)
