Review
Biochemistry & Molecular Biology
Konstantinos Parperis, Nikolaos Velidakis, Elina Khattab, Evangelia Gkougkoudi, Nikolaos P. E. Kadoglou
Summary: Pulmonary hypertension is commonly seen in patients with systemic lupus erythematosus, presenting with non-specific symptoms and negatively affecting survival. It can result from immune system dysregulation, as well as various other conditions. Early diagnosis and identification of underlying pathogenetic mechanisms are crucial for introducing targeted therapy and preventing irreversible pulmonary vascular damage. The management of pulmonary hypertension in SLE patients is similar to that of idiopathic PAH, but specific diagnostic tools for early diagnosis seem to be unavailable yet.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Respiratory System
Jingge Qu, Mengtao Li, Xiao Zhang, Miaojia Zhang, Xiaoxia Zuo, Ping Zhu, Shuang Ye, Wei Zhang, Yi Zheng, Wufang Qi, Yang Li, Zhuoli Zhang, Feng Ding, Jieruo Gu, Yi Liu, Junyan Qian, Can Huang, Jiuliang Zhao, Qian Wang, Yongtai Liu, Zhuang Tian, Yanhong Wang, Wei Wei, Xiaofeng Zeng
Summary: This study aimed to develop a practical model for predicting long-term prognosis in patients with systemic lupus erythematosus-associated pulmonary arterial hypertension.
RESPIRATORY RESEARCH
(2023)
Article
Medicine, General & Internal
Jingge Qu, Mengtao Li, Xiaofeng Zeng, Xiao Zhang, Wei Wei, Xiaoxia Zuo, Ping Zhu, Shuang Ye, Wei Zhang, Yi Zheng, Wufang Qi, Yang Li, Zhuoli Zhang, Feng Ding, Jieruo Gu, Yi Liu, Miaojia Zhang, Junyan Qian, Can Huang, Jiuliang Zhao, Qian Wang, Yongtai Liu, Zhuang Tian, Yanhong Wang
Summary: The REVEAL models show good discriminatory ability in predicting 1-year overall survival in SLE-PAH patients, but caution should be taken when interpreting results related to renal insufficiency, WHO FC III, and heart rate >92 bpm, as there may be some underestimations or discrepancies in these specific risk factors.
FRONTIERS IN MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Qian Wang, Junyan Qian, Mengtao Li, Xiao Zhang, Wei Wei, Xiaoxia Zuo, Ping Zhu, Shuang Ye, Wei Zhang, Yi Zheng, Wufang Qi, Yang Li, Zhuoli Zhang, Feng Ding, Jieruo Gu, Yi Liu, Can Huang, Jiuliang Zhao, Yongtai Liu, Zhuang Tian, Yanhong Wang, Miaojia Zhang, Xiaofeng Zeng
Summary: This study evaluates the prognostic value of multivariable risk assessment for systemic lupus erythematosus (SLE)-associated pulmonary arterial hypertension (PAH). The results show that risk assessment can significantly differentiate long-term survival at baseline and first follow-up, and noninvasive risk assessment methods can be helpful during follow-up when right heart catheterization (RHC) is not available. Additionally, baseline serositis may predict a good treatment response in SLE-associated PAH patients.
THERAPEUTIC ADVANCES IN CHRONIC DISEASE
(2022)
Review
Rheumatology
Mucong Li, Zhuang Tian, Junyan Qian, Can Huang, Jiuliang Zhao, Qian Wang, Yijun Song, Xinping Tian, Mengtao Li, Juntao Liu, Xiaofeng Zeng
Summary: This study investigated the clinical characteristics and outcomes of pregnancy complicated by SLE-associated pulmonary arterial hypertension. The results showed that successful pregnancy is possible in women with SLE-PAH if proper treatment goals are achieved.
LUPUS SCIENCE & MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Tzung-Hai Yen, Wan-Jing Ho, Yung-Hsin Yeh, Ying-Ju Lai
Summary: The study established an animal model to evaluate pulmonary arterial remodeling associated with SLE-related PAH, and found that inhibiting Cat S protein can significantly improve SLE and PAH, providing new approaches for the treatment of SLE-PAH.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cardiac & Cardiovascular Systems
Chantal Lokhorst, Sjoukje van der Werf, Rolf M. F. Berger, Johannes M. M. Douwes
Summary: This systematic review examines the variables and prognostic value of risk stratification models in adult and pediatric pulmonary arterial hypertension. The study finds that the most commonly used variables in current risk stratification models are WHO functional class, 6-minute walk distance, and BNP/NT-proBNP. The c-statistics of risk stratification models range from 0.56 to 0.83 in adults and 0.69 to 0.78 in children.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Immunology
Menghui Yao, Chunyi Zhang, Congcong Gao, Qianqian Wang, Mengmeng Dai, Runzhi Yue, Wenbo Sun, Wenfang Liang, Zhaohui Zheng
Summary: Using WGCNA, significant modules related to SLE and PAH were identified, with shared genes showing a highly activated type I IFN response as a common feature in the pathophysiology of both diseases. Validation in another cohort confirmed these findings. A disease road model was proposed based on shared and unique gene signatures in SLE and PAH, suggesting a potential role for hsa-miR-146a in regulating IFN-induced genes and its importance in PAH secondary to SLE. This work highlights the high IFN response in SLE patients as a crucial susceptible factor for PAH and identifies novel gene candidates that could serve as biomarkers or therapeutic targets.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Medicine, General & Internal
Jianguo Yang, Fuyu Zhou, Xinpeng Zhou, Yuying Sun, Xueping Lun, Jiaojiao Cao, Bing Fan
Summary: This meta-analysis evaluated the survival rates and prognosis of SLE patients with PH, indicating that the survival rates of SLE-PH patients have improved in recent years. Patients diagnosed with echocardiography have a worse prognosis compared to those diagnosed with right heart catheterization.
Article
Cardiac & Cardiovascular Systems
Xiaoxiao Guo, Jinzhi Lai, Hui Wang, Zhuang Tian, Qian Wang, Jiuliang Zhao, MengTao Li, Quan Fang, Ligang Fang, Yongtai Liu, Xiaofeng Zeng
Summary: The TAPSE/PASP ratio and 6MWD are independent predictors for the endpoint in patients with SLE-associated PAH. Combining assessment of these two factors can help identify a subgroup of patients at high risk for poor prognosis.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2021)
Review
Immunology
Paul Curtiss, Amanda M. Walker, Benjamin F. Chong
Summary: This study reviewed patient cohorts and populations to investigate the progression of cutaneous lupus to systemic lupus. The study found variations in the progression rates between adult and pediatric groups, which were attributed to differences in patient populations, study design, diagnostic criteria, and follow-up time. Risk factors associated with the development of systemic lupus included positive anti-nuclear antibodies, hematologic abnormalities, and a higher number of lupus classification criteria at baseline.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Rheumatology
Yuqi Liu, Zhen Cheng, Bowen Zha, Xiaodong Chen, Zhiyu Gong, Lang Ji, Lingling Wei
Summary: This study aimed to identify the risk factors of pulmonary arterial hypertension (PAH) related to systemic lupus erythematosus (SLE) through systematic reviews and meta-analyses. The results showed that female gender, interstitial lung disease, alopecia, Raynaud's phenomenon, systemic hypertension, serositis, pericardial effusion, anti-RNP, anti-SSA, anti-SSB, anti-U1RNP, thrombocytopenia, and current smokers were all risk factors for PAH related to SLE.
Article
Critical Care Medicine
Hussein J. Hassan, Mario Naranjo, Nour Ayoub, Traci Housten, Steven Hsu, Aparna Balasubramanian, Catherine E. Simpson, Rachel L. Damico, Stephen C. Mathai, Todd M. Kolb, Paul M. Hassoun
Summary: This study compared the characteristics and survival rates of patients with systemic sclerosis-associated pulmonary hypertension (SSc-PH) between the last two decades. The results showed that the transplant-free survival rate has significantly improved for patients with group 1 disease over the past decade, possibly due to earlier detection and better therapeutic management. In contrast, patients with group 2 or 3 disease continue to have a poor prognosis.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Rheumatology
Mengmeng Dai, Chunyi Zhang, Chaoying Li, Qianqian Wang, Congcong Gao, Runzhi Yue, Menghui Yao, Zhaohui Su, Zhaohui Zheng
Summary: This study aimed to explore the clinical characteristics and prognosis of systemic lupus erythematosus-associated pulmonary arterial hypertension (SLE-PAH) through consensus clustering and risk prediction model. Two distinct SLE-PAH subtypes were identified through clustering analysis and were associated with survival outcomes. A risk prediction model was also constructed based on four prognostic factors.
ARTHRITIS RESEARCH & THERAPY
(2023)
Article
Rheumatology
Maria Vlachou, Hossam Fayed, Adele Dawson, Sally Reddecliffe, Alexander Stevenson, Ross J. Thomson, Benjamin Emmanuel Schreiber, J. Gerry Coghlan
Summary: The study evaluated survival rates and short-term impact of i.v. prostanoids on SSc-PAH patients. Significant improvements in clinical and haemodynamic parameters were observed with i.v. prostanoid therapy. However, survival remains poor and risk scoring at baseline and during therapy can improve prognostication.
Review
Oncology
Argin Malakian, Shan Mohammed, Rouhi Fazelzad, Rand Ajaj, Angelina Artemenko, Samantha J. Mayo
Summary: Many studies did not mention the role of nursing in this area, while some mentioned a non-interventionist role for nurses in the research study. A few studies highlighted nurses as interventionists/psychotherapists, focusing on feasibility, acceptability, and patient-related outcomes of brief psychotherapies. The limited discussion on nursing's ability to deliver psychotherapies to adults with advanced cancer points to a gap in the research that needs to be addressed.
EUROPEAN JOURNAL OF ONCOLOGY NURSING
(2022)
Review
Oncology
Rebecca M. Goldberg, Soyoun Rachel Kim, Rouhi Fazelzad, Xuan Li, Theodore J. Brown, Taymaa May
Summary: Complete SCS and SCS with no residual disease are associated with improved PFS and OS in patients with recurrent LGSC. SCS may be a better initial treatment strategy than systemic chemotherapy, with disease distribution and functional status taken into account for evaluation. Prospective studies are needed to further explore the role of SCS in patients with recurrent LGSC.
GYNECOLOGIC ONCOLOGY
(2022)
Review
Genetics & Heredity
Ramy R. Saleh, Jordan L. Scott, Nicholas Meti, Danielle Perlon, Rouhi Fazelzad, Alberto Ocana, Eitan Amir
Summary: High expression of PD-L1 is associated with worse prognosis in solid tumors with significant heterogeneity among tumor types. The effect is consistent in early-stage and metastatic disease and is not sensitive to the method of PD-L1 quantification. This data can provide additional information for counseling cancer patients about prognosis.
MOLECULAR DIAGNOSIS & THERAPY
(2022)
Article
Oncology
Ainhoa Madariaga, Jenny Lau, Arunangshu Ghoshal, Tomasz Dzierzanowski, Philip Larkin, Jacek Sobocki, Andrew Dickman, Kate Furness, Rouhi Fazelzad, Gregory B. Crawford, Stephanie Lheureux
Summary: This study provides evidence-based recommendations and suggestions for the management of malignant bowel obstruction in patients with advanced cancer, covering various aspects such as symptom management, bowel obstruction resolution, and prognosis.
SUPPORTIVE CARE IN CANCER
(2022)
Article
Medicine, General & Internal
Jenny Lau, Philip Ding, Samantha Lo, Rouhi Fazelzad, Andrea D. Furlan, Sarina R. Isenberg, Sheryl Spithoff, Alissa Tedesco, Camilla Zimmermann, Daniel Z. Buchman
Summary: Palliative care interventions for people who use substances during communicable disease outbreaks are crucial, but currently, there is limited knowledge about this issue, especially in resource-limited countries. Further research and guidance are needed.
Review
Health Care Sciences & Services
Daniel Z. Buchman, Samantha Lo, Philip Ding, Naheed Dosani, Rouhi Fazelzad, Andrea D. Furlan, Sarina R. Isenberg, Sheryl Spithoff, Alissa Tedesco, Camilla Zimmermann, Jenny Lau
Summary: This scoping review explores the impact of communicable disease epidemics and pandemics on palliative care for people who use drugs. The findings indicate limited knowledge about palliative care for this population during epidemics and pandemics other than HIV/AIDS. Further research is needed to provide optimal palliative care for people who use drugs during future epidemics and pandemics, along with suggestions for better preparedness.
PALLIATIVE MEDICINE
(2023)
Review
Health Care Sciences & Services
Mohamed Abdelaal, Jonathan Avery, Ronald Chow, Nasreen Saleem, Rouhi Fazelzad, Pamela Mosher, Breffni Hannon, Camilla Zimmermann, Ahmed Al-Awamer
Summary: This scoping review examined the palliative and end-of-life care needs and experiences of adolescents and young adults with advanced life-limiting illnesses. The findings highlight the differences in palliative care experiences and knowledge gaps for this underserved patient population, emphasizing the need for further research and tailored palliative care programs.
PALLIATIVE MEDICINE
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Heba Hussein, Engy Abbas, Sareh Keshavarzi, Rouhi Fazelzad, Karina Bukhanov, Supriya Kulkarni, Frederick Au, Sandeep Ghai, Abdullah Alabousi, Vivianne Freitas
Summary: In this systematic review and meta-analysis, MRI was found to be the best supplemental breast cancer screening modality for women at average risk or intermediate risk with dense breasts and negative mammogram, leading to an increased cancer detection rate.
Review
Medicine, General & Internal
Viranda H. Jayalath, Roderick Clark, Katherine Lajkosz, Rouhi Fazelzad, Neil E. Fleshner, Laurence H. Klotz, Robert J. Hamilton
Summary: This meta-analysis found that concurrent statin use was associated with reduced overall mortality and prostate cancer-specific mortality among men receiving androgen-ablative therapies for advanced prostate cancer.
Review
Public, Environmental & Occupational Health
Mijia Murong, Eleni Giannopoulos, Lorraine Pirrie, Meredith Elana Giuliani, Rouhi Fazelzad, Jacqueline Bender, Jennifer Jones, Janet Papadakos
Summary: This scoping review examined the experiences of informal cancer caregivers (CGs) who are newcomers with limited language proficiency. A comprehensive literature search yielded 11,289 articles, with 57 articles ultimately included. Most studies were qualitative and published in North America. Communication challenges with healthcare professionals were a significant issue for newcomer CGs, exacerbated by a lack of medical interpreters and the complexity of oncology health information. Efforts are needed to integrate newcomer CGs into cancer care.
JOURNAL OF IMMIGRANT AND MINORITY HEALTH
(2023)
Review
Health Care Sciences & Services
Christian J. Lopez, Kylie Teggart, Mohammed Ahmed, Anita Borhani, Jeffrey Kong, Rouhi Fazelzad, David M. Langelier, Kristin L. Campbell, Tony Reiman, Jonathan Greenland, Jennifer M. Jones, Sarah E. Neil-Sztramko
Summary: Electronic prospective surveillance models (ePSMs) are implemented in cancer care to monitor the development of treatment toxicities and impairments using electronic patient-reported outcomes. They aim to bridge the knowledge-to-practice gap between the high incidence of impairments and low uptake of rehabilitation services.
IMPLEMENTATION SCIENCE
(2023)
Article
Information Science & Library Science
Schnell D'Souza, Gregory Downs, Shawn Hendrikx, Rouhi Fazelzad, Gabriel Boldt, Karen Burns, Darlene Chapman, Declan Dawes, Antonia Giannarakos, Lori Anne Oja, Risa Schorr, Maureen Babb, Amanda Hodgson, Jessica McEwan, Pamela Jacobs, Tracy Stockley, Tim Tripp, Ian King
Summary: Clinical cancer genomics providers need to search biomedical literature to determine the clinical significance of tumor genome alterations. This study found that most journals have open access policies, but access to literature through hospital systems varies.
JOURNAL OF THE MEDICAL LIBRARY ASSOCIATION
(2023)
Review
Health Policy & Services
Mohamed Ugas, Rebecca Mackinnon, Shawn Amadasun, Zaira Escamilla, Bhajan Gill, Meredith Guiliani, Rouhi Fazelzad, Hilary Martin, Diana Samoil, Janet Papadakos
Summary: This study aimed to explore health literacy and limited language proficiency (LLP) by examining the published literature on the barriers and facilitators to health care. Limited language proficiency was associated with low health literacy, and age was a consistent predictor of LLP. Low health literacy was associated with poorer health outcomes.
JOURNAL OF HEALTH CARE FOR THE POOR AND UNDERSERVED
(2023)
Review
Oncology
Caitlin Lazurko, Revital Linder, Kate Pulman, Genevieve Lennox, Tomer Feigenberg, Rouhi Fazelzad, Taymaa May, Tiffany Zigras
Summary: Low-grade serous ovarian cancer (LGSOC) is a rare histologic subtype with limited evidence-based treatment options. Traditional treatments have poor response rates, while biologic therapies like bevacizumab have shown some activity in LGSOC.
Article
Oncology
Matthew Dankner, Yifan Wang, Rouhi Fazelzad, Benny Johnson, Caroline A. Nebhan, Ibiayi Dagogo-Jack, Nathaniel J. Myall, Georg Richtig, Jillian W. P. Bracht, Marco Gerlinger, Eiji Shinozaki, Takayuki Yoshino, Daisuke Kotani, Jason R. Fangusaro, Oliver Gautschi, Julien Mazieres, Jeffrey A. Sosman, Scott Kopetz, Vivek Subbiah, Michael A. Davies, Anna L. Groover, Ryan J. Sullivan, Keith T. Flaherty, Douglas B. Johnson, Andrea Benedetti, David W. Cescon, Anna Spreafico, George Zogopoulos, April A. N. Rose
Summary: Non-V600 mutations account for approximately 35% of all BRAF mutations in cancer and can be classified into three classes. This meta-analysis suggests that MAPK pathway targeted therapy (MAPK TT) has clinical activity in some BRAF-mutant cancers, and the class of BRAF mutation may determine responsiveness to treatment strategies.
JCO PRECISION ONCOLOGY
(2022)
