Article
Virology
Massimo De Paschale, Claudia Pavia, Teresa Cerulli, Debora Cagnin, Maria T. Manco, Luisa Belvisi, Alessia Paganini, Laura Pogliani, Elena Ceriani, Alessandro Porta, Luciana Parola, Paola Mirri, Bianca Osnaghi, Laura Vismara, Pierangelo Clerici
Summary: Parvovirus B19 (B19V) infection in pregnancy is common in Italy, with higher IgG seroprevalence among Italian women compared to non-Italian women. The prevalence of viremia is low and does not lead to significant fetal damage at birth.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Virology
Daniela P. Mendes-de-Almeida, Joanna Paes Barreto Bokel, Arthur Daniel Rocha Alves, Alexandre G. Vizzoni, Isabel Cristina Ferreira Tavares, Mayara Secco Torres Silva, Juliana dos Santos Barbosa Netto, Beatriz Gilda Jegerhorn Grinsztejn, Luciane Almeida Amado Leon
Summary: Parvovirus B19 (B19V) infection can cause chronic anemia and transient aplastic crisis in patients with immunosuppression or chronic hemolysis. We report three rare cases of Brazilian adults living with HIV with B19V infection. All cases presented severe anemia and required red blood cell transfusions.
Article
Nutrition & Dietetics
Rhiannon R. Penkert, Melissa Azul, Robert E. Sealy, Bart G. Jones, Jola Dowdy, Randall T. Hayden, Li Tang, A. Catharine Ross, Jane S. Hankins, Julia L. Hurwitz
Summary: Infections of human parvovirus B19 can cause severe anemia in individuals with sickle cell disease. The levels of vitamins A and D are associated with the disease consequences and immune responses to the virus. Maintaining sufficient levels of vitamins A and D may serve as prophylaxis against complications.
Review
Immunology
Alireza Khatami, Mohammad Hossein Razizadeh, Monire Ghadirali, Shahrooz Yazdani, Saeed Bahadory, Alireza Soleimani
Summary: A significant association between Parvovirus B19 and myocarditis with a high prevalence was found, while no significant association was found with dilated cardiomyopathy.
MICROBIAL PATHOGENESIS
(2022)
Article
Infectious Diseases
Trine H. Mogensen, Morten Kelder Skouboe, Ingolf Molle
Summary: Human infection with parvovirus B19 can lead to various clinical manifestations, and treatment can be challenging. This case report presents a 43-year-old man with persistent parvovirus B19 infection and anaemia. The patient showed resistance to standard treatments but responded well to pegylated interferon alfa-2a. This highlights the potential of interferon alfa-2a as a treatment option for persistent parvovirus B19 infection.
LANCET INFECTIOUS DISEASES
(2023)
Article
Virology
Claudia Maria Tucciarone, Giovanni Franzo, Matteo Legnardi, Elena Lazzaro, Andrea Zoia, Matteo Petini, Tommaso Furlanello, Marco Caldin, Mattia Cecchinato, Michele Drigo
Summary: The study explored the molecular epidemiology of feline panleukopenia virus at both Italian and international levels, revealing the impact of viral evolution on disease severity. Despite a primarily local spread in Italy, a few long-distance introduction events also influenced the transmission pathways of FPV.
Review
Microbiology
Rita de CNC Garcia, Luciane A. A. Leon
Summary: Research in Brazil has shown that B19V infection is prevalent in the general population and follows a cyclical pattern of occurrence every 4-5 years, with a wide range of clinical manifestations during epidemic periods. However, many infections may be asymptomatic or have mild symptoms, making timely diagnosis challenging.
FUTURE MICROBIOLOGY
(2021)
Review
Immunology
Xi Hu, Chen Jia, Jianyong Wu, Jian Zhang, Zhijie Jiang, Kuifen Ma
Summary: This review discusses the clinical manifestations and current treatment options for Parvovirus B19 (B19V) infection. It highlights the lack of specific therapeutic methods for B19V and emphasizes the importance of identifying potential targets by understanding the virus's life cycle. The review also presents antiviral agents that block viral invasion and inhibit enzymes or regulatory proteins involved in DNA synthesis, and outlines the applications of nanotechnology in B19V treatment.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Medicine, General & Internal
Heinz-Peter Schultheiss, Thomas Bock, Heiko Pietsch, Ganna Aleshcheva, Christian Baumeier, Friedrich Fruhwald, Felicitas Escher
Summary: The study demonstrated that suppression of B19V transcriptional activity by the nucleoside analogue telbivudine (LTD) improved clinical outcomes significantly, especially in terms of cardiac function and quality of life for patients.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Oncology
Li Gong, Jing Tian, Yan Zhang, Zheng Feng, Qiannan Wang, Yan Wang, Fuqin Zhang, Wei Zhang, Gaosheng Huang
Summary: The presence of germinal centers (GCs) in thymomas is closely associated with the pathogenesis of myasthenia gravis (MG), and infection by human parvovirus B19 (B19V) may contribute to the formation of ectopic GCs in thymoma. This study provides new insights into the etiopathogenic mechanism of MG and the role of B19V in thymoma-associated MG.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Immunology
Junshuang Guo, Yating Wang, Mian Zhang, Hongxiang Zheng, Qiuling Zang, Peipei Huang, Lijun Wen, Dandan Song, Fan Yang, Ruirui Dong, Wang Miao
Summary: A retrospective analysis of hospitalized patients suspected of microbial infection revealed a HPV B19 infection rate of 2.22%. Most infected patients had a history of decreased immunity and blood transfusion. NGS technology can detect HPV B19 in various bodily fluids and tissues. Severe infections may lead to nervous system damage. Early diagnosis and treatment can improve prognosis.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Immunology
Hidehiko Suzuki, Takafumi Noguchi, Keiji Ogawa, Paola Miyazato, Yu Hatakeyama, Eiji Morita, Hirotaka Ebina
Summary: The fusion of RBD with PspA enhances neutralizing antibody production, providing protective immunity against both B19 and Streptococcus pneumoniae infections. T cells specific to PspA support immunoglobulin class switching of both RBD and PspA-specific B cells.
Article
Virology
Wei Zou, Kang Ning, Peng Xu, Xuefeng Deng, Fang Cheng, Steve Kleiboeker, Jianming Qiu
Summary: The study revealed that the 5-68 amino acid sequence of VP1 can effectively inhibit B19V infection, independent of dimerization but likely dependent on three predicted alpha-helices. This specific sequence may function as a receptor-binding ligand during virus entry, making it a potential antiviral peptide candidate for combating B19V infection.
JOURNAL OF VIROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yixi Zhang, Zhiwei Shao, Yanqing Gao, Boming Fan, Jie Yang, Xi Chen, Xin Zhao, Qiyuan Shao, Weizhen Zhang, Chulei Cao, Hehua Liu, Jianhua Gan
Summary: Infection of human parvovirus B19 can lead to various diseases, and the NS1_Nuc protein plays a crucial role in viral DNA replication through its unique binding mode with single-stranded DNA.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2022)
Article
Immunology
Omid Rezahosseini, Christina Ekenberg, Dina Leth Moller, Soren Schwartz Sorensen, Neval Ete Wareham, Michael Perch, Finn Gustafsson, Allan Rasmussen, Nikolai Kirkby, Joanne Reekie, Jens Lundgren, Susanne Dam Nielsen
Summary: Routine monitoring of parvovirus B19 in seronegative solid organ transplant recipients may not be necessary, as targeted screening 1 month posttransplantation and screening upon clinical suspicion could be alternative strategies.
JOURNAL OF INFECTIOUS DISEASES
(2021)