Article
Urology & Nephrology
Tiffany N. Caza, Samar I. Hassen, Michael Kuperman, Shree G. Sharma, Zeljko Dvanajscak, John Arthur, Rick Edmondson, Aaron Storey, Christian Herzog, Daniel J. Kenan, Christopher P. Larsen
Summary: Research has identified neural cell adhesion molecule 1 (NCAM1) as a target antigen in some cases of membranous lupus nephritis and rare cases of primary membranous nephropathy, colocalizing with IgG in glomerular immune deposits. Circulating antibodies to NCAM1 have been detected in serum of patients with NCAM1-associated membranous nephropathy, suggesting diagnostic significance. Future studies are needed to determine whether anti-NCAM1 antibody levels correlate with disease activity or response to therapy.
KIDNEY INTERNATIONAL
(2021)
Review
Immunology
Mengdi Liu, Lei Zhang, Yixin Wang, Weijie Hu, Chunhong Wang, Zhenke Wen
Summary: Lupus nephritis is a severe renal disease caused by the deposition of immune complexes in renal tissue, leading to damage and excessive proliferation of mesangial cells. In addition to their structural role, mesangial cells are involved in immune regulation and inflammatory responses, contributing to immune-mediated renal damage.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Marta Monticolo, Krzysztof Mucha, Bartosz Foroncewicz
Summary: Lupus nephritis is a common and serious complication of systemic lupus erythematosus, with genetic and environmental factors, including dysbiosis, playing a role in its development. The relationship between the human microbiome, genetic determinants, individual variability, and clinical consequences needs further investigation. Bacterial metabolites that mimic autoantigens and stimulate autoimmune responses may be a potential target for future interventions in Lupus nephritis.
Article
Immunology
Tomohiro Koga, Kunihiro Ichinose, George C. Tsokos
Summary: Systemic lupus erythematosus (SLE) is an autoimmune disease that affects multiple organs. Immune abnormalities contribute to the expression of the disease, with elements of the immune system instigating cellular damage. Correcting immune aberrations and preventing organ damage are both important.
CLINICAL IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Camila Barbosa Oliveira, Camilla Albertina Dantas Lima, Gisele Vajgel, Paula Sandrin-Garcia
Summary: This review manuscript discusses the relationship between the NLRP3 inflammasome, SLE, and LN, emphasizing the impact of genetic susceptibility of NLRP3 polymorphisms on the disease and exploring NLRP3 inhibition mechanisms for the development of potential therapeutic drugs for LN.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Allison C. Billi, Feiyang Ma, Olesya Plazyo, Mehrnaz Gharaee-Kermani, Rachael Wasikowski, Grace A. Hile, Xianying Xing, Christine M. Yee, Syed M. Rizvi, Mitra P. Maz, Celine C. Berthier, Fei Wen, Lam C. Tsoi, Matteo Pellegrini, Robert L. Modlin, Johann E. Gudjonsson, J. Michelle Kahlenberg
Summary: This study analyzed the skin and circulating immune cells of lupus patients using integrated single-cell RNA sequencing and spatial RNA sequencing. The findings reveal that the normal-appearing skin of patients with lupus is characterized by an interferon-rich environment and that CD16+ dendritic cells undergo interferon education in the skin, leading to proinflammatory phenotypes. These results provide important insights into the pathogenesis of cutaneous lupus erythematosus.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Article
Immunology
Jingquan He, Chiyu Ma, Donge Tang, Shaoyun Zhong, Xiaofang Yuan, Fengping Zheng, Zhipeng Zeng, Yumei Chen, Dongzhou Liu, Xiaoping Hong, Weier Dai, Lianghong Yin, Yong Dai
Summary: This study investigated the alteration of oxylipins in the serum of systemic lupus erythematosus (SLE) patients and identified potential biomarkers for SLE classification. The results showed that certain oxylipins were correlated with lupus nephritis (LN) and SLE disease activity. Additionally, a combination of 5 oxylipins was found to have high accuracy in classifying SLE patients. The findings provide insights into the characteristics of SLE and the development of new tools for classification.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Aifen Li, Fengbiao Guo, Quanren Pan, Shuxian Chen, Jiaxuan Chen, Hua-feng Liu, Qingjun Pan
Summary: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with unclear pathogenesis and lack of effective treatments. Mesenchymal stem cell (MSC) therapy has shown promise in treating refractory SLE by modulating immune cells, but its effectiveness and safety in SLE patients require further validation through experimental and clinical evidence.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biotechnology & Applied Microbiology
Marlene Pluess, Silvia Piantoni, Bjoern Tampe, Alfred H. J. Kim, Peter Korsten
Summary: Advances in the treatment and management of systemic lupus erythematosus have improved patient outcomes, but lupus nephritis remains a major complication. Belimumab has been shown to be superior as an add-on therapy for lupus nephritis, and personalized treatment options are expected with the development of new therapeutic agents.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2022)
Article
Immunology
Atsushi Nomura, Miho Mizuno, Daisuke Noto, Aki Aoyama, Taiga Kuga, Goh Murayama, Asako Chiba, Sachiko Miyake
Summary: Mounting evidence suggests the importance of aberrant TLR7 signaling in the development of SLE. However, the exact mechanism remains unclear. In this study, an IMQ-induced lupus model was used to investigate the mechanism related to aberrant TLR7 signals. The results showed that monocytes and monocyte-related cells in the peripheral blood, lymph nodes, and kidneys of IMQ-induced lupus mice exhibited different expression patterns, and these cells played a crucial role in inflammatory response and kidney damage progression.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Environmental Sciences
Heming Bai, Lei Jiang, Ting Li, Chong Liu, Xiaoxia Zuo, Yi Liu, Shaoxian Hu, Linyun Sun, Miaojia Zhang, Jin Lin, Weiguo Xiao, Qingwen Wang, Dongbao Zhao, Huaxiang Wu, Xiaodan Kong, Wenkang Gao, Wanxin Hou, Myeongsu Seong, Yuanpeng Zhang, Fangfang Chen, Sheng Chen, Xin Wu, Chunde Bao, Li Wang, Huji Xu
Summary: The study found that air pollutants PM2.5 and NO2 may be risk factors for lupus nephritis (LN), while short-term exposure to CO and O-3 does not generally have an association with LN. Furthermore, negative associations of LN with SO2 were observed for the entire region and east China.
ENVIRONMENTAL RESEARCH
(2021)
Article
Rheumatology
Xin-yu Zhao, Shuang-shuang Li, Ying-xin He, Li-jie Yan, Fu Lv, Qi-meng Liang, Yu-hui Gan, Li-pei Han, Hong-de Xu, Yong-chun Li, Yuan-yuan Qi
Summary: The study reveals that SGLT2 inhibitors provide renal protection in patients with lupus nephritis. The use of SGLT2 inhibitors decreases anti-dsDNA IgG-specific antibody levels, serum creatinine, and proteinuria. Furthermore, SGLT2 inhibitors alleviate glomerular and tubulointerstitial damages. This study provides more evidence for non-immunosuppressive therapies to improve renal function in classic autoimmune kidney diseases such as lupus nephritis.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Review
Immunology
Masahiro Nakano, Yukiko Iwasaki, Keishi Fujio
Summary: Studies on SLE have identified several disease-relevant signatures, including the IFN signature, myeloid lineage/neutrophil and plasma cell signatures, and the exhaustion signature in CD8(+) T cells, which are correlated with disease activity, nephritis, and complications of pregnancy. Further research is needed to identify treatment targets and patient stratification in SLE, as well as to understand the molecular heterogeneity and distinct subpopulations involved in the pathogenesis of SLE.
INFLAMMATION AND REGENERATION
(2021)
Article
Immunology
Fatima K. Alduraibi, Kathryn A. Sullivan, Hui-Chen Hsu, W. Winn Chatham, John D. Mountz
Summary: Elevated IFNy and IL-17 levels were found in SLE patients, correlated with autoantibody production, while elevated IL-10 levels were associated with LN. LN patients had higher plasma levels of anti-DNA and anti-Sm/RNP. Decreased levels of anti-Sm/RNP were associated with acute mucocutaneous manifestations.
CLINICAL IMMUNOLOGY
(2023)
Article
Rheumatology
Antonis Fanouriakis, Myrto Kostopoulou, Jeanette Andersen, Martin Aringer, Laurent Arnaud, Sang-Cheol Bae, John Boletis, Ian N. Bruce, Ricard Cervera, Andrea Doria, Thomas Doerner, Richard A. Furie, Dafna D. Gladman, Frederic A. Houssiau, Luis Sousa Ines, David Jayne, Marios Kouloumas, Laszlo Kovacs, Chi Chiu Mok, Eric F. Morand, Gabriella Moroni, Marta Mosca, Johanna Mucke, Chetan B. Mukhtyar, Gyoergy Nagy, Sandra Navarra, Ioannis Parodis, Jose M. Pego-Reigosa, Michelle Petri, Bernardo A. Pons-Estel, Matthias Schneider, Josef S. Smolen, Elisabet Svenungsson, Yoshiya Tanaka, Maria G. Tektonidou, Y. K. Onno Teng, Angela Tincani, Edward M. Vital, Ronald F. van Vollenhoven, Chris Wincup, George Bertsias, Dimitrios T. Boumpas
Summary: The EULAR recommendations for the management of systemic lupus erythematosus (SLE) have been updated based on emerging new evidence. The updated recommendations provide consensus guidance on the use of various medications and treatment strategies to control the disease, as well as recommendations for assessing treatment response and tapering therapy.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Medicine, General & Internal
Si Wu, Xiaojun Tang, Liping Wu, Liangjing Lu, Xuebing Feng
Summary: This study analyzed the clinical significance of anti-Ro52 autoantibodies targeting the TRIM21 protein in various connective tissue diseases. The research found that these antibodies may appear in the early stages of CTD with lung involvement, warranting long-term follow-up.
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
(2021)
Article
Rheumatology
Ziyi Jin, Fan Wang, Wenyou Pan, Lin Liu, Min Wu, Huaixia Hu, Xiang Ding, Hua Wei, Yaohong Zou, Xian Qian, Meimei Wang, Jian Wu, Juan Tao, Jun Tan, Zhanyun Da, Miaojia Zhang, Jing Li, Xuebing Feng, Lingyun Sun
Summary: The study showed that antimalarial drugs were associated with a lower mortality risk in SLE patients, especially in cases of renal insufficiency and other organ involvement-related deaths. The protective effects on survival may be enhanced by adherence to and full dosage of these drugs.
Letter
Rheumatology
Ziyi Jin, Jinkou Zhao, Lingyun Sun
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Linyu Geng, Jian Zhao, Yun Deng, Ivan Molano, Xue Xu, Lingxiao Xu, Phillip Ruiz, Quanzhen Li, Xuebing Feng, Miaojia Zhang, Wenfeng Tan, Diane L. Kamen, Sang-Cheol Bae, Gary S. Gilkeson, Lingyun Sun, Betty P. Tsao
Summary: The NCF1-H90 variant contributes to the development of systemic lupus erythematosus by reducing macrophage efferocytosis, enhancing Tfh2 responses, promoting autoantibody production, and causing kidney damage in both mice and patients with SLE.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Rheumatology
Ziyi Jin, Xuebing Feng, Dandan Wang, Yun Zhu, Jun Liang, Huayong Zhang, Jinkou Zhao, Lingyun Sun
Summary: Using data from the Global Burden of Diseases Study 2019, this study quantified the temporal trend of disability-adjusted life years for musculoskeletal disorders based on sex, age, region, and cause. The study found significant disparities in the trends of disability-adjusted life years by cause on global, regional, and national levels, highlighting the need for differentiated prevention and management strategies for musculoskeletal disorders.
Article
Immunology
Yantong Zhu, Xiaojun Tang, Yang Xu, Si Wu, Weilin Liu, Linyu Geng, Xiaolei Ma, Betty P. Tsao, Xuebing Feng, Lingyun Sun
Summary: Systemic lupus erythematosus (SLE) is characterized by the production of pathogenic autoantibodies. This study found that Ribonuclease A family member 2 (RNase2) is highly expressed in SLE patients and is associated with the increase of autoreactive B cells known as age-associated B cells (ABCs). Reduction of RNASE2 expression led to a decrease in ABCs, accompanied by a reduction in total IgG and IL-10 levels. It was also found that both RNASE2 and IL-10 in SLE patients were mainly derived from monocytes. The study concluded that RNASE2 might induce the production of ABCs via IL-10 secreted from monocytes, contributing to the pathogenesis of SLE.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Rheumatology
Linyu Geng, Wenqiang Qu, Sen Wang, Jiaqi Chen, Yang Xu, Wei Kong, Xue Xu, Xuebing Feng, Cheng Zhao, Jun Liang, Huayong Zhang, Lingyun Sun
Summary: By analyzing and evaluating the effectiveness of different antibodies in detecting rheumatoid arthritis (RA) and related autoimmune diseases, this study aims to establish a machine learning model for predicting RA diagnosis. The results show that the combination of multiple antibodies and patient symptoms improves diagnostic accuracy compared to single antibody tests. In-depth analysis of autoantibodies and reliable early diagnosis based on neural networks can guide treatment plans and enable early intervention with antirheumatic drugs.
CLINICAL RHEUMATOLOGY
(2022)
Article
Rheumatology
Yoosuf Ali Ashraf Muhammad Hussenbocus, Ziyi Jin, Wenyou Pan, Lin Liu, Min Wu, Huaixia Hu, Xiang Ding, Hua Wei, Yaohong Zou, Xian Qian, Meimei Wang, Jian Wu, Juan Tao, Jun Tan, Zhanyun Da, Miaojia Zhang, Jing Li, Xuebing Feng, Lingyun Sun
Summary: The study revealed that low dosage use of cyclophosphamide (CYC) reduced the overall mortality risk of SLE. CYC may improve the survival of SLE patients with renal, neuropsychiatric, cardiopulmonary, gastrointestinal, and hematological involvements.
CLINICAL RHEUMATOLOGY
(2022)
Article
Rheumatology
Mei Li, Jun Liang, Wenyou Pan, Lin Liu, Min Wu, Fuwan Ding, Huaixia Hu, Xiang Ding, Hua Wei, Yaohong Zou, Xian Qian, Meimei Wang, Jian Wu, Juan Tao, Jun Tan, Zhanyun Da, Miaojia Zhang, Jing Li, Xuebing Feng, Lihui Wen, Huayong Zhang, Lingyun Sun
Summary: This study analyzed the factors associated with improvement in disease activity after the first hospitalized treatment based on the systemic lupus erythematosus disease activity index (SLEDAI). The results showed that organ damage or comorbidities at admission had a negative impact on the improvement of the disease, while factors such as positive anti-dsDNA antibody, hypocomplementemia, musculoskeletal involvement, and leflunomide treatment were positively associated with disease activity improvement in systemic lupus erythematosus (SLE).
CLINICAL RHEUMATOLOGY
(2022)
Article
Multidisciplinary Sciences
Lihui Wen, Ziyan Chen, Ziyi Jin, Wenyou Pan, Lin Liu, Min Wu, Fuwan Ding, Huaixia Hu, Xiang Ding, Hua Wei, Yaohong Zou, Xian Qian, Meimei Wang, Jian Wu, Juan Tao, Jun Tan, Zhanyun Da, Miaojia Zhang, Jing Li, Xuebing Feng, Jun Liang, Huayong Zhang, Lingyun Sun
Summary: This multicentre study compared the clinical manifestations and laboratory findings of systemic lupus erythematosus among different age-onset patients in China. The results showed that younger-onset patients had higher disease activity and were more likely to have mucocutaneous symptoms and proteinuria. On the other hand, later-onset patients were more prone to cardiopulmonary involvement.
SCIENTIFIC REPORTS
(2022)
Article
Immunology
Linyu Geng, Wenqiang Qu, Jun Liang, Wei Kong, Xue Xu, Wenyou Pan, Lin Liu, Min Wu, Fuwan Ding, Huaixia Hu, Xiang Ding, Hua Wei, Yaohong Zou, Xian Qian, Meimei Wang, Jian Wu, Juan Tao, Jun Tan, Zhanyun Da, Miaojia Zhang, Jing Li, Huayong Zhang, Xuebing Feng, Jiaqi Chen, Lingyun Sun
Summary: This study developed survival analysis models using data mining techniques to predict the survival outcomes and status of hospitalized systemic lupus erythematosus patients in Jiangsu province. Cox proportional hazards model and neural network models were used for analysis and prediction, and semi-supervised learning and cost-sensitivity were employed to address data imbalance and pseudo label credibility. The study identified the impact of cardiopulmonary and neuropsychiatric involvement, abnormal blood urea nitrogen levels, and alanine aminotransferase level on patient survival time, and developed a graphical user interface to assist physicians in diagnosis and treatment.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Rheumatology
Wenjing Li, Dandan Wang, Ling Ma, Yun Zhu, Fan Wang, Bingzhu Hua, Hong Wang, Xuebing Feng
Summary: This study assessed the remission rate of eltrombopag in severe immune thrombocytopenia (ITP) secondary to connective tissue disease (CTD) and explored factors related to drug efficacy. The results showed that patients with higher white blood cell counts, lower triglyceride levels, or prior use of multiple immunosuppressants had better efficacy. Patients with megakaryocytopenia in bone marrow tended to have a lower remission rate. Pooled data from literature also supported the association between leukopenia, megakaryocytopenia, and fewer prior immunosuppressants with poor remission.
CLINICAL RHEUMATOLOGY
(2023)
Article
Medicine, General & Internal
Huixian Chen, Fan Wang, Ye Yang, Bingzhu Hua, Hong Wang, Jie Chen, Xuebing Feng
Summary: Research shows that hearing loss is not uncommon in patients with systemic lupus erythematosus, and extended high frequency audiometry can help identify early hearing impairment. A high Systemic Lupus International Collaborating Clinics Damage Index and secondary Sjogren's syndrome may predict the presence of hearing loss in SLE patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Yan Han, Ziyi Jin, Ling Ma, Dandan Wang, Yun Zhu, Shanshan Chen, Bingzhu Hua, Hong Wang, Xuebing Feng
Summary: This study explores the clinical features of patients with systemic lupus erythematosus and Sjogren's syndrome overlap and develops predictive tools for screening SLE-SS cases.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Rheumatology
Shengnan Zhao, Xiaolei Ma, Xin Zhang, Ziyi Jin, Wei Hu, Bingzhu Hua, Hong Wang, Xuebing Feng, Lingyun Sun, Zhiyong Chen
Summary: This study evaluates the clinical significance of HScore and MS score in predicting the prognosis of anti-MDA5-positive DM-ILD patients. It found that older age, male gender, and high HScore were independent risk factors for mortality among these patients.
MODERN RHEUMATOLOGY
(2022)
