Review
Immunology
Susan Yung, Tak Mao Chan
Summary: Lupus nephritis is a severe manifestation of systemic lupus erythematosus, and early diagnosis and management are crucial. Kidney biopsy remains the gold standard for diagnosis, but it is invasive and cannot be frequently repeated. Current clinical indicators are non-specific, and novel biomarkers are needed for better management.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Neurosciences
Jonathan D. Drake, Alison B. Chambers, Brian R. Ott, Lori A. Daiello
Summary: The study found that plasma-based vascular biomarkers, particularly VCAM-1 and ICAM-1, were associated with Alzheimer's disease (AD) and clinical impairment. VCAM-1 was linked with clinical dementia rating sum-of-boxes (CDR-SB) scores, with the APOE epsilon 4 genotype modifying this relationship. Additionally, combining VCAM-1 and cerebrospinal fluid (CSF) biomarkers showed independent associations with AD-related clinical impairment.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Retraction
Biochemistry & Molecular Biology
Zu-Dong Meng, Xiao-Lan Wang, Tian-Ping Du, Yu Wang, Gui-Fang Qin, Hong-Bo Zhao, Yu-Jie Chen, Bo Tian
Summary: The study on the effects of RNA interference-mediated E-selectin gene silencing on vascular endothelial cells of mice with immunologic contact urticaria was retracted due to image elements of the experimental data being published elsewhere in a different scientific context.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2021)
Article
Urology & Nephrology
Tiffany N. Caza, Samar I. Hassen, Michael Kuperman, Shree G. Sharma, Zeljko Dvanajscak, John Arthur, Rick Edmondson, Aaron Storey, Christian Herzog, Daniel J. Kenan, Christopher P. Larsen
Summary: Research has identified neural cell adhesion molecule 1 (NCAM1) as a target antigen in some cases of membranous lupus nephritis and rare cases of primary membranous nephropathy, colocalizing with IgG in glomerular immune deposits. Circulating antibodies to NCAM1 have been detected in serum of patients with NCAM1-associated membranous nephropathy, suggesting diagnostic significance. Future studies are needed to determine whether anti-NCAM1 antibody levels correlate with disease activity or response to therapy.
KIDNEY INTERNATIONAL
(2021)
Article
Rheumatology
Kelvin Y. C. Yu, Susan Yung, Mel K. M. Chau, Colin S. O. Tang, Desmond Y. H. Yap, Alexander H. N. Tang, Shirley K. Y. Ying, Cheuk Kwong Lee, Tak Mao Chan
Summary: The study found that levels of syndecan-1, HA, and thrombomodulin were significantly elevated in patients with active lupus nephritis and correlated with various clinical parameters. Longitudinal studies showed that syndecan-1 and thrombomodulin levels increased before clinical renal flare, while HA levels increased at the time of nephritic flare. These biomarkers have the potential to differentiate between active lupus nephritis and other conditions, and may provide insight into the pathogenesis of the disease.
Article
Immunology
Yiwei Shen, Kamala Vanarsa, Zhihua Yin, Ting Zhang, Jessica Castillo, Min Dai, Linghua Zou, Ling Qin, Jieying Wang, Qiang Guo, Ramesh Saxena, Michelle Petri, Nan Shen, Zhizhong Ye, Chandra Mohan, Huihua Ding
Summary: This study reports a non-invasive urinary biomarker, L-selectin, which shows potential value in the diagnosis and treatment of lupus nephritis (LN) across different ethnic groups.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Rheumatology
Kelvin Y. C. Yu, Susan Yung, Mel K. M. Chau, Colin S. O. Tang, Desmond Y. H. Yap, Alexander H. N. Tang, Shirley K. Y. Ying, Cheuk Kwong Lee, Tak Mao Chan
Summary: The study investigates the clinical-pathological associations of serum VCAM-1 and ICAM-1 levels in patients with biopsy-proven Class III/IV +/- V lupus nephritis. VCAM-1 level is correlated with proteinuria, serum creatinine, anti-dsDNA antibodies, and histopathological features in active LN kidney biopsies, while ICAM-1 level is correlated with proteinuria but not with other markers. Monitoring VCAM-1 may facilitate early diagnosis of flare, and combining selected biomarkers may be advantageous in diagnosing active LN.
Review
Cardiac & Cardiovascular Systems
Jessica R. Pickett, Yuao Wu, Lucia F. Zacchi, Hang T. Ta
Summary: Vascular cell adhesion molecule-1 (VCAM-1) plays a crucial role in atherosclerosis and has been targeted for anti-atherosclerotic drug development. Most current VCAM-1-inhibiting drug candidates indirectly down-regulate VCAM-1 expression by inhibiting upstream cytokines, but optimizing dosage to balance pathological activity and normal physiological function is challenging. Recently, specific strategies that selectively inhibit VCAM-1 function, such as peptide- and antibody-based therapeutics, have emerged. However, studies on these novel VCAM-1-directed therapies are limited by the complexity of atherosclerosis pathophysiology.
CARDIOVASCULAR RESEARCH
(2023)
Article
Medicine, Research & Experimental
Masaki Arioka, Fumi Seto-Tetsuo, Takeru Inoue, Koichi Miura, Shin Ishikane, Kazunobu Igawa, Katsuhiko Tomooka, Fumi Takahashi-Yanaga, Toshiyuki Sasaguri
Summary: This study reveals that DIF-1 reduces the adhesion of tumor cells to blood vessels by inhibiting mTORC1-S6K signaling and decreasing the expression of adhesion molecule VCAM-1 on vascular endothelial cells. These findings highlight the potential of DIF-1 as a promising compound for the development of anti-cancer drugs with anti-metastatic properties.
Article
Rheumatology
Yuji Nozaki, Toshihiko Shiga, Chisato Ashida, Daisuke Tomita, Tetsu Itami, Kazuya Kishimoto, Koji Kinoshita, Itaru Matsumura
Summary: The study suggests that urinary levels of KIM-1 are correlated with disease activity and renal histopathology in LN, and may serve as a predictor of treatment response.
Article
Immunology
Qianqian Guo, Kunimaro Furuta, Shahidul Islam, Nunzia Caporarello, Enis Kostallari, Kobe Dielis, Daniel J. J. Tschumperlin, Petra Hirsova, Samar H. H. Ibrahim
Summary: The study reveals that VCAM1 not only functions as a scaffold for leukocyte adhesion during liver injury, but also modulates LSEC capillarization and liver fibrosis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Rheumatology
Walaa Hosny Mohammed Ibrahim, Alaa AbdelAziz Sabry, Ahmed Raafat Abdelmoneim, Hamdy Fouad Ali Marzouk, Rasha Mahmoud AbdelFattah
Summary: This study aimed to investigate urinary biomarkers in lupus nephritis and their relation to kidney damage. The results showed that before treatment, the lupus nephritis group had higher levels of uNGAL and uKIM-1, which significantly decreased after treatment. uNGAL and uKIM-1 can be used as predictors and markers of disease activity for lupus nephritis.
CLINICAL RHEUMATOLOGY
(2023)
Article
Biology
Sandra Marinovic Kulisic, Marta Takahashi, Marta Himelreich Peric, Vedrana Muzic Radovic, Ruzica Jurakic Toncic
Summary: This study evaluated the expression of E-selectin, ICAM-1, and VCAM-1 in skin biopsy specimens of patients with AD using a computer program. The results showed that the number of ICAM-1 and VCAM-1 positive cells decreased, while the E-selectin positive epidermal surface area increased in AD patients. The endothelial area positive for E-selectin and ICAM1 was significantly larger in AD-affected skin. In addition, strong signals of E-selectin were detected in skin macrophages and ICAM-1 in dermal vessel endothelium. VCAM-1 signal could not be found in the endothelial cells of AD-affected skin. The expression of E-selectin, ICAM-1, and VCAM-1 shows significant changes in AD-affected skin compared to control skin.
Article
Biochemistry & Molecular Biology
Taichi Matsumoto, Junichi Matsumoto, Yuka Matsushita, Moeno Arimura, Kentaro Aono, Mikiko Aoki, Kazuki Terada, Masayoshi Mori, Yutaka Haramaki, Takuya Imatoh, Atsushi Yamauchi, Keisuke Migita
Summary: This study investigated the effect of bortezomib (BTZ) on vascular permeability and expression of cell-cell junction molecules in human pulmonary microvascular endothelial cells. The findings showed that clinically relevant concentrations of BTZ increased the permeability of endothelial cell monolayers and downregulated the expression of claudin-5, occludin, and VE-cadherin at both protein and mRNA levels. This suggests that BTZ-induced pulmonary toxicity may be mediated by increased vascular permeability caused by the downregulation of these cell-cell junction molecules.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Immunology
Elisabeth J. M. Huijbers, Kabir A. Khan, Robert S. Kerbel, Arjan W. Griffioen
Summary: Tumors can escape immunity by inducing a state of unresponsiveness in tumor vasculature, leading to compromised immune responses. By mimicking embryonic mechanisms through angiogenesis, tumors enforce immune privileged conditions to ensure uninterrupted growth.
SCIENCE IMMUNOLOGY
(2022)
