Article
Rheumatology
Jung Sun Lee, Eun-Ju Lee, Jeonghun Yeom, Ji Seon Oh, Seokchan Hong, Chang-Keun Lee, Bin Yoo, Kyunggon Kim, Yong-Gil Kim
Summary: This study identified urinary APOH as a potential biomarker for diagnosing SLE, with high sensitivity and specificity, making it a promising screening tool in clinical settings when SLE is suspected.
Article
Immunology
Ming-long Cai, Lan Gui, He Huang, Yu-kun Zhang, Li Zhang, Zhu Chen, Yu-jun Sheng
Summary: This study revealed heterogeneity in the pathogenesis of SLE between male and female patients, with male SLE showing higher levels of neutrophil activation. These findings provide a basis for the development of gender-specific treatments.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Ji-Won Kim, Wook-Young Baek, Ju-Yang Jung, Hyoun-Ah Kim, Cheong In Yang, Seung-Ju Kim, Chang-Hee Suh
Summary: This study found that seasonal vitamin D levels are correlated with clinical manifestations and disease activity in lupus patients. Adequate vitamin D levels are important for achieving a low disease activity state in both winter and summer.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Biochemistry & Molecular Biology
Ju-Yang Jung, Jin-Young Nam, Keun-Sil Ryu, In-Ok Son, Joo-Ho Shin, Wook-Young Baek, Hyoun-Ah Kim, Chang-Hee Suh
Summary: Through proteomic analysis, it was found that salivary IGHG3 levels were associated with SLE and lupus disease activity, indicating that salivary IGHG3 may be a promising noninvasive biomarker for SLE.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Jingquan He, Donger Tang, Dongzhou Liu, Xiaoping Hong, Chiyu Ma, Fengping Zheng, Zhipeng Zeng, Yumei Chen, Jie Du, Lin Kang, Lianghong Yin, Qianjin Lu, Yong Dai
Summary: Proteomics and metabolomics analyses of serum from SLE patients and healthy individuals revealed significant changes in 90 proteins and 76 metabolites. Several apolipoproteins and a metabolite were associated with disease activity, while others were correlated with renal function. Using these significantly changed molecules, a random forest model identified potential biomarkers for SLE diagnosis.
CLINICAL IMMUNOLOGY
(2023)
Review
Immunology
Paul Curtiss, Amanda M. Walker, Benjamin F. Chong
Summary: This study reviewed patient cohorts and populations to investigate the progression of cutaneous lupus to systemic lupus. The study found variations in the progression rates between adult and pediatric groups, which were attributed to differences in patient populations, study design, diagnostic criteria, and follow-up time. Risk factors associated with the development of systemic lupus included positive anti-nuclear antibodies, hematologic abnormalities, and a higher number of lupus classification criteria at baseline.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Oncology
Kaichi Kaneko, Hao Chen, Matthew Kaufman, Isaak Sverdlov, Emily M. Stein, Kyung-Hyun Park-Min
Summary: Osteonecrosis is a complex and devastating complication of systemic lupus erythematosus, with variable prevalence in SLE patients. The use of high-dose glucocorticoid therapy is strongly associated with the development of osteonecrosis in SLE patients, although the exact pathophysiology and risk factors for osteonecrosis in this population are not fully understood.
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Article
Immunology
Xiaoyue Qiao, Li Lu, Kangxing Zhou, Liping Tan, Xuan Liu, Jiali Ni, Yayi Hou, Jun Liang, Huan Dou
Summary: This study evaluated the correlation between PRG2 and NPSLE for the first time. The findings showed that PRG2 protein was overexpressed in NPSLE patients and correlated with the subset scores of psychosis. Additionally, the study revealed a correlation between hippocampal PRG2 level and learning and memory ability in mice.
CLINICAL IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Valeria Rella, Cinzia Rotondo, Alberto Altomare, Francesco Paolo Cantatore, Addolorata Corrado
Summary: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with a wide range of clinical manifestations. Dysregulation of the immune system due to genetic, hormonal, and environmental factors can lead to various complications, including bone involvement such as osteoporosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Shunxiang Li, Huihua Ding, Ziheng Qi, Jing Yang, Jingyi Huang, Lin Huang, Mengji Zhang, Yuanjia Tang, Nan Shen, Kun Qian, Qiang Guo, Jingjing Wan
Summary: Serum metabolic fingerprints can be used for disease diagnosis and biomarker discovery. By analyzing the serum metabolic fingerprints of systemic lupus erythematosus (SLE) patients and healthy controls, early diagnosis and precision medicine for SLE can be achieved. This study identified the unique metabolic pattern of SLE patients and screened out a panel of metabolic biomarkers.
Article
Medical Laboratory Technology
Guisheng Zhou, Peng Wei, Jinshan Lan, Qiongzi He, Feng Guo, Yunke Guo, Wanjian Gu, Tingting Xu, Shijia Liu
Summary: This study compared the protein profiles of healthy individuals and SLE patients to reveal the pathogenesis of SLE and identify specific biomarkers for diagnosis. SAA1 and CD248 were identified as reliable biomarkers for early immune diagnosis of SLE.
CLINICA CHIMICA ACTA
(2022)
Review
Medicine, General & Internal
Johan Frostegard
Summary: The prognosis in systemic lupus erythematosus (SLE) has improved, but cardiovascular disease (CVD) still remains a significant clinical problem. Atherosclerosis and antiphospholipid antibody syndrome are the main underlying causes of CVD in SLE. Inflammation and low levels of anti-phosphorylcholine also contribute to the increased risk of CVD in SLE. Close monitoring and treatment of both traditional and non-traditional risk factors are important.
JOURNAL OF INTERNAL MEDICINE
(2023)
Review
Immunology
Jiaxuan Chen, Shuzhen Liao, Wanxian Pang, Fengbiao Guo, Lawei Yang, Hua-feng Liu, Qingjun Pan
Summary: Systemic lupus erythematosus (SLE) is a highly heterogeneous autoimmune disease that primarily affects women. This review explores the mechanisms of SLE pathogenesis, focusing on the impact of lifestyle factors. Studies have found associations between diet, cigarette smoking, ultraviolet radiation exposure, alcohol and caffeine-rich beverage consumption, and SLE susceptibility. The review summarizes these relationships and outlines directions for future research.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Haitao Yu, Yasuo Nagafuchi, Keishi Fujio
Summary: Systemic lupus erythematosus (SLE) is a clinically heterogeneous disease characterized by immune dysfunction. Clinical and immunological biomarkers are crucial for diagnosing, assessing, and controlling SLE, including novel biomarkers discovered through omics research.
Review
Immunology
Weijie Wang, Yongsheng Fan, Xinchang Wang
Summary: This review discusses the dual role of Lactobacillus in systemic lupus erythematosus (SLE), as it can both affect the development of SLE and have therapeutic and anti-inflammatory effects. The involvement of Lactobacillus in SLE sheds light on the understanding of its development and provides evidence for the development of microbiota-targeted therapies.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemical Research Methods
Biying Hu, Dandan Li, Zhipeng Zeng, Zeyu Zhang, Rui Cao, XiangNan Dong, Chen Yun, Ling Li, Bernhard Kramer, Stanislao Morgera, Berthold Hocher, Donge Tang, Lianghong Yin, Yong Dai
Summary: This study reveals the proteomic features of Kmal in RA for the first time and suggests that malonylation may be involved in the NETosis pathway.
JOURNAL OF PROTEOMICS
(2022)
Article
Biochemical Research Methods
Jingjing Dong, Jingquan He, Zeyu Zhang, Wei Zhang, Yixi Li, Dandan Li, Hongliang Xie, Wenxin Zuo, Jianming Tang, Zhipeng Zeng, Wanxia Cai, Liusheng Lai, Manhua Yun, Lingjun Shen, Lianghong Yin, Donge Tang, Yong Dai
Summary: This study conducted the first comparative analysis of Kac modification in oral squamous cell carcinoma using LC-MS/MS, identifying multiple upregulated and downregulated Kac sites. Further analysis revealed that these acetylation proteins were enriched in the ribosome biogenesis pathway and may be associated with the pathogenesis of OSCC.
JOURNAL OF PROTEOMICS
(2022)
Article
Immunology
Wei Zhang, Lintai Li, Jianxuan Li, Haiyan Yu, Fengping Zheng, Bin Yan, Wanxia Cai, Yumei Chen, Lianghong Yin, Donge Tang, Yong Xu, Yong Dai
Summary: This study found a positive correlation between the expression of neurotransmitter receptors and relapse-free survival rates in breast cancer patients. Specifically, the expression of HTR6 was significantly decreased in advanced breast cancer. Further analysis revealed the potential regulatory role of HTR6 in signaling pathways and its association with the immune microenvironment. The study also identified possible reasons for the down-regulation of HTR6 in breast cancer.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Zongchao Yu, Xiaoping Hong, Xiaoli Zhang, Fengping Zheng, Fanna Liu, Huixuan Xu, Chengxin Zhu, Wanxia Cai, Dongzhou Liu, Lianghong Yin, Bo Hu, Donge Tang, Yong Dai
Summary: This study investigated potential pathways involved in the pathogenesis of new-onset ankylosing spondylitis (AS) through systematic proteomic and phosphorylation analyses, and identified proteins that could be used as candidate markers for AS diagnosis and new therapeutic targets.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Hongwei Wu, Jingjing Dong, Haiyan Yu, Kang Wang, Weier Dai, Xinzhou Zhang, Nan Hu, Lianghong Yin, Donge Tang, Fanna Liu, Yong Dai
Summary: This study integrated single-cell RNA sequencing (scRNA-seq) and single-cell assay for transposase-accessible chromatin sequencing (scATAC-seq) to investigate the transcriptional program and chromosomal accessibility of peripheral mononuclear cells (PBMCs) in maintenance hemodialysis patients. The study found that hemodialysis suppressed the expression of immune-related genes in CD4+ T cells and monocytes, inhibited downstream pathways of T cell receptor signaling, and altered cellular communication patterns between PBMC subgroups. Additionally, hemodialysis affected the chromatin accessibility profile and expression of transcription factors. This study provides a valuable framework for studying hemodialysis-related immune dysregulation and identifies potential therapeutic targets.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Wenbiao Chen, Donge Tang, Junqi Lin, Xiaoming Huang, Shaoming Lin, Guanle Shen, Yong Dai
Summary: This study investigated the biological function of circSHKBP1 in NSCLC and found that it enhanced proliferation, migration, invasion, and stemness of NSCLC cells. The study also identified the miR-1294/PKM2 axis as the mechanism by which circSHKBP1 regulates NSCLC progression. These findings suggest that circSHKBP1 may serve as a potential prognostic biomarker and therapeutic target for NSCLC.
MOLECULAR THERAPY-ONCOLYTICS
(2022)
Review
Immunology
Yixi Li, Donge Tang, Lianghong Yin, Yong Dai
Summary: Lupus nephritis (LN) is a complex autoimmune disease, and recent research has shown the potential of regulatory T (Treg) cell therapy in treating autoimmune diseases. However, there is limited understanding of Treg cell therapy for LN patients. This review aims to summarize new insights into Treg-targeting techniques in LN patients.
AUTOIMMUNITY REVIEWS
(2022)
Article
Rheumatology
Huixuan Xu, Haiyan Yu, Fengping Zheng, Cantong Zhang, Wanxia Cai, Xinzhou Zhang, Donge Tang, Yong Dai
Summary: This study provides a new perspective for understanding the pathophysiology of chronic hepatitis B (CHB) by analyzing the gene regulatory network in CHB patients using single-cell ATAC sequencing. The specific cell types associated with CHB were found to be located in B-0 and T-3. The regulatory network of the hepatitis B signal pathway composed of genes linked to the differentially expressed peaks of these two CHB disease-specific cell types was drawn.
CLINICAL RHEUMATOLOGY
(2022)
Article
Immunology
Yafang Zhong, Wei Zhang, Xiaoping Hong, Zhipeng Zeng, Yumei Chen, Shengyou Liao, Wanxia Cai, Yong Xu, Gang Wang, Dongzhou Liu, Donge Tang, Yong Dai
Summary: Our study identified ABCB1, IFI27, and PLSCR1 as potential diagnostic genes for Chinese SLE patients and uncovered their most relevant immune cells. The findings in this paper provide possible biomarkers for diagnosing Chinese SLE patients.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Haiyan Yu, Donge Tang, Hongwei Wu, Chunhong Li, Yongping Lu, Fang He, Xiaogang Zhang, Yane Yang, Wei Shi, Wenlong Hu, Zhipeng Zeng, Weier Dai, Minglin Ou, Yong Dai
Summary: This study used integrated single-cell RNA sequencing and single-cell transposase-accessible chromatin sequencing analyses to investigate cellular heterogeneity and transcriptional regulatory networks during human spine development. The findings revealed that fibroblasts with stem cell characteristics can differentiate into chondrocytes and neurons may originate from neuroendocrine cells. The interaction between macrophages and neurons involving NRP2_SEMA3C and CD74_APP is crucial for spinal cord development.
Article
Multidisciplinary Sciences
Wencong Song, Chunhong Li, Jie Qiu, Jiyou Dong, Dongzhou Liu, Yong Dai
Summary: This study examined the expression profiles of exosomal miRNAs and proteins in the plasma of SLE patients and healthy subjects and discussed the underlying signaling network of circulating exosomes. The study identified differentially expressed exosomal miRNAs and proteins in SLE patients and healthy controls, as well as consensus molecules and signaling pathways. These findings indicate the potential application of exosomes in the clinical treatment and diagnosis of SLE disease.
Article
Rheumatology
Fengping Zheng, Lishan Tan, Fan Zhang, Sanmu Li, Zhiwei Lai, Huixuan Xu, Zuying Xiong, Yong Dai
Summary: This study investigated the role of circRNA in systemic lupus erythematosus (SLE) by analyzing its expression in plasma and peripheral blood mononuclear cells (PBMCs). Differentially expressed circRNAs were identified and their potential diagnostic and pathogenic roles in SLE were explored through network analysis.
CLINICAL RHEUMATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Wenjun Pu, Xi Wang, Xiaoni Zhong, Dong Zhao, Zhipeng Zeng, Wanxia Cai, Yafang Zhong, Jianrong Huang, Donge Tang, Yong Dai
Summary: This study analyzed and compared the spatial distribution of metabolites in healthy control and hepatitis B cirrhosis tissue samples using LC-MS/MS and mass spectrometry imaging system. The results showed that hepatitis B cirrhosis induced region-specific autophagy and dysregulation of unsaturated fatty acids, amino acids, and phosphatidylcholines metabolism. The mass spectrometry imaging system provided additional metabolites' spatial information, which can promote biomarker screening technology and support the exploration of novel mechanisms in liver cirrhosis.
HEPATOLOGY COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Yan Yang, Chiyu Ma, Shishi Li, Wanxia Cai, Weier Dai, Xinzhou Zhang, Lianghong Yin, Donge Tang, Fanna Liu, Yong Dai
Summary: By analyzing the microbiota and serum metabolites in urine samples from patients with diabetic kidney disease (DKD), it was found that DKD patients had a different urinary microbiota compared to the healthy controls, with the most abundant microbiota being Proteobacteria and Acidobacteria. Short-chain fatty acids and protein-bound uremic toxins were shown to be specific to DKD. Furthermore, the study revealed that the metabolism of arginine and proline may play a major role in the regulation of DKD.
Article
Biochemistry & Molecular Biology
Yingwei Zhang, Zeyu Zhang, Chundi Li, Donge Tang, Yong Dai
Summary: This study demonstrated that Empagliflozin treatment can significantly improve the metabolites involved in fatty acid oxidation pathway in the heart of db/db diabetic mice, suggesting its potential therapeutic intervention for diabetic cardiomyopathy.
