Article
Medicine, General & Internal
Hongshuang Dai, Lin Li, Yikun Yang, Huang Chen, Xin Dong, Yousheng Mao, Yanning Gao
Summary: A risk model for predicting the prognosis of lung adenocarcinoma patients was constructed by screening and validating miRNAs associated with the prognosis. The model shows good consistency with the actual prognosis of patients.
ANNALS OF MEDICINE
(2023)
Article
Oncology
Irina Robinson, Alexandra Bertsch, Katharina Leithner, Philipp Stiegler, Horst Olschewski, Andelko Hrzenjak
Summary: The study found significant differences in the expression of miRNAs between lung adenocarcinoma cells and healthy donor cells. Four miRNAs were found to be deregulated in plasma samples of lung adenocarcinoma patients, and their target genes are closely related to the mechanisms of tumor development and progression.
Article
Oncology
Dahua Liu, Min An, Guimin Wen, Yanan Xing, Pu Xia
Summary: With the high incidence and mortality rate of lung cancer, it is of great importance to analyze the molecular mechanism and identify early diagnosis markers. SLC3A2 protein, which is highly expressed in lung cancer, plays a crucial role in tumorigenesis and development, and has the potential to become a new target for tumor treatment. The levels of SLC3A2 in serum and tissue can serve as prognostic markers for lung cancer and provide valuable insights for diagnosis, treatment, and prognosis.
Review
Oncology
Scott M. MacKenzie, Hannah Saunders, Josie C. van Kralingen, Stacy Robertson, Alexandra Riddell, Maria-Christina Zennaro, Eleanor Davies
Summary: Many patients are at increased risk of primary aldosteronism (PA) due to difficulties in accurate diagnosis. Circulating microRNAs are being explored as potential biomarkers for PA, but reproducibility of studies has been a challenge due to technical reasons.
Article
Multidisciplinary Sciences
Lecai Xiong, Xueyu He, Le Wang, Peng Dai, Jinping Zhao, Xuefeng Zhou, Hexiao Tang
Summary: This study investigated the hypoxia-associated molecular hallmarks in LUAD, constructed prognostic models based on hypoxia-related DEGs, and explored the ceRNA network underlying the potential mechanism of poor prognosis.
SCIENTIFIC REPORTS
(2022)
Article
Genetics & Heredity
Chong Zhang, Zhehao He, Ling Cheng, Jinlin Cao
Summary: The study focused on exploring potential prognostic markers of LUAD and successfully built a five-gene prognostic model, which effectively divided samples into high- and low-risk groups with favorable survival outcomes in the training set. Further analysis using GSEA, TMB, and immune infiltration revealed differences in gene expression, mutation frequency, and immune activity between the two risk groups.
FRONTIERS IN GENETICS
(2021)
Article
Multidisciplinary Sciences
Kang Sun, Zhiqiang Zhang, Dongqin Wang, Yinlong Huang, Jing Zhang, Chaoqun Lian
Summary: This study aims to find new early diagnosis and prognosis markers and explore the relationship among the markers, immunity, and hypoxia to improve lung adenocarcinoma patients' prognosis. By analyzing the clinical database, critical clinicopathological parameters affecting patients' prognosis were determined, and risk genes related to early prognosis were screened. The risk model based on these risk genes was accurate and stable, closely related to immunity and hypoxia.
SCIENTIFIC REPORTS
(2023)
Article
Endocrinology & Metabolism
Haixia Lin, Kelly E. Mercer, Xiawei Ou, Kori Mansfield, Robert Buchmann, Elisabet Borsheim, Emir Tas
Summary: This study aimed to assess the relationship between serum miRNA profile in children with obesity, insulin resistance (IR), and non-alcoholic fatty liver disease (NAFLD). The results showed that several miRNAs were differentially expressed in children with IR and NAFLD, which may provide new targets for the diagnosis and treatment of pediatric NAFLD.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Oncology
Liang Huang, Anqi Zhang, Chunyan Tang, Jinmei Wei, Miao Li, Shishan Yuan, Huihui Zhang, Xia Zhang
Summary: In this study, potential biomarkers and treatment targets for LUAD were investigated using data from The Cancer Genome Atlas. A total of 4,485 differentially expressed genes (DEGs) were identified between tumor and adjacent control tissues. Functional analysis revealed enrichment of DEGs in pathways related to system development, cell cycle and cell adhesion. Hub gene analysis identified five hub genes that showed associations with tumor onset and patient prognosis. Further experiments confirmed the downregulation of SLC6A4 in LUAD tumor tissues and revealed that SLC6A4 overexpression inhibited cell growth, invasion and migration.
MOLECULAR MEDICINE REPORTS
(2023)
Review
Biochemistry & Molecular Biology
Michal Eid, Paraskevi Karousi, Lumir Kunovsky, Stepan Tucek, Dagmar Brancikova, Zdenek Kala, Ondrej Slaby, Jiri Mayer, Christos K. Kontos, Jan Trna
Summary: PDAC is increasing in incidence and associated with high mortality rates. Radical surgery is the only potential curative procedure, but only a minority of patients achieve radicality. miRNAs play an important role in PDAC, potentially serving as non-invasive diagnostic and prognostic biomarkers.
Article
Cell Biology
Alexia Monastirioti, Chara Papadaki, Konstantinos Rounis, Despoina Kalapanida, Dimitrios Mavroudis, Sofia Agelaki
Summary: The study revealed that high expression of miR-202 in non-small cell lung cancer patients is associated with disease progression, shorter progression-free survival, and overall survival. In subgroup analysis, miR-202 and miR-26a expression had different impacts on overall survival in squamous and non-squamous subgroups. These findings suggest that circulating miRNAs may serve as potential biomarkers in NSCLC patients.
Article
Oncology
Shunsuke Shikanai, Noriyuki Yamada, Naoki Yanagawa, Mayu Sugai, Mitsumasa Osakabe, Hajime Saito, Makoto Maemondo, Tamotsu Sugai
Summary: This study investigated the association between macrophage phenotypes and prognosis in lung adenocarcinoma. The expression levels of CD68/phospho-STAT1 and CD68/c-Maf were found to be correlated with overall survival and disease-free survival. Additionally, the M1/M2 ratio was identified as an important prognostic factor.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Cell Biology
Shuzhen Tan, Zesong Li, Kai Li, Yingqi Li, Guosheng Liang, Zhenye Tang, Jianhao Kang, Wenqing Chen, Minhua Li, Zhilin Zou, Guoliang Pi, Xiao Zhu
Summary: The study analyzed the correlation between m(6)A RNA methylation regulators and the occurrence and development of lung cancer, revealing that some m(6)A regulators have high expression in lung cancer and risk score is an independent prognostic factor in lung cancer.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Ting -Fang Che, Chao-Hua Chiu, Yu-Chung Wu, Jia-Yang Chen, Teh-Ying Chou, Yi-Chun Cheng, Chi-Lu Chiang, Chien-Sheng Huang, I-Shuan Tuang, Yang-Hui Ho, Jian-Hua Hong, Yen-Jang Huang, Hsiang-Ling Ho, Ying-Chih Chang
Summary: We evaluated the clinical significance of circulating tumor cells (CTCs) in lung adenocarcinoma (LUAD) by combining efficient CTC isolation and in-vitro cultivation. The cultured CTC count and proliferative ability were highly associated with cancer prognosis, indicating their potential as prognostic biomarkers in LUAD patients.
Article
Medicine, General & Internal
Davida Mirra, Erika Cione, Giuseppe Spaziano, Renata Esposito, Mario Sorgenti, Elisabetta Granato, Ida Cerqua, Lucia Muraca, Pasquale Iovino, Luca Gallelli, Bruno D'Agostino
Summary: This study compares the serum expression of microRNAs between asthmatic patients, obese patients (the most common comorbidity in asthma), and healthy controls, and identifies the specific involvement of microRNAs in the regulation of lung inflammatory response. It highlights the potential of microRNAs as a clinical marker for asthma evaluation and management.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Jorine E. Hartman, Felix J. F. Herth, Pallav Shah, Christophe Pison, Arschang Valipour, Dirk-Jan Slebos
Summary: This post-hoc analysis investigated the changes in airway CT-parameters after targeted lung denervation (TLD) and their association with treatment response. Improvement in air trapping was significantly associated with an improvement in residual volume (RV) in the treatment group. Furthermore, improvements in Pi10 and airway lumen were significantly associated with improvements in both RV and FEV1. Findings suggest that improving airway characteristics leads to reduced air trapping and improved clinical outcomes.
RESPIRATORY MEDICINE
(2023)
Article
Oncology
Joaquina C. Baranda, Francisco J. Diaz, Larry Rubinstein, Anthony F. Shields, Farshid Dayyani, Amitkumar Mehta, Janice M. Mehnert, Jonathan Trent, Rodwell Mabaera, Margaret Mooney, Jeffrey A. Moscow, James Doroshow, Brittany Waters, Percy Ivy, Steven D. Gore, Alexandra Thomas
Summary: The National Cancer Institute-funded CATCH-UP.2020 program was established to address disparities in cancer outcomes for underserved populations. The program successfully activated and enrolled patients from racial, ethnic, and socioeconomically underserved populations to early phase clinical trials, expanding access to targeted cancer therapy options.
JNCI CANCER SPECTRUM
(2023)
Article
Oncology
Claudia M. Denkinger, Maike Janssen, Ulrike Schaekel, Julia Gall, Albrecht Leo, Patrick Stelmach, Stefan F. Weber, Johannes Krisam, Lukas Baumann, Jacek Stermann, Uta Merle, Markus A. Weigand, Christian Nusshag, Lars Bullinger, Jens-Florian Schrezenmeier, Martin Bornhaeuser, Nael Alakel, Oliver Witzke, Timo Wolf, Maria J. G. T. Vehreschild, Stefan Schmiedel, Marylyn M. Addo, Felix Herth, Michael Kreuter, Phil-Robin Tepasse, Bernd Hertenstein, Mathias Haenel, Anke Morgner, Michael Kiehl, Olaf Hopfer, Mohammad-Amen Wattad, Carl C. Schimanski, Cihan Celik, Thorsten Pohle, Matthias Ruhe, Winfried Kern, Anita Schmitt, Hanns-Martin Lorenz, Margarida Souto-Carneiro, Mary Gaeddert, Niels Halama, Stefan Meuer, Hans-Georg Kraeusslich, Barbara Mueller, Paul Schnitzler, Sylvia Parthe, Ralf Bartenschlager, Martina Gronkowski, Jennifer Klemmer, Michael Schmitt, Peter Dreger, Katharina Kriegsmann, Richard F. Schlenk, Carsten Muller-Tidow
Summary: Patients with cancer and compromised immune systems may benefit from convalescent/vaccinated plasma treatment to improve COVID-19 outcomes.
Article
Oncology
Tommaso A. Dragani, Thomas Muley, Marc A. Schneider, Sonja Kobinger, Martin Eichhorn, Hauke Winter, Hans Hoffmann, Mark Kriegsmann, Sara Noci, Matteo Incarbone, Davide Tosi, Sara Franzi, Francesca Colombo
Summary: This study examined the relationships between smoking habit, clinical stage, and sex with age at diagnosis of lung adenocarcinoma. The results showed that smoking, advanced stage, and female sex were associated with younger age at diagnosis. This study provides new insights into the clinical variables influencing age at diagnosis and opens up possibilities for further research on the genetic and molecular mechanisms responsible for these associations.
Review
Oncology
Kenneth N. Huynh, Sriram Rao, Bradley Roth, Theodore Bryan, Dayantha M. Fernando, Farshid Dayyani, David Imagawa, Nadine Abi-Jaoudeh
Summary: Hypoxia-inducible factor 1 alpha (HIF-1a) is a transcription factor that regulates the cellular response to hypoxia and is upregulated in all types of solid tumor. Hepatocellular carcinoma (HCC) is a highly vascular and hypoxic tumor, and treatments like TACE and TAE can exacerbate hypoxia in HCC. Hypoxia-activated prodrugs (HAPs) have potential as a targeted treatment for hypoxic HCC, but more research is needed to understand their effects in combination with embolization.
Correction
Oncology
Farastuk Bozorgmehr, Inn Chung, Petros Christopoulos, Johannes Krisam, Marc A. Schneider, Lena Brueckner, Daniel Wilhelm Mueller, Michael Thomas, Stefan Rieken
Letter
Medicine, General & Internal
Quncheng Zhang, Xuan Wu, Huizhen Yang, Ya Sun, Ziqi Wang, Li Yang, Nan Wei, Yihua Zhang, Yuanjian Yang, Xingru Zhao, Felix J. F. Herth, Xiaoju Zhang
CHINESE MEDICAL JOURNAL
(2023)
Meeting Abstract
Oncology
Arsha Ostowari, Jingjing Yu, Amber Gonda, Chanon Chantaduly, Brittany G. Sullivan, Alexander Kreger, Yingjoy Li, Oliver S. Eng, Farshid Dayyani, Peter D. Chang, Maheswari Senthil
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Respiratory System
Christoph Lederer, Katharina Mayer, Vivien Somogyi, Katharina Kriegsmann, Mark Kriegsmann, Katharina Buschulte, Markus Polke, Peter Findeisen, Felix Herth, Michael Kreuter
Summary: This study evaluated KL-6 as a predictive biomarker in Caucasian patients with fILDs and found that a decline in KL-6 levels was associated with stable lung function. This suggests that KL-6 may be a predictive biomarker with clinical relevance.
Article
Respiratory System
David E. Ost, David J. Feller-Kopman, Anne V. Gonzalez, Horiana B. Grosu, Felix Herth, Peter Mazzone, John E. S. Park, Jose M. Porcel, Samira Shojaee, Ioana Tsiligianni, Anil Vachani, Jonathan Bernstein, Richard Branson, Patrick A. Flume, Cezmi A. Akdis, Martin Kolb, Esther Barreiro Portela, Alan Smyth
Summary: Diagnostic testing is crucial in medicine, but there is significant variation in the methodology, definitions, and reporting of results in studies of diagnostic testing in respiratory medicine, leading to conflicting or ambiguous results. To address this issue, a group of 20 respiratory journal editors developed reporting standards for such studies, providing a rigorous methodology for authors, peer reviewers, and researchers. The standards cover four key areas, including defining the reference standard of truth, measures of test performance for dichotomous outcomes, measures of test performance for multichotomous outcomes, and a useful definition of diagnostic yield. The importance of using contingency tables for reporting results is emphasized, along with a practical checklist for reporting diagnostic testing studies.
JOURNAL OF BRONCHOLOGY & INTERVENTIONAL PULMONOLOGY
(2023)
Article
Respiratory System
Judith Maria Brock, Sonja Zehetmayer, Daniela Gompelmann
Summary: Gender inequality is still an issue in the field of medicine, particularly in interventional pulmonology (IP). This study found that although there is an increasing proportion of female physicians, men still dominate leading positions and receive more academic awards in IP.
Meeting Abstract
Respiratory System
M. Schellenberg, L. Kehler, F. Trudzinski, F. Herth
Meeting Abstract
Respiratory System
F. Trinkmann, M. Abdo, A. Kirsten, K. Rabe, F. Herth, H. Watz
Meeting Abstract
Respiratory System
F. Trudzinski, J. Schubert-Haack, B. Neetz, K. Tanck, G. Iberl, M. Mueller, A. Kempa, C. Neurohr, J. Forstner, A. Ghiani, C. Andritschky, A. Schneider, A. Rheinhold, P. Gehrig, J. Szecsenyi, F. Herth
Meeting Abstract
Respiratory System
A. Unterschemmann, F. Trudzinski, J. Brock, D. Gompelmann, F. Herth, R. Eberhardt, K. Kontogianni