Article
Biochemistry & Molecular Biology
Wei Guo, Qilin Huai, Huan Wan, Lei Guo, Peng Song, Shugeng Gao, Jie He
Summary: Through analysis of multiple datasets, it is found that IGF2BP3 is abnormally highly expressed in LUAD, leading to worse prognosis. This suggests that IGF2BP3 may be an oncogene and potential prognostic biomarker for LUAD.
DNA AND CELL BIOLOGY
(2021)
Article
Oncology
Cui Zhao, Jian Liu, Haomiao Zhou, Xin Qian, Hui Sun, Xuewen Chen, Miaosen Zheng, Tingting Bian, Lei Liu, Yifei Liu, Jianguo Zhang
Summary: This study demonstrated that high expression of NEIL3 in LUAD is associated with advanced stage, larger tumor size, and worse survival outcomes, potentially through activation of cell cycle progression and the P53 signaling pathway. A 10-gene prognostic signature, including NEIL3 and its co-expressed genes, was developed and showed superior diagnostic accuracy in LUAD.
CANCER CELL INTERNATIONAL
(2021)
Article
Oncology
Yangwei Wang, Jiaping Chen, Wangyang Meng, Rong Zhao, Wei Lin, Peiyuan Mei, Han Xiao, Yongde Liao
Summary: This study investigated the expression differences and clinical significance of CENP proteins in lung adenocarcinoma. The results showed that 5 CENPs were significantly associated with patient prognosis and could be potential targets for treatment. qRT-PCR experiments confirmed the upregulated expression of these proteins in tumor tissues.
TRANSLATIONAL CANCER RESEARCH
(2023)
Article
Respiratory System
Anne-Sophie Lamort, Jan Christian Kaiser, Mario A. A. Pepe, Ioannis Lilis, Giannoula Ntaliarda, Kalman Somogyi, Magda Spella, Sabine J. Behrend, Georgia A. Giotopoulou, Willem Kujawa, Michael Lindner, Ina Koch, Rudolf A. Hatz, Juergen Behr, Rocio Sotillo, Andrea C. Schamberger, Georgios T. Stathopoulos
Summary: Two molecular subtypes of LUAD have been identified, and their identification provides important prognostic information.
EUROPEAN RESPIRATORY JOURNAL
(2022)
Article
Oncology
Ning Qi, Yuxu Niu, Zheng Li, Li Xiao, Dongfang Tang, Wen Gao
Summary: This study found that CENPM is upregulated in LUAD patients and is associated with higher pathological stages and poor survival rates. CENPM affects cell proliferation, cell cycle, cell migration and invasion capacity, and apoptosis in LUAD cell lines through the regulation of AKT1/mTOR signaling pathway.
TRANSLATIONAL CANCER RESEARCH
(2022)
Article
Medicine, Research & Experimental
Yishan Huo, Kainan Zhang, Songtao Han, Yangchun Feng, Yongxing Bao
Summary: The study found that LCP2 is a favorable prognostic biomarker in LUAD patients, with its expression correlated with clinical stage and lymph node metastasis. High LCP2 expression was associated with increased overall survival, potentially due to an enrichment of immune functions. Additionally, LCP2 expression was positively correlated with PD-L1 expression in LUAD tissues.
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2021)
Article
Oncology
Marc A. Schneider, Sarah Richtmann, Anna R. Grunding, Sabine Wrenger, Tobias Welte, Michael Meister, Mark Kriegsmann, Hauke Winter, Thomas Muley, Sabina Janciauskiene
Summary: This study found that lower expression of TMPRSS2 in tumor tissues is associated with poor overall survival in patients with lung adenocarcinoma. The correlation between AAT and TMPRSS2 proteins requires further investigation.
INTERNATIONAL JOURNAL OF ONCOLOGY
(2022)
Article
Oncology
Kota Ishioka, Hiroyuki Yasuda, Junko Hamamoto, Hideki Terai, Katsura Emoto, Tae-Jung Kim, Shigemichi Hirose, Takashi Kamatani, Sachiyo Mimaki, Daisuke Arai, Keiko Ohgino, Tetsuo Tani, Keita Masuzawa, Tadashi Manabe, Taro Shinozaki, Akifumi Mitsuishi, Toshiki Ebisudani, Takahiro Fukushima, Mari Ozaki, Shinnosuke Ikemura, Ichiro Kawada, Katsuhiko Naoki, Morio Nakamura, Takashi Ohtsuka, Hisao Asamura, Katsuya Tsuchihara, Yuichiro Hayashi, Ahmed E. Hegab, Susumu S. Kobayashi, Takashi Kohno, Hideo Watanabe, David M. Ornitz, Tomoko Betsuyaku, Kenzo Soejima, Koichi Fukunaga
Summary: In this study, FGF9 was found to play a crucial role in the transdifferentiation of lung adenocarcinoma to small cell lung cancer. The upregulation of FGF9 was confirmed to induce neuroendocrine differentiation in established human lung adenocarcinoma cells, providing direct evidence for FGF9-mediated SCLC transdifferentiation and proposing the FGF9-FGFR axis as a therapeutic target for transdifferentiated SCLC.
Article
Pathology
Yen-Lin Huang, Yi-Jung Chen, Yi-Hsiu Juan, Shang-Gin Wu, Kuei-Pin Chung
Summary: The phosphorylation of DRP1 is not related to the prognosis of patients with advanced lung adenocarcinoma.
PATHOLOGY RESEARCH AND PRACTICE
(2022)
Article
Oncology
Qianqian Xue, Yue Wang, Qiang Zheng, Lijun Chen, Yicong Lin, Yan Jin, Xuxia Shen, Yuan Li
Summary: This study found that tumor microenvironment factors are associated with recurrence/metastasis and survival in stage I lung adenocarcinoma patients. Higher levels of CD8+ T lymphocytes, B lymphocytes, and myeloid DC infiltration are associated with better survival outcomes, while higher levels of neutrophils are associated with no recurrence/metastasis. Additionally, different immune cell expression patterns were observed in tumor and stromal regions.
AMERICAN JOURNAL OF CANCER RESEARCH
(2023)
Article
Medical Laboratory Technology
Quanchao Wan, Jingming Qu, Longfei Li, Feng Gao
Summary: GBP1 is upregulated in lung adenocarcinoma tumor tissues compared to adjacent tissues, and its high expression is associated with advanced tumor features, worse survival profiles, and serves as an independent predictor of disease-free and overall survival. Data analysis from the KMplot database further validates GBP1 as a prognostic biomarker in lung adenocarcinoma management.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2021)
Article
Multidisciplinary Sciences
Xiaoling Liu, Yichen Jia, Changyuan Shi, Dechen Kong, Yuanming Wu, Tiantian Zhang, Anjie Wei, Dan Wang
Summary: This study found significantly decreased expression of CYP4B1 in patients with LUAD, which was associated with age, treatment history, gene mutations, and survival status. Low CYP4B1 expression was linked to shorter survival time in LUAD patients.
Article
Oncology
Zhendong Huang, Zhendong Liu, Xingbo Cheng, Zhibin Han, Jiwei Li, Tian Xia, Yanzheng Gao, Li Wei
Summary: Elevated HSF2BP in patients with LUAD poses a threat to prognosis, potentially involved in tumorigenesis by influencing genomic stability and promoting tumor immune evasion. These findings suggest that HSF2BP may be a vulnerable target for improving and enhancing treatment of LUAD.
ANNALS OF TRANSLATIONAL MEDICINE
(2021)
Article
Oncology
Minjun Du, Yicheng Liang, Zixu Liu, Xingkai Li, Mei Liang, Boxuan Zhou, Yushun Gao
Summary: This study identified five key genes related to prognosis and CD8+ T-cell infiltration in LUAD, and established a risk assessment model based on them. The risk score could predict the prognosis of LUAD, showing a negative correlation with CD8+ T-cell infiltration and correlation with advanced tumor stage. The results were validated by GEO database and tissue microarray experiments, indicating potential implications for exploring the mechanism of tumor immune microenvironment in LUAD.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Kehong Chen, Taihao Zheng, Cai Chen, Liangzhong Liu, Zhengjun Guo, Yuan Peng, Xiaoyue Zhang, Zhenzhou Yang
Summary: Pregnancy zone protein (PZP) expression is significantly reduced in lung adenocarcinoma (LUAD) and is closely correlated with clinical stage, making it a potential independent unfavorable prognostic factor. The high expression of PZP is mainly involved in immune-related molecules and shows significant correlation with immune cell infiltrations.
