Article
Radiology, Nuclear Medicine & Medical Imaging
Esben Andreas Carlsen, Mathias Loft, Annika Loft, Anne Kiil Berthelsen, Seppo W. Langer, Ulrich Knigge, Andreas Kjaer
Summary: This study evaluated uPAR expression in patients with neuroendocrine neoplasms using a uPAR PET tracer and found that uPAR-positive lesions were present in the majority of patients. Furthermore, uPAR expression was associated with a worse prognosis, suggesting that uPAR may be a promising target for therapy in NEN patients.
JOURNAL OF NUCLEAR MEDICINE
(2022)
Article
Cell Biology
Koji Sugioka, Teruo Nishida, Aya Kodama-Takahashi, Junko Murakami, Fukutaro Mano, Kiyotaka Okada, Masahiko Fukuda, Shunji Kusaka
Summary: Corneal fibroblasts are regulated by collagen, and the targeting of Endo180 and uPA receptor may play a role in the regulation of alpha-SMA expression in a manner dependent on TGF-beta signaling. uPA deficiency may promote the interaction between collagen and Endo180 and increase alpha-SMA expression.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Article
Multidisciplinary Sciences
Zhiwei Wang, Kunxiong Wang, Xin Gao, Zhenxiang Liu, Zengshu Xing
Summary: This study found that high expression levels of PLAUR in clear cell renal cell carcinoma (ccRCC) are associated with poor prognosis. PLAUR is involved in the progression of ccRCC and has functions in inflammatory and immune-related pathways. PLAUR may serve as an important immunotherapy target for ccRCC.
Article
Nanoscience & Nanotechnology
June Yong Park, Yuseon Shin, Woong Roeck Won, Chaemin Lim, Jae Chang Kim, Kioh Kang, Patihul Husni, Eun Seong Lee, Yu Seok Youn, Kyung Taek Oh
Summary: An AE147 peptide-conjugated nanocarrier system was developed to target metastatic tumors, displaying potential and effective accumulation at tumor metastatic sites.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Yuki Matsui, Ken Kadoya, Yusuke Nagano, Takeshi Endo, Masato Hara, Gen Matsumae, Tomoaki Suzuki, Yasuhiro Yamamoto, Mohamad Alaa Terkawi, Norimasa Iwasaki
Summary: This study demonstrates that IL4 stimulated M2 macrophages can directly stimulate axon growth and enhance axon regeneration. The central axis underlying this effect is uPA-uPAR signaling pathway. These findings provide a potential novel therapy for peripheral nerve injury (PNI).
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Review
Oncology
Virginia Metrangolo, Michael Ploug, Lars H. Engelholm
Summary: The urokinase-type plasminogen activator receptor (uPAR) has emerged as a promising therapeutic target for aggressive malignancies due to its abundant expression in cancerous tissues. Therapeutic strategies targeting uPAR have shifted towards cytotoxic approaches to selectively eradicate cancer cells expressing this receptor. Research is focusing on innovative immune- or stroma targeting therapies to enhance treatment efficacy.
Review
Biochemistry & Molecular Biology
Torry A. Tucker, Steven Idell
Summary: This review discusses the fibrinolytic pathway, how local derangements of fibrinolysis promote extravascular fibrin deposition, and how pleural mesothelial cells contribute to lung scarring. It also explores the diagnostic value of soluble uPAR in grading pleural effusions, and the clinical importance of single-chain urokinase plasminogen activator (uPA) for treating loculated pleural collections.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Alessio Biagioni, Anastasia Chilla, Mario Del Rosso, Gabriella Fibbi, Francesca Scavone, Elena Andreucci, Silvia Peppicelli, Francesca Bianchini, Lido Calorini, Anna Li Santi, Pia Ragno, Francesca Margheri, Anna Laurenzana
Summary: Loss of uPAR in melanoma and colon cancer results in cells acquiring stem-like characteristics and completely inhibits tumorigenesis. Reintroduction of the 3'UTR of PLAUR gene restores wild-type status, suggesting this region may act as a molecular sponge.
FRONTIERS IN ONCOLOGY
(2021)
Review
Cell Biology
Manuel Yepes
Summary: The repair of injured tissue involves complex processes such as cell proliferation, differentiation, and migration. Experimental evidence suggests that urokinase-type plasminogen activator (uPA) promotes cell migration by binding to its receptor (uPAR) on the cell surface. Neuronal cadherin and glycogen synthase kinase 3 beta also play important roles in this process.
NEURAL REGENERATION RESEARCH
(2022)
Article
Urology & Nephrology
Victor M. Schuettfort, Benjamin Pradere, David D'Andrea, Nico C. Grossmann, Fahad Quhal, Hadi Mostafaei, Ekaterina Laukhtina, Keiichiro Mori, Michael Rink, Pierre I. Karakiewicz, Reza Sari Motlagh, Satoshi Katayama, Yair Lotan, Douglas Scherr, Mohammad Abufaraj, Harun Fajkovica, Eva Comperat, Dmitry Enikeev, Shahrokh F. Shariat
Summary: Elevated preoperative plasma levels of uPA, SuPAR, and PAI-one were confirmed to be associated with aggressive disease features and worse survival outcomes in patients treated with RC for UCB. These biomarkers have the potential to identify patients who may benefit from intensified/multimodal therapy and improve the discriminatory power of predictive/prognostic models.
JOURNAL OF UROLOGY
(2021)
Article
Medicine, General & Internal
Marie Obro Fosbol, Jann Mortensen, Peter Meidahl Petersen, Annika Loft, Jacob Madsen, Andreas Kjaer
Summary: This Phase II study aimed to investigate the potential of uPAR PET in assessing response and prognosis in patients receiving (RaCl2)-Ra-223 therapy. The baseline SUVmax was associated with overall survival (OS), while it was found to be a significant predictor of symptomatic skeletal events (SSE).
Article
Cell Biology
Ke Zhu, Kamalika Mukherjee, Changli Wei, Salim S. Hayek, Agnieszka Collins, Changkyu Gu, Kristin Corapi, Mehmet M. Altintas, Yong Wang, Sushrut S. Waikar, Antonio C. Bianco, Alexander Koch, Frank Tacke, Jochen Reiser, Sanja Sever
Summary: D2D3 protein is associated with kidney diseases and insulin-dependent diabetes mellitus. It impairs the function of pancreatic beta cells and the kidneys, and targeting this protein could potentially provide a therapy.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Review
Oncology
Gary Tincknell, Ann-Katrin Piper, Morteza Aghmesheh, Therese Becker, Kara Lea Vine, Daniel Brungs, Marie Ranson
Summary: The text discusses the impact of uPAS expression in GOC patients, leading to shorter life expectancies due to early metastasis. uPAS expression in the tumor microenvironment is associated with worse outcomes like tumor recurrence and patient survival. This highlights the potential of uPAS as a biomarker for GOC.
Article
Oncology
Fan Zeng, Guanzhang Li, Xiu Liu, Kenan Zhang, Hua Huang, Tao Jiang, Ying Zhang
Summary: The study revealed the clinical significance of plasminogen activator urokinase receptor (PLAUR) in gliomas, providing insights into immunosuppressive effects and potential implications for immunotherapy. High PLAUR expression was associated with immune response, infiltration of macrophages, and immunosuppressive markers, suggesting PLAUR as a potential marker for treatment decisions and predicting patient outcomes.
Review
Biochemistry & Molecular Biology
Manuel Yepes, Yena Woo, Cynthia Martin-Jimenez
Summary: The neurovascular unit is a complex structure involving various cells and components that are essential for maintaining normal neuronal function. Plasminogen activators play a crucial role in regulating the function of the neurovascular unit, with dysfunction leading to neurodegenerative disorders. Research on the expression and function of tissue-type plasminogen activator and urokinase-type plasminogen activator in the neurovascular unit has provided valuable insights into neurovascular and neurodegenerative disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
