Article
Chemistry, Multidisciplinary
Seul Gi Kim, Akhmad Irhas Robby, Byung Chan Lee, Gibaek Lee, Sung Young Park
Summary: The design of ROS- and GSH-responsive PTX-loaded polymer dot with mitochondria-targeting capability allows for selective release of PTX in cancer cells, leading to enhanced apoptosis and reduced effects on normal cells.
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
(2021)
Article
Cell Biology
Lina Zhao, Wenjun Xia, Peng Jiang
Summary: The study reveals that CREB1 and ATF1 regulate GSH biosynthesis by suppressing the expression of GCLM and GSS, leading to increased susceptibility of cells to oxidative stress. Targeting GCLM or oxidative stress may offer potential therapeutic approaches for tumors with high expression of CREB1 family proteins.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Chemistry, Multidisciplinary
Chenyang Zhang, Xin Wang, Jiangfeng Du, Zhanjun Gu, Yuliang Zhao
Summary: ROS play a vital role in physiological and pathological processes, and research on regulating ROS for disease treatments has gained wide attention. Advances in nanotechnology have led to the development of numerous nanomaterials with the ability to regulate ROS, aiming to find new and effective ROS-related nanotherapeutic modalities. Despite significant progress in ROS-based nanomedicines, there is a need to address fundamental principles for designing ROS-associated nanomedicines to minimize gaps in biomedical applications. This review summarizes current progress in ROS-associated nanomedicines in disease treatments and presents key principles for their design. Future perspectives in the development of ROS-associated nanomedicines are also discussed.
Review
Medicine, Research & Experimental
Liu Yang, Yewei Zhang, Yingyi Zhang, Zhe Fan
Summary: Colorectal cancer (CRC) is a serious threat to human health and ferroptosis, a unique iron-dependent oxidative cell death, has attracted worldwide attention. It plays a significant role in various diseases and may serve as a new therapeutic target. This article reviews the mechanism of ferroptosis and the possibility of targeting ferroptosis pathways in CRC, providing new ideas for diagnosis and treatment.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Cardiac & Cardiovascular Systems
Elizabeth Murphy, Julia Liu
Summary: Cardiomyocytes have a high density of mitochondria, which play a crucial role in energy production and cellular functions. The regulation of mitochondrial calcium and reactive oxygen species is important in the development of cardiovascular disease.
CARDIOVASCULAR RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Evan A. Bordt, Naibo Zhang, Jaylyn Waddell, Brian M. Polster
Summary: Mdivi-1 exhibits moderate antioxidant activity, able to scavenge free radicals to a certain extent. However, it has a reduced capacity compared to the vitamin E analog Trolox.
Article
Multidisciplinary Sciences
Young Yun Jung, In Jin Ha, Jae-Young Um, Gautam Sethi, Kwang Seok Ahn
Summary: The study demonstrates that fangchinoline (FCN) can attenuate tumor growth and survival by modulating the STAT3 signaling pathway and inducing apoptosis in malignant cells. FCN abrogated protein expression levels of STAT3 and upstream signals, inhibited STAT3 DNA binding ability and translocation, increased SHP-1 levels, induced ROS production, and effectively suppressed tumor progression and STAT3 activation in a preclinical myeloma model.
JOURNAL OF ADVANCED RESEARCH
(2022)
Article
Oncology
Hailong Shi, Yuanyuan Cheng, Qimei Shi, Wenzhi Liu, Xue Yang, Shuang Wang, Lin Wei, Xiangming Chen, Hao Fang
Summary: Myoferlin is a newly identified oncogene that is associated with tumor metastasis, intracellular ROS production, and energy metabolism. Its function in regulating gastric cancer cell migration and ROS accumulation has not been determined.
FRONTIERS IN ONCOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Xin Chai, Zetan Fan, Ming-Ming Yu, Jian Zhao, Lele Li
Summary: This study reports a new strategy for imaging ATP and GSH in mitochondria, utilizing nanoparticle targeting capability and redox-activatable aptamer sensor design. The system allows for correlated imaging of ATP and GSH in mitochondria, as well as specific imaging of tumors in vivo. This work highlights the potential of DNA nanodevices in imaging mitochondrial multivariate targets.
Article
Horticulture
Xiaohui Lu, Huijie Zhang, Na Zhang, Chenghu Dong, Haipeng Ji, Jinze Yu, Zhaojun Ban, Ruixiang Yan, Ting Zhang, Cunkun Chen, Yumei Jiang
Summary: This study investigated the effect of ozone treatment on the ascorbic acid-glutathione (ASA-GSH) cycle metabolism of cantaloupe after harvest. The results showed that ozone decreased the formation of reactive oxygen species (ROS) and increased the accumulation of ASA and GSH in cantaloupe. Ozone also promoted the activity of key enzymes in the ASA-GSH cycle and stimulated the expression of specific genes. This study provides a foundation for future research on the effects of ozone on the ASA-GSH cycle in various fruits and vegetables.
SCIENTIA HORTICULTURAE
(2023)
Article
Biotechnology & Applied Microbiology
Hongwei Wang, Hongyan Niu, Xi Luo, Nan Zhu, Jingfeng Xiang, Yan He, Zhian Chen, Guoxin Li, Yanfeng Hu
Summary: Radiotherapy (RT) is effective in treating gastric cancer, but its efficacy is limited by radioresistance and toxicity. In this study, a nanosystem was developed by loading Pyrogallol (PG) into mesoporous organosilica nanoparticles (MON@pG), which improved the radiosensitivity of gastric cancer cells by disrupting redox balance and augmenting ferroptosis.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Environmental Sciences
Liuliang Yuan, Wen-Xiong Wang
Summary: In this study, the subcellular fate and behavior of Zn and Cu in zebrafish cells were investigated. The results showed completely different behaviors and distributions of Zn and Cu, with implications for understanding their toxicity and cellular functions.
ENVIRONMENTAL POLLUTION
(2022)
Article
Agriculture, Multidisciplinary
Haijiao Liu, Jiaqing Wu, Yingwei Su, Yingbin Li, Denghong Zuo, Hongbin Liu, Yixiang Liu, Xinyue Mei, Huichuan Huang, Min Yang, Shusheng Zhu
Summary: The study showed that Brassica juncea volatiles, particularly allyl isothiocyanate (AITC), exhibit dose-dependent antimicrobial activity against Panax notoginseng root rot pathogens. Integrated transcriptome and metabolome analysis revealed that AITC inhibits Fusarium solani by interfering with energy production and induces the accumulation of ROS by decreasing the content of glutathione (GSH). Overall, B. juncea can be used as a rotation crop or soil fumigant to inhibit soil-borne pathogens and alleviate root rot disease.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Xiangyu Teng, Josephine Brown, Laurence Morel
Summary: Metformin has shown promise as a treatment for systemic lupus erythematosus (SLE), with encouraging results in clinical trials and preclinical studies. However, there are still gaps in knowledge regarding whether metformin restores redox homeostasis and in which cell types it acts.
ANTIOXIDANTS & REDOX SIGNALING
(2022)
Article
Multidisciplinary Sciences
Wilfred Lopez-Perez, Kazuhito Sai, Yosuke Sakamachi, Cameron Parsons, Sophia Kathariou, Jun Ninomiya-Tsuji
Summary: Inhibition of TAK1 induces the production of ROS, which effectively destroys intracellular bacteria. This mechanism initiates a host defense response by recognizing the impairment of TAK1 by pathogens.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)