期刊
LUNG CANCER
卷 60, 期 1, 页码 136-140出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.lungcan.2007.08.021
关键词
lung cancer; atypical adenomatous hyperplasia; bronchioloalveotar carcinoma; mixed adenocarcinoma; epidermal growth factor receptor mutations; gefitinib
It has been proposed that stepwise progression occurs from atypical adenomatous hyperplasia (AAH) through bronchioloalveolar carcinoma (BAC) to invasive lung adenocarcinoma. However, the underlying molecular mechanisms have not been identified. We report a patient with a mixed adenocarcinoma of the lung that had different EGFR mutations in the papillary subtype, the acinar subtype, and the surrounding AAH and BAC areas. EGFR mutations may accumulate during tumor progression and lead to heterogeneity of EGFR mutations within the tumor. (C) 2007 Elsevier Ireland Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据