Article
Radiology, Nuclear Medicine & Medical Imaging
Qiang Cai, Natthaya Triphuridet, Yeqing Zhu, Nan You, Rowena Yip, David F. Yankelevitz, Claudia Henschke
Summary: Bronchiectasis is prevalent in smokers undergoing low-dose CT screening, and the occurrence of respiratory symptoms and acute events increases with the severity of the Early Lung and Cardiac Action Program Bronchiectasis score.
Article
Medicine, General & Internal
Lisa Jungblut, Harry Etienne, Caroline Zellweger, Alessandra Matter, Miriam Patella, Thomas Frauenfelder, Isabelle Opitz
Summary: This pilot study in Switzerland assesses the implementation and performance of low-dose CT lung cancer screening and explores its potential impact on reducing mortality rates. The study enrolls participants meeting specific criteria and uses LDCT scans for assessment. Preliminary results suggest the feasibility of LDCT lung cancer screening in Switzerland.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Oncology
R. Edward Hendrick, Robert A. Smith
Summary: Based on the data from three lung cancer screening trials, the benefit-to-radiation-risk ratios are favorable. Modern CT technologies, low diagnostic follow-up rates, and minimizing radiation doses are crucial for successful lung cancer screening practices.
Article
Radiology, Nuclear Medicine & Medical Imaging
Eui Jin Hwang, Jin Mo Goo, Hyae Young Kim, Jaeyoun Yi, Yeol Kim
Summary: Elevating the diameter threshold for solid nodules from 6 to 9 mm may lead to a substantial reduction in unnecessary follow-up LDCTs with a small proportion of diagnostic delay of lung cancers.
EUROPEAN RADIOLOGY
(2021)
Article
Oncology
Yuki Tomonaga, Koen de Nijs, Heiner C. Bucher, Harry de Koning, Kevin ten Haaf
Summary: This study evaluates the cost-effectiveness of lung cancer screening strategies in Switzerland and finds that risk-based screening is more cost-effective than pack-year-based screening. The most efficient strategy is biennial screening for ever-smokers aged 55 to 80 with a 1.6% risk. This strategy can significantly reduce lung cancer mortality and has a lower cost per QALY gained compared to pack-year-based screening.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Oncology
Louise M. Henderson, Danielle D. Durham, Martin C. Tammemagi, Thad Bene, Mary W. Marsh, Patricia Rivera
Summary: Patients with a prior history of cancer have higher cancer detection rates, invasive procedure rates, and complication rates in lung cancer screening compared to those without prior cancer history.
JOURNAL OF THORACIC ONCOLOGY
(2021)
Article
Oncology
Jingmin Yuan, Yan Sun, Ke Wang, Zhiyi Wang, Duo Li, Meng Fan, Xiang Bu, Mingwei Chen, Hui Ren
Summary: This study provides the optimal lung cancer screening strategy in China based on cost-effectiveness analysis. The results suggest that starting screening at 50 years old can achieve the maximum net health benefits for heavy smokers.
CANCER PREVENTION RESEARCH
(2022)
Review
Medicine, General & Internal
Lanwei Guo, Yue Yu, Funa Yang, Wendong Gao, Yu Wang, Yao Xiao, Jia Du, Jinhui Tian, Haiyan Yang
Summary: Low-dose computed tomography (LDCT) screening is an accurate method for detecting lung cancer. In this meta-analysis, the AUC of LDCT screening for lung cancer was found to be 0.98, with a sensitivity of 0.97 and specificity of 0.87. Long-term follow-up of the entire study population is necessary to improve the accuracy of LDCT screening.
CHINESE MEDICAL JOURNAL
(2023)
Article
Gastroenterology & Hepatology
Meylin Caballeros Lam, Paula Pujols, Ana Ezponda Casajus, Fernando Guillen Valderrama, Maria Jose Garcia Velloso, Alejandra Wyss, Loreto Garcia del Barrio, Javier Larrache Latasa, Jesus Pueyo Villoslada, Maria Dolores Lozano Escario, Juan P. de-Torres, Ana Belen Alcaide Ocana, Aranzazu Campo Ezquibela, Luis Seijo Maceiras, Luis Montuenga Badia, Javier Zulueta, Mercedes Inarrairaegui Bastarrica, Ignacio Herrero Santos, Gorka Bastarrika Aleman
Summary: In this study, a lung cancer screening program was implemented in liver transplant recipients (LTR) using low-dose CT and F-18-fluorodeoxyglucose positron emission tomography (FDG-PET). The results showed that 9.7% of the LTR were diagnosed with lung cancer, most of which were non-small cell subtype. The majority of lung cancers (82.3%) were diagnosed at stage I, indicating the effectiveness of the screening program in detecting early-stage lung cancer.
LIVER TRANSPLANTATION
(2023)
Review
Medicine, General & Internal
Daniel E. Jonas, Daniel S. Reuland, Shivani M. Reddy, Max Nagle, Stephen D. Clark, Rachel Palmieri Weber, Chineme Enyioha, Teri L. Malo, Alison T. Brenner, Charli Armstrong, Manny Coker-Schwimmer, Jennifer Cook Middleton, Christiane Voisin, Russell P. Harris
Summary: Screening high-risk individuals with LDCT can decrease lung cancer mortality but may also result in false positives, overdiagnosis, incidental findings, distress, and rarely radiation-induced cancers. More research is needed to optimize nodule evaluation protocols to minimize harms associated with screening.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2021)
Article
Oncology
Hilary A. Robbins, Karine Alcala, Anthony J. Swerdlow, Minouk J. Schoemaker, Nick Wareham, Ruth C. Travis, Philip A. J. Crosbie, Matthew Callister, David R. Baldwin, Rebecca Landy, Mattias Johansson
Summary: In UK cohorts, the ability of risk prediction models to classify future lung cancer cases as eligible for screening was best for LCDRAT/LCRAT, very good for PLCOm2012, and lowest for LLPv2. This highlights the importance of validating prediction tools in specific countries.
BRITISH JOURNAL OF CANCER
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Gianluca Milanese, Roberta Eufrasia Ledda, Federica Sabia, Margherita Ruggirello, Stefano Sestini, Mario Silva, Nicola Sverzellati, Alfonso Vittorio Marchiano, Ugo Pastorino
Summary: The purpose of this study was to compare the effectiveness of Low-Dose Computed Tomography (LDCT) and four different Ultra-Low-Dose Computed Tomography (ULDCT) protocols for PN classification based on LungRADS. The results showed that ULDCT had good agreement with LDCT and could be used as a feasible approach in lung cancer screening.
EUROPEAN JOURNAL OF RADIOLOGY
(2023)
Article
Oncology
Feng Rong, Rui Shi, Lili Hu, Ran Chen, Daoyue Wang, Xiazhi Lv, Yong Zhao, Wei Huang, Yang Yang, Hongyang Zhou, Kaige Hong
Summary: This study conducted a randomized controlled trial to evaluate the performance of low-dose computed tomography screening in a Chinese population, revealing the importance of including active smokers and female non-smokers/passive smokers in lung cancer screening programs. The study found that the incidence of lung cancer was significantly higher in female non-smokers/passive smokers than in smokers. Further studies are needed to explore the risk factors and long-term cost-benefit of screening Asian non-smoking women.
FRONTIERS IN ONCOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Jinxin Huang, Na Yue, Jingwei Wu, Naiyang Shi, Qiang Wang, Tingting Cui, Mengyun Zheng, Siqing Sun, Hui Jin
Summary: This study synthesized the screening rate and influential factors of low-dose computed tomography (LDCT)-screened lung cancer in Asian population. The findings revealed that unlike European and American populations, female and adults > 50 years were more likely to receive lung cancer screening in Asian populations. This highlights the importance of further studying the benefits of lung cancer screening with LDCT in Asian populations.
JOURNAL OF PUBLIC HEALTH
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Mario Silva, Giulia Picozzi, Nicola Sverzellati, Sandra Anglesio, Maurizio Bartolucci, Edoardo Cavigli, Annalisa Deliperi, Massimo Falchini, Fabio Falaschi, Domenico Ghio, Paola Gollini, Anna Rita Larici, Alfonso Marchiano, Stefano Palmucci, Lorenzo Preda, Chiara Romei, Carlo Tessa, Cristiano Rampinelli, Mario Mascalchi
Summary: Smoking is the main risk factor for lung cancer, and low dose computed tomography (LDCT) screening has been proven to reduce lung cancer mortality, especially in women. Several Italian initiatives are currently offering LDCT screening and smoking cessation to high-risk individuals, with the aim of implementing a population-based screening program. This position paper provides recommendations for LDCT scan protocol, nodule classification, and management based on international guidelines.
Article
Infectious Diseases
Cassandra Laurie, Mariam El-Zein, Joseph E. Tota, Farzin Khosrow-Khavar, Pierre-Paul Tellier, Francois Coutlee, Alexandra de Pokomandy, Eduardo L. Franco
Summary: The study aimed to assess the efficacy of carrageenan gel in reducing the risk of new anal HPV detections among gbMSM, but the interim analysis showed no protective effect of carrageenan and instead found a higher proportion of adverse events associated with its use.
SEXUALLY TRANSMITTED INFECTIONS
(2022)
Article
Immunology
Cassandra Laurie, Mariam El-Zein, Joseph Tota, Farzin Khosrow-Khavar, Pierre-Paul Tellier, Francois Coutlee, Alexandra de Pokomandy, Eduardo L. Franco
Summary: The study found that there was no significant difference between carrageenan-based gel and placebo gel in clearing HPV infections among gbMSM. This was true for all infections as well as for specific HPV types and different human immunodeficiency virus statuses.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Oncology
Erika Hurtado-Salgado, Eduardo Ortiz-Panozo, Jorge Salmeron, Rufino Luna-Gordillo, Betania Allen-Leigh, Nenetzen Saavedra-Lara, Eduardo L. Franco, Eduardo Lazcano-Ponce
Summary: This article examines the prevalence of cervical high-risk human papillomavirus infection in a middle-income country, and explores variation by age, community marginalization, and region. The results provide valuable evidence for developing policies to improve cervical cancer screening strategies.
CANCER CAUSES & CONTROL
(2023)
Article
Immunology
Samantha Morais, Michel D. Wissing, Farzin Khosrow-Khavar, Ann N. Burchell, Pierre-Paul Tellier, Francois Coutlee, Tim Waterboer, Mariam El-Zein, Eduardo L. Franco
Summary: We analyzed the humoral response to natural HPV infection in unvaccinated women and found that the associations between HPV-specific antibodies depended on phylogenetic relatedness.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Infectious Diseases
Patricia Savio de Araujo-Souza, Mariam El-Zein, Aline do N. Bolpetti, Paulo Cesar Maciag, Tatiana Rabachini, Eduardo L. Franco, Luisa L. Villa
Summary: A study in Brazilian women found that human leukocyte antigen polymorphisms may influence the natural history of human papillomavirus infections, suggesting that genetic factors play a role in the risk of cervical neoplasia.
SEXUALLY TRANSMITTED DISEASES
(2023)
Review
Immunology
Wei (Vivian) Wang, Smita Kothari, Hanane Khoury, Linda Niccolai, Suzanne M. Garland, Karin Sundstrom, Gerard de Pouvourville, Paolo Bonanni, Ya-Ting Chen, Eduardo L. Franco
Summary: Assessing progress towards global elimination of cervical cancer requires monitoring vaccination coverage and its impact. A review of HPV-related data systems from seven high-income countries revealed differences in development approach, geographical scope, and data collection methods. The information provided by these data systems can inform improvements to existing prevention programs and the implementation of new programs in other countries.
EXPERT REVIEW OF VACCINES
(2023)
Review
Biology
Parker Tope, Eliya Farah, Rami Ali, Mariam El-Zein, Wilson H. Miller, Eduardo L. Franco
Summary: This study provides a systematic review of pre-pandemic evidence on the association between lag time to cancer diagnosis and treatment and mortality- and morbidity-related outcomes. The results highlight the importance of lag time in cancer care and emphasize the need for standardized methodology in lag time research.
Editorial Material
Oncology
Eduardo Franco
Summary: The American Cancer Society (ACS) believes that the time has come for primary human papillomavirus (HPV) screening in the United States, but it requires educating the public and healthcare providers and overcoming logistical barriers. ACS is taking the lead by utilizing its resources to promote primary HPV screening in the US and sharing best practices from other countries through its Primary HPV Screening Initiative.
Article
Oncology
Eduardo L. Franco
Summary: As a cancer epidemiologist in the field of cervical cancer prevention and control, the author visited the home of his hero, Georgios Nikolaou Papanikolaou, whose pioneering work on the Pap test has saved countless female lives worldwide, creating a remarkable story in public health.
CANCER CYTOPATHOLOGY
(2023)
Article
Oncology
Talla Malagon, Samantha Morais, Parker Tope, Mariam El-Zein, Eduardo L. Franco
Summary: By linking data, the study found that non-White racial groups have higher site-specific cancer incidence rates than the overall population. Immigration status is an important modifier of cancer risk.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2023)
Article
Medicine, General & Internal
Cassandra Laurie, Mariam El-Zein, Sarah Botting-Provost, Joseph E. Tota, Pierre-Paul Tellier, Francois Coutlee, Ann N. Burchell, Eduardo L. Franco
Summary: The use of a carrageenan-based gel can reduce the risk of incident genital HPV infections in women without increasing adverse events, which may complement HPV vaccination.
Article
Oncology
Parker Tope, Samantha Morais, Mariam El-Zein, Eduardo L. Franco, Talia Malagon
Summary: Income, a component of socioeconomic status, influences cancer risk as a social determinant of health. This study evaluated the independent associations between individual- and area-level income and site-specific cancer incidence in Canada. The findings suggest that individual- and area-level income have significant effects on cancer incidence, with lower income associated with higher rates of certain cancers and wealthier income associated with higher rates of other cancers.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Oncology
Mariam El-Zein, David Cheishvili, Moshe Szyf, Eduardo L. Franco
Summary: In this study, new methylation markers were identified and validated for their role in cervical intraepithelial neoplasia (CIN) grades and cervical cancer. The methylation state of CA10, DPP10, FMN2 and HAS1 genes were evaluated in independent study populations using next-generation sequencing. The Marker Polygenic Score (MPS) calculated from these genes accurately predicted cervical cancer and showed potential for use in clinical settings. Further evaluation of these biomarkers in prospective studies is needed.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Editorial Material
Biology
Eduardo L. Franco, Diane M. Harper
Summary: eLife has released a special issue that discusses the impact of the COVID-19 pandemic on cancer prevention, control, care, and survivorship.
Article
Biology
Mariam El-Zein, Rami Ali, Eliya Farah, Sarah Botting-Provost, Eduardo L. Franco
Summary: This study investigated the effects of the COVID-19 pandemic on cervical cancer screening activities. The survey results showed high cancellation rates for screening appointments and consistent decreases in the number of screening Pap tests and colposcopy procedures across provinces. Approximately 90% of healthcare professionals adopted telemedicine for patient communication.