期刊
APPLIED SURFACE SCIENCE
卷 356, 期 -, 页码 1282-1288出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.apsusc.2015.07.151
关键词
Mesoporous silica nanoparticles; Disulfide bond; Poly(acrylic acid); Gatekeepers; Dual responsive
类别
资金
- National Basic Research Program of China (973 Program) [2015CB932100]
- National Natural Science Foundation of China [81473165]
- Liaoning Provincial Key Laboratory of Drug Preparation Design & Evaluation of Liaoning Provincial Education Department [LZ2015068]
In this paper, a mesoporous silica nanoparticles (MSN)-based redox and pH dual-responsive delivery system (MSN-SS-PAA) was developed for site-specific drug delivery, in which poly(acrylic acid) (PAA), a polyanion polymer, was grafted on the outlets of MSN via the cleavable disulfide bonds. PAA was chosen as a gatekeeper to block drugs within the mesopores of MSN mainly because PAA possesses many favorable features, such as appropriate molecular weight to block the entrances of MSNs, good biocompatibility, and ability to prolong the blood circulation time and improve the dispersing stability of MSN in physiological conditions. RhB, a fluorescent dye, was used as a model drug. In vitro release profiles indicated that RhB was markedly blocked within the mesopores in the absence of GSH or in pH 7.4 PBS; however, the release of RhB was dramatically increased after the addition of GSH or in pH 5.0 PBS. Moreover, the release of RhB was further improved in the simultaneous presence of GSH and pH 5.0 PBS. This paper provided an exploration of stimuli-responsive delivery system and the results demonstrated that MSN-SS-PAA exhibiting dual-responsive drug release property can be further considered as a promising candidate for cancer therapy. (C) 2015 Elsevier B.V. All rights reserved.
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