4.5 Article

Determination of phenformin hydrochloride using molecular imprinting technology coupled with flow-injection chemiluminescence

期刊

LUMINESCENCE
卷 27, 期 4, 页码 297-301

出版社

WILEY-BLACKWELL
DOI: 10.1002/bio.1350

关键词

molecular imprinting; chemiluminescence; phenformin hydrochloride; eosin Y; N-bromosuccinimide

资金

  1. National Natural Science Foundation of China [20973149]
  2. Department of Science and Technology of Shandong Province [2009GG10009053]
  3. Outstanding Youth Natural Science Foundation of Shandong Province [JQ201006]

向作者/读者索取更多资源

A novel method was developed using molecular imprinting technology (MIT) coupled with flow-injection chemiluminescence (FI-CL) for highly sensitive detection of phenformin hydrochloride (PH). The phenformin imprinted polymer was synthesized with methacrylic acid (MAA) as a functional monomer and ethylene glycol dimethacrylate (EGDMA) as a cross-linker. Newly synthesized molecularly imprinted polymer (MIP) particles were packed into a column as a selective recognition element for determination of PH. A CL method for the determination of PH was developed based on the CL reaction of PH with N-bromosuccinimide sensitized by eosin Y in basic media. The optimization of detection conditions was investigated. The CL intensity responded linearly to the concentration of PH in the range 0.092.0?mu g/mL, with a correlation coefficient of 0.9920. The detection limit was 0.031?mu g/mL. The relative standard deviation for the determination of 1.0?mu g/mL PH solution was 1.0% (n?=?11). The method was applied to the determination of PH in urine samples, with satisfactory results. Copyright (c) 2011 John Wiley & Sons, Ltd.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.5
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据