Article
Gastroenterology & Hepatology
Tatsunori Hanai, Kayoko Nishimura, Takao Miwa, Toshihide Maeda, Yuki Nakahata, Kenji Imai, Atsushi Suetsugu, Koji Takai, Masahito Shimizu
Summary: This study developed a new shortened Stroop test (On1-2Time) that can be used to identify CHE and estimate the risk of progression to OHE in Japanese patients with cirrhosis.
JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Medicine, General & Internal
Simon Johannes Gairing, Chiara Mangini, Lisa Zarantonello, Stefania Gioia, Elise Jonasson Nielsen, Sven Danneberg, Anna S. Lok, Philippe Sultanik, Peter Robert Galle, Joachim Labenz, Dominique Thabut, Jens Uwe Marquardt, Patricia P. Bloom, Mette Munk Lauridsen, Sara Montagnese, Silvia Nardelli, Christian Labenz
Summary: This large multicenter study demonstrates that screening for minimal hepatic encephalopathy (MHE) is a useful tool for predicting the development of overt hepatic encephalopathy (OHE) and poorer survival.
JOURNAL OF INTERNAL MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Takao Miwa, Tatsunori Hanai, Maeda Toshihide, Yui Ogiso, Kenji Imai, Atsushi Suetsugu, Koji Takai, Makoto Shiraki, Naoki Katsumura, Masahito Shimizu
Summary: Zinc deficiency may predict the development of OHE and mortality in LC patients with MHE.
HEPATOLOGY RESEARCH
(2021)
Article
Gastroenterology & Hepatology
Barjesh Chander Sharma, Sudhir Maharshi, Sanjeev Sachdeva, Bhawna Mahajan, Ashok Sharma, Sushma Bara, Siddharth Srivastava, Ajay Kumar, Ashok Dalal, Ujjwal Sonika
Summary: This study examined the effects of nutritional therapy on patients with liver cirrhosis and associated minimal hepatic encephalopathy (MHE). The results showed that nutritional therapy effectively improved cognitive functions, health-related quality of life, anthropometry, endotoxins, and inflammatory markers in these patients.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yue Cheng, Jing-Li Li, Jia-Min Zhou, Gao-Yan Zhang, Wen Shen, Xiao-Dong Zhang
Summary: This study investigated changes in sub-regional thalamic functional connectivity after liver transplantation in cirrhotic patients with and without a history of overt hepatic encephalopathy (OHE). The results showed that the renormalization of FC in the cortico-thalamic loop might be a neuro-substrate for the recovery of cognitive function after LT in cirrhotic patients, and hyperconnectivity between thalamic subregions and the inferior parietal lobe might be an important feature of OHE. Changes in FC in the thalamus could potentially serve as biomarkers for the recovery of cognitive function in cirrhotic patients after LT.
KOREAN JOURNAL OF RADIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Archana Arjunan, Dhiraj Kumar Sah, Young Do Jung, Juhyun Song
Summary: Hepatic encephalopathy is a severe metabolic syndrome associated with liver disorders, with limited treatment options available. The disease is a neuropsychiatric complication linked with cognitive decline, coma, and death, and its pathogenesis remains unclear. Melatonin, as the sole endogenous hormone related to HE, has neuroprotective effects by crossing the blood-brain barrier.
Article
Medicine, General & Internal
Razvan Igna, Irina Girleanu, Camelia Cojocariu, Cristina Muzica, Laura Huiban, Catalin Sfarti, Tudor Cuciureanu, Stefan Chiriac, Ana-Maria Singeap, Oana Cristina Petrea, Remus Stafie, Sebastian Zenovia, Robert Nastasa, Ermina Stratina, Adrian Rotaru, Carol Stanciu, Anca Trifan, Mihaela Blaj
Summary: This study evaluated the role of presepsin in the early diagnosis of infections in patients with liver cirrhosis (LC) and hepatic encephalopathy (HE). The results showed that presepsin levels >980 pg/mL could enhance the suspicion of bacterial infections, and it may be an adequate non-invasive tool for the early diagnosis of infections in these patients.
Article
Medicine, General & Internal
Yuki Nakahata, Tatsunori Hanai, Takao Miwa, Toshihide Maeda, Kenji Imai, Atsushi Suetsugu, Koji Takai, Masahito Shimizu
Summary: This study found that selenium deficiency is highly prevalent in patients with chronic liver disease (CLD) and is associated with an increased risk of overt hepatic encephalopathy (OHE) development. The serum selenium levels were lower in patients with cirrhosis compared to those with chronic hepatitis, and they were negatively correlated with several disease severity indicators. The ALBI score remained significantly associated with selenium deficiency, and selenium deficiency was associated with the occurrence of OHE during the follow-up period.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Neurosciences
Yue Cheng, Wen Shen, Junhai Xu, Rachel C. Amey, Li-Xiang Huang, Xiao-Dong Zhang, Jing-Li Li, Cameron Akhavan, Ben A. Duffy, Julia Pia Simon, Wenjuan Jiang, Mengting Liu, Hosung Kim
Summary: Neurocognitive impairment is present in cirrhosis, but liver transplantation can partially reverse this damage. This study found significant disrupted connectivity in cirrhotic patients, which improved after transplantation, showing potentially different recovery trajectories for patients with and without overt hepatic encephalopathy (OHE).
Article
Immunology
Ke Shi, Yunyi Huang, Qun Zhang, Chongping Ran, Jie Hou, Yi Zhang, Yufei Bi, Xianbo Wang
Summary: A dynamic nomogram has been developed to predict the risk of 30-day transplant-free mortality in patients with OHE and HBC. The MELD score and NLR are independently associated with the 30-day mortality. The nomogram shows good predictive accuracy and can guide clinical decision-making.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Review
Gastroenterology & Hepatology
Kok Ban Teh, Jing Hong Loo, Yew Chong Tam, Yu Jun Wong
Summary: The systematic review and meta-analysis showed that albumin infusion is beneficial in the treatment and prevention of hepatic encephalopathy. Albumin infusion was associated with reduced risk of OHE and inpatient mortality. Further well-powered randomized trials are needed to confirm these findings.
DIGESTIVE AND LIVER DISEASE
(2021)
Article
Medicine, General & Internal
Christophe Bureau, Dominique Thabut, Caroline Jezequel, Isabelle Archambeaud, Louis D'Alteroche, Sebastien Dharancy, Patrick Borentain, Frederic Oberti, Aurelie Plessier, Victor De Ledinghen, Nathalie Ganne-Carrie, Nicolas Carbonell, Vanessa Rousseau, Agnes Sommet, Jean Marie Peron, Jean Pierre Vinel
Summary: The study demonstrated that rifaximin significantly reduces the incidence of overt HE after TIPS, with good tolerability. However, the results primarily apply to patients with alcoholic cirrhosis, and further research is needed to evaluate the effects on other types of cirrhosis.
ANNALS OF INTERNAL MEDICINE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yang Yang, Xueqing Liang, Shirui Yang, Xiaofeng He, Mingsheng Huang, Wenfeng Shi, Junyang Luo, Chongyang Duan, Xinghui Feng, Sirui Fu, Ligong Lu
Summary: Preoperative prediction of OHE in patients with variceal bleeding treated using TIPS procedure was performed. A prediction model combining clinical and radiological factors was developed, which showed satisfactory performance in both training and validation cohorts.
EUROPEAN JOURNAL OF RADIOLOGY
(2022)
Review
Gastroenterology & Hepatology
Dominique Thabut, Charlotte Bouzbib, Lucy Meunier, Manon Haas, Nicolas Weiss, Alexandre Louvet, Francois Imbert-Bismut, Fanny Mochel, Yann Nadjar, Antoine Santiago, Thierry Thevenot, Veronique Duhalde, Frederic Oberti, Claire Francoz, Audrey Coilly, Marie-Noelle Hilleret, Pascal Lebray, Amelie Liou-Schischmanoff, Louise Barbier, Christophe Duvoux, Georges-Philippe Pageaux, Michael Bismuth, Damien Galanaud, Thomas De Broucker, Jean-Francois Cadranel, Vincent Leroy, Vincent Di Martino, Dominique Larrey, Christophe Camus, Olivier Scatton, Victor De Ledinghen, Ariane Mallat, Marika Rudler, Christophe Bureau
Summary: Hepatic encephalopathy (HE) is a frequent and severe complication of liver disease that often goes undiagnosed due to a lack of understanding and consensus on diagnosis. Non-specific symptoms and comorbidities in cirrhotic patients make differential diagnosis challenging. Guidelines are provided to assist clinicians in diagnosing and treating HE. Liver transplantation may be indicated for HE, but its reversibility post-transplantation and the consequences in patients with other neurological disorders remain controversial.
LIVER INTERNATIONAL
(2023)
Article
Health Care Sciences & Services
Lihong Gu, Xiaochun Yin, Yang Cheng, Xixuan Wang, Ming Zhang, Xiaoping Zou, Lei Wang, Yuzheng Zhuge, Feng Zhang
Summary: The study investigated the impact of body mass index (BMI) on the occurrence of overt hepatic encephalopathy (OHE) after the transjugular intrahepatic portosystemic shunt (TIPS) procedure in decompensated cirrhotic patients. A retrospective observational cohort study of 145 cirrhotic patients receiving TIPS was conducted, and the relationship between BMI and clinical outcomes, as well as risk factors for post-TIPS OHE, was analyzed. The results showed that overweight/obese patients had a higher frequency of OHE compared to normal weight patients, and overweight/obesity and older age were identified as independent risk factors for post-TIPS OHE according to the logistic regression analysis. The study concludes that overweight/obesity and older age may increase the risk of post-TIPS OHE in cirrhotic patients.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
