Article
Gastroenterology & Hepatology
Benjamin G. Wiggins, Laura J. Pallett, Xiaoyan Li, Scott P. Davies, Oliver E. Amin, Upkar S. Gill, Stephanie Kucykowicz, Arzoo M. Patel, Konstantinos Aliazis, Yuxin S. Liu, Gary M. Reynolds, Brian R. Davidson, Amir Gander, Tu Vinh Luong, Gideon M. Hirschfield, Patrick T. F. Kennedy, Yuehua Huang, Mala K. Maini, Zania Stamataki
Summary: This study found that high and intermediate CD69 expressions marked human hepatic CD4(+) T-RM and a novel functionally distinct recirculating population, both shaped by the liver microenvironment to achieve diverse immunosurveillance.
Article
Cell Biology
Carlos van der Putten, Ester B. M. Remmerswaal, Matty L. Terpstra, Nelly D. van der Bom, Jesper Kers, Ineke J. M. ten Berge, Suzanne E. Geerlings, Rene A. W. van Lier, Frederike J. Bemelman, Michiel C. van Aalderen
Summary: In this study, the researchers aimed to investigate the presence and function of T-RM cells in healthy and allograft kidney tissue by analyzing the phenotype and function of T cells through multichannel flow cytometry. The results showed that kidney tissue samples contained a significant number of CD8 and CD4 T cells that were more actively cycling, expressed specific markers CXCR3 and CXCR6, produced higher levels of IFN gamma, and displayed polyfunctionality compared to circulating T cells.
Article
Cell Biology
Pingping Wang, Lifen Yao, Meng Luo, Wenyang Zhou, Xiyun Jin, Zhaochun Xu, Shi Yan, Yiqun Li, Chang Xu, Rui Cheng, Yan Huang, Xiaoyu Lin, Kexin Ma, Huimin Cao, Hongxin Liu, Guangfu Xue, Fang Han, Huan Nie, Qinghua Jiang
Summary: The study reveals the presence of a large population of CD8(+) T cells progressing continuously and remarkably expanded CD4 CTLs in PD patients through TCR tracking. Additionally, potential TCR-antigen pairs were identified, providing evidence for peripheral T cells to participate in neuronal degeneration.
Review
Cardiac & Cardiovascular Systems
Andrew J. Smith
Summary: With the increasing research and understanding of the cardiotoxic side-effects of anticancer therapy, it is crucial to consider the range of myocardial cell types affected. The role of cardiac stem/progenitor cells in myocardial repair and renewal is significant, but their functions may be limited and worsened by cardiotoxins, impacting long-term prognosis of patients.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Review
Immunology
Ziwei Shen, Wei Huang, Jun Liu, Jie Tian, Shengjun Wang, Ke Rui
Summary: Research indicates that mesenchymal stem cell-derived exosomes (MSC-EXOs) have a significant inhibitory effect on effector cells involved in the immune response, and can be used to treat various autoimmune diseases, serving as a promising cell-free treatment strategy.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biodiversity Conservation
Emile Brisson-Curadeau, Kyle Elliott, Charles-Andre Bost
Summary: The adaptation of king penguins to climate varies in different geographical environments, resulting in differences in breeding success rates. The king penguin population on Kerguelen island showed higher breeding success in warmer years, possibly due to increased prey abundance and improved chick survival in winter with warmer air temperature. In contrast, the penguin population in Crozet experienced lower breeding success in warmer years, as productive currents shifted away from the colony, affecting foraging behavior.
GLOBAL CHANGE BIOLOGY
(2022)
Article
Oncology
Max Heiduk, Anna Klimova, Charlotte Reiche, David Digomann, Carolin Beer, Daniela E. Aust, Marius Distler, Jurgen Weitz, Adrian M. Seifert, Lena Seifert
Summary: Immunotherapy has revolutionized the treatment of cancer, but its effectiveness in PDAC is limited. By analyzing the expression of inhibitory immune checkpoint receptors (ICRs) on T cells in PDAC patients, we can gain insight into the insufficient T-cell-mediated antitumor immunity.
CLINICAL CANCER RESEARCH
(2023)
Article
Developmental Biology
Odemaris Narvaez del Pilar, Maria Jose Gacha Garay, Jichao Chen
Summary: By using single-cell RNA-sequencing, 3D imaging and lineage tracing, the study classified the mouse lung mesenchyme into three axes based on their association with the endothelium, epithelium and interstitium. The classification revealed distinct morphology of mesenchymal cell populations and provides a framework applicable to other organs.
Article
Immunology
Alasdair G. Kay, James M. Fox, James P. Hewitson, Andrew P. Stone, Sophie Robertson, Sally James, Xiao-nong Wang, Elizabeth Kapasa, Xuebin B. Yang, Paul G. Genever
Summary: The heterogeneity of bone marrow mesenchymal stromal cells (MSCs) poses challenges for their clinical development. A subtype of MSCs characterized by CD317 expression has been identified, and they show a constitutive interferon signature linked to human disease. CD317(pos) MSCs induce tissue damage in a skin inflammation model, while CD317(neg) MSCs have no effect. CD317(neg) MSCs can suppress the proliferation of activated human T cells, while CD317(pos) MSCs increase the polarization towards pro-inflammatory Th1 cells. CD317(neg) and CD317(pos) MSCs can suppress leukocyte recruitment, but only CD317(neg) MSCs suppress macrophage numbers.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Environmental Sciences
Ling Chen, Bei Su, Jing Yu, Jinfeng Wang, Haidong Hu, Hong-Qiang Ren, Bing Wu
Summary: This study analyzed the combined effects of arsenic and 2,2-dichloroacetamide (DCAcAm) on different cell populations in zebrafish liver using single-cell RNA sequencing. It found that the hepatocytes were the main target cell subtype and showed different toxic responses to arsenic and DCAcAm exposure. In addition, hepatic duct cells and endothelial cells were not affected by these exposures.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Immunology
Dakshika Gangani, Wathsala Dissanayake, Rajiva de Silva, Kaushalya Anuradha, Lilani Karunanayake, Narmada Fernando, Senaka Rajapakse, Sunil Premawansa, Shiroma Handunnetti
Summary: The immune response induced by two types of Leptospira antigen preparations was compared in this study. The LPS extract of L. interrogans serovar Pyrogenes induced a higher IgM response compared to the sonicated antigen preparation, and a higher IgM response was also observed with L. interrogans serovar Pyrogenes compared to L. biflexa serovar Patoc. Equivalent IgG responses were observed with all four antigen preparations. The percentage of B2 cells in the peritoneal cavity increased significantly during the immunization period, indicating their potential role in generating humoral response against Leptospira antigens.
Article
Medicine, General & Internal
Jin Hyuk Paek, Ye Na Kim, Ho Sik Shin, Yeonsoon Jung, Hark Rim
Summary: This study evaluated the distribution of regulatory T cells (Tregs) and their effects on kidney allograft function in Korean kidney transplant recipients. The results showed that patients receiving lower doses of cyclosporine had higher proportions of Tregs. However, no significant relationship was found between Tregs and kidney allograft function in stable kidney transplant recipients.
Article
Engineering, Environmental
Fei Shi, Minshan Yao, Yao Huang, Zhilong Chen, Jin Xiao, Fanbin Zhan, Yanan Li, Li Lin, Zhendong Qin
Summary: Antibiotics are widely used for treating diseases in animals and humans globally. However, the contamination of water supply with antibiotics and other secondary metabolites poses a significant risk to human health. A comprehensive investigation is currently studying the effects of dietary antibiotics on the liver of fish, particularly their impacts on oxidative stress, transcriptome profiles, toxicity, and apoptosis. The study found that the administration of enrofloxacin or florfenicol to grass carp induced oxidative stress, impaired the PPAR signal pathway, and caused apoptosis in liver tissue.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2023)
Article
Cell Biology
Zhichao Lang, Yifei Li, Lifan Lin, Xinmiao Li, Qiqi Tao, Yuhang Hu, Menglu Bao, Lei Zheng, Zhengping Yu, Jianjian Zheng
Summary: Recently, it has been shown that Salidroside (Sal) can inhibit hepatic stellate cell (HSC) activation and decrease hepatocyte injury, both of which are crucial for liver fibrosis development. This study aimed to investigate the role of exosomal miRNAs from Sal-treated hepatocytes in HSC activation and liver fibrosis. The results showed that Sal suppressed carbon tetrachloride (CCl4)-induced liver fibrosis, and Sal-treated hepatocytes inhibited HSC activation and proliferation. Furthermore, miR-146a-5p, which was up-regulated by Sal, was found to be transferred via exosomes and contributed to HSC inactivation by suppressing EIF5A2 and epithelial-mesenchymal transition (EMT) process.
CELL DEATH DISCOVERY
(2023)
Article
Oncology
Morten Ritso, Lin Wei Tung, Fabio M. Rossi
Summary: Healthy skeletal muscle relies on both skeletal muscle stem cells and tissue-resident stromal cells for repair and maintenance. Different subpopulations of stromal cells play distinct roles in the regenerative process, and dysregulation of communication among cell populations can lead to pathological changes and decline in muscle function. Restoring proper stromal cell function is crucial for therapeutic targeting and maintaining muscle homeostasis.
EXPERIMENTAL CELL RESEARCH
(2022)
Article
Cell & Tissue Engineering
Iran Rashedi, Alejandro Gomez-Aristizabal, Xing-Hua Wang, Sowmya Viswanathan, Armand Keating
Article
Orthopedics
A. Gomez-Aristizabal, A. Sharma, M. A. Bakooshli, M. Kapoor, P. M. Gilbert, S. Viswanathan, R. Gandhi
OSTEOARTHRITIS AND CARTILAGE
(2017)
Article
Chemistry, Multidisciplinary
Hans C. Fischer, Tanya S. Hauck, Alejandro Gomez-Aristizabal, Warren C. W. Chan
ADVANCED MATERIALS
(2010)
Article
Biochemistry & Molecular Biology
Alejandro Gomez-Aristizabal, John Edward Davies
BIOCHEMISTRY AND CELL BIOLOGY-BIOCHIMIE ET BIOLOGIE CELLULAIRE
(2013)
Review
Biotechnology & Applied Microbiology
Alejandro Gomez-Aristizabal, Armand Keating, John E. Davies
Article
Multidisciplinary Sciences
Alejandro Gomez-Aristizabal, Kyung-Phil Kim, Sowmya Viswanathan
Article
Cell & Tissue Engineering
Alejandro Gomez-Aristizabal, John Edward Davies
TISSUE ENGINEERING PART A
(2012)