Article
Surgery
Felix J. Krendl, Margot Fodor, Franka Messner, Agnes Balog, Anja Vales, Benno Cardini, Thomas Resch, Manuel Maglione, Christian Margreiter, Marina Riedmann, Hanno Ulmer, Dietmar Oefner, Rupert Oberhuber, Stefan Schneeberger, Annemarie Weissenbacher
Summary: A positive crossmatch is usually not recommended for solid abdominal organ transplantation, except for liver transplantation. However, conflicting reports exist on the effects of a positive crossmatch on post-transplant outcomes. This study aimed to assess the influence of a positive crossmatch on relevant outcome parameters in liver transplantation patients. The results showed that a positive crossmatch did not affect patient and graft survival, rejection episodes, or the incidence of biliary and arterial complications. An association was found between a strong positive crossmatch and infection with PCR+ CMV.
TRANSPLANT INTERNATIONAL
(2023)
Review
Multidisciplinary Sciences
Rosamond L. Naylor, Ronald W. Hardy, Alejandro H. Buschmann, Simon R. Bush, Ling Cao, Dane H. Klinger, David C. Little, Jane Lubchenco, Sandra E. Shumway, Max Troell
Summary: The sustainability of aquaculture has been intensely debated since 2000, with major contributions coming from inland aquaculture in Asia. There have been significant advances in feed efficiency and fish nutrition, but reliance on marine ingredients remains a challenge. Molluscs and seaweed have potential for ecosystem services and global nutritional security, but their quantification, valuation, and market development are still underexploited.
Article
Surgery
William C. Goggins, Burcin Ekser, Zachary Rokop, Andrew J. Lutz, Plamen Mihaylov, Richard S. Mangus, Jonathan A. Fridell, John A. Powelson, Chandrashekhar A. Kubal
Summary: The study indicates that the delayed kidney transplant approach in XM+ combined liver-kidney transplantations leads to a significant reduction in total and class I donor-specific antibodies, without delayed graft function or antibody-mediated rejection. One-year patient survival with this approach is comparable to that of crossmatch recipients.
Review
Pediatrics
Harveen Singh, Chayarani Kelgeri, Charlotte Passingham, Lauren Johansen, Indra van Mourik, Evelyn Ong, M. Thamara P. R. Perera, Darius Mirza, Khalid Sharif, Jane Hartley, Girish L. Gupte
Summary: This study characterized pediatric acute-on-chronic liver failure (ACLF) at Birmingham Children's Hospital (BCH) using European Association of Liver Disease CLIF criteria. The study found that ACLF has high mortality rates, with increased use of vasopressors and ventilation in patients who died from ACLF.
Article
Pharmacology & Pharmacy
Jingshu Qi, Yunkai Dai, Xin Sun, Chenghai Liu
Summary: This study used bibliometric analyses to explore the study of the mechanism of liver regeneration (MoLR) in the last 20 years. The United States, University of Pittsburgh, and Cunshuan Xu were found to be the most influential country, institution, and author, respectively. Hepatology was identified as the journal with the most articles on MoLR.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Surgery
Qingyong Xu, Puneet Sood, Dennis Helmick, Jon S. Lomago, Amit D. Tevar, Adriana Zeevi
Summary: This case study reports a patient awaiting a second kidney transplantation who tested positive for B cell flow cytometry crossmatch 37 days after receiving the COVID-19 vaccine. The emergence of antibodies to HLA-DR7 following vaccination highlights the potential impact of COVID-19 immunization on alloimmunity among transplant candidates. Utilizing multiple assays and history of allo-sensitization is crucial in assessing immunological risks associated with organ transplantation.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Review
Immunology
Johan Noble, Thomas Jouve, Paolo Malvezzi, Lionel Rostaing
Summary: Access to kidney transplantation can be facilitated by desensitization strategies targeting HLA-specific sensitization. This review provides an overview of the clinical experience gained in the past 20 years using various tools, including drugs and apheresis options, to achieve desensitization before kidney transplantation.
Article
Gastroenterology & Hepatology
Samy Riad, Elizabeth S. Aby, Phuoc Le Nguyen, Scott Jackson, Nicholas Lim, John Lake
Summary: The long-term outcomes of positive crossmatch simultaneous liver-kidney transplantations do not have a negative impact on recipient, liver graft, and kidney graft survival. However, there is a slightly higher risk of early kidney allograft rejection in positive crossmatch recipients.
LIVER TRANSPLANTATION
(2022)
Review
Immunology
Anushka Das, Timucin Taner, Jim Kim, Juliet Emamaullee
Summary: Simultaneous liver-kidney transplantation (SLKT) has seen increased utilization since the 1960s, with ongoing debates regarding the immunological privilege of the liver, role of donor-specific HLA antibody (DSA) and crossmatch testing. Studies suggest that while the liver can reduce rejection rates, pretransplant risk assessment should consider liver function, previous transplants, and other factors. Furthermore, the role of specific DSAs and evolving immunosuppression protocols require further research to optimize outcomes for SLKT recipients.
Article
Pharmacology & Pharmacy
Yun-Kai Dai, Zhi-Min Zhao, Chenghai Liu
Summary: This study analyzed the research hotspots, evolution, and trends of the treatment of liver fibrosis in the past 20 years, providing important insights for scholars in this field. It revealed the key areas of research and the development direction, indicating that the field is still in a stage of rapid development and will continue to be a research hotspot in the future.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Gastroenterology & Hepatology
Thomas Enke, Sherry Livingston, Jody Rule, Todd Stravitz, Jorge Rakela, Nathan Bass, Adrian Reuben, Shannan Tujios, Anne Larson, Norman Sussman, Valerie Durkalski, William Lee, Daniel Ganger
Summary: Autoimmune hepatitis is a common cause of acute liver failure, and treatment includes steroids and liver transplantation. This study aims to characterize acute liver failure due to autoimmune hepatitis and identify predictors of 21-day transplant-free survival. Data from hospitalized patients with acute liver failure were analyzed, and a multivariable logistic regression model was developed using variables associated with survival.
LIVER TRANSPLANTATION
(2023)
Article
Pediatrics
Malgorzata Markiewicz-Kijewska, Piotr Kalicinski, Juan Torres Canizales, Angelo Di Giorgio, Ulrich Baumann, Carl Jorns, Alastair Baker, Maria Francelina Lopes, Esteban Frauca Remacha, Eduardo Lopez-Granados, Paloma Jara Vega, Maria-Sole Basso, Grzegorz Kowalewski, Diana Kaminska, Sandra Ferreira, Daniela Liccardo, Andrea Pietrobattista, Marco Spada
Summary: AB0-incompatible (AB0i) liver transplantations in pediatric patients have been found to be affected significantly by donor type, urgency of transplantation, and development of vascular complications. A longer time from the first AB0i LT in the study results in better outcomes, indicating an international learning experience.
Correction
Multidisciplinary Sciences
Rosamond L. Naylor, Ronald W. Hardy, Alejandro H. Buschmann, Simon R. Bush, Ling Cao, Dane H. Klinger, David C. Little, Jane Lubchenco, Sandra E. Shumway, Max Troell
Summary: A correction to this paper has been published, readers are encouraged to check the link for accurate information.
Review
Oncology
Gian Piero Guerrini, Giuseppe Esposito, Tiziana Olivieri, Paolo Magistri, Roberto Ballarin, Stefano Di Sandro, Fabrizio Di Benedetto
Summary: This article compares the surgical and long-term outcomes of Salvage Liver Transplantation (SLT) and Primary Liver Transplantation (PLT) for HCC through a meta-analysis. The results show that SLT has comparable surgical outcomes but slightly poorer long-term survival compared to PLT.
Article
Surgery
Lionel Couzi, Paolo Malvezzi, Lucile Amrouche, Dany Anglicheau, Gilles Blancho, Sophie Caillard, Marine Freist, Gwenda Line Guidicelli, Nassim Kamar, Carmen Lefaucheur, Christophe Mariat, Alice Koenig, Johan Noble, Olivier Thaunat, Antoine Thierry, Jean-Luc Taupin, Dominique Bertrand
Summary: Imlifidase has been authorized for highly sensitized adult kidney transplant candidates with a positive crossmatch against an ABO-compatible deceased donor. These French consensus guidelines aim to standardize patient selection, treatments, and follow-up. Eligible patients must meet specific criteria, and the decision to use Imlifidase is based on crossmatch results and post-treatment testing. Immunosuppressive therapy is recommended, and monitoring for DSA rebound and rejection is crucial.
TRANSPLANT INTERNATIONAL
(2023)
Article
Immunology
Liza Johannesson, E. Colin Koon, Johanna Bayer, Gregory J. McKenna, Anji Wall, Hoylan Fernandez, Eric J. Martinez, Amar Gupta, Richard Ruiz, Nicholas Onaca, Giuliano Testa
Summary: The study compared early outcomes and morbidity of robot-assisted donor hysterectomy with traditional open surgery, finding that the robot-assisted approach was safer and offered advantages such as shorter hospital stays and quicker recovery for donors.
Article
Surgery
Giuliano Testa, Greg J. McKenna, Johanna Bayer, Anji Wall, Hoylan Fernandez, Eric Martinez, Amar Gupta, Richard Ruiz, Nicholas Onaca, Robert T. Gunby, Anthony R. Gregg, Michael Olausson, E. Colin Koon, Liza Johannesson
Article
Gastroenterology & Hepatology
Allison J. Kwong, Avegail Flores, Giovanna Saracino, Jodi Boutte, Greg McKenna, Giuliano Testa, Ranjeeta Bahirwani, Anji Wall, W. Ray Kim, Goran Klintmalm, James F. Trotter, Sumeet K. Asrani
LIVER TRANSPLANTATION
(2020)
Article
Obstetrics & Gynecology
Liza Johannesson, Giuliano Testa, J. Michael Putman, Gregory J. McKenna, E. Colin Koon, Jackie R. York, Johanna Bayer, Lilly Zhang, Zachary S. Rubeo, Robert T. Gunby, Anthony R. Gregg
Summary: This study describes the aggregated pregnancy outcomes of 20 women who underwent uterus transplantation at a single center, with a live birth rate of 55% per attempted transplant and 79% per technically successful transplant. Uterus transplantation resulted in third-trimester live births in all cases where pregnancies reached 20 weeks gestation, although maternal medical and obstetric complications were observed.
OBSTETRICS AND GYNECOLOGY
(2021)
Article
Obstetrics & Gynecology
Jackie R. York, Giuliano Testa, Robert T. Gunby, J. Michael Putman, Gregory J. McKenna, Eric C. Koon, Johanna Bayer, Lilly Zhang, Anthony R. Gregg, Liza Johannesson
Summary: This study described the hospital course and laboratory findings in the first 2 months of life of 12 infants born after uterus transplantation. The infants had a gestational age that reflected the time of delivery and showed no identified malformations or organ dysfunctions. At 2 months of age, all infants achieved developmental and behavioral milestones, but longer follow-up and more participants are needed to confirm these observations.
AMERICAN JOURNAL OF PERINATOLOGY
(2023)
Article
Surgery
Nicholas Onaca, Eric Martinez, Johanna Bayer, Anji Wall, Hoylan Fernandez, Richard Ruiz, Tsung-Wei Ma, Amar Gupta, Gregory McKenna, Giuliano Testa
Summary: Non-contrast pelvic computed tomography can detect severe iliac artery calcifications that may contraindicate kidney transplantation. Screening for these calcifications in selected candidates can assist with surgical decision-making, but the risks of cost and radiation exposure need to be weighed against the potential benefits of avoiding unnecessary surgery.
CLINICAL TRANSPLANTATION
(2021)
Article
Surgery
Teodoro Bottiglieri, Xuan Wang, Erland Arning, Hoylan Fernandez, Anji Wall, Greg McKenna, Richard Ruiz, Nicholas Onaca, James Trotter, Michael Lawrence, Bashoo Naziruddin, Sumeet K. Asrani, Giuliano Testa
Summary: This study found significant changes in 15 primary and secondary plasma bile acids following major hepatectomy, with most occurring 2 days post-surgery and persisting up to 3 months. Additionally, alterations were observed in acylcarnitine, phospholipid, and amino acid metabolism. The research supports the full restoration of metabolic processes 3 months after surgery and suggests further investigation into the impact of metabolic changes on donors' hepatic function.
CLINICAL TRANSPLANTATION
(2022)
Article
Surgery
Anji E. Wall, Briget da Graca, Sumeet K. Asrani, Richard Ruiz, Hoylan Fernandez, Amar Gupta, Eric Martinez, Johanna Bayer, Gregory J. McKenna, Robert Goldstein, Nicholas Onaca, James F. Trotter, Giuliano Testa
Summary: This study analyzed the changes in costs associated with liver acquisition after the implementation of the Acuity circles liver allocation policy. While there were no significant differences in MELD scores, match run sequence, travel distance, and percentage of donors requiring flights between pre-AC and post-AC periods, the total costs per accepted and declined donor significantly increased. Factors contributing to the cost increase included higher proportions of import fees and surgeon fees, increased acquisition fees, and higher flight expenses.
Article
Surgery
Giuliano Testa, Greg J. McKenna, Liza Johannesson
Article
Obstetrics & Gynecology
Liza Johannesson, Anji E. Wall, Johanna Bayer, Greg J. Mckenna, Matthew Rosenzweig, Briget Da Graca, Eric C. Koon, Giuliano Testa
Summary: This study demonstrates the feasibility and reproducible success of using uterine grafts from living donors procured by robotic-assisted donor hysterectomies with transvaginal extraction. The recipients had shorter surgical time, less estimated blood loss, and good graft viability, resulting in a high live birth rate.
CLINICAL OBSTETRICS AND GYNECOLOGY
(2022)
Article
Obstetrics & Gynecology
Greg J. Mckenna, Liza Johannesson, Giuliano Testa
Summary: Uterus transplantation is a relatively new field, and it is difficult to identify specific technological advances. However, there have been improvements in donor screening through diagnostic imaging, the adoption of robotic surgery for minimally invasive procedures, and future advancements in biotechnology such as perfusion pumps and bioengineering for increased donor supply.
CLINICAL OBSTETRICS AND GYNECOLOGY
(2022)
Editorial Material
Gastroenterology & Hepatology
Greg J. McKenna
LIVER TRANSPLANTATION
(2022)
Article
Urology & Nephrology
Anji E. Wall, Michele Finotti, Matthew Rosenzweig, Eric Martinez, Amar Gupta, Greg J. McKenna, Johanna Bayer, Angelito Yango, Teena Sam, Cedric Spak, Bernard Fischbach, Giuliano Testa
Summary: The study suggests that kidney grafts from donors with a recent history of severe SARS-CoV-2 infection but with preserved kidney function can be safely transplanted and have good early outcomes.
CLINICAL NEPHROLOGY
(2022)
Article
Surgery
Vivienne N. Hannon, Pascale Tinguely, Greg J. McKenna, Raffaele Brustia, Fady M. Kaldas, Olivier Scatton, Michael Spiro, Dimitri Aristotle Raptis, Ronald W. Busuttil, Goran B. Klintmalm
Summary: There are similarities between the history of ERAS and liver transplantation. Despite traditional beliefs that liver transplantation is too complex for ERAS, some studies have shown its safety and benefits. To advance the field, the International Liver Transplantation Society has created expert panels and will generate expert recommendations using the GRADE approach. These recommendations will be voted on to create the ERAS4OLT.org Enhanced Recovery after Liver Transplantation Pathway.
CLINICAL TRANSPLANTATION
(2022)
Article
Surgery
Sumeet K. Asrani, Giovanna Saracino, Anji Wall, James F. Trotter, Giuliano Testa, Ruben Hernaez, Pratima Sharma, Allison Kwong, Srikanta Banerjee, Gregory McKenna
Summary: Accurate assessment of donor quality at the time of organ offer for liver transplantation candidates may be inadequately captured by the donor risk index. A novel objective and simple model, called the ID(2)EAL score, was developed and validated to assess donor risk using donor level variables available at the time of organ offer. The ID(2)EAL score had better discrimination than the donor risk index and may serve as an important tool for patient discussion about donor risk and decisions regarding offer acceptance.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)