Article
Radiology, Nuclear Medicine & Medical Imaging
Yuling Zhang, Bei Li, Qing He, Zhiqiang Chu, Qian Ji
Summary: In this study, the liver regeneration trends between donors and recipients after living-donor liver transplantation (LDLT) were compared, and potential influencing factors were searched. The results showed that donors had more significant and faster liver regeneration than recipients, and factors such as graft with or without middle hepatic vein, initial liver volume, and preoperative liver function status of the recipients significantly affected liver regeneration.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2022)
Article
Immunology
Hillary J. Braun, Joshua D. Grab, Jennifer L. Dodge, Shareef M. Syed, Garrett R. Roll, Marisa P. Schwab, Iris H. Liu, Alexa C. Glencer, Chris E. Freise, John P. Roberts, Nancy L. Ascher
Summary: The study found that approximately 10% of patients who underwent living donor liver transplantation required retransplantation. Patients who received retransplantation had significantly lower survival rates compared to those who only underwent primary transplantation.
Article
Gastroenterology & Hepatology
Tomoharu Yoshizumi, Shinji Itoh, Mototsugu Shimokawa, Shoichi Inokuchi, Noboru Harada, Kazuki Takeishi, Yohei Mano, Shohei Yoshiya, Takeshi Kurihara, Yoshihiro Nagao, Toru Ikegami, Yuji Soejima, Masaki Mori
Summary: The study demonstrates that simultaneous splenectomy after living donor liver transplantation can prevent small-for-size graft syndrome and improve graft survival rates. It is recommended to perform simultaneous splenectomy for patients with predicted small grafts, portal hypertension, or high portal pressure.
JOURNAL OF HEPATOLOGY
(2021)
Article
Medicine, General & Internal
Jongman Kim, Jae Heon Kim, Hyun Jung Kim
Summary: This study found that living liver donors have a significantly higher incidence of liver and thyroid cancer compared to a matched healthy control group. The findings suggest the need for medical surveillance, especially for liver cancer, among living liver donors.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2023)
Article
Immunology
Basri Satilmis, Sami Akbulut, Tevfik Tolga Sahin, Yasin Dalda, Adem Tuncer, Zeynep Kucukakcali, Zeki Ogut, Sezai Yilmaz
Summary: This study evaluated the course of liver regeneration after living donor hepatectomy using routine and regeneration-related biomarkers. The results showed that regenerative markers increased in a sustained fashion following the surgery, especially in right-lobe grafts, indicating progenitor-associated liver regeneration.
Article
Surgery
Yong K. Kwon, Navpreet Kaur, Kambiz Etesami, Shannon Zielsdorf, Brian Kim, Jeffrey Kahn, George Yanni, Ana Padilla, Hyosun Han, Yuri Genyk
Summary: Living donor liver transplantation is an effective solution to organ shortage, but ABO incompatibility or inadequate liver volume often prevents potential living donors from donating. Liver paired exchange (LPE) offers a practical solution to overcome these obstacles, and this study reports the world's first LPE case involving pediatric and adult recipients. This approach aims to avoid surgical complexity in the pediatric recipient and improve the graft-to-recipient weight ratio in the adult recipient of two ABO compatible pairs.
AMERICAN JOURNAL OF TRANSPLANTATION
(2023)
Article
Surgery
Zhihao Li, Ashwin Rammohan, Vasanthakumar Gunasekaran, Suyoung Hong, Itsuko Chih-Yi Chen, Jongman Kim, Kris Ann Hervera Marquez, Shih Chao Hsu, Elvan Onur Kirimker, Nobuhisa Akamatsu, Oren Shaked, Michele Finotti, Marcus Yeow, Lara Genedy, Philipp Dutkowski, Silvio Nadalin, Markus U. Boehnert, Wojciech G. Polak, Glenn K. Bonney, Abhishek Mathur, Benjamin Samstein, Jean C. Emond, Giuliano Testa, Kim M. Olthoff, Charles B. Rosen, Julie K. Heimbach, Timucin Taner, Tiffany CL. Wong, Chung-Mau Lo, Kiyoshi Hasegawa, Deniz Balci, Mark Cattral, Gonzalo Sapisochin, Nazia Selzner, Long Bin Jeng, Dieter Broering, Jae-Won Joh, Chao-Long Chen, Kyung-Suh Suk, Mohamed Rela, Pierre-Alain Clavien
Summary: This study aims to establish benchmark values for adult-to-adult living-donor liver transplantation (LDLT). By analyzing data from 15 high-volume centers, it was found that benchmark LDLT can reduce waitlist mortality, with Asian centers outperforming others and non-benchmark low-volume centers displaying inferior outcomes.
Review
Surgery
Tetsuro Sakai, Justin Sangwook Ko, Cara E. Crouch, Sathish Kumar, Michael B. Little, Min Suk Chae, Armando Ganoza, Luis Gomez-Salinas, Abhi Humar, Sang Hyun Kim, Bon-Nyeo Koo, Gonzalo Rodriguez, Joel Sirianni, Natalie K. Smith, Jun-Gol Song, Aisha Ullah, Adrian Hendrickse
Summary: Living donor liver transplantation is an alternative method developed to address the limited access to deceased donor organs in Asia. It has become a widely practiced transplantation method for adult patients with end-stage liver disease and successfully solved the shortage of deceased donors. This review provides a comprehensive overview of the perioperative management of adult living liver transplantation recipients.
CLINICAL TRANSPLANTATION
(2022)
Article
Surgery
Okjoo Lee, Jong Man Kim, Sang Jin Kim, Jinsoo Rhu, Gyu-Seong Choi, Jae-Won Joh
Summary: This study found that spousal donation is feasible and safe in living donor liver transplantation (LDLT). Compared with donations from children, spousal donors had shorter operation time and lower complication rate, and the overall survival of recipients was not reduced.
WORLD JOURNAL OF SURGERY
(2022)
Article
Surgery
Ruveena B. Rajaram, Thevaraajan Jayaraman, Boon-Koon Yoong, Peng-Soon Koh, Pui San Loh, Jun-Kit Koong, Alizan A. Khalil, Noorjahan Haneem Md Hashim, Fadhil H. Jamaluddin, Sanjiv Mahadeva
Summary: The study revealed that obesity and NAFLD are significant challenges to the emerging LDLT program in Malaysia, with 74.5% of potential donors being not utilized due to these issues. Unsuitable donors typically have higher BMI, CAP scores, and rates of dyslipidaemia and NAFLD compared to suitable donors.
ASIAN JOURNAL OF SURGERY
(2022)
Article
Surgery
Arianna Barbetta, Mayada Aljehani, Michelle Kim, Christine Tien, Aaron Ahearn, Hannah Schilperoort, Linda Sher, Juliet Emamaullee
Summary: A systematic review comparing adult living donor liver transplantation (LDLT) and deceased donor liver transplantation (DDLT) found that LDLT is associated with improved patient survival, reduced waiting time, and lower MELD score, despite an increased risk of biliary complications. Hepatic artery thrombosis rates did not differ between the two types of transplantation.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Article
Biotechnology & Applied Microbiology
Xiping Chen, Huan Xiao, Chunjiang Yang, Jingyu Chen, Yang Gao, Yi Tang, Xiaojuan Ji
Summary: This study investigated hemodynamic changes in infants undergoing living donor liver transplantation due to biliary atresia. Results showed a decrease in hepatic artery peak systolic velocity and resistivity index, and an increase in portal vein velocity and flow on the first day post-transplant. These changes remained stable within the first month after surgery.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Surgery
Hillary J. Braun, Ana Marie Torres, Finesse Louie, Sandy Weinberg, Sang-Mo Kang, Nancy L. Ascher, John P. Roberts
Summary: Living donor liver transplantation (LDLT) is more common in Asia than in North America, where living donor kidney transplantation, including paired exchanges for ABO-incompatible pairs, is prevalent. The first liver paired exchange (LPE) in the United States, completed over two consecutive days, was initiated by a non-directed donor and benefited an ABO-incompatible pair. This innovative approach demonstrates the feasibility of LPE in centers with experience in LDLT, offering new possibilities for transplantation in cases of ABO incompatibility.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Article
Health Care Sciences & Services
Wei-Chen Lee, Chen-Fang Lee, Tsung-Han Wu, Hao-Chien Hung, Jin-Chiao Lee, Yu-Chao Wang, Chih-Hsien Cheng, Ting-Jung Wu, Hong-Shiue Chou, Kun-Ming Chan
Summary: ABO incompatible living donor liver transplantation can be successful, but anti-ABO isoagglutinin rebound may lead to antibody-mediated rejection and graft loss. Adding bortezomib to the desensitization regimen can mitigate the risk of isoagglutinin rebound and prevent clinical AMR in patients with high isoagglutinin titers.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Surgery
Cheon-Soo Park, Young-In Yoon, Nayoung Kim, Shin Hwang, Tae-Yong Ha, Dong-Hwan Jung, Gi-Won Song, Deok-Bog Moon, Chul-Soo Ahn, Gil-Chun Park, Ki-Hun Kim, Yong-Pil Cho, Sung-Gyu Lee
Summary: Living-donor liver transplantation is a viable option for patients with hepatorenal syndrome. This study aimed to describe outcomes after LDLT among HRS recipients and determine predictors of poor renal recovery. The results indicated that renal recovery was important for survival, and the interval between HRS and LDLT was significantly associated with renal recovery after transplantation.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)