Article
Medicine, Research & Experimental
Satoshi Miyairi, Daisuke Ueda, Takafumi Yagisawa, Daigo Okada, Karen S. Keslar, Kazunari Tanabe, Nina Dvorina, Anna Valujskikh, William M. Baldwin, Stanley L. Hazen, Robert L. Fairchild
Summary: Recipient myeloid cells producing MPO play a crucial role in the development of acute ABMR, and their absence leads to the occurrence of chronic ABMR.
Article
Multidisciplinary Sciences
Andrew P. Hederman, Harini Natarajan, Leo Heyndrickx, Kevin K. Arien, Joshua A. Wiener, Peter F. Wright, Evan M. Bloch, Aaron A. R. Tobian, Andrew D. Redd, Joel N. Blankson, Amihai Rottenstreich, Gila Zarbiv, Dana Wolf, Tessa Goetghebuer, Arnaud Marchant, Margaret E. Ackerman
Summary: This study investigates the breadth and potency of antibodies after infection and vaccination. The findings reveal that variants associated with vaccination have significantly greater functional antibody breadth and potency compared to those associated with immunologically vulnerable populations. However, convalescent individuals exhibit higher antibody functional activity against the endemic coronavirus OC43, indicating recognition differences between close and distant human coronavirus strains associated with exposure history.
NATURE COMMUNICATIONS
(2023)
Article
Immunology
Boyeon Kim, Sinyoung Kim, Younhee Park, Hyon-Suk Kim
Summary: The study analyzed the potential false-positive results of the single-antigen bead assay (SABA) for detecting anti-human leukocyte antigen (HLA) antibodies, finding a high prevalence of false reactivity, with HLA-C*17:01 antibody displaying the highest frequency ratio. Recommendations include confirming results with different methods if false-positive reactivity is suspected and comparing positive rates with allele frequencies to aid interpretation.
Article
Multidisciplinary Sciences
Asuka Tanaka, Kentaro Ide, Yuka Tanaka, Masahiro Ohira, Hiroyuki Tahara, Hideki Ohdan
Summary: Pretransplant desensitization with rituximab was found to enhance anti-donor CD4(+) T cell responses in DSA-positive transplant recipients, while IL-10(+) CD5(+) B cells were shown to suppress excessive responses of anti-donor CD4(+) T cells.
SCIENTIFIC REPORTS
(2021)
Review
Urology & Nephrology
Natavudh Townamchai, Yingyos Avihingsanon
Summary: HLA incompatibility and ABO incompatibility are the main mechanisms of antibody-mediated rejection in kidney transplantation, but the management of ABMR has been improved with the use of new drugs and the acceptance of ABO-incompatible kidney transplantation.
CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION
(2023)
Review
Microbiology
Yoshiko Matsuda, Takahisa Hiramitsu, Xiao-kang Li, Takeshi Watanabe
Summary: Current studies have shown that in addition to IgG-type DSAs, IgM-type DSAs are nonspecific against antigens post organ transplantation, nevertheless, the potential of IgM antibodies from innate and conventional B cells in preventing AMR has been explored, indicating significant clinical application value.
Review
Transplantation
Delphine Kervella, Alba Torija, Jose M. Zuniga, Oriol Bestard
Summary: The implementation of highly sensitive immune assays has modified alloimmune risk stratification and diagnosis of rejection. Better characterizing the cellular components of the humoral immune response could help to further stratify the alloimmune risk stratification and enable discovery of new therapeutic targets.
CURRENT OPINION IN ORGAN TRANSPLANTATION
(2023)
Article
Medicine, General & Internal
Luyanda Kwofie, Ronald Anderson, Helen Steel, Pieter Meyer Wa
Summary: This study compared three methods for detecting lymphocytotoxic antibodies and found that the DSAXM method has advantages in pre-transplant screening, as it can identify pre-sensitised patients who may not reject the donor graft due to the absence of donor-specific antibodies.
AFRICAN HEALTH SCIENCES
(2021)
Article
Surgery
Jessie M. Barra, Veronika Kozlovskaya, KaLia S. Burnette, Ronadip R. Banerjee, Christopher A. Fraker, Eugenia Kharlampieva, Hubert M. Tse
Summary: The study explores the use of islet encapsulation technologies to enhance graft survival and function in type 1 diabetes without systemic immunosuppression. The encapsulation with TA, PVPON, and CTLA-4-Ig leads to localized immunosuppression and prolongs islet allograft function. This is achieved by suppressing proinflammatory macrophage and T cell responses, enhancing regulatory T cells, and inhibiting T cell activation.
AMERICAN JOURNAL OF TRANSPLANTATION
(2023)
Article
Immunology
Liesbeth Daniels, Frans H. J. Claas, Cynthia S. M. Kramer, Aleksandar Senev, Marleen Vanden Driessche, Marie-Paule Emonds, Steven Van Laecke, Rachel Hellemans, Daniel Abramowicz, Maarten Naesens
Summary: The impact of HLA-DP mismatches on renal allograft outcome is still not fully understood. Isolated HLA-DP DSA can be rare but pose a significant risk for antibody mediated rejection. High MFI values of HLA-DP DSA do not always correlate with positive crossmatch results.
TRANSPLANT IMMUNOLOGY
(2021)
Article
Rheumatology
Y. Yoshizawa, T. Nakao, K. Tsuritani, T. Yamada, N. Watanabe, A. Chiba, W. H. Robinson, S. Miyake
Summary: This study aimed to identify citrullinated proteins that may play an important role in the onset and progression of rheumatoid arthritis (RA) using an individualized anti-citrullinated protein antibody (ACPA) evaluation system with citrullinated peptides as probes.
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Richard Issitt, Pooja Shetty, Richard Crook, Nigel Cross, Sophie Henwood, Michael Broadhead, Helen Spencer, Paul Aurora, Arun Gupta, Delordson Kallon, Matthew Fenton, Nagarajan Muthialu
Summary: Sensitised patients undergoing Human Leukocyte Antigen-incompatible transplantation are at increased risk of rejection and complications. We present a case of primary lung transplantation with late identification of donor specific antibodies, treated with intraoperative target plasma exchange, showing potential as a desensitisation technique.
Article
Gastroenterology & Hepatology
Sinja Ohlsson, Simone Kathemann, Denisa Pilic, Benas Prusinskas, Hideo Andreas Baba, Sarah Theurer, Alexander Dechene, Andreas Paul, Andreas Heinold, Peter Friedrich Hoyer, Elke Lainka
Summary: The study evaluated the results of protocol liver biopsies in 92 pediatric patients after liver transplantation, revealing a high prevalence of graft fibrosis and inflammation. The safety and utility of PLB make it a useful tool for detecting transplant injuries.
EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
(2021)
Article
Immunology
Tathagat Narula, Samir Khouzam, Francisco Alvarez, David Erasmus, Zhuo Li, Yousif Abdelmoneim, Mohamed Elrefaei
Summary: The study found that induction immunosuppression with a single dose of rATG is associated with a significant reduction in de novo DSA production in lung transplant recipients.
IMMUNITY INFLAMMATION AND DISEASE
(2021)
Review
Immunology
Zhong-Yu Kang, Chun Liu, Wei Liu, Dai-Hong Li
Summary: This systematic review found that kidney transplant recipients with C1q-binding DSAs had a higher risk of antibody-mediated rejection, graft loss, and death compared to patients without C1q-binding DSAs.
TRANSPLANT IMMUNOLOGY
(2022)
Article
Surgery
P. Talayero, E. Mancebo, J. Calvo-Pulido, S. Rodriguez-Munoz, I. Bernardo, R. Laguna-Goya, F. L. Cano-Romero, A. Garcia-Sesma, C. Loinaz, C. Jimenez, I. Justo, E. Paz-Artal
AMERICAN JOURNAL OF TRANSPLANTATION
(2016)
Article
Immunology
Francisco Boix-Giner, Olga Millan, David San Segundo, Pedro Munoz-Cacho, Esther Mancebo, Santiago Llorente, Lourdes Rafael-Valdivia, Antoni Rimola, Emilio Fabrega, Anna Mrowiec, Luis Allende, Alfredo Minguela, Jose M. Bolarin, Estela Paz-Artal, Marcos Lopez-Hoyos, Merce Brunet, Manuel Muro
INTERNATIONAL IMMUNOLOGY
(2016)
Letter
Immunology
Mario Fernandez-Ruiz, Francisco Lopez-Medrano, Rafael San Juan, Luis M. Allende, Estela Paz-Artal, Jose Maria Aguado
JOURNAL OF INFECTIOUS DISEASES
(2016)
Article
Transplantation
Elena Sanchez-Zapardiel, Maria Jose Castro-Panete, Esther Mancebo, Pablo Morales, Rocio Laguna-Goya, Jose Maria Morales, Jacqueline Apaza, Amado de Andres, Paloma Talayero, Estela Paz-Artal
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2016)
Article
Surgery
Diana Maria Valero-Hervas, Elena Sanchez-Zapardiel, Maria Jose Castro, Fernando Gallego-Bustos, Felix Cambra, Iago Justo, Rocio Laguna-Goya, Carlos Jimenez-Romero, Enrique Moreno, Francisco Lopez-Medrano, Rafael San Juan, Mario Fernandez-Ruiz, Jose Maria Aguado, Estela Paz-Artal
CLINICAL TRANSPLANTATION
(2017)
Article
Surgery
Maria Asuncion Perez-Jacoiste Asin, Mario Fernandez-Ruiz, Francisco Lopez-Medrano, Carolina Aquilino, Esther Gonzalez, Tamara Ruiz-Merlo, Eduardo Gutierrez, Rafael San Juan, Estela Paz-Artal, Amado Andres, Jose Maria Aguado
TRANSPLANT INTERNATIONAL
(2016)
Article
Immunology
M. Serrano, O. Cabrera-Marante, J. A. Martinez-Flores, P. Morales, D. Perez, S. Mora, F. Garcia, E. Gonzalez, E. Paz-Artal, J. M. Morales, A. Serrano
TRANSPLANTATION PROCEEDINGS
(2016)
Article
Pathology
Paloma Talayero, Lola Alonso-Guirado, Guillermo Padilla, Haydee Artaza, Ana Dopazo, Fatima Sanchez-Cabo, Sarbelio Rodriguez-Munoz, Jorge Calvo-Pulido, Esther Mancebo, Mario Garcia de lacoba, Estela Paz-Artal
EXPERIMENTAL AND MOLECULAR PATHOLOGY
(2017)
Article
Immunology
Jose Maria Morales, Manuel Serrano, Jose Angel Martinez-Flores, Dolores Perez, Maria Jose Castro, Elena Sanchez, Florencio Garcia, Alfredo Rodriguez-Antolin, Marina Alonso, Eduardo Gutierrez, Enrique Morales, Manuel Praga, Esther Gonzalez, Amado Andres, Estela Paz-Artal, Miguel Angel Martinez, Antonio Serrano
Article
Medical Laboratory Technology
Laura Perez-Martinez, Laura Ochoa-Callejero, Susana Rubio-Mediavilla, Judit Narro, Ivan Bernardo, Jose-Antonio Oteo, Jose-Ramon Blanco
TRANSLATIONAL RESEARCH
(2018)
Article
Genetics & Heredity
Samuel Martin-Rodriguez, Alicia Calvo-Ferrer, Nerea Ortega-Unanue, Laura Samaniego-Jimenez, Maria Pilar Sanz-Izquierdo, Ivan Bernardo-Gonzalez
ANNALS OF HUMAN GENETICS
(2019)
Review
Medical Laboratory Technology
Laura Casamayor-Polo, Marta Lopez-Nevado, Estela Paz-Artal, Alberto Anel, Frederic Rieux-Laucat, Luis M. Allende
Summary: Apoptosis plays a crucial role in controlling the adaptive immune response and immune cell homeostasis, and impaired apoptosis can lead to autoimmunity and immune dysregulation. Autoimmune lymphoproliferative syndrome (ALPS) is a genetic disorder characterized by nonmalignant lymphoproliferation, autoimmunity, and an increased risk of lymphoma due to defects in lymphocyte apoptosis. The genetic defects associated with ALPS include mutations in ALPS-FAS, ALPS-FASLG, ALPS-CASP10, ALPS-FADD, and ALPS-CASP8. Efficient genetic and immunological diagnostic approaches are essential for patients suspected of having ALPS or ALPS-like syndromes to establish specific therapeutic strategies for improving patient prognosis and quality of life.
CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES
(2021)
Article
Medical Laboratory Technology
Carlos Martinez-Carretero, Fernando Iguaz Pascual, Antonio Rus, Ivan Bernardo
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2017)
Article
Cardiac & Cardiovascular Systems
Manuel Serrano, Jose A. Martinez-Flores, Dolores Perez, Florencio Garcia, Oscar Cabrera, Daniel Pleguezuelo, Estela Paz-Artal, Jose M. Morales, Esther Gonzalez, Antonio Serrano
Article
Clinical Neurology
Cristina Guijarro-Castro, Elena Sanchez-Zapardiel, Delicias Munoz, Oscar Fernandez, Laura Leyva, M. Jose Castro-Panete, Carmen Picon-Munoz, Marta Talise, Ana Martinez-Feito, Estela Paz-Artal
REVISTA DE NEUROLOGIA
(2016)