☆ 4.7 Article

Relation between Ku80 and microRNA-99a expression and late rectal bleeding after radiotherapy for prostate cancer

RADIOTHERAPY AND ONCOLOGY (2015)

期刊

RADIOTHERAPY AND ONCOLOGY

卷 115, 期 2, 页码 235-239

出版社

ELSEVIER IRELAND LTD

DOI: 10.1016/j.radonc.2015.04.008

关键词

Prostate cancer, Radiotherapy; Late rectal toxicity; RNA array; Micro RNA

类别

Oncology Radiology, Nuclear Medicine & Medical Imaging

资金

Ministry of Education, Culture, Sports, Science and Technology of Japan
program for developing the support system for upgrading education and research in Sapporo Medical University
Grants-in-Aid for Scientific Research [24591846, 25861114, 25430115, 24591845] Funding Source: KAKEN

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Protocol

Reagent

摘要

Background and purpose: Late rectal bleeding is one of the severe adverse events after radiotherapy for prostate cancer. New biomarkers are needed to allow a personalized treatment. Materials and methods: Four patients each with grade 0-1 or grade 2-3 rectal bleeding were randomly selected for miRNA array to examine miRNA expression in peripheral blood lymphocytes (PBLs). Based on results of miRNA array, 1 of 348 miRNAs was selected for microRNA assays. Then, expression of DNA-dependent protein kinase mRNA and miR-99a was analyzed in the PBLs of 97 patients. PBLs were exposed to 4 Gy of X-ray ex-vivo. Results: In the discovery cohort, grade 2-3 rectal bleeding was significantly higher in the Ku80 <1.09 expression group compared with >= 1.09 group (P = 0.011). In radiation-induced expression of miR-99a, grade 2-3 rectal bleeding was significantly higher in the miR-99a IR(+)/IR(-) >0.93 group compared with <= 0.93 group (P = 0.013). Most patients with grade 2-3 rectal bleeding were in the group with low Ku80 and high miR-99a expression. In the validation cohort, similar results were obtained. Conclusion: A combination of low Ku80 expression and highly-induced miR-99a expression could be a promising marker for predicting rectal bleeding after radiotherapy. (C) 2015 Elsevier Ireland Ltd. All rights reserved.

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Sara Ronchi, Alessandro Cicchetti, Maria Bonora, Rossana Ingargiola, Anna Maria Camarda, Stefania Russo, Sara Imparato, Paolo Castelnuovo, Ernesto Pasquini, Piero Nicolai, Mohssen Ansarin, Michele Del Vecchio, Marco Benazzo, Ester Orlandi, Barbara Vischioni

Summary: This study evaluates the efficacy and toxicity of carbon ion radiotherapy (CIRT) in locally advanced head and neck mucosal melanoma patients. The results show that CIRT is safe and effective in treating the local region, and immunotherapy after relapse can improve overall survival. However, further prospective trials are needed to assess the role of targeted/immune- systemic therapy in this disease.

RADIOTHERAPY AND ONCOLOGY (2024)

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Article Oncology

The rise of negative portrayals of radiation oncology: A textual analysis of media news

Dominik Wawrzuta, Justyna Klejdysz, Marzanna Chojnacka

Summary: This study analyzed articles about radiation oncology published in The New York Times since its inception in 1851, and identified changes in media sentiment and prevalent themes related to radiotherapy. The findings suggest an increasing negative sentiment in media coverage towards radiotherapy, with a shift towards reporting treatment errors, toxicity, and ineffectiveness.

RADIOTHERAPY AND ONCOLOGY (2024)

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Article Oncology

Season of radiotherapy and outcomes of head & neck cancer patients in the MACH-NC & MARCH meta-analyses

Elaine Limkin, Pierre Blanchard, Benjamin Lacas, Jean Bourhis, Mahesh Parmar, Lisa Licitra, Quynh-Thu Le, Sue S. Yom, Catherine Fortpied, Johannes Langendijk, Jan B. Vermorken, Jacques Bernier, Jens Overgaard, Jonathan Harris, Jean-Pierre Pignon, Anne Auperin

Summary: This study investigated the impact of season of radiotherapy on the outcomes of head and neck squamous cell cancer patients. The results showed that the season of radiotherapy did not have any significant effect on patient outcomes.

RADIOTHERAPY AND ONCOLOGY (2024)

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Article Oncology

Meta-analysis of 5-day preoperative radiotherapy for soft tissue sarcoma (5D-PREORTS)

Fabio L. Cury, Gustavo A. Viani, Andre G. Gouveia, Camila V. S. Freire, Gabriel de A. Grisi, Fabio Y. Moraes

Summary: In limb-sparing treatment of soft tissue sarcoma patients, a 5-day course of preoperative radiotherapy results in high local control and favorable R0 margins, with acceptable complication rates, particularly for patients receiving higher biological equivalent doses.

RADIOTHERAPY AND ONCOLOGY (2024)

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