Article
Medicine, Research & Experimental
Poliana C. Marinello, Paola S. Cella, Mayra T. J. Testa, Phillipe B. Guirro, Walison Augusto da Silva Brito, Camila S. Padilha, Alessandra L. Cecchini, Robin P. da Silva, Jose Alberto R. Duarte, Rafael Deminice
Summary: This study investigated the effects of creatine supplementation on the pathogenesis of non-alcoholic fatty liver disease and alcoholic liver disease. The results showed that creatine supplementation prevented high-fat diet-induced non-alcoholic fatty liver disease but exacerbated ethanol-induced alcoholic liver disease. The exacerbating effects may be related to oxidative stress and inflammation-mediated upregulation of ethanol metabolism.
Article
Medicine, Research & Experimental
Yvelise Ferro, Roberta Pujia, Elisa Mazza, Lidia Lascala, Oscar Lodari, Samantha Maurotti, Arturo Pujia, Tiziana Montalcini
Summary: This study evaluated the effects of a novel combination of nutraceuticals in treating fatty liver disease in adults, and showed that the nutraceutical was both safe and effective in reducing liver fat content over a 12-week period.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Review
Nutrition & Dietetics
Maitane Gonzalez-Arceo, Saioa Gomez-Zorita, Leixuri Aguirre, Maria P. Portillo
Summary: An overview of scientific evidence on the beneficial effects of microalgae and macroalgae extracts on non-alcoholic fatty liver disease (NAFLD) shows improvement in the condition. Further research is needed to understand the mechanisms of action and confirm the effects observed in rodents in human studies.
Article
Immunology
Yamei Duan, Xiongfeng Pan, Jiayou Luo, Xiang Xiao, Jingya Li, Prince L. Bestman, Miyang Luo
Summary: This study found a significant association between inflammatory cytokines and non-alcoholic fatty liver disease (NAFLD). Increased concentrations of C-reactive protein (CRP), interleukin-1 beta (IL-1 beta), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), and intercellular adhesion molecule-1 (ICAM-1) were significantly associated with increased risks of NAFLD.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biotechnology & Applied Microbiology
Margalida Monserrat-Mesquida, Cristina Bouzas, Catalina M. Mascaro, Silvia Tejada, Antoni Sureda
Summary: Background: NAFLD is a common liver disease with increasing prevalence, and there is currently no clear management strategy or specific pharmacological treatment available. This review summarizes the potential therapeutic effects of probiotics in NAFLD, based on studies conducted in animal models and clinical trials. The results demonstrate that probiotic supplementation can reduce liver steatosis, normalize lipid profiles and liver enzyme activities, decrease lipogenesis, increase lipolysis, alleviate oxidative and inflammatory states, and normalize intestinal dysbiosis. Clinical trials have also shown improvements in serum transaminases, lipid profiles, and inflammatory markers. Therefore, probiotic supplementation can be considered as a potential therapy for managing NAFLD.
FERMENTATION-BASEL
(2023)
Review
Gastroenterology & Hepatology
Asako Nogami, Masato Yoneda, Michihiro Iwaki, Takashi Kobayashi, Yasushi Honda, Yuji Ogawa, Kento Imajo, Satoru Saito, Atsushi Nakajima
Summary: Non-alcoholic fatty liver disease is the most common chronic liver disease, with a global prevalence of up to 25%. Simple fatty liver, previously considered benign, is now known to have prognostic significance. Future focus should be on quantifying liver fat. Traditional histological evaluation for fatty liver is invasive, but advancements in technology have made non-invasive imaging methods such as ultrasound, CT, and MRI possible. Quantitative and qualitative measurements for detecting fatty liver are available, and this review summarizes current qualitative evaluations and discusses the future development of quantitative evaluations.
CLINICAL AND MOLECULAR HEPATOLOGY
(2023)
Article
Medicine, General & Internal
Marco Castellana, Rossella Donghia, Vito Guerra, Filippo Procino, Luisa Lampignano, Fabio Castellana, Roberta Zupo, Rodolfo Sardone, Giovanni De Pergola, Francesco Romanelli, Pierpaolo Trimboli, Gianluigi Giannelli
Summary: The fatty liver index (FLI) has been shown to perform well in stratifying the risk of non-alcoholic fatty liver disease (NAFLD) but has weak evidence in excluding or diagnosing the disorder. Studies found similar performance in using ultrasound versus other imaging modalities.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Medicine, General & Internal
Elizabeth E. Powell, Vincent Wai-Sun Wong, Mary Rinella
Summary: Non-alcoholic fatty liver disease (NAFLD) is a common global health issue with significant associations with metabolic syndrome and type 2 diabetes, leading to serious complications like cirrhosis and hepatocellular carcinoma. While cardiovascular disease and extrahepatic malignancy are the main causes of death in NAFLD patients, advanced liver fibrosis is a key prognostic marker for liver-related outcomes and overall mortality.
Article
Gastroenterology & Hepatology
Caizhi Liu, Bing Zhou, Meiyao Meng, Wenjun Zhao, Dongmei Wang, Youwen Yuan, Ying Zheng, Jin Qiu, Yu Li, Guoqiang Li, Xuelian Xiong, Hua Bian, Huijie Zhang, Hua Wang, Xinran Ma, Cheng Hu, Lingyan Xu, Yan Lu
Summary: The study identified FOXA3 as a key bridging molecule connecting ER stress and NAFLD progression, with its deficiency alleviating fatty liver. Increased levels of FOXA3 were found in the livers of obese mice and patients with NAFLD, suggesting FOXA3 as a potential therapeutic target for fatty liver disease.
JOURNAL OF HEPATOLOGY
(2021)
Review
Nutrition & Dietetics
Ludovico Abenavoli, Tiziana Larussa, Alessandro Corea, Anna Caterina Procopio, Luigi Boccuto, Marcello Dallio, Alessandro Federico, Francesco Luzza
Summary: NAFLD, characterized by a wide spectrum of liver disorders, is considered a major public health issue globally. Polyphenols, known for their anti-inflammatory and antioxidant properties, are believed to have potential benefits in preventing and treating NAFLD, though limited human clinical trials are available.
Article
Multidisciplinary Sciences
Nikolaj H. Schmidt, Pia Svendsen, Julian Albarran-Juarez, Soren K. Moestrup, Jacob Fog Bentzon
Summary: Feeding high-fructose diets to pigs led to upregulation of hepatic DNL proteins but did not result in steatosis or hepatocellular ballooning, suggesting pigs rely on adipose tissue rather than liver for de novo lipogenesis in response to fructose, which differs from rodents and humans who develop NAFLD when exposed to high-fructose diets.
SCIENTIFIC REPORTS
(2021)
Article
Gastroenterology & Hepatology
Gi-Ae Kim, Chi Hyuk Oh, Jung Wook Kim, Su Jin Jeong, In-Hwan Oh, Jin San Lee, Key-Chung Park, Jae-Jun Shim
Summary: This study found an association between non-alcoholic fatty liver disease (NAFLD) and an increased risk of dementia, especially among females and non-obese NAFLD subjects.
LIVER INTERNATIONAL
(2022)
Review
Medicine, Research & Experimental
Vlad Padureanu, Dalia Dop, Alice Nicoleta Dragoescu, Rodica Padureanu, Anca Emanuela Musetescu, Laurentiu Nedelcu
Summary: NAFLD is associated with iron abnormalities, with excess iron deposits linked to liver fibrosis and hepatocellular carcinoma risk. Further research is needed to determine if NAFLD has an independent risk for hematologic symptoms and to assess its impact on the vascular complications of this systemic disease.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Endocrinology & Metabolism
Wen Guo, Pei Qin, Xiao-Na Li, Juan Wu, Jing Lu, Wen-Fang Zhu, Qing-qing Diao, Nian-Zhen Xu, Qun Zhang
Summary: The study demonstrates a positive association between FT3 levels and the severity of hepatic steatosis and the presence of liver fibrosis in euthyroid patients with NAFLD. Furthermore, in non-obese individuals, FT3 levels can serve as an independent risk factor for the severity of hepatic steatosis.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Medicine, Research & Experimental
Berkan Lafci, Anna Hadjihambi, Madita Determann, Christos Konstantinou, Clara Freijo, Joaquin L. Herraiz, Sena Bluemel, Luc Pellerin, Neal C. Burton, Xose Luis Dean-Ben, Daniel Razansky
Summary: Non-alcoholic fatty liver disease (NAFLD) is a group of conditions associated with fat deposition and damage to liver tissue. Early detection of fat accumulation is crucial in preventing the progression of NAFLD to serious stages such as cirrhosis and hepatocellular carcinoma. The study used transmission-reflection optoacoustic ultrasound (TROPUS) to assess NAFLD in mice, providing spectroscopic differentiation of lipid content and mapping of speed of sound changes in lipid-rich regions.
Article
Peripheral Vascular Disease
Andrea Vecchiola, Killen Garcia, Luis M. Gonzalez-Gomez, Alejandra Tapia-Castillo, Rocio Artigas, Rene Baudrand, Alexis M. Kalergis, Cristian A. Carvajal, Carlos E. Fardella
Summary: The study showed that PAI-1 and adiponectin have the strongest associations with MetS components, indicating that unfavorable adipose tissue performance is a key contributor to these metabolic anomalies. Further prospective analyses are needed to determine if these adipocytokines can predict the progression of MetS and cardiovascular risk.
AMERICAN JOURNAL OF HYPERTENSION
(2022)
Review
Gastroenterology & Hepatology
Anand V. Kulkarni, Karan Kumar, Roberto Candia, Juan P. Arab, Harsh V. Tevethia, Madhumita Premkumar, Mithun Sharma, Balachandandran Menon, Guduru V. Rao, Nageshwar D. Reddy, Nagaraja P. Rao
Summary: Terlipressin therapy can reduce the risk of AKI after transplantation, but no significant effect was shown in randomized controlled trials. Terlipressin therapy can reduce the need for other vasopressors and increase mean arterial pressure and systemic vascular resistance. However, terlipressin therapy has no effect on blood loss, duration of hospital/ICU stay, and mortality.
JOURNAL OF CLINICAL AND EXPERIMENTAL HEPATOLOGY
(2022)
Review
Endocrinology & Metabolism
Cristian A. Carvajal, Alejandra Tapia-Castillo, Jorge A. Perez, Carlos E. Fardella
Summary: Primary aldosteronism is an endocrine related condition that causes arterial hypertension due to inappropriately high and unregulated aldosterone concentration. Recent studies have recognized a broad spectrum of this condition, posing new challenges in early identification. Extracellular vesicles (EVs) and their cargo have shown potential as novel biomarkers for diagnosing and predicting outcomes in primary aldosteronism.
Review
Gastroenterology & Hepatology
Luis Antonio Diaz, Tamara Garcia-Salum, Eduardo Fuentes-Lopez, Diego Reyes, Javier Ortiz, Javier Chahuan, Jorge Levican, Leonardo I. Almonacid, Gonzalo H. Valenzuela, Eileen Serrano, Sigall Budnik, Vicente Gandara, Andrea Gallardo, Maria Francisca Seydewitz, Marcela Ferres, Colomba Cofre, Manuel Alvarez, Carolina Pavez, Roberto Candia, Hugo Monrroy, Alberto Espino, Gabriel Rada, Luis Ortiz, Sebastian Valderrama, Erick Salinas, Adriana Toro, Marcos Ortega, Margarita Pizarro, Rafael A. Medina, Arnoldo Riquelme
Summary: The frequency of viral RNA detection in stools is high among patients infected with SARS-CoV-2. The clearance time of SARS-CoV-2 in stools is longer than in nasopharyngeal secretions.
GASTROENTEROLOGIA Y HEPATOLOGIA
(2022)
Article
Gastroenterology & Hepatology
Diego Reyes, Javier Ortiz, Eduardo Fuentes-Lopez, Sigall Budnik, Vicente Gandara, Andrea Gallardo, Maria Francisca Seydewitz, Roberto Candia, Jose Ignacio Vargas, Maria Paz Rollan, Javiera Godoy, Antonio Rollan, Rodrigo Mansilla, Alex Arenas, Javier Chahuan, Alberto Espino, Margarita Pizarro, Arnoldo Riquelme
Summary: This retrospective observational study in Chile evaluated the efficacy of different Helicobacter pylori eradication therapies. The results showed that quadruple therapies and concomitant therapy were more effective than standard triple therapy, and dual therapy showed promise. Further studies are needed to determine the most cost-effective therapies.
GASTROENTEROLOGIA Y HEPATOLOGIA
(2022)
Article
Gastroenterology & Hepatology
Roberto Candia, Macarena Vinuela, Javier Chahuan, Luis A. Diaz, Vicente Gandara, Pedro Errazuriz, Luis Bustamante, Alejandro Villalon, Alvaro Huete, Fernando Crovari, Eduardo Briceno
Summary: Gallbladder polyps in a high-risk Hispanic population appear to have a low risk of neoplasia, with polyp size and number being the main factors associated with neoplasia.
Article
Multidisciplinary Sciences
Jessica Pavani, Jaime Cerda, Luis Gutierrez, Ines Varas, Ivan Gutierrez, Leonardo Jofre, Oscar Ortiz, Gabriel Arriagada
Summary: This study examines the factors associated with the duration of lockdowns in Chile, including demographic, socioeconomic, and epidemiological factors. The results show that overcrowding, number of active cases, and positivity index are significantly associated with longer lockdown duration.
SCIENTIFIC REPORTS
(2022)
Review
Medicine, General & Internal
Thomas Uslar, Roberto Olmos, Alejandro Martinez-Aguayo, Rene Baudrand
Summary: Congenital adrenal hyperplasia (CAH) is a common genetic disorder caused by a deficiency of the 21-hydroxylase enzyme. It is characterized by overproduction of androgen and varying degrees of cortisol and aldosterone deficiency. Early diagnosis can provide information about the severity of enzymatic defects and potential complications. Treatment goals include hormone supplementation, controlling androgen production, managing fertility, and optimizing quality of life.
JOURNAL OF CLINICAL MEDICINE
(2023)
Meeting Abstract
Gastroenterology & Hepatology
A. Arenas, M. J. Moreta, I. Ordas, A. Fernandez-Clotet, B. Caballol, M. Gallego, A. Vara, R. Barastegui, A. Giner, C. Prieto, M. C. Masamunt, E. Ricart
JOURNAL OF CROHNS & COLITIS
(2023)
Article
Gastroenterology & Hepatology
Roberto Candia, Alex Arenas, Javier Chahuan, Carlos Riquelme, Gonzalo P. Mendez
REVISTA ESPANOLA DE ENFERMEDADES DIGESTIVAS
(2023)
Proceedings Paper
Engineering, Aerospace
Vladimiro Noce, Salvatore Varisco, Federico Landini, Herve Haudemand, Roberto Candia, Marco Barbera, Ugo Lo Cicero, Fabio Frassetto, Luca Zangrilli, Valeria Caracci, Davide Loreggia, Alfonso Collura, Silvano Fineschi, Rocco Pellegrini, Enrico Cavallini, Marco Pizzarelli, Christian Circi
Summary: Helianthus is a phase A study of a space weather station with solar photonic propulsion. The scientific payload includes an X-ray spectrometer, a coronagraph, a plasma analyzer, and a magnetometer. The importance of the coronagraph and X-ray spectrometer lies in remotely and timely mapping the status of the Sun and providing early warning for potentially disruptive events. A measurement campaign was conducted at the INAF XACT facility in Palermo, Italy to evaluate the performance of the Amptek FAST-SDD spectrometer.
SPACE TELESCOPES AND INSTRUMENTATION 2022: ULTRAVIOLET TO GAMMA RAY
(2022)
Meeting Abstract
Gastroenterology & Hepatology
Gonzalo Latorre, Felipe Silva, Isabella Montero, Miguel Bustamante, Eitan Dukes, Vicente Gandara, Camila Robles, Javier Uribe, Oscar Corsi, Francisca Crispi, Manuel A. Espinoza, Cristobal Cuadrado, Eduardo Fuentes-Lopez, Shailja Shah, M. Constanza Camargo, Javiera Torres, Juan Carlos Roa, Alejandro H. Corvalan, Roberto Candia, Carlos Aguero, Robinson G. Gonzalez, Jose Ignacio Vargas, Alberto Espino, Arnoldo Riquelme
Article
Pediatrics
Daniela Quiroga, Maria Jose Bruera, Josefa Vidaurre, Jaime Cerda, Andreina Cattani, Hernan Garcia
Summary: This study compared the concordance of two validated height prediction methods and genetic target height in girls with central precocious puberty. The results showed that these two methods provided similar height predictions compared to the calculation of genetic target height, and had better concordance with the final height obtained.
Article
Endocrinology & Metabolism
Alejandra Tapia-Castillo, Cristian A. Carvajal, Jorge A. Perez, Carlos E. Fardella
Summary: This study identified adult subjects with a combined condition of nonclassic apparent mineralocorticoid excess (NCAME) and primary aldosteronism (PA), who had higher blood pressure and increased markers of renal and endothelial damage. Additionally, certain miRNA expressions were associated with this novel combined phenotype.
Article
Endocrinology & Metabolism
Valentina Pasten, Alejandra Tapia-Castillo, Carlos E. Fardella, Andrea Leiva, Cristian A. Carvajal
Summary: This study found that 18% of normotensive pregnant women had either high aldosterone or high renin levels, suggesting a subclinical status similar to primary aldosteronism or hyperreninemia, respectively. sEVs and their specific cargo should be further studied to clarify their role as potential biomarkers of RAAS alterations in pregnant women.