Article
Oncology
Jihye Lim, Young Eun Chon, Mi Na Kim, Joo Ho Lee, Seong Gyu Hwang, Han Chu Lee, Yeonjung Ha
Summary: This study validated the clinical usefulness of the CAGE-B score in a large number of Asian patients treated with long-term entecavir or tenofovir, providing the basis for the reappraisal of hepatocellular carcinoma surveillance strategies.
Article
Immunology
Jie Li, Hwai- Yang, Ming-Lun Yeh, Michael H. Le, An K. Le, Yee Hui Yeo, Chia-Yen Dai, Scott Barnett, Jian Q. Zhang, Jee-Fu Huang, Huy N. Trinh, Christopher Wong, Clifford Wong, Joseph K. Hoang, Ramsey Cheung, Ming-Lung Yu, Mindie H. Nguyen
Summary: This study found that concurrent FL in patients with CHB significantly reduces the risk of cirrhosis and HCC, as well as increases the rate of HBsAg seroclearance. Further research is needed to confirm these findings and investigate the underlying mechanisms of FL on CHB.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Review
Biochemistry & Molecular Biology
Nicholas Noverati, Rukaiya Bashir-Hamidu, Dina Halegoua-DeMarzio, Hie-Won Hann
Summary: Hepatitis B virus is a significant cause of hepatocellular carcinoma globally. The complex mechanisms of this virus include interactions with the host's immune system. Factors such as stress can amplify these mechanisms. Chronic stress, harmful to health, can suppress or activate the host's defense system, leading to tumor initiation and progression in liver cancer. Chronic stress, often overlooked, should be recognized as a potential risk factor.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Virology
James Lok, Kosh Agarwal
Summary: Multiple models have been developed to predict the risk of HCC development in individuals with chronic hepatitis B infection, with most models derived from Asian populations. Further research is needed to validate and refine these models for more tailored HCC surveillance programs in the future.
Article
Virology
Kuo-Chin Chang, Ming-Tsung Lin, Jing-Houng Wang, Chao-Hung Hung, Chien-Hung Chen, Sherry Yueh-Hsia Chiu, Tsung-Hui Hu
Summary: This study found that in chronic hepatitis B-related liver cirrhosis (LC) patients undergoing long-term antiviral therapy, patients with higher levels of HBV core-related antigen (HBcrAg) are at a significantly increased risk for hepatocellular carcinoma (HCC) development. Especially for patients with lower levels of HBsAg quantification (HBsAg-HQ), HBcrAg level is an independent risk factor for HCC development.
Article
Multidisciplinary Sciences
Satoru Joshita, Masao Ota, Hiroyuki Kobayashi, Shun-ichi Wakabayashi, Yuki Yamashita, Ayumi Sugiura, Tomoo Yamazaki, Eiji Tanaka, Takeji Umemura
Summary: This study revealed significant associations of KIR/HLA with HCC development (KIR2DS3) and freedom from NUC therapy (KIR3DL1/HLA-Bw4) in HBV patients, although larger case studies are needed for statistical purposes.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Hye Won Lee, Hyun Woong Lee, Jae Seung Lee, Yun Ho Roh, Hyein Lee, Seung Up Kim, Jun Yong Park, Do Young Kim, Sang Hoon Ahn, Beom Kyung Kim
Summary: Dynamic changes in fibrosis markers occur under long-term antiviral treatment for chronic hepatitis B. Lowering the on-treatment liver stiffness cutoff to 6.4 kPa is more predictive for hepatocellular carcinoma risk in patients receiving long-term antiviral treatment, compared to 12 kPa or cirrhosis on ultrasonography. Further studies are needed for validation.
JOURNAL OF HEPATOCELLULAR CARCINOMA
(2021)
Article
Gastroenterology & Hepatology
Daniel Q. Huang, Xiaohe Li, Michael H. Le, An K. Le, Yee Hui Yeo, Huy N. Trinh, Jian Zhang, Jiayi Li, Christopher Wong, Clifford Wong, Ramsey C. Cheung, Hwai- Yang, Mindie H. Nguyen
Summary: This study found that a significant proportion of patients with chronic hepatitis B are in the indeterminate phase. Of these patients, around half remain indeterminate and one-fifth transition to the immune active phase. The risk of hepatocellular carcinoma is significantly higher in persistently indeterminate CHB patients, particularly in those aged 45 years and older.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Won-Mook Choi, Gi-Ae Kim, Jonggi Choi, Gwang Hyeon Choi, Yun Bin Lee, Dong Hyun Sinn, Young-Suk Lim
Summary: This study aimed to investigate the association between baseline HBV viral load and on-treatment HCC risk in patients with CHB without cirrhosis. The study found that patients with moderate baseline viral load had the highest HCC risk.
Article
Gastroenterology & Hepatology
Jung Hwan Yu, Soon Gu Cho, Young-Joo Jin, Jin-Woo Lee
Summary: Chronic hepatitis B is a serious threat to human health, causing a large number of deaths from complications such as hepatitis B and hepatocellular carcinoma (HCC). While the use of oral antiviral agents has improved the prognosis and reduced the risk of HCC in patients with CHB, the hepatitis B virus remains a major factor in HCC development. Therefore, numerous studies have been conducted to assess the risk of HCC in CHB patients and predict its development using different models. Understanding the characteristics and variables used in each model is essential for accurate evaluation.
CLINICAL AND MOLECULAR HEPATOLOGY
(2022)
Article
Oncology
Ho Soo Chun, Sojeong Park, Minjong Lee, Yuri Cho, Ha Sung Kim, A. Reum Choe, Hwi Young Kim, Kwon Yoo, Tae Hun Kim
Summary: The study found a significant association between physical activity and development of hepatocellular carcinoma (HCC) in chronic hepatitis B (CHB) patients treated with potent antiviral therapy, with increasing physical activity being beneficial in reducing the risk of HCC development.
Review
Microbiology
Maria Bousali, George Papatheodoridis, Dimitrios Paraskevis, Timokratis Karamitros
Summary: HBV is an Old World virus with a high mutation rate, originating in Africa alongside Homo sapiens. It can lead to chronic infection by integrating its genome into host DNA, affecting various genes including those related to cell proliferation and oncogenes.
Article
Oncology
Jae Seung Lee, Hyun Woong Lee, Tae Seop Lim, Hye Jung Shin, Hye Won Lee, Seung Up Kim, Jun Yong Park, Do Young Kim, Sang Hoon Ahn, Beom Kyung Kim
Summary: A novel risk-scoring model for predicting hepatocellular carcinoma development in treatment-naive patients with chronic hepatitis B virus infection starting antiviral therapy has been developed, showing better performance in Asian patients. This model is important for developing individualized surveillance methods.
Article
Virology
Peng Lin, Dong-Yue Wen, Jin-Shu Pang, Wei Liao, Yu-Ji Chen, Yun He, Hong Yang
Summary: This study developed an overall survival prediction model based on protein expression profiles in HBV-infected nontumor liver tissues, demonstrating the feasibility of using protein expression profiles in nontumor liver tissues for survival prediction.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Gastroenterology & Hepatology
Jonggi Choi, Nabihah Tayob, Young-Suk Lim
Summary: This study evaluated the performance of the parametric empirical Bayes (PEB) longitudinal AFP screening algorithm in patients with hepatitis B compared to AFP surveillance with a fixed threshold. The results showed that the PEB algorithm improved the accuracy of hepatocellular carcinoma (HCC) screening in patients with hepatitis B compared to AFP alone, without additional cost or inconvenience to patients.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Kwan Soo Byun, Jonggi Choi, Ji-Hoon Kim, Yung Sang Lee, Han Chu Lee, Yoon Jun Kim, Byung Chul Yoo, So Young Kwon, Geum-Youn Gwak, Young-Suk Lim
Summary: The study findings suggest that TAF may have better bone and renal safety profiles compared to TDF in patients with multidrug-resistant HBV, without compromising efficacy. However, concerns may arise due to increases in body weight and cholesterol levels with TAF treatment.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Tae Hyung Kim, Soon Ho Um, Young-Sun Lee, Sun Young Yim, Young Kul Jung, Yeon Seok Seo, Ji Hoon Kim, Hyunggin An, Hyung Joon Yim, Jong Eun Yeon, Kwan Soo Byun
Summary: The study identified six clinical parameters, including alpha-fetoprotein and timing of antiviral therapy, which were combined into a scoring system to accurately predict early re-compensation in patients with HBV-related decompensated cirrhosis.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Microbiology
Geum-Young Lee, Won-Keun Kim, Seungchan Cho, Kyungmin Park, Jongwoo Kim, Seung-Ho Lee, Jingyeong Lee, Young-Sun Lee, Ji Hoon Kim, Kwan Soo Byun, Jin-Won Song
Summary: This study used multiplex PCR-based NGS to obtain nearly whole-genome HAV sequences and analyze the genetic diversity and phylogenetic relationships. The VP3 region may be used to track the origin of HAV outbreaks. Additionally, a VP3-specific qPCR method was developed for molecular diagnosis of HAV infection.
Article
Gastroenterology & Hepatology
Woo Jin Yang, Danbee Kang, Myung Gyu Song, Tae-Seok Seo, Ji Hoon Kim
Summary: This study investigated the impact of socioeconomic status (SES) on mortality in hepatocellular carcinoma patients and analyzed the effect of SES on initial treatment allocation. The results showed that patients in the lower SES group, especially those not eligible for curative treatment, had an increased risk of mortality. Additionally, the association between SES and the risk for mortality was stronger in the lower-income percentile than in the moderate to higher income percentiles.
Article
Gastroenterology & Hepatology
Sung Hwan Lee, Sun Young Yim, Yun Seong Jeong, Qi-Xiang Li, Sang-Hee Kang, Bo Hwa Sohn, Shwetha V. Kumar, Ji-Hyun Shin, You Rhee Choi, Jae-Jun Shim, Hayeon Kim, Ji Hoon Kim, Shin Kim, Sheng Guo, Randy L. Johnson, Ahmed Kaseb, Koo Jeong Kang, Yun Shin Chun, Hee Jin Jang, Byoung Gill Lee, Hyun Goo Woo, Min Jin Ha, Rehan Akbani, Lewis R. Roberts, David A. Wheeler, Ju-Seog Lee
Summary: By integrating 16 established genomic signatures, five distinct HCC subtypes (STM, CIN, IMH, BCM, and DLP) were identified. These subtypes are correlated with clinical outcomes and have significant implications for patient prognosis. The study also developed a robust predictor of consensus subtype with 100 genes and identified potential serum biomarkers for stratifying patients.
Article
Gastroenterology & Hepatology
Young-Sun Lee, Ji Eun Lee, Hyon-Seung Yi, Young Kul Jung, Dae Won Jun, Ji Hoon Kim, Yeon Seok Seo, Hyung Joon Yim, Baek-hui Kim, Jeong Woo Kim, Chang Hee Lee, Jong Eun Yeon, Juneyoung Lee, Soon Ho Um, Kwan Soo Byun
Summary: This study aimed to develop a scoring system for the diagnosis of nonalcoholic steatohepatitis (NASH) using multiparametric magnetic resonance (MR) and clinical indicators. The MRE-based NASH score showed satisfactory accuracy in diagnosing NASH in patients with nonalcoholic fatty liver disease (NAFLD).
HEPATOLOGY INTERNATIONAL
(2022)
Article
Medicine, General & Internal
Jung-Hee Kim, Sung-Eun Kim, Do-Seon Song, Hee-Yeon Kim, Eileen L. Yoon, Tae-Hyung Kim, Young-Kul Jung, Ki-Tae Suk, Baek-Gyu Jun, Hyung-Joon Yim, Jung-Hyun Kwon, Sung-Won Lee, Seong-Hee Kang, Moon-Young Kim, Soung-Won Jeong, Jae-Young Jang, Jeong-Ju Yoo, Sang-Gyune Kim, Young-Joo Jin, Gab-Jin Cheon, Byung-Seok Kim, Yeon-Seok Seo, Hyung-Su Kim, Dong-Hyun Sinn, Woo-Jin Chung, Hwi-Young Kim, Han-Ah Lee, Seung-Woo Nam, In-Hee Kim, Jung-Il Suh, Ji-Hoon Kim, Hee-Bok Chae, Joo-Hyun Sohn, Ju-Yeon Cho, Yoon-Jun Kim, Jin-Mo Yang, Jung-Gil Park, Won Kim, Hyun-Chin Cho, Dong-Joon Kim
Summary: A lower PWR level is associated with adverse outcomes in LC patients with AD.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Han Ah Lee, Jungwon Kwak, Sung Bum Cho, Young-Sun Lee, Young Kul Jung, Ji Hoon Kim, Seung Up Kim, Hyonggin An, Hyung Joon Yim, Jong Eun Yeon, Yeon Seok Seo
Summary: This study compared the effectiveness of endoscopic variceal obturation (EVO) and retrograde transvenous obliteration (RTO) in the treatment of acute cardiofundal variceal bleeding. The results showed that both methods effectively controlled bleeding with low complication rates. However, RTO was found to be superior to EVO in preventing various types of variceal rebleeding during long-term follow-up.
BMC GASTROENTEROLOGY
(2022)
Article
Medicine, General & Internal
Seong Hee Kang, Hyung Joon Yim, Ji-won Hwang, Mi-jung Kim, Young-Sun Lee, Young Kul Jung, Hyungshin Yim, Baek-Hui Kim, Hae-Chul Park, Yeon Seok Seo, Ji Hoon Kim, Jong Eun Yeon, Soon Ho Um, Kwan Soo Byun
Summary: Combination therapy with a statin, simvastatin, and a COX-2 inhibitor, NS-398, has synergistic anti-fibrotic effects through multiple pathways. These findings provide a theoretical basis for the clinical application of this treatment strategy in advanced liver diseases with hepatic fibrosis.
KOREAN JOURNAL OF INTERNAL MEDICINE
(2022)
Article
Chemistry, Medicinal
Hyung Joon Yim, Ji Hoon Kim, Yong Kyun Cho, Young Oh Kweon, Hyun Chin Cho, Jae Seok Hwang, Changhyeong Lee, Moon Soo Koh, Yang-Hyun Baek, Young-Min Park, Jeong-Hoon Lee, Seung Up Kim, Min-Kyu Kang, Neung Hwa Park, June Sung Lee, Young Eun Chon, Gab Jin Cheon, Hee Bok Chae, Joo Hyun Sohn, Young-Suk Lim
Summary: The study evaluated the antiviral effects and safety of switching from TDF to TD treatment in patients with chronic hepatitis B. TD was non-inferior to TDF in maintaining viral suppression in CHB patients, with less impact on renal function.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2022)
Article
Gastroenterology & Hepatology
Han Ah Lee, Young-Sun Lee, Young Kul Jung, Ji Hoon Kim, Hyung Joon Yim, Jong Eun Yeon, Yeon Seok Seo, Jae Seung Lee, Hye Won Lee, Beom Kyung Kim, Jun Yong Park, Do Young Kim, Sang Hoon Ahn, Seung Up Kim
Summary: This study aimed to investigate whether antiviral therapy improves outcomes in patients with HBV-related decompensated cirrhosis and undetectable HBV-DNA. The results showed that antiviral therapy did not reduce the risk of death or hepatocellular carcinoma.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Medicine, General & Internal
Ji Hun Lee, Seung Kak Shin, Seong Hee Kang, Tae Hyung Kim, Hyung Joon Yim, Sun Young Yim, Young-Sun Lee, Young Kul Jung, Ji Hoon Kim, Yeon Seok Seo, Jong Eun Yeon, Oh Sang Kwon, Soon Ho Um, Kwan Soo Byun
Summary: This study developed a precise and simple risk score model for predicting the development of hepatocellular carcinoma in patients with chronic hepatitis B. The model showed improved long-term prediction and provided three distinct risk categories for HCC.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Yoonseok Lee, Seryun Bae, Ji Hoon Kim, Minjung Kwak, So Yeon Jeon, Taehyung Kim, Sun Young Yim, Young-Sun Lee, Young Kul Jung, Yeon Seok Seo, Hyung Joon Yim, Jong Eun Yeon, Kwan Soo Byun
Summary: This study evaluated the diagnostic efficacy of serum Asialo alpha 1-acid glycoprotein (AsAGP) levels in classifying the severity of liver fibrosis in patients with chronic hepatitis B (CHB) and distinguishing them from healthy controls. The results showed significant differences in serum AsAGP levels between the CHB group, healthy control group, and CHB with liver cirrhosis group. Serum AsAGP levels were also positively correlated with liver stiffness. Therefore, serum AsAGP levels may serve as a potential biomarker for predicting the progression of liver disease in CHB.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Geum-Young Lee, Kyungmin Park, Young-Sun Lee, Ji Hoon Kim, Kwan Soo Byun, Jongwoo Kim, Won-Keun Kim, Jin-Won Song
Summary: This study evaluated the use of multiplex PCR-based nanopore sequencing to obtain whole-genome sequences of HAV for rapid molecular diagnosis of viral genotypes. The results showed high genome coverage rates (90.4-99.5%) of HAV within 8 hours using singleplex nanopore sequencing. TaqMan qPCR demonstrated the ability to detect and quantify multiple HAV genes. This study provides valuable insights for rapid molecular diagnosis during hepatitis A outbreaks and may enhance public health disease surveillance in the hospital and epidemiology field.
Review
Gastroenterology & Hepatology
Myung Han Hyun, Ji Hoon Kim, Jeong Won Jang, Jeong Eun Song, Do Seon Song, Hye Won Lee, Young Youn Cho, Gi-Ae Kim, Eileen L. Yoon, Dong Hyun Sinn, Soon Sun Kim, Sun Young Yim, Hyun Yang, Jihyun An
Summary: This meta-analytical study found that acupuncture increases the risk of hepatitis C transmission. Caution should be exercised when performing acupuncture and other medical and social practices due to the contagiousness of hepatitis C.
KOREAN JOURNAL OF GASTROENTEROLOGY
(2023)