Article
Oncology
Alicia Leon-Castillo, Nanda Horeweg, Elke E. M. Peters, Tessa Rutten, Natalja ter Haar, Vincent T. H. B. M. Smit, Cor D. Kroon, Marie Boennelycke, Estrid Hogdall, Claus Hogdall, Remi R. A. Nout, Carien L. Creutzberg, Gitte Ortoft, Tjalling Bosse
Summary: The study evaluates the clinical outcome of molecular subgroups in high-grade endometrial cancer (EC) patients staged with lymphadenectomy and those without adjuvant treatment. The molecular classification has strong prognostic value, independent of clinicopathological factors. The unfavorable prognosis of early-stage p53abn EC is not due to undetected lymph node metastasis, and the indolent behavior of POLEmut EC is independent of adjuvant treatment.
GYNECOLOGIC ONCOLOGY
(2022)
Review
Oncology
Xiaoying Jin, Chunjuan Shen, Xiaodi Yang, Yayuan Yu, Jianzhang Wang, Xuan Che
Summary: This study conducted a meta-analysis and found that primary tumor size > 20 mm was significantly associated with depth of MI, positive LVSI, positive LNM, recurrence, and poor OS. Therefore, considering the value of tumor size is crucial in the clinicopathological staging of endometrial carcinoma, and tumor size > 20 mm should be integrated into the intraoperative algorithm for performing a full surgical staging.
FRONTIERS IN ONCOLOGY
(2022)
Review
Oncology
Jianzhang Wang, Ping Xu, Xueying Yang, Qin Yu, Xinxin Xu, Gen Zou, Xinmei Zhang
Summary: This meta-analysis study found that deep myometrial invasion is positively associated with lymphovascular space invasion, lymph node metastasis, cancer recurrence, and overall survival in endometrial cancer patients. It suggests that myometrial invasion can be a useful evaluation criterion for clinical outcomes and prognosis of endometrial cancer, highlighting the importance of paying attention to myometrial invasion in clinical practice. Further investigation into the underlying mechanisms is warranted.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Bo Bae Choi
Summary: Pathologic tumor size, mass margin, internal enhancement pattern, kinetic enhancement curve, DWI rim sign, and the difference between maximum and minimum ADC were found to be significantly correlated with LVI in node-negative invasive breast cancer patients. Therefore, DCE-MRI with DWI may be helpful in predicting LVI status in this patient population.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Xingfeng Li, Michele Dessi, Diana Marcus, James Russell, Eric O. O. Aboagye, Laura Burney Ellis, Alexander Sheeka, Won-Ho Edward Park, Nishat Bharwani, Sadaf Ghaem-Maghami, Andrea G. G. Rockall
Summary: Machine learning classification methods can be used to predict deep myometrial infiltration, clinical risk category, histological type, and lymphovascular space invasion in endometrial cancer. Combining clinical and image signatures can improve the accuracy of these prediction models, which has important implications for patient management.
Article
Medicine, General & Internal
Sang Il Kim, Joo Hee Yoon, Sung Jong Lee, Min Jong Song, Jin Hwi Kim, Hae Nam Lee, Gyul Jung, Ji Geun Yoo
Summary: The study identified tumor size, depth of myometrial invasion, and presence of cervical stromal invasion as risk factors for lymphovascular space invasion (LVSI) in patients with endometrioid endometrial cancer. A simplified LVSI prediction model was developed and shown to have good predictive value for clinical use.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jing Liu, Xiaolin Xu, Jing Yan, Jian Guo, XinYan Wang, Junfang Xian
Summary: The combination of MRI and DWI has higher accuracy in detecting optic nerve invasion in retinoblastoma patients, which can be determined by observing imaging features such as optic nerve signal intensity, enlargement, enhancement, and ADC. Thoroughly studying the combination of these features is crucial for diagnosing optic nerve invasion in retinoblastoma patients.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Biology
Xueliang Zhu, Jie Ying, Haima Yang, Le Fu, Boyang Li, Bin Jiang
Summary: This study proposes a novel computerized method for accurately detecting deep myometrial invasion on MRI by utilizing the geometric feature LS and texture features in the ensemble model EPSVM. The results demonstrate that EPSVM outperforms commonly used classifiers in terms of accuracy, sensitivity, and specificity, and LS plays a significant role in DMI detection.
COMPUTERS IN BIOLOGY AND MEDICINE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Takashi Ota, Takahiro Tsuboyama, Hiromitsu Onishi, Atsushi Nakamoto, Hideyuki Fukui, Keigo Yano, Toru Honda, Kengo Kiso, Mitsuaki Tatsumi, Noriyuki Tomiyama
Summary: This study compared the image quality of high-resolution diffusion-weighted imaging (DWI) using multiplexed sensitivity encoding (MUSE) and reduced field-of-view (rFOV) techniques in endometrial cancer (EC), and compared their diagnostic performance with dynamic contrast-enhanced (DCE) MRI for assessing myometrial invasion. The results showed that MUSE-DWI had better image quality than rFOV-DWI, and both were almost equivalent to DCE-MRI in terms of diagnostic performance.
Article
Medicine, General & Internal
Sultan Deniz Altindag, Seyran Yigit, Serhat Sen
Summary: This study examines the frequency of the microcystic, elongated, and fragmented (MELF) pattern in endometrioid endometrial carcinoma (EEC) and its association with clinicopathological parameters and survival rates. The results show that the presence of MELF pattern is associated with lymphovascular space invasion, deep myometrial invasion, lymph node metastasis, and reduced overall survival and disease-free survival rates.
TURKISH JOURNAL OF MEDICAL SCIENCES
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Guangyi Wang, Wanwei Jian, Xiaoping Cen, Lijuan Zhang, Hui Guo, Zaiyi Liu, Changhong Liang, Wu Zhou
Summary: The study explored the value of diffusion-weighted magnetic resonance imaging in predicting microvascular invasion of hepatocellular carcinoma using Convolutional Neural Networks. Results showed that the fusion of deep features from different b-value images yielded the best performance for MVI prediction.
ACADEMIC RADIOLOGY
(2021)
Article
Oncology
Jingya Chen, Xiaorong Wang, Haoyi Lv, Wei zhang, Ying Tian, Lina Song, Zhongqiu Wang
Summary: A radiomics model based on MRI scans and clinical characteristics was developed to predict lymphovascular invasion in endometrial cancer patients. The model performed well in training, internal validation, and external validation cohorts. This noninvasive tool could be useful for predicting LVSI in EC patients.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Biology
Eric M. Anderson, Michael Luu, Mitchell Kamrava
Summary: The presence of lymph node involvement in endometrial cancer patients guides treatment decisions. This study used a database of patients diagnosed between 2004 and 2016 to identify predictors of lymph node involvement. In addition to tumor characteristics, patient age and race were found to be associated with a higher risk of lymph node involvement.
Article
Radiology, Nuclear Medicine & Medical Imaging
Thierry L. Lefebvre, Yoshiko Ueno, Anthony Dohan, Avishek Chatterjee, Martin Vallieres, Eric Winter-Reinhold, Sameh Saif, Ives R. Levesque, Xing Ziggy Zeng, Reza Forghani, Jan Seuntjens, Philippe Soyer, Peter Savadjiev, Caroline Reinhold
Summary: This study evaluated the performance of multiparametric MRI three-dimensional radiomics-based machine learning models in endometrial carcinoma. The results showed that radiomics had better performance than radiologists in identifying high-risk histopathologic markers and advanced-stage endometrial carcinoma.
Article
Radiology, Nuclear Medicine & Medical Imaging
Myoung Seok Lee, Min Hoan Moon, Sang Youn Kim, Siwon Jang, Sohee Oh, Jeong Yeon Cho
Summary: The purpose of this study was to compare the use of CE MRI and DWI in the risk stratification of women with endometrial cancer for lymph node metastasis. The results showed no significant difference between CE MRI and DWI in the rate of lymph node metastasis according to the risk stratification, suggesting that DWI may be a comparable alternative to CE MRI.
EUROPEAN JOURNAL OF RADIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Shaza Alsharif, Ann Aldis, Ahmad Subahi, Mona El Khoury, Benoit Mesurolle
Summary: The study reviewed breast magnetic resonance imaging (MRI) features of radial scars (RS) with and without associated atypia/malignancy, finding that MRI does not help differentiate between RS with or without associated atypia/malignancy.
CANADIAN ASSOCIATION OF RADIOLOGISTS JOURNAL-JOURNAL DE L ASSOCIATION CANADIENNE DES RADIOLOGISTES
(2021)
Article
Oncology
Salah Khayat, Gianluca Cassese, Francois Quenet, Christophe Cassinotto, Eric Assenat, Francis Navarro, Boris Guiu, Fabrizio Panaro
Summary: This study presents the oncological outcomes of Liver Venous Deprivation (LVD) in 17 patients with Colorectal Liver Metastases, showing comparable 1-year and 3-year overall survival rates to Portal Vein Embolization (PVE). Although postoperative complications were observed in 47% of patients, there were no deaths, and hepatic recurrence rate was 52.9%.
Article
Medicine, General & Internal
Lauranne Piron, Emmanuel Deshayes, Christophe Cassinotto, Francois Quenet, Fabrizio Panaro, Margaux Hermida, Carole Allimant, Eric Assenat, Georges-Philippe Pageaux, Nicolas Molinari, Boris Guiu
Summary: The study found that liver volume and function progress independently regardless of vascular conditions. Hepatic congestion from outflow obstruction drives volume increase but also results in early impaired function.
Article
Obstetrics & Gynecology
Stephanie Nougaret, Teresa Margarida Cunha, Nadia Benadla, Mathias Neron, Jessica B. Robbins
OBSTETRICS AND GYNECOLOGY CLINICS OF NORTH AMERICA
(2021)
Article
Oncology
Ancelin Preel, Margaux Hermida, Carole Allimant, Eric Assenat, Chloe Guillot, Cecilia Gozzo, Serge Aho-Glele, Georges-Philippe Pageaux, Christophe Cassinotto, Boris Guiu
Summary: The study found that in Western patients, bi- and trifocal HCC significantly increased the risk of distant recurrence, especially very early recurrence. Overall survival after PTA of trifocal HCC was significantly below what was expected after curative treatment.
Article
Chemistry, Medicinal
Audrey Fohlen, Karim Bordji, Eric Assenat, Celine Gongora, Celine Bazille, Jeremy Boulonnais, Mikael Naveau, Cecile Breuil, Elodie A. Peres, Myriam Bernaudin, Boris Guiu
Summary: This study investigated the response of different cell lines to 12 cytotoxic agents, finding that idarubicin was the most cytotoxic to most colorectal cancer cell lines, while gemcitabine was most effective for certain cell lines. Interestingly, commonly used cytotoxic agents in the treatment of colorectal liver metastases showed limited cytotoxicity in the tested cell lines.
Article
Oncology
Marie Cantaloube, Florence Castan, Morgane Creoff, Jessica Prunaretty, Karl Bordeau, Morgan Michalet, Eric Assenat, Boris Guiu, Georges-Philippe Pageaux, Marc Ychou, Norbert Ailleres, Pascal Fenoglietto, David Azria, Olivier Riou
Summary: The study demonstrates that stereotactic body radiation therapy (SBRT) using volumetric modulated arc therapy (VMAT) and real-time adaptive tumor gating for hepatocellular carcinoma (HCC) is effective with optimal local control and low toxicity, especially in patients not eligible for other local therapies. Additionally, the diameter of lesions and the volume of PTV were found to be associated with disease-free survival and overall survival in HCC patients receiving SBRT with VMAT.
Article
Psychology, Clinical
Khalid M. Alshamrani, Abdulkader A. Alkenawi, Reham Kaifi, Shaza Alsharif, Abdulaziz S. Merdah, Wael E. Munshi, Ahmed K. Alattas, Majid Althaqafy, Abdulaziz A. Qurashi, Walaa M. Alsharif, Ali S. Alshareef
Summary: This study investigated burnout among Saudi radiological sciences students during the COVID-19 pandemic. The findings showed that 73.3% of the students experienced moderate to high levels of burnout during the pandemic. Burnout increased as students progressed to the fourth year. Implementing a block/modular curriculum structure for fourth-year courses may be necessary to reduce burnout among these students. Academic counseling can help alleviate students' emotional stress and decrease the risk of burnout.
PSYCHOLOGY RESEARCH AND BEHAVIOR MANAGEMENT
(2022)
Article
Medicine, General & Internal
Karl Bordeau, Morgan Michalet, Aicha Keskes, Simon Valdenaire, Pierre Debuire, Marie Cantaloube, Morgane Cabaille, William Jacot, Roxana Draghici, Sylvain Demontoy, Xavier Quantin, Marc Ychou, Eric Assenat, Thibault Mazard, Ludovic Gauthier, Marie Dupuy, Boris Guiu, Celine Bourgier, Norbert Ailleres, Pascal Fenoglietto, David Azria, Olivier Riou
Summary: Liver stereotactic body radiotherapy (SBRT) provides effective local control and minimal toxicity for liver metastases. This study presents the first clinical results of stereotactic MR-guided radiotherapy (MRgRT) for liver metastases from a prospective registry. The treatment was well-tolerated, with low rates of acute and late toxicities. The overall survival and local control rates were promising, but distant relapse remains a challenge.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Oncology
Cyprien Toubert, Boris Guiu, Bader Al Taweel, Eric Assenat, Fabrizio Panaro, Francois-Regis Souche, Jose Ursic-Bedoya, Francis Navarro, Astrid Herrero
Summary: Surgical resection is the optimal treatment for hepatocellular carcinoma (HCC), but recurrence is common. This retrospective study analyzed survival after HCC recurrence following liver resection. The time and type of recurrence treatment were found to be major prognostic factors. However, overall survival did not significantly differ between patients who experienced recurrence and those who did not after receiving curative treatment.
Review
Medicine, General & Internal
Shaza Alsharif, Ghalib Alasaad, Mohammed K. Bukhari, Abdulaziz Sharkar, Mohammed Altaf, Shaymaa Milibari, Roaa Alsulimani, Khalid M. Alshamrani
Summary: The majority of follow-up imaging recommendations by radiologists to referring physicians were not carried out. Improving communication and compliance with follow-up recommendations is crucial for optimizing patient healthcare.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Article
Oncology
Camille Goislard de Monsabert, Yann Touchefeu, Boris Guiu, Boris Campillo-Gimenez, Olivier Farges, David Tougeron, Isabelle Baumgaertner, Ahmet Ayav, Luc Beuzit, Marc Pracht, Astrid Lievre, Samuel Le Sourd, Karim Boudjema, Yan Rolland, Etienne Garin, Eveline Boucher, Julien Edeline
Summary: The combination of selective internal radiotherapy (SIRT) and chemotherapy with cisplatin and gemcitabine as first-line treatment for unresectable intrahepatic cholangiocarcinomas (ICCs) was found to maintain patients' quality of life (QoL). Although there were no clinically significant changes in the global health score or QoL sub-scales during follow-up, some functional and symptom scores worsened during treatment.
Review
Radiology, Nuclear Medicine & Medical Imaging
Shaza AlSharif, Khalid Misfer Alshamrani, Anabel Scaranelo, Nuha Khoumais, Ahmad Subahi, Benoit Mesurolle
Summary: Most male breast masses are benign with gynecomastia being the most common entity, while primary male breast cancer is rare due to lack of hormonal influence. Imaging features of male breast masses are similar to the female breast, and knowledge of the female breast can aid in the diagnosis and management of male breast abnormalities.
JOURNAL OF CLINICAL IMAGING SCIENCE
(2021)
Article
Medicine, General & Internal
Shaza Alsharif, Ahmed Subahi, Bader Shirah, Khalid M. Alshamrani, Turki A. Alhazmi, Benoit Mesurolle
Summary: Gonadal vein thrombosis is a rare but serious condition that primarily affects females, with a small percentage in males. This study conducted in Saudi Arabia found that the incidence of gonadal vein thrombosis in oncology patients is similar to that in obstetric patients. Prompt initiation of anticoagulation therapy is crucial in managing this condition and reducing complications.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2021)
Review
Radiology, Nuclear Medicine & Medical Imaging
S. Nougaret, Cathal McCague, Hichem Tibermacine, Hebert Alberto Vargas, Stefania Rizzo, E. Sala
Summary: Despite significant progress in chemotherapy and surgery, ovarian cancer remains one of the most lethal gynecological cancers in the world due to the impact of tumor heterogeneity on treatment response and prognosis. Radiomics offers a method to evaluate the heterogeneity of the whole tumor, instead of relying on single biopsy samples.
ABDOMINAL RADIOLOGY
(2021)
