Article
Neurosciences
Evie Kourtidou, Dimitrios Kasselimis, Georgia Angelopoulou, Efstratios Karavasilis, Georgios Velonakis, Nikolaos Kelekis, Ioannis Zalonis, Ioannis Evdokimidis, Constantin Potagas, Michael Petrides
Summary: This study investigated the white matter structure in the right hemisphere of chronic post-stroke aphasic patients, and found increased axial diffusivity in the RH tracts of the aphasic patients. The results suggest a compensatory role of the right hemisphere tracts in language functions when the LH networks are disrupted.
FRONTIERS IN HUMAN NEUROSCIENCE
(2021)
Article
Neurosciences
Jie Zhang, Ye Yao, Jin-song Wu, Edmund T. Rolls, Ce-chen Sun, Ling-hao Bu, Jun-feng Lu, Ching-po Lin, Jian-feng Feng, Ying Mao, Liang-fu Zhou
Summary: This study used multi-modal neuroimaging analyses to localize the cortical regions and white matter tracts responsible for auditory language comprehension. The results showed that cortical areas in the posterior temporal lobe are crucial for language comprehension. The fiber integrity of the arcuate fasciculus and the inferior longitudinal fasciculus was strongly correlated with auditory comprehension and the grey matter volume of the inferior temporal and middle temporal gyri.
HUMAN BRAIN MAPPING
(2023)
Article
Neurosciences
Lucia Vaquero, Neus Ramos-Escobar, David Cucurell, Clement Francois, Vesa Putkinen, Emma Segura, Minna Huotilainen, Virginia Penhune, Antoni Rodriguez-Fornells
Summary: This study explored individual differences in the white-matter connectivity of the arcuate fasciculus and its relationship to auditory change detection. Results demonstrate that left fronto-temporal white-matter connectivity plays a crucial role in pre-attentive rhythm modulations detection within a melody.
Article
Multidisciplinary Sciences
Joanna Sierpowska, Katherine L. Bryant, Nikki Janssen, Guilherme Blazquez Freches, Manon Romkens, Margot Mangnus, Rogier B. Mars, Vitoria Piai
Summary: This study reveals the anatomical differences in language connectivity between humans and chimpanzees. Compared to chimpanzees, humans have expanded connectivity in the posterior temporal lobe, not only to the ventral frontal cortex but also to the parietal cortex. Conversely, chimpanzees have stronger connectivity between the posterior temporal regions and the ventral white matter. Additionally, humans have unique combinations of connections through different bundles in the anterior temporal lobe, which may underlie the anatomical basis for full-fledged language capacity.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Oncology
Wei-Han Chang, Kuo-Chen Wei, Pin-Yuan Chen, Yi-Chun Chen, Yah-Yuan Wu, Hong-Chieh Tsai, Mei-Hui Chen, Yi-Ping Chao, Ko-Ting Chen
Summary: The reorganization of language networks during glioma growth leads to varying language performance in patients. Different language domains involving different neural networks were analyzed to investigate neuroplastic potential. Patient factors and tumor characteristics were found to affect the abnormal performance of different language domains.
JOURNAL OF NEURO-ONCOLOGY
(2023)
Article
Clinical Neurology
Andrea Gajardo-Vidal, Diego L. Lorca-Puls, Holly Warner, Bawan Pshdary, Jennifer T. Crinion, Alexander P. Leff, Thomas M. H. Hope, Sharon Geva, Mohamed L. Seghier, David W. Green, Howard Bowman, Cathy J. Price
Summary: By studying the impact of damage to Broca's area and surrounding regions, it was found that long-term speech production outcome is mainly influenced by damage to white matter above the insula, in the vicinity of the anterior part of the arcuate fasciculus, rather than damage to Broca's area alone.
Article
Oncology
Sergey A. Goryaynov, Svetlana B. Buklina, Ivan V. Khapov, Artyom I. Batalov, Alexander A. Potapov, Igor N. Pronin, Artem U. Belyaev, Andrey A. Aristov, Vadim U. Zhukov, Galina V. Pavlova, Evgenii Belykh
Summary: The simultaneous use of 5-ALA fluorescence and awake speech mapping in patients with left frontal gliomas can enhance the extent of resection for infiltrative high-grade gliomas and identify foci of anaplasia in non-enhancing gliomas, while maintaining safe limits of functional resection based on speech mapping. Positive 5-ALA fluorescence in diffuse Grade 2 gliomas may indicate a more aggressive disease course.
FRONTIERS IN ONCOLOGY
(2022)
Article
Behavioral Sciences
Jingjing Zhao, Yueye Zhao, Zujun Song, Michel Thiebaut de Schotten, Irene Altarelli, Franck Ramus
Summary: This study investigates the relationship between lateralization of three segments of the arcuate fasciculus (AF) and literacy skills in developmental dyslexia. The results show that the lateralization index (LI) of the anterior segment (AFAS) and long segment (AFLS) are positively correlated with reading accuracy in children with dyslexia. Specifically, the LI of AFAS is correlated with nonword and meaningless text reading accuracy, while the LI of AFLS is associated with word reading accuracy. The findings suggest adaptive compensation and functional dissociation of AF lateralization in developmental dyslexia.
Article
Multidisciplinary Sciences
Fang-Cheng Yeh
Summary: This study constructed a connectome that quantifies the probability of white matter tracts innervating cortical regions, and revealed different networks and fiber bundle systems based on hierarchical clustering analysis.
NATURE COMMUNICATIONS
(2022)
Article
Neurosciences
Elise B. Barbeau, Shanna Kousaie, Kanontienentha Brass, Maxime Descoteaux, Michael Petrides, Denise Klein
Summary: Phonological working memory (PWM) is crucial for language learning and processing. The middle frontal gyrus (MFG) and its connections with the posterior temporal region, specifically through the dorsal branch of the arcuate fasciculus (AFd) and the temporo-frontal extreme capsule fasciculus (TFexcF), play a significant role in PWM processes. Brain activation in area 8A of the left AFd is associated with attentional aspects of executive control, while area 9/46v of the MFG is critical for monitoring information in memory.
Review
Neurosciences
Ehsan Shekari, Nazbanou Nozari
Summary: This study provides a comprehensive review of the role of white matter in connecting cortical areas involved in language processing. Hypotheses about the functions of major tracts connecting these areas are evaluated using data from studies in neurotypical individuals, neuropsychological data, and intraoperative stimulation studies. The study highlights the conclusions supported by the data and identifies areas requiring further investigation.
FRONTIERS IN HUMAN NEUROSCIENCE
(2023)
Article
Neurosciences
Qiwei Yu, Wenjun Qian
Summary: This study presents a clinical case of poor spontaneous recovery of aphemia, highlighting the importance of the anterior segment of the left arcuate fasciculus in speech production deficits and the crucial role of the intact posterior segment in residual language comprehension ability.
Article
Neurosciences
Xiaonan Li, Robert J. Zatorre, Yi Du
Summary: Musical training is associated with improved language skills, with musicians showing differences in white matter features and brain hemodynamics related to speech perception. The differential microstructural plasticity of bilateral arcuate fasciculus segments may serve as a neural foundation for the cross-domain transfer effect of musical experience to speech perception.
Article
Clinical Neurology
Davide Giampiccolo, Sylvie Moritz-Gasser, Sam Ng, Anne-Laure Lemaitre, Hugues Duffau
Summary: The study reveals that jargonaphasia is caused by white matter stimulation, suggesting disconnection as a significant factor. The involvement of white matter pathways in different forms of jargonaphasia indicates a continuum of disorders distinguished by semantic impairment.
Review
Clinical Neurology
Davide Giampiccolo, Hugues Duffau
Summary: The arcuate fasciculus, a white matter pathway in the dorsal fronto-temporal region, has been traditionally believed to link frontal language production regions with auditory perception in the temporal lobe. However, recent research findings indicate that the projections of the arcuate fasciculus may not be unique to the temporal lobe and that it may also play a role in other regions involved in language processing.
Article
Clinical Neurology
K. T. Chen, O. Adeyeri, T. N. Toueg, M. Zeineh, E. Mormino, M. Khalighi, G. Zaharchuk
Summary: Accurate amyloid PET images can be generated using enhanced ultra-low-dose PET and either nonsimultaneous or simultaneous MR imaging, broadening the utility of ultra-low-dose amyloid PET imaging.
AMERICAN JOURNAL OF NEURORADIOLOGY
(2022)
Article
Marine & Freshwater Biology
Hai Doan-Nhu, Tam-Vinh Nguyen, Hoang Do-Huu, Joseph P. Montoya, Lam Nguyen-Ngoc
Summary: This study investigates the impact of the Mekong River and the Southern Vietnamese coastal upwelling on the copepod community based on their functional traits. The results show that copepods in different habitats exhibit distinct functional traits.
JOURNAL OF PLANKTON RESEARCH
(2022)
Article
Engineering, Biomedical
Samuel J. Raymond, Nicholas J. Cecchi, Hossein Vahid Alizadeh, Ashlyn A. Callan, Eli Rice, Yuzhe Liu, Zhou Zhou, Michael Zeineh, David B. Camarillo
Summary: This work presents a new physics-informed machine learning model for analyzing kinematic data and detecting impacts to the head. By simulating head impacts and creating a large synthetic dataset, the model achieves improved performance compared to traditional impact detectors. It shows the best results to date for impact detection in American football.
ANNALS OF BIOMEDICAL ENGINEERING
(2022)
Article
Biotechnology & Applied Microbiology
Zhou Zhou, Xiaogai Li, August G. Domel, Emily L. Dennis, Marios Georgiadis, Yuzhe Liu, Samuel J. Raymond, Gerald Grant, Svein Kleiven, David Camarillo, Michael Zeineh
Summary: Hippocampal injury is common in traumatic brain injury patients, and this study found that the adjacent fluid-containing temporal horn may exacerbate the vulnerability of the hippocampus. The presence of the temporal horn was associated with increased strain and strain rate in the hippocampus, indicating a mechanobiological dependency of the hippocampus on the temporal horn.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Engineering, Biomedical
Xianghao Zhan, Yiheng Li, Yuzhe Liu, Nicholas J. Cecchi, Olivier Gevaert, Michael M. Zeineh, Gerald A. Grant, David B. Camarillo
Summary: This study investigates the relationship between brain strain and kinematic features in different types of head impacts. The researchers used a data-driven approach and found piecewise multivariate linearity between cumulative strain damage (CSDM) and head kinematic features. They compared different partition methods and found that the K-means clustering method showed significantly higher regression accuracy for CSDM. The study suggests that this method may contribute to the rapid prediction of CSDM in the future.
ANNALS OF BIOMEDICAL ENGINEERING
(2022)
Article
Clinical Neurology
Gustavo Chau Loo Kung, Andrew Chiu, Zach Davey, Nicole Mouchawar, Mackenzie Carlson, Hossein Moein Taghavi, Douglas Martin, Kevin Graber, Babak Razavi, Jennifer McNab, Michael Zeineh
Summary: This study explores the use of DTI and NODDI to identify microstructural abnormalities in the hippocampus and diagnose mesial temporal sclerosis (MTS) at the subfield level. The results suggest that analyzing diffusion metrics in the dentate gyrus and CA1 may aid in the clinical confirmation of MTS.
Review
Neurosciences
Dean Tran, Phillip DiGiacomo, Donald E. Born, Marios Georgiadis, Michael Zeineh
Summary: Alzheimer's disease is a debilitating brain disorder with no effective treatment. The accumulation of beta-amyloid and tau proteins are key markers for the disease, but the exact mechanisms behind neurodegeneration in AD are still not well understood. Abnormal iron accumulation may play a role in the pathogenesis of AD, and further research is needed to develop iron-based biomarkers or therapeutic targets.
FRONTIERS IN HUMAN NEUROSCIENCE
(2022)
Article
Engineering, Biomedical
Xianghao Zhan, Yuzhe Liu, Nicholas J. Cecchi, Olivier Gevaert, Michael M. Zeineh, Gerald A. Grant, David B. Camarillo
Summary: The study utilized principal component analysis (PCA) to analyze the spatial co-variation of injury metrics in four types of head impacts, aiding in the improvement of the machine learning head model (MLHM). PCA-MLHM reduced model parameters by 74% with comparable MPS estimation accuracy.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2022)
Article
Engineering, Biomedical
Xianghao Zhan, Anna Oeur, Yuzhe Liu, Michael M. Zeineh, Gerald A. Grant, Susan S. Margulies, David B. Camarillo
Summary: This review explores the connection between biomechanics and the pathology of mild traumatic brain injury (mTBI) by utilizing neuroimaging, neurobehavioral tests, and pathological studies across different species. The study findings suggest that strain and strain rate can predict the pathology of mTBI, and the results are applicable to various species.
CURRENT OPINION IN BIOMEDICAL ENGINEERING
(2022)
Article
Marine & Freshwater Biology
Lam Nguyen-Ngoc, Sarah C. Weber, Hai Doan-Nhu, Ajit Subramaniam, Maren Voss, Joseph P. Montoya
Summary: The South China Sea is a complex and dynamic marginal sea with great economic importance. It experiences strong seasonal forcing from the monsoon cycle, which affects river runoff and circulation. A study found a wide distribution of host diatoms and Diatom-Diazotroph Associations (DDAs) in different habitats of the South China Sea, with the lowest infection rates and intensities in waters affected by coastal upwelling.
Article
Biology
Miriam Menzel, David Grassel, Ivan Rajkovic, Michael M. Zeineh, Marios Georgiadis
Summary: Disentangling human brain connectivity requires an accurate description of nerve fiber trajectories, which is challenging due to the crossing of axons. This study applies scattered light imaging (SLI) and small-angle X-ray scattering (SAXS) techniques to validate diffusion magnetic resonance imaging (dMRI) for axonal orientation imaging. The results show that SLI and SAXS can provide quantitative micrometer 3D fiber orientations with high resolution and specificity, facilitating detailed investigations of complex fiber architecture in the animal and human brain.
Article
Hospitality, Leisure, Sport & Tourism
Xianghao Zhan, Yiheng Li, Yuzhe Liu, Nicholas J. Cecchi, Samuel J. Raymond, Zhou Zhou, Hossein Vahid Alizadeh, Jesse Ruan, Saeed Barbat, Stephen Tiernan, Olivier Gevaert, Michael M. Zeineh, Gerald A. Grant, David B. Camarillo
Summary: This study investigated the spectral characteristics of different head impact types using kinematics classification. The machine-learning-based classifier showed high accuracy in classifying head impact types, and different types of impacts had different distributions of spectral densities in low- and high-frequency ranges. This research contributes to a better understanding of impact kinematics in different sports.
JOURNAL OF SPORT AND HEALTH SCIENCE
(2023)
Article
Clinical Neurology
Maged Goubran, Brian David Mills, Marios Georgiadis, Mahta Karimpoor, Nicole Mouchawar, Sohrab Sami, Emily Larson Dennis, Carolyn Akers, Lex Mitchell, Brian Boldt, David Douglas, Phillip Scott Digiacomo, Jarrett Rosenberg, Gerald Grant, Max Wintermark, David Benjamin Camarillo, Michael Zeineh
Summary: This study investigated longitudinal changes in brain microstructure of high-contact (football) and low-contact (volleyball) collegiate athletes using advanced diffusion MRI. It found significant differences in microstructural metrics and tracts between football and volleyball players, especially in concussed football players. The findings suggest alterations in white matter development in football athletes due to concussive and repeated subconcussive impacts.
Article
Psychiatry
Bhavana Rai, Paige E. Naylor, Monica Siqueiros-Sanchez, Max Wintermark, Mira M. Raman, Booil Jo, Allan L. Reiss, Tamar Green
Summary: This study examines the effects of Noonan syndrome on brain anatomy and cognitive-behavioral data, and reveals widespread effects on cortical and subcortical volumes. It also identifies associations between PTPN11 gene expression and cortical surface area and thickness.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Pathology
Li Lei, Eric Van Staalduinen, Megan Troxell, Michael G. Ozawa, Michael Zeineh, Gerald Berry
Summary: This case report describes a 62-year-old male patient with a salivary gland tumor that exhibited complex pathological features. The treatment included surgical resection, immunotherapy, and chemotherapy, and the patient is currently alive.
HEAD & NECK PATHOLOGY
(2022)