Article
Biochemistry & Molecular Biology
Chak Kwong Cheng, Huanyu Ding, Minchun Jiang, Huiyong Yin, Maik Gollasch, Yu Huang
Summary: Perivascular adipose tissue (PVAT) refers to the aggregate of adipose tissue surrounding the vasculature, exhibiting the phenotypes of white, beige and brown adipocytes. PVAT is actively involved in the regulation of reactive oxygen species (ROS) homeostasis and inflammation in the vascular system. The phenotype-genotype of PVAT varies in different regions of the vasculature and plays a role in cardiovascular pathogenesis. Treatments targeting PVAT may provide new therapeutic insights for cardiovascular diseases.
Article
Neurosciences
Yunli Qi, Mengqi Lin, Yunjun Yang, Yanxuan Li
Summary: The study found a positive association between abdominal visceral fat and CSO-dPVS scores, especially prominent in males, while no significant correlation was found between subcutaneous fat and dPVS scores.
FRONTIERS IN NEUROSCIENCE
(2021)
Review
Cardiac & Cardiovascular Systems
Gianluca Iacobellis
Summary: Patients with obesity are at a higher risk of developing cardiovascular diseases. However, regional and organ specific adiposity appear to play a stronger role than obesity itself. Epicardial adipose tissue, located around the heart, is directly involved in major obesity-related cardiovascular complications. Current imaging techniques can assess epicardial fat to predict cardiovascular risk. Pharmacological modulation of epicardial fat can reduce cardiovascular risk. Assessing epicardial fat could change the traditional paradigm linking obesity to heart disease.
PROGRESS IN CARDIOVASCULAR DISEASES
(2023)
Review
Medicine, Research & Experimental
Anirban Goutam Mukherjee, Kaviyarasi Renu, Abilash Valsala Gopalakrishnan, Rama Jayaraj, Abhijit Dey, Balachandar Vellingiri, Raja Ganesan
Summary: Epicardial adipose tissue (EAT) is a visceral fat deposit that is morphologically and physiologically connected to the myocardium and coronary arteries. It has cardioprotective characteristics, but under clinical processes, it can impact the heart and coronary arteries by secreting proinflammatory cytokines. The factors affecting this equilibrium are still not fully understood. This review focuses on the physiological and pathophysiological dimensions of EAT and its various clinical utilities.
Article
Gastroenterology & Hepatology
Wei Shen, Michael S. Middleton, Guilherme M. Cunha, Timoteo I. Delgado, Tanya Wolfson, Anthony Gamst, Kathryn J. Fowler, Adina Alazraki, Andrew T. Trout, Michael A. Ohliger, Shetal N. Shah, Mustafa R. Bashir, David E. Kleiner, Rohit Loomba, Brent A. Neuschwander-Tetri, Arun J. Sanyal, Jane Zhou, Claude B. Sirlin, Joel E. Lavine
Summary: This study investigated the relationship between reduction in adipose tissue compartment volumes and hepatic histologic improvement in adults with obesity and non-alcoholic steatohepatitis (NASH). The findings showed that reductions in deep subcutaneous adipose tissue and visceral adipose tissue volumes were associated with histologic improvement in NASH.
JOURNAL OF HEPATOLOGY
(2023)
Article
Medicine, General & Internal
Ilkay S. Idilman, Hsien Min Low, Tolga Gidener, Kenneth Philbrick, Taofic Mounajjed, Jiahui Li, AlMa M. Allen, Meng Yin, Sudhakar K. Venkatesh
Summary: The MRI-determined VAT can be utilized for predicting the presence of HS, NASH, and HF in patients with known or suspected NAFLD. VAT showed moderate correlation with liver PDFF and weak correlation with Lvol, Svol, and pancreas PDFF. The cut-off VAT volumes for predicting HS, NASH, and HF were calculated.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Hong Shi, Hanping Wu, Michael A. Winkler, Eric J. Belin de Chantemele, Richard Lee, Ha Won Kim, Neal L. Weintraub
Summary: This review article discusses the link between perivascular adipose tissue (PVAT) and the pathogenesis of cardiovascular disease (CVD) in patients with autoimmune rheumatic diseases (ARDs). The research suggests that inflammation within PVAT may contribute to the development of CVD. Novel PVAT imaging techniques can help define disease risk and evaluate responses to biological therapies.
PHARMACOLOGICAL RESEARCH
(2022)
Review
Immunology
Meichao Cai, Dongsheng Zhao, Xiao Han, Shuang Han, Wenxin Zhang, Zhennan Zang, Chenchen Gai, Rong Rong, Tian Gao
Summary: Perivascular adipose tissue and the vessel wall are connected through intricate bidirectional paracrine and vascular secretory signaling pathways. The interaction between them is of great value for the assessment of vascular inflammation and cardiovascular ischemic disease.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Hematology
Celestina Mazzotta, Sanchita Basu, Adam C. Gower, Shakun Karki, Melissa G. Farb, Emily Sroczynski, Elaina Zizza, Anas Sarhan, Ashvin N. Pande, Kenneth Walsh, Nikola Dobrilovic, Noyan Gokce
Summary: This study identifies an inflamed region in perivascular adipose tissue (PVAT) associated with atherosclerosis, with higher inflammation levels in obese individuals. Dysfunctional PVAT may contribute to vascular disease mechanisms, especially in the context of obesity.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Auriane C. Ernault, Veronique M. F. Meijborg, Ruben Coronel
Summary: Obesity is a significant risk factor for arrhythmic cardiovascular death. A review investigates the influence of epicardial adipose tissue (EAT) on arrhythmogenesis, highlighting its impact on atrial and ventricular conduction delay, structural cross talk with the heart, and secretion of substances that influence cardiomyocyte electrophysiology. The interaction between EAT and cardiomyocytes facilitates arrhythmias via activation delay, conduction slowing, and increased risk of block.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Cell Biology
Yunying Huang, Yaozhong Liu, Yingxu Ma, Tao Tu, Na Liu, Fan Bai, Yichao Xiao, Chan Liu, Zhengang Hu, Qiuzhen Lin, Mohan Li, Zuodong Ning, Yong Zhou, Xiquan Mao, Qiming Liu
Summary: This study used Mendelian randomization (MR) analysis to evaluate the genetic associations of visceral adipose tissue (VAT) with metabolic risk factors and cardiovascular disease (CVD). It found that genetically predicted VAT mass was associated with various metabolic risk factors and CVD endpoints. Additionally, a network analysis identified potential proteins that may mediate the relationship between VAT and CVDs.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Marta Lopez-Yus, Silvia Lorente-Cebrian, Raquel Del Moral-Bergos, Carlos Horndler, Maria Pilar Garcia-Sobreviela, Carmen Casamayor, Alejandro Sanz-Paris, Vanesa Bernal-Monterde, Jose M. Arbones-Mainar
Summary: This study investigated the molecular mechanisms of subcutaneous white adipose tissue (scWAT) in the progression of nonalcoholic fatty liver disease (NAFLD). Through RNA sequencing analysis and in vitro experiments, potential key genes related to NAFLD progression were identified. These findings provide new potential targets for future therapies against liver steatosis.
Article
Immunology
Hong Shi, Brandee Goo, David Kim, Taylor C. Kress, Mourad Ogbi, James Mintz, Hanping Wu, Eric Belin J. de Chantemele, David Stepp, Xiaochun Long, Avirup Guha, Richard Lee, Laura Carbone, Brian H. Annex, David Y. Hui, Ha Won Kim, Neal L. Weintraub
Summary: Patients with systemic lupus erythematosus (SLE) are at elevated risk for cardiovascular disease (CVD) due to accelerated atherosclerosis. Compared to heathy control subjects, lupus patients have higher volumes and densities of thoracic aortic perivascular adipose tissue (PVAT), which independently associates with vascular calcification, a marker of subclinical atherosclerosis. However, the biological and functional role of PVAT in SLE has not been directly investigated.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Sara Leo, Elena Tremoli, Letizia Ferroni, Barbara Zavan
Summary: Obesity and insulin resistance are risk factors for cardiovascular diseases, associated with inflamed and defective adipose tissue. Extracellular vesicles, involved in insulin resistance, diabetes, and CVDs, play a role in the onset and development of these pathologies. Inflammation triggers the transition of adipose tissue secretome, leading to an increase in pro-inflammatory mediators.
Review
Endocrinology & Metabolism
Cheng Li, Xinyu Liu, Binay Kumar Adhikari, Liping Chen, Wenyun Liu, Yonggang Wang, Huimao Zhang
Summary: In recent decades, the epicardial adipose tissue (EAT) has been extensively studied for its various roles in the pathogenesis of cardiovascular diseases (CVDs). Under physiological conditions, EAT acts as a cushion and protects the coronary arteries and myocardium. However, under pathological conditions, EAT dysfunction promotes the progression of various CVDs. EAT might serve as an early predictor and a potential therapeutic target for CVD management.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
O. L. Barbarash, V. V. Kashtalap, M. Zykov, O. N. Hryachkova, I. A. Shibanova
Article
Multidisciplinary Sciences
Olga Gruzdeva, Evgenya Uchasova, Yulia Dyleva, Daria Borodkina, Olga Akbasheva, Viktoria Karetnikova, Natalia Brel, Kokov Alexander, Olga Barbarash
Article
Immunology
Olga Gruzdeva, Evgenya Uchasova, Yulia Dyleva, Daria Borodkina, Olga Akbasheva, Larisa Antonova, Vera Matveeva, Ekaterina Belik, Sergei Ivanov, Anton Sotnikov, Kirill Kozyrin, Natalia Brel, Maxim Sinitsky, Victoria Karetnikova, Alexander Kokov, Evgenya Bychkova, Tamara Pecherina, Olga Barbarash
FRONTIERS IN IMMUNOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Maxim Yu Sinitsky, Yulia A. Dyleva, Evgenya G. Uchasova, Ekaterina Belik, Arseniy E. Yuzhalin, Olga Gruzdeva, Vera G. Matveeva, Anastasia Ponasenko
Summary: This study compared the gene expression levels of adipocytes in different adipose tissues of coronary artery disease patients. It was found that DPP4 and APLN mRNA were higher expressed in epicardial adipose tissue, while ITLN1 gene was overexpressed in this tissue. Additionally, APLN and DPP4 mRNA expression were correlated with blood lipid levels.
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
(2022)
Article
Hematology
Christoph Male, Anthonie W. A. Lensing, Joseph S. Palumbo, Riten Kumar, Ildar Nurmeev, Kerry Hege, Damien Bonnet, Philip Connor, Helene L. Hooimeijer, Marcela Torres, Anthony K. C. Chan, Gili Kenet, Susanne Holzhauer, Amparo Santamaria, Pascal Amedro, Elizabeth Chalmers, Paolo Simioni, Rukhmi V. Bhat, Donald L. Yee, Olga Lvova, Jan Beyer-Westendorf, Tina T. Biss, Ida Martinelli, Paola Saracco, Marjolein Peters, Krisztian Kallay, Cynthia A. Gauger, M. Patricia Massicotte, Guy Young, Akos F. Pap, Madhurima Majumder, William T. Smith, Jurgen F. Heubach, Scott D. Berkowitz, Kirstin Thelen, Dagmar Kubitza, Mark Crowther, Martin H. Prins, Paul Monagle
LANCET HAEMATOLOGY
(2020)
Article
Medicine, General & Internal
Tamara Pecherina, Anton Kutikhin, Vasily Kashtalap, Victoria Karetnikova, Olga Gruzdeva, Oksana Hryachkova, Olga Barbarash
Article
Cardiac & Cardiovascular Systems
A. A. Khorlampenko, V. N. Karetnikova, A. M. Kochergina, J. S. Ignatova, J. A. Dyleva, O. Gruzdeva, O. L. Barbarash
Article
Medicine, General & Internal
E. Belik, O. Gruzdeva, O. F. Akbasheva, Yu A. DYleva, D. A. Borodkina, M. Yu Sinitsky, A. Sotnikov, K. A. Kozyrin, N. K. Brel, D. Yu Naumov, A. A. Shilov, E. E. Bychkova, V. N. Karetnikova, O. L. Barbarash
TERAPEVTICHESKII ARKHIV
(2020)
Article
Medicine, General & Internal
Natalia K. Brel, Olga Gruzdeva, Alexander N. Kokov, Vladislava L. Masenko, Yulia A. Dyleva, Ekaterina Belik, Olga L. Barbarash
Summary: This study assessed the relationship between visceral obesity (VO) prevalence and coronary calcification (CC) severity in patients with verified CAD. The study found that the VAT/SAT index had a direct correlation with CC, indicating that VAT morphology could be an important diagnostic sign of massive CC in CAD patients, affecting treatment and prognosis.
TERAPEVTICHESKII ARKHIV
(2021)
Article
Health Care Sciences & Services
Olga V. Gruzdeva, Yulia A. Dyleva, Ekaterina V. Belik, Maxim Y. Sinitsky, Aleksandr N. Stasev, Aleksandr N. Kokov, Natalia K. Brel, Evgenia O. Krivkina, Evgenia E. Bychkova, Roman S. Tarasov, Olga L. Barbarash
Summary: This study assessed the expression and secretion of adipocytokine genes in the adipose tissue of patients with coronary artery disease (CAD) and patients with aortic or mitral valve replacement. The results showed that epicardial fat depots in CAD patients exhibited more pronounced changes and increased pro-inflammatory activity compared to the group with heart defects.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Medicine, General & Internal
E. G. Uchasova, O. Gruzdeva, E. Belik, Yu A. Dyleva
BYULLETEN SIBIRSKOY MEDITSINY
(2020)
Article
Medicine, General & Internal
V. N. Karetnikova, V. V. Kalaeva, M. V. Evseeva, O. V. Gruzdeva, M. V. Zykov, V. V. Kashtalap, O. L. Barbarash
TERAPEVTICHESKII ARKHIV
(2019)
