Article
Pediatrics
Debra K. Katzman, Tim Guimond, Wendy Spettigue, Holly Agostino, Jennifer Couturier, Mark L. Norris
Summary: Evidence suggests that children and adolescents with avoidant/restrictive food intake disorder (ARFID) have heterogeneous clinical presentations. This study used latent class analysis (LCA) to identify three distinct classes in pediatric patients with ARFID: Acute Medical (AM), Lack of Appetite (LOA), and Sensory (S). The findings highlight the importance of recognizing these different presentations as clinical and treatment needs vary.
Article
Immunology
Xiao Zhuang, Bing Zhan, Yufeng Jia, Chaoze Li, Nan Wu, Ming Zhao, Nuo Chen, Yaxin Guo, Yingxin Du, Yi Zhang, Baihui Cao, Yan Li, Faliang Zhu, Chun Guo, Qun Wang, Yuan Li, Lining Zhang
Summary: Hyper-inflammatory reaction can activate anxiety circuits by suppressing BDNF and GABAergic neurons transmission.
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Article
Clinical Neurology
Fadi T. Maalouf, Riwa Haidar, Fatima Mansour, Martine Elbejjani, Joseph El Khoury, Brigitte Khoury, Lilian A. Ghandour
Summary: This study investigates the mental health impact of the Beirut Port explosion on children. The results show that approximately two thirds of the surveyed children are likely to have anxiety, over half are likely to have PTSD, and about one third are likely to have depression. Children who are farther away from the explosion site or were not in Beirut during the blast have lower odds of anxiety and PTSD. Children who sustained physical injuries or witnessed casualties have higher odds of PTSD. Children whose homes sustained minor damages, experienced temporary displacement, had poorer perceived economic status and academic performance, and had prior mental health care seeking have higher odds for all mental health disorders. The study highlights the importance of emergency mental health response, prioritizing disadvantaged communities and children with prior mental health problems.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Allergy
Diana Garcia-Sanchez, Darsy Darssan, Sheleigh P. Lawler, Christopher M. Warren, Adel De Klerk-Braasch, Nicholas J. Osborne
Summary: Asthma in children increases the risk of developing anxiety later in life, according to a long-term study of Australian children.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2023)
Article
Psychology, Multidisciplinary
Valerie Chevalier, Valerie Simard, Julie Achim, Pamela Burmester, Thalie Beaulieu-Tremblay
Summary: The study found that clinically anxious children and adolescents have adequate reflective functioning (RF), making them more sensitive to their own and others' mental states. Additionally, youths' self-reflective functioning was associated with maternal attachment preoccupation.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Neurosciences
Fantao Meng, Jing Liu, Juanjuan Dai, Haifeng Lian, Shujun Jiang, Qiongyu Li, Min Wu, Wentao Wang, Dan Wang, Di Zhao, Cuilan Liu, Changyun Qiu, Chen Li
Summary: This study revealed that PPM1F may regulate anxiety-related behaviors by modulating BDNF expression and H3S10 phosphorylation-mediated epigenetic modification, serving as potentially pathological genes associated with anxiety or other mental diseases.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Behavioral Sciences
Rabia Yilmaz, Didem Behice Oztop, Elif Funda Sener, Merve Cikili-Uytun, Fatma Dal, Emrah Yildiz, Musa Sahpolat, Gokmen Zararsiz
Summary: The study indicates that BDNF gene expression is more associated with psychiatric disorders rather than suicide attempt in children and adolescents. The suicide group showed significantly higher scores in problem-solving skills and childhood trauma experiences compared to the control group.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Public, Environmental & Occupational Health
Fengxiao Li
Summary: Student mental health has been significantly impacted by COVID-19, with students requiring greater discipline and motivation to complete online learning, and an increase in mental health issues.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Food Science & Technology
Lan Tang, Shengnan Li, Jie Yu, Yujie Zhang, Lilin Yang, Dayan Tong, Jie Xu
Summary: This study found that chronic exposure to nonylphenol (NP) can increase anxiety behavior in rats and reduce the expression of key proteins/genes in the BDNF/TrkB/CREB signaling network.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Oncology
Natalie A. Pride, Kristina M. Haebich, Karin S. Walsh, Francesca Lami, Melissa Rouel, Alice Maier, Anita K. Chisholm, Jennifer Lorenzo, Stephen J. C. Hearps, Kathryn N. North, Jonathan M. Payne
Summary: Difficulties in sensory processing are common in neurodevelopmental disorders and can significantly impact a child's functioning. This study aimed to explore sensory processing in children with NF1 and found that 61% of them showed differences in how they respond to sensory stimuli compared to typically developing children. These difficulties were associated with other neurodevelopmental issues and highlight the need for accommodations and support.
Article
Psychology, Clinical
Rebecca G. Etkin, Eli R. Lebowitz, Wendy K. Silverman
Summary: Anxiety disorders often greatly impair the functioning of youth in important areas. However, existing clinical research and assessment have not focused enough on measuring anxiety-related impairment. This article reviews the evidence for five rating scales of youth anxiety-related impairment, highlighting their potential utility and recommending their incorporation into clinical and research assessment processes.
Review
Psychology, Developmental
Arvid N. Kildahl, Sissel B. Helverschou, Anne L. Rysstad, Elisabeth Wigaard, Jane M. A. Hellerud, Linn B. Ludvigsen, Patricia Howlin
Summary: Diagnoses of pathological demand avoidance have been on the rise, but the issue remains controversial. Most studies rely on parental reports for symptom/diagnosis, with methodological limitations and little consideration of relationships with other disorders like anxiety. Further research is needed to explore these connections.
Article
Psychiatry
Pietro De Rossi, Barbara D'Aiello, Italo Pretelli, Deny Menghini, Silvia Di Vara, Stefano Vicari
Summary: This naturalistic study on 750 children and adolescents with ADHD found that ADHD symptoms were significantly higher in children than in adolescents. However, adolescents showed worse global functioning, lower adaptive skills, higher levels of anxiety and depressive symptoms, somatic complaints, emotional dysregulation, social problems, and aggression, despite having lower severity of ADHD-specific symptoms. These results suggest a potential course characterized by worsening of functioning, reduction in ADHD-specific symptoms, and increase in general psychopathology during the transition from childhood to adolescence, which should be confirmed in longitudinal observational studies of adequate sample size.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Cell Biology
Frideriki Poutoglidou, Chryssa Pourzitaki, Maria Eleni Manthou, Athanasios Saitis, Foteini Malliou, Dimitrios Kouvelas
Summary: Chronic treatment with infliximab and tocilizumab was found to reduce anxiety-like behavior, improve cognitive function, reverse neuropathological changes, as well as increase central BDNF expression in a juvenile arthritis rat model. These findings may have implications for addressing behavioral comorbidities associated with JIA in humans.
Review
Nutrition & Dietetics
Naara L. Godina-Flores, Yareni Yunuen Gutierrez-Gomez, Marcela Garcia-Botello, Lizet Lopez-Cruz, Carlos Francisco Moreno-Garcia, Magaly Aceves-Martins
Summary: This systematic review examines the association between obesity and mental health issues among Mexican children and adolescents. While the evidence regarding the association between obesity and anxiety is unclear, most studies indicate that Mexican children and adolescents with overweight or obesity are more likely to experience depression or report a higher number of depressive symptoms compared to those with normal weight, especially among females.
Article
Psychiatry
Leticia Sanguinetti Czepielewski, Marcia Kaurer-Sant Anna, Flavio Kapczinski, Joana Bucker
EUROPEAN JOURNAL OF PSYCHIATRY
(2023)
Article
Neurosciences
Natividade de Sa Couto Pereira, Querusche Klippel Zanona, Marcelo Pastore Bernardi, Joelma Alves, Carla Dalmaz, Maria Elisa Calcagnotto
Summary: Maternal separation in male rats can lead to resistant memory labilization in adulthood. The desynchronization between the dorsal hippocampus and the basolateral amygdala during fear memory reactivation may be responsible for this impairment.
JOURNAL OF NEUROSCIENCE RESEARCH
(2023)
Article
Psychology, Clinical
Marina S. Borges, Mauricio S. Hoffmann, Andre Simioni, Luiza K. Axelrud, Danielle S. Teixeira, Andre Zugman, Andrea Jackowski, Pedro M. Pan, Rodrigo A. Bressan, Nadine Parker, Jurgen Germann, Patricia P. Bado, Theodore D. Satterthwaite, Michael P. Milham, M. Mallar Chakravarty, Luis Augusto Paim Rohde, Euripedes Constantino Miguel, Tomas Paus, Giovanni A. Salum
Summary: This study investigates the relationship between deviations in cerebellar volume and psychopathology, executive functions, and academic achievement in children and adolescents. The findings suggest that deviations in typical cerebellar development are associated with long-lasting consequences in youth. This study highlights the potential of typical developing models and emphasizes the important role of the cerebellum in mental health, cognition, and education.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychology, Developmental
Arielle S. Keller, Allyson P. Mackey, Adam Pines, Damien Fair, Eric Feczko, Mauricio S. Hoffman, Giovanni A. Salum, Ran Barzilay, Theodore D. Satterthwaite
Summary: Individual differences in cognitive abilities emerge early and caregiving behaviors play an important role in shaping youth cognition. This large-scale study found a positive association between child reports of caregiver monitoring and general cognition abilities, which partially mediated the relationship between household income and cognition.
DEVELOPMENTAL SCIENCE
(2023)
Article
Behavioral Sciences
Joao Ricardo Sato, Claudinei Eduardo Biazoli, Ana Paula Arantes Bueno, Arthur Caye, Pedro Mario Pan, Marcos Santoro, Jessica Honorato-Mauer, Giovanni Abrahao Salum, Marcelo Queiroz Hoexter, Rodrigo Affonseca Bressan, Andrea Parolin Jackowski, Euripedes Constantino Miguel, Sintia Belangero, Luis Augusto Rohde
Summary: Neuroimaging studies suggest that brain development mechanisms may explain some ADHD symptoms. However, the mechanisms by which genetic factors influence brain development in relation to ADHD remain largely unknown. This study aimed to investigate the associations between an ADHD polygenic risk score and brain network functioning. The findings suggest correlations between the ADHD polygenic risk score and the segregation of cingulo-opercular networks and the default mode network, supporting the role of attentional networks and DMN in attention processes. However, these associations were not found at follow-up.
GENES BRAIN AND BEHAVIOR
(2023)
Article
Psychiatry
Catarina Rodrigues Cordeiro, Beatriz Romao Corte-Real, Rodrigo Saraiva, Benicio N. Frey, Flavio Kapczinski, Taiane de Azevedo Cardoso
Summary: This systematic review aimed to identify triggers of acute mood episodes in bipolar disorder (BD). The review found that pharmacotherapy, particularly the use of antidepressants, was the trigger with the strongest evidence for manic/hypomanic relapse. Other identified triggers for mania included brain stimulation, energy drinks, acetyl-lcarnitine, St. John's wort, seasonal changes, hormonal changes, and viral infections. However, there is a lack of evidence regarding triggers for depressive relapses in BD, highlighting the need for further research in this area.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Article
Psychiatry
Thiago Henrique Roza, Francisco Diego Rabelo-da-Ponte, Daniel Tornaim Spritzer, Mauricio Scopel Hoffmann, Raffael Massuda, Giovanni Abrahao Salum, Euripedes Constantino Miguel, Luis Augusto Rohde, Pedro Mario Pan, Felix Henrique Paim Kessler, Ary Gadelha, Ives Cavalcante Passos
Summary: This study aimed to investigate the relationship between maternal depression in childhood and problematic gaming in late adolescence/young adulthood. Data from a large Brazilian school-based cohort were collected and analyzed, and it was found that maternal depression in childhood was significantly associated with problematic gaming in later developmental stages, partially mediated by internalizing psychopathology.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Article
Psychiatry
Jennifer E. Siegel-Ramsay, Bryan Wu, Flavio Kapczinski, Teresa Lanza di Scalea, Spelber David, Benicio N. Frey, Stephen M. Strakowski, Jorge R. C. Almeida
Summary: The Functional Assessment Short Test (FAST) is a validated clinician-administered assessment scale for measuring psychosocial dysfunction in individuals with bipolar disorder. This study found significant positive correlations between self-report and clinician-administered FAST scores, supporting the use of FAST as a self-report scale. The self-report application of FAST will increase its utility in busy clinical workflows and contribute to comprehensive clinical assessments and interventions.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Article
Neurosciences
Patricia Pelufo Silveira, Michael J. Meaney
Summary: We explore how integrating datasets from different species can help us understand the impact of gene-environment interactions on mental disorders. We discuss various levels of gene expression regulation and the corresponding data available in humans. We also highlight the importance of multilevel integration of diverse types of data in improving vulnerability detection and informing preventive and therapeutic interventions.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Pediatrics
Angela M. Jaramillo-Ospina, Gabriel T. Roman, Danitsa M. Rodrigues, Sachin Patel, Irina Pokhvisneva, Valentina G. Chakr, Robert D. Levitan, Michael J. Meaney, Patricia P. Silveira
Summary: This study examined the relationship between the genetic background associated with increased production of omega-3 PUFA and eating behaviors in infants with intrauterine growth restriction (IUGR). The findings suggest that a higher genetic score for omega-3 PUFA is associated with a decreased risk of eating behavior alterations in infants born IUGR, while a higher genetic score for the omega-6/omega-3 PUFA ratio increases the risk of eating behavior alterations.
PEDIATRIC RESEARCH
(2023)
Article
Neurosciences
Sondos Ayyash, Aleeza Sunderji, Heather D. Gallant, Alexander Hall, Andrew D. Davis, Irina Pokhvisneva, Michael J. Meaney, Patricia Pelufo Silveira, Roberto B. Sassi, Geoffrey B. Hall
Summary: This study investigates the impact of poor maternal mental health and socioeconomic context during the perinatal period on network connectivity in middle childhood using an anatomically weighted functional connectivity (awFC) approach. The results indicate that maternal adversity during the perinatal period can affect offspring's resting-state network connectivity during middle childhood, particularly in the ventral attention network. These findings highlight the importance of considering both structural and functional imaging data in studying network maturation.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Neurosciences
Danusa Mar Arcego, Jan-Paul Buschdorf, Nicholas O'Toole, Zihan Wang, Barbara Barth, Irina Pokhvisneva, Nirmala Arul Rayan, Sachin Patel, Euclides Jose de Mendonca Filho, Patrick Lee, Jennifer Tan, Ming Xuan Koh, Chu Ming Sim, Carine Parent, Randriely Merscher Sobreira de Lima, Andrew Clappison, Kieran J. O'Donnell, Carla Dalmaz, Janine Arloth, Nadine Provencal, Elisabeth B. Binder, Josie Diorio, Patricia Pelufo Silveira, Michael J. Meaney
Summary: This study investigates the impact of environmental influences on mental health by integrating transcriptomic data from animal models with human data. The results suggest that hippocampal glucocorticoid-related transcriptional activity mediates the effects of early adversity on neural mechanisms implicated in psychiatric disorders.
BIOLOGICAL PSYCHIATRY
(2024)
Review
Clinical Neurology
Beatriz Corte-Real, Rodrigo Saraiva, Catarina Rodrigues Cordeiro, Benicio N. Frey, Flavio Kapczinski, Taiane de Azevedo Cardoso
Summary: The study aimed to investigate whether atypical antipsychotics (AA) can induce mania in mood disorders. A systematic review and meta-analysis showed that AA-induced mania is rare and the use of AA is more effective in preventing the development of mania compared to placebo.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Public, Environmental & Occupational Health
Aashita Batra, Santiago Cuesta, Marcio Bonesso Alves, Jose Maria Restrepo, Michel Giroux, Daniela Pereira Laureano, Amanda Brondani Mucellini Lovato, Patricia Maidana Miguel, Tania Diniz Machado, Roberta Dalle Molle, Cecilia Flores, Patricia Pelufo Silveira
Summary: Fetal restriction affects insulin sensitivity and may impact the development of the dopamine system and related behaviors. The Netrin-1/DCC system is involved in the maturation of the DA circuitry. This study found that FR downregulates Netrin-1 levels at birth and affects Dcc expression in response to insulin in adult rodents, possibly through miR-218 regulation.
JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE
(2023)
Article
Pediatrics
Gabriele Luiza Caprara, Otavio von Ameln Lovison, Andreza Francisco Martins, Juliana Rombaldi Bernardi, Marcelo Zubaran Goldani
Summary: This study investigated the transfer of gut microbiota from mother to newborn. The analysis of maternal and newborn samples revealed a correlation between the gut microbiota of mothers and infants, indicating evidence of specific transfer. Vaginal delivery showed a positive impact on the transfer of microbiota, while cesarean section had a negative impact.
EUROPEAN JOURNAL OF PEDIATRICS
(2023)