期刊
LIPIDS IN HEALTH AND DISEASE
卷 13, 期 -, 页码 -出版社
BMC
DOI: 10.1186/1476-511X-13-136
关键词
Apolipoprotein E; Adipocyte; Triglyceride; Receptor-mediated endocytosis
资金
- National Natural Science Foundation of China [81270956]
- Hunan Provincial Natural Science Foundation of China [10JJ1008, 11JJ7005]
- Program for Changjiang Scholars and Innovative Research Team in University [IRT1195]
Excessive energy storage of adipose tissue makes contribution to the occurrence and progression of obesity, which accompanies with multiple adverse complications, such as metabolic syndrome, cardiovascular diseases. It is well known that apolipoprotein E, as a component of lipoproteins, performs a key role in maintaining plasma lipoproteins homeostasis. Interestingly, apolipoprotein E is highly expressed in adipocyte and has positive relation with body fat mass. Apolipoprotein E knock-out mice show small fat mass compared to wild type mice. Moreover, adipocyte deficiency in apolipoprotein E shows impaired lipoproeteins internalization and triglyceride accumulation. Apolipopreotein E-deficient lipoproteins can not induce preadipocyte to form round full-lipid adipocyte, whereas apolipoprotein E-containing lipoproteins can. This article mainly reviews the modulation of apolipoprotein E synthesized by adipocyte and apolipoprotein E carried on lipoproteins in adipocyte triglyceride content.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据