Article
Medicine, Research & Experimental
Fatemeh Koohi, Davood Khalili, Mohammad Ali Mansournia, Farzad Hadaegh, Hamid Soori
Summary: The study identified seven distinct multi-trajectories of blood lipid levels and found that individuals with rising triglyceride levels over time, even with optimal LDL-C levels, faced a significantly increased risk of cardiovascular disease. Despite the decline in LDL-C levels, there remained a considerable residual risk for CVD, emphasizing the importance of monitoring and potentially lowering triglyceride concentrations to reduce this risk.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Clinical Neurology
Zhirong Yang, Duncan Edwards, Stephen Burgess, Carol Brayne, Jonathan Mant
Summary: This study investigated the potential associations between blood LDL-C, HDL-C, and triglycerides and post-stroke dementia. The results showed that higher LDL-C levels were associated with an increased risk of dementia, while lower triglyceride levels were associated with a decreased risk. There was no association between HDL-C levels and dementia.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Obstetrics & Gynecology
Maria C. Adank, Anja K. Johansen, Laura Benschop, Sophia P. Van Streun, Anna M. Smak Gregoor, Linn K. L. Oyri, Monique T. Mulder, Eric A. P. Steegers, Kirsten B. Holven, Jeanine E. Roeters van Lennep
Summary: Maternal lipid levels in early pregnancy are positively associated with childhood lipid levels in offspring, independent of maternal BMI and diet. This suggests that gestational lipid levels can be used as an early predictor of children's long-term health.
BMC PREGNANCY AND CHILDBIRTH
(2022)
Article
Endocrinology & Metabolism
Xiaoyu Wang, Chenhao Zhao, Hongliang Feng, Guohua Li, Lei He, Lulu Yang, Yan Liang, Xiao Tan, Yanmin Xu, Ruixiang Cui, Yujing Sun, Sheng Guo, Guoan Zhao, Jihui Zhang, Sizhi Ai
Summary: This study finds that more frequent insomnia symptoms are significantly associated with insulin resistance (IR) and its related traits. These findings suggest that insomnia symptoms can serve as a promising target for improving IR and preventing type 2 diabetes (T2D).
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Review
Biochemistry & Molecular Biology
Saeed Aslani, Bahman Razi, Danyal Imani, Keyhan Mohammadi, Tannaz Jamialahmadi, Zeljko Reiner, Amirhossein Sahebkar
Summary: A systematic review and meta-analysis showed that statin therapy effectively lowered levels of total cholesterol, LDL-C, and TG, and increased levels of HDL-C in patients with different CVDs.
CURRENT MEDICINAL CHEMISTRY
(2023)
Article
Oncology
Pik-Fang Kho, Frederic Amant, Daniela Annibali, Katie Ashton, John Attia, Paul L. Auer, Matthias W. Beckmann, Amanda Black, Louise Brinton, Daniel D. Buchanan, Stephen J. Chanock, Chu Chen, Maxine M. Chen, Timothy H. T. Cheng, Linda S. Cook, Marta Crous-Bous, Kamila Czene, Immaculata De Vivo, Joe Dennis, Thilo Doerk, Sean C. Dowdy, Alison M. Dunning, Matthias Duerst, Douglas F. Easton, Arif B. Ekici, Peter A. Fasching, Brooke L. Fridley, Christine M. Friedenreich, Montserrat Garcia-Closas, Mia M. Gaudet, Graham G. Giles, Ellen L. Goode, Maggie Gorman, Christopher A. Haiman, Per Hall, Susan E. Hankinson, Alexander Hein, Peter Hillemanns, Shirley Hodgson, Erling A. Hoivik, Elizabeth G. Holliday, David J. Hunter, Angela Jones, Peter Kraft, Camilla Krakstad, Diether Lambrechts, Loic Le Marchand, Xiaolin Liang, Annika Lindblom, Jolanta Lissowska, Jirong Long, Lingeng Lu, Anthony M. Magliocco, Lynn Martin, Mark McEvoy, Roger L. Milne, Miriam Mints, Rami Nassir, Geoffrey Otton, Claire Palles, Loreall Pooler, Tony Proietto, Timothy R. Rebbeck, Stefan P. Renner, Harvey A. Risch, Matthias Ruebner, Ingo Runnebaum, Carlotta Sacerdote, Gloria E. Sarto, Fredrick Schumacher, Rodney J. Scott, V. Wendy Setiawan, Mitul Shah, Xin Sheng, Xiao-Ou Shu, Melissa C. Southey, Emma Tham, Ian Tomlinson, Jone Trovik, Constance Turman, Jonathan P. Tyrer, David van den Berg, Zhaoming Wang, Nicolas Wentzensen, Lucy Xia, Yong-Bing Xiang, Hannah P. Yang, Herbert Yu, Wei Zheng, Penelope M. Webb, Deborah J. Thompson, Amanda B. Spurdle, Dylan M. Glubb, Tracy A. O'Mara
Summary: This study used Mendelian randomization analysis to investigate the relationship between blood lipids and endometrial cancer risk. Genetically elevated LDL cholesterol levels were associated with reduced risk of endometrial cancer, while higher predicted HDL cholesterol levels were linked to increased risk of non-endometrioid endometrial cancer. Obesity may influence these associations, but triglycerides showed no evidence of involvement in endometrial cancer development.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Nutrition & Dietetics
Monika Lund Machlik, Laila Arnesdatter Hopstock, Tom Wilsgaard, Patrik Hansson
Summary: The study aimed to investigate the associations between different types of fermented dairy products and blood lipid concentrations. Results showed that cheese intake was positively associated with HDL-C, and inversely associated with LDL-C and triglycerides, while total intake of fermented dairy products was inversely associated with triglycerides. Yogurt intake showed no significant associations with blood lipids.
FRONTIERS IN NUTRITION
(2021)
Article
Public, Environmental & Occupational Health
Susana Cararo Confortin, Liliana Yanet Gomez Aristizabal, Elma Izze da Silva Magalhaes, Aline Rodrigues Barbosa, Cecilia Claudia Costa Ribeiro, Rosangela Fernandes Lucena Batista, Antonio Augusto Moura da Silva
Summary: There is no association between sleep duration and cardiometabolic risk factors in adolescents.
Review
Pharmacology & Pharmacy
Changyu Lv, Wencui Zhang, Xia Tan, Xianping Shang, Mihnea-Alexandru Gaman, Hany Salem, Ahmed Abu-Zaid, Xiaohong Wang
Summary: Tibolone treatment decreases total cholesterol, high-density lipoprotein cholesterol, and triglyceride levels, with a significant reduction in low-density lipoprotein cholesterol observed when administered for <= 26 weeks. The decrease in triglyceride and total cholesterol concentrations is more pronounced in patients with a BMI >= 25 kg/m(2).
PHARMACOLOGICAL RESEARCH
(2021)
Article
Geriatrics & Gerontology
Sylvia E. Badon, Kelley Pettee Gabriel, Carrie Karvonen-Gutierrez, Barbara Sternfeld, Ellen B. Gold, L. Elaine Waetjen, Catherine Lee, Lyndsay A. Avalos, Samar R. El Khoudary, Monique M. Hedderson
Summary: Most women in midlife exhibited low trajectories of physical activity and blood lipid levels. Although no clear association was found between long-term trajectories of physical activity and blood lipids in this study, the importance of promoting regular and sustained physical activity for midlife women to achieve cardiovascular and metabolic benefits was highlighted.
Article
Nutrition & Dietetics
Vittoria Carmela Danese, Jessica Pepe, Federica Ferrone, Luciano Colangelo, Viviana De Martino, Luciano Nieddu, Giancarlo Ferrazza, Enrico Panzini, Roberto Pascone, Frank Blocki, Salvatore Minisola, Cristiana Cipriani
Summary: The study investigates the relationship between bone, glucose, and lipid metabolism. Hypovitaminosis D leads to worsening lipid profiles through PTH, while higher PTH levels are associated with elevated glucose and LDL-C levels.
Review
Nutrition & Dietetics
Yixue Yang, Shoumeng Yan, Nan Yao, Yinpei Guo, Han Wang, Mengzi Sun, Wenyu Hu, Xiaotong Li, Ling Wang, Bo Li
Summary: This meta-analysis examined the impact of vitamin D supplementation on blood lipid levels in prediabetic individuals. The results showed that vitamin D intervention significantly reduced triglyceride levels, especially among obese individuals, males, and studies with intervention durations longer than 1 year. Both low and high doses of vitamin D supplementation were effective in reducing triglyceride levels, and this effect was observed in both Northern Europe and Asian countries. However, no significant effects were found on total cholesterol, HDL cholesterol, and LDL cholesterol levels.
FRONTIERS IN NUTRITION
(2023)
Review
Biochemistry & Molecular Biology
Julia Nowowiejska, Anna Baran, Iwona Flisiak
Summary: Psoriasis is a common skin disease affecting about 1%-3% of the general population, often accompanied by cardiometabolic disorders. Research indicates that lipid expression and metabolism disorders are more common in psoriatic patients, playing a significant role in the pathogenesis of psoriasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Rami A. Ballout, Hyesik Kong, Maureen Sampson, James D. Otvos, Andrea L. Cox, Sean Agbor-Enoh, Alan T. Remaley
Summary: There is a complex relationship between plasma lipoproteins and inflammation, especially in the context of diseases like atherosclerosis and respiratory viral infections. Severe COVID-19 patients exhibit altered plasma lipoprotein levels, including reduced HDL particles and increased triglyceride-rich lipoprotein particles, along with elevated levels of GlycA, branched-chain amino acids, and beta-hydroxybutyrate. Additionally, elevated levels of lipoproteins X and Z, markers of hepatic dysfunction, were detected in most participants, indicating a potential novel finding in this study.
Article
Medicine, General & Internal
Jakub Ratajczak, Aldona Kubica, Piotr Michalski, Lukasz Pietrzykowski, Aleksandra Bialczyk, Agata Kosobucka-Ozdoba, Katarzyna Bergmann, Krzysztof Buczkowski, Magdalena Krintus, Piotr Jankowski, Jacek Kubica
Summary: In this cross-sectional study of 200 primary care patients without diagnosed cardiovascular disease, age, diabetes, material status, BMI, gender, and hypertension were found to be related to abnormal lipid parameters.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Yoichi Imori, Ken Kato, Victoria L. Cammann, Konrad A. Szawan, Manfred Wischnewsky, Sara Dreiding, Michael Wuerdinger, Maximilian Schoenberger, Vanya Petkova, David Niederseer, Rena A. Levinson, Davide Di Vece, Sebastiano Gili, Burkhardt Seifert, Masaki Wakita, Noriko Suzuki, Rodolfo Citro, Eduardo Bossone, Susanne Heiner, Maike Knorr, Thomas Jansen, Thomas Muenzel, Fabrizio D'Ascenzo, Jennifer Franke, Ioana Sorici-Barb, Hugo A. Katus, Annahita Sarcon, Jerold Shinbane, L. Christian Napp, Johann Bauersachs, Milosz Jaguszewski, Reiko Shiomura, Shunichi Nakamura, Hitoshi Takano, Michel Noutsias, Christof Burgdorf, Iwao Ishibashi, Toshiharu Himi, Wolfgang Koenig, Heribert Schunkert, Holger Thiele, Behrouz Kherad, Carsten Tschope, Burkert M. Pieske, Lawrence Rajan, Guido Michels, Roman Pfister, Shingo Mizuno, Alessandro Cuneo, Claudius Jacobshagen, Gerd Hasenfuss, Mahir Karakas, Hiroki Mochizuki, Alexander Pott, Wolfgang Rottbauer, Samir M. Said, Ruediger C. Braun-Dullaeus, Adrian Banning, Toshiaki Isogai, Akihisa Kimura, Florim Cuculi, Richard Kobza, Thomas A. Fischer, Tuija Vasankari, K. E. Juhani Airaksinen, Yasuhiro Tomita, Monika Budnik, Grzegorz Opolski, Rafal Dworakowski, Philip MacCarthy, Christoph Kaiser, Stefan Osswald, Leonarda Galiuto, Filippo Crea, Wolfgang Dichtl, Tsutomu Murakami, Yuji Ikari, Klaus Empen, Daniel Beug, Stephan B. Felix, Clement Delmas, Olivier Lairez, Tetsuo Yamaguchi, Ibrahim El-Battrawy, Ibrahim Akin, Martin Borggrefe, John D. Horowitz, Martin Kozel, Petr Tousek, Petr Widimsky, Ekaterina Gilyarova, Alexandra Shilova, Mikhail Gilyarov, Michael Neuhaus, Philippe Meyer, Jose David Arroja, Christina Chan, Paul Bridgman, Jan Galuszka, Gregor Poglajen, Pedro Carrilho-Ferreira, Fausto J. Pinto, Christian Hauck, Lars S. Maier, Kan Liu, Carlo Di Mario, Carla Paolini, Claudio Bilato, Matteo Bianco, Lucas Joerg, Hans Rickli, David E. Winchester, Christian Ukena, Michael Boehm, Jeroen J. Bax, Abhiram Prasad, Charanjit S. Rihal, Shigeru Saito, Yoshio Kobayashi, Thomas F. Luscher, Frank Ruschitzka, Wataru Shimizu, Jelena R. Ghadri, Christian Templin
Summary: This study compared clinical characteristics and in-hospital outcomes between Japanese and European takotsubo syndrome (TTS) patients, revealing differences in triggers and outcomes between the two ethnic groups. Despite worse in-hospital outcomes for Japanese patients, ethnicity itself does not appear to impact TTS patient outcomes. Machine learning analysis identified physical stressors as the most important prognostic factor for both Japanese and European TTS patients.
CLINICAL RESEARCH IN CARDIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Cornelia Then, Christian Herder, Barbara Thorand, Chaterina Sujana, Margit Heier, Christa Meisinger, Annette Peters, Wolfgang Koenig, Wolfgang Rathmann, Michael Roden, Michael Stumvoll, Haifa Maalmi, Holger Then, Uta Ferrari, Juergen Scherberich, Jochen Seissler
Summary: This study found that serum uromodulin is inversely associated with pro-inflammatory adipokines chemerin and retinol-binding protein-4. The association is stronger in participants with type 2 diabetes, but the association of uromodulin with type 2 diabetes is independent of chemerin and retinol-binding protein-4.
Article
Cardiac & Cardiovascular Systems
Chaterina Sujana, Veikko Salomaa, Frank Kee, Jochen Seissler, Pekka Jousilahti, Charlotte Neville, Cornelia Then, Wolfgang Koenig, Kari Kuulasmaa, Jaakko Reinikainen, Stefan Blankenberg, Tanja Zeller, Christian Herder, Ulrich Mansmann, Annette Peters, Barbara Thorand
Summary: The study found that higher concentrations of CT-proET-1 and MR-proADM are associated with incident type 2 diabetes, especially in obese individuals. Mendelian randomisation analysis suggests a probable causal link for CT-proET-1.
CARDIOVASCULAR DIABETOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Jean Claude Tardif, Marc A. Pfeffer, Simon Kouz, Wolfgang Koenig, Aldo P. Maggioni, John J. McMurray, Vincent Mooser, David D. Waters, Jean C. Gregoire, Philippe L. L'Allier, J. Wouter Jukema, Harvey D. White, Therese Heinonen, Donald M. Black, Fouzia Laghrissi-Thode, Sylvie Levesque, Marie Claude Guertin, Marie Pierre Dube, Dal-GenE Investigators
Summary: The dal-GenE study aimed to test the pharmacogenetic hypothesis that the effect of dalcetrapib on cardiovascular events is influenced by an ADCY9 gene polymorphism. However, the study found that dalcetrapib did not significantly reduce the risk of occurrence of ischemic cardiovascular events. Further trials are needed to investigate the effect of dalcetrapib on patients with the AA genotype.
EUROPEAN HEART JOURNAL
(2022)
Article
Transplantation
Xinting Cai, Barbara Thorand, Simon Hohenester, Wolfgang Koenig, Wolfgang Rathmann, Annette Peters, Jana Nano
Summary: This German cohort study aimed to evaluate the relationship between fatty liver and kidney function/chronic kidney disease (CKD). The study found that fatty liver is associated with kidney function and CKD, and this association is partially mediated by metabolic factors such as inflammation, diabetes, and hypertension.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Review
Cardiac & Cardiovascular Systems
Natalie Arnold, Wolfgang Koenig
Summary: This review critically summarizes the emerging cholesterol-lowering therapy targeting PCSK9, with a focus on the use of anti-PCSK9 monoclonal antibodies (mAbs) and inclisiran. Although both drug classes show similar efficacy in reducing LDL-C levels, the long-term safety and CV outcomes of inclisiran are still unknown.
CURRENT CARDIOLOGY REPORTS
(2022)
Article
Cardiac & Cardiovascular Systems
Wolfgang Koenig, Lorena Garcia Conde, Ulf Landmesser, Lawrence A. Leiter, Kausik K. Ray, Gregory G. Schwartz, R. Scott Wright, Jackie Han, Frederick J. Raal
Summary: This study analyzed the lipid-lowering efficacy and safety of inclisiran versus placebo in patients with and without polyvascular disease (PVD). The results showed that twice-yearly inclisiran dosing effectively reduced LDL-C levels and was well tolerated in patients, irrespective of PVD status.
CARDIOVASCULAR DRUGS AND THERAPY
(2022)
Article
Cardiac & Cardiovascular Systems
Betul Toprak, Stephanie Brandt, Jan Brederecke, Francesco Gianfagna, Julie K. K. Vishram-Nielsen, Francisco M. Ojeda, Simona Costanzo, Christin S. Borschel, Stefan Soderberg, Ioannis Katsoularis, Stephan Camen, Erkki Vartiainen, Maria Benedetta Donati, Jukka Kontto, Martin Bobak, Ellisiv B. Mathiesen, Allan Linneberg, Wolfgang Koenig, Maja-Lisa Lochen, Augusto Di Castelnuovo, Stefan Blankenberg, Giovanni de Gaetano, Kari Kuulasmaa, Veikko Salomaa, Licia Iacoviello, Teemu Niiranen, Tanja Zeller, Renate B. Schnabel
Summary: The study aims to find reliable circulating predictors for incident atrial fibrillation (AF) using classical regressions and machine learning techniques. Fourteen routinely available biomarkers reflecting different pathophysiological pathways were examined in relation to incident AF. NT-proBNP was identified as the strongest blood-based predictor of incident AF.
Article
Cardiac & Cardiovascular Systems
Kausik K. Ray, Frederick J. Raal, David G. Kallend, Mark J. Jaros, Wolfgang Koenig, Lawrence A. Leiter, Ulf Landmesser, Gregory G. Schwartz, David Lawrence, Andrew Friedman, Lorena Garcia Conde, R. Scott Wright
Summary: Exploratory findings from the ORION trials suggest that treatment with inclisiran is associated with reductions in major cardiovascular events, providing potential cardiovascular benefits.
EUROPEAN HEART JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Qiuling Dong, Sidra Sidra, Christian Gieger, Rui Wang-Sattler, Wolfgang Rathmann, Cornelia Prehn, Jerzy Adamski, Wolfgang Koenig, Annette Peters, Harald Grallert, Sapna Sharma
Summary: Obesity is closely related to insulin resistance and diabetes, but the specific molecular mechanism that links these conditions remains unclear. This study analyzed the metabolomic profiles of a cohort of 1715 participants and found significant associations between certain metabolites and both obesity and type 2 diabetes. Further analysis suggested that lipids such as sphingomyelin and diacylphosphatidylcholine may mediate the effect of obesity on diabetes. Additionally, genetic research and experiments with mice supported the hypothesis that changes in sphingolipid and phosphatidylcholine metabolism contribute to the development of early-stage type 2 diabetes.
Letter
Hematology
Jordan M. Kraaijenhof, Tjerk S. J. Opstal, Jan H. Cornel, Dipender Gill, G. Kees Hovingh, Alberico L. Catapano, Wolfgang Koenig, Paul M. Ridker, Erik S. G. Stroes, Nick S. Nurmohamed
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Nick S. Nurmohamed, Jordan M. Kraaijenhof, Manuel Mayr, Stephen J. Nicholls, Wolfgang Koenig, Alberico L. Catapano, Erik S. G. Stroes
Summary: Given the limited accuracy of clinically used risk scores, novel risk algorithms based on proteomics and lipidomics data could provide more reliable ASCVD risk prediction. Retrospective studies have consistently shown the additive prognostic value of these panels over traditional risk scores, and prospective studies are needed to determine their clinical utility.
EUROPEAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Paul M. Haller, Alina Gossling, Christina Magnussen, Hermann Brenner, Ben Schoettker, Licia Iacoviello, Simona Costanzo, Frank Kee, Wolfgang Koenig, Allan Linneberg, Chaterina Sujana, Barbara Thorand, Veikko Salomaa, Teemu J. Niiranen, Stefan Soederberg, Henry Voelzke, Marcus Doerr, Susana Sans, Teresa Padro, Stephan B. Felix, Matthias Nauck, Astrid Petersmann, Luigi Palmieri, Chiara Donfrancesco, Roberto De Ponti, Giovanni Veronesi, Marco M. Ferrario, Kari Kuulasmaa, Tanja Zeller, Francisco M. Ojeda, Stefan Blankenberg, Dirk Westermann
Summary: This study demonstrates the role of cardiac biomarkers in predicting cardiovascular events and death in both general population and individuals with known diabetes. The findings suggest that these biomarkers can help identify individuals at highest risk for cardiovascular events and improve early identification of high-risk individuals. Therefore, they should be considered for routine risk assessment and can enhance the initiation of preventive therapies.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Wolfgang Koenig, Elke S. Lorenz, Lea Beier, Ioanna Gouni-Berthold
Summary: This study investigated the real-world persistence and adherence to lipid-lowering therapies in German patients with cardiovascular disease. The findings showed low persistence and adherence rates, especially in women. The study also found that patients who discontinued treatment had a relatively short average treatment duration, and only about 10% of patients persisted in medication for more than 300 days. Overall, the persistence rates with lipid-lowering therapies were low at 36 months.
CLINICAL RESEARCH IN CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Julia Karady, Thomas Mayrhofer, James L. Januzzi, James E. Udelson, Jerome L. Fleg, Bela Merkely, Michael T. Lu, William F. Peacock, John T. Nagurney, Wolfgang Koenig, Maros Ferencik, Udo Hoffmann
Summary: This study aimed to determine the concordance of different high-sensitivity cardiac troponin (hs-cTn) assays in risk stratification for cardiovascular disease and compare the differences in patient management, cost, and predicted quality of care.
EUROPEAN HEART JOURNAL-ACUTE CARDIOVASCULAR CARE
(2023)