Article
Medical Laboratory Technology
Chun Gu, Na Wang, Peng Ren, Xuemei Wu, Bo Pang, Shuying Zhang, Xueyun Hou, Dan Xu, Yuliang Yuan, Guijian Liu
Summary: The study shows that postprandial lipoprotein subclass concentrations can effectively stratify cardiovascular disease risk. In the intermediate/high-risk FRS group, levels of fasting and postprandial VLDL1 + 2 and RLP, as well as postprandial LDL4 and VLDL3, were significantly higher than in the low-risk group.
CLINICAL BIOCHEMISTRY
(2021)
Article
Nutrition & Dietetics
Elise Grytten, Johnny Laupsa-Borge, Pavol Bohov, Bodil Bjorndal, Elin Strand, Jon Skorve, Jan Erik Nordrehaug, Rolf K. Berge, Espen Rostrup, Gunnar Mellgren, Simon N. Dankel, Ottar K. Nygard
Summary: The high-dose supplementation of n-3 (EPA + DHA) or n-6 (LA) PUFAs led to reductions in TAG- or cholesterol-related markers, respectively, indicating potential benefits for cardiometabolic risk reduction, even among individuals with normal TAG or LDL-C levels.
CLINICAL NUTRITION
(2021)
Article
Biophysics
Jianfang Cao, Peiying Lv, Yang Shu, Jianhua Wang
Summary: A multiplexed sensor platform combined with an encoder system is introduced for accurate analysis of multiple lipoproteins in complex matrix, achieving highly facile and precise identification for lipoprotein subclasses. The system can accurately identify LDL at 0.05-37.5 μg/mL and 11 typical proteins including three lipoprotein subclasses in human serum, as well as different molar ratios of lipoprotein subclasses from real clinical serum samples.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Biotechnology & Applied Microbiology
Hongjuan Tang, Zhicong Xiang, Longyu Li, Xiaofei Shao, Qin Zhou, Xu You, Chongxiang Xiong, Jing Ning, Tong Chen, David Deng, Hequn Zou
Summary: The study found that with the deterioration of metabolic disease, the distribution of HDL subclasses and related structural proteins also changed, while lymphocytes and inflammation factors gradually increased. The level of HDL2b was negatively associated with WBC, lymphocytes, and hs-CRP, and high levels of HDL3 and low levels of HDL2b increased the probability of having an unfavorable metabolic unhealth/obesity status. This suggests that HDL2b particles may play an anti-inflammatory role by negatively regulating lymphocyte activation and could be a potential therapeutic target for future metabolic diseases.
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
(2021)
Article
Medical Laboratory Technology
Bertrand Lefrere, Emmanuel Curis, Randa Bittar, Antoine Levasseur, Pierre Gres, Zoe Guilbert, Belkacem Zenati, Corinne Cherfils, Mehdi Sakka, Dominique Bonnefont-Rousselot
Summary: Chylous abdominal effusions are serious complications that can be triggered by various causes. The detection of chylomicrons in ascites or in peritoneal fluid capsules is the biochemical diagnosis of chyle leakage. Assaying the concentration of triglycerides in the fluid is the first-line tool. This study aimed to provide practical triglyceride thresholds for diagnosing chylous ascites in humans.
Article
Biochemistry & Molecular Biology
Saska Djekic, Jelena Vekic, Aleksandra Zeljkovic, Jelena Kotur-Stevuljevic, Srdjan Kafedzic, Marija Zdravkovic, Ivan Ilic, Sasa Hinic, Milivoje Cerovic, Milica Stefanovic, Marija Mihajlovic, Aleksandar Neskovic, Natasa Bogavac-Stanojevic
Summary: The aim of this study was to assess the impacts of oxidative stress, inflammation, and the presence of sdLDL on the antioxidative function of HDL subclasses and the distribution of PON1 activity within HDL in patients with STEMI. The results showed significant differences in the proportions of HDL subclasses and the distribution of PON1 in STEMI patients compared to the control group. There were positive associations between sdLDL and PON1 activity within HDL subclasses. The increased oxidative stress and sdLDL in STEMI patients are closely related to the compromised antioxidative function of small HDL3 particles and the altered PON1 distribution within HDL.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Elena Grao-Cruces, Alejandro Santos-Mejias, Ignacio Ortea, Elvira Marquez-Paradas, Maria E. Martin, Sergio Barrientos-Trigo, Beatriz Bermudez, Sergio Montserrat-de la Paz
Summary: This research aimed to study the protein composition of high-density lipoproteins (HDL) associated with postprandial hyperlipidemia. The results showed that compared to baseline, the expression of APOM, APOE, APOB, and APOA2 in HDL proteins was significantly altered in postprandial hyperlipidemia.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Sport Sciences
Heath M. Burton, Edward F. Coyle
Summary: Reducing daily step counts to approximately 2500-5000 steps per day impairs the acute exercise-induced increase in fat oxidation and attenuation of postprandial plasma triglyceride increases in young healthy individuals. Exercise resistance seems to occur in individuals taking approximately 5000 or fewer steps per day, while 8500 steps per day protect against exercise resistance in fat metabolism. Fat metabolism appears to be more influenced by the inhibitory effects of inactivity than by the stimulating effects derived from 1 h of moderate-intensity running.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2021)
Article
Endocrinology & Metabolism
Yunpeng Guan, Xiaoyu Hou, Peipei Tian, Luping Ren, Yong Tang, An Song, Jiajun Zhao, Ling Gao, Guangyao Song
Summary: The study investigated mechanisms of postprandial hypertriglyceridemia (PPT) through analyzing serum lipid and apolipoprotein levels before and after a high-fat meal. Results showed significantly higher levels of various parameters in the PPT group, indicating that elevated ApoCIII levels may be a risk factor for PPT.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Nutrition & Dietetics
Lucia Camacho-Barcia, Jesus Garcia-Gavilan, Christopher Papandreou, Thea T. Hansen, Jo A. Harrold, Graham Finlayson, John E. Blundell, Anders Sjodin, Jason C. G. Halford, Monica Bullo
Summary: The study identified a positive association between higher levels of glycine and linoleic acid and postprandial satiety in overweight and obese individuals. Conversely, sucrose and certain sphingomyelins were negatively associated with satiety sensations. The correlations between metabolomic profiles and satiety sensations were moderate but consistent in two different appetite assessments.
Article
Biochemistry & Molecular Biology
Julia T. Stadler, Sonja Lackner, Sabrina Morkl, Nathalie Meier-Allard, Hubert Scharnagl, Alankrita Rani, Harald Mangge, Sieglinde Zelzer, Sandra J. Holasek, Gunther Marsche
Summary: Anorexia nervosa has detrimental effects on lipid metabolism and increases atherosclerotic risk factors.
Article
Nutrition & Dietetics
Malene R. Christiansen, Mario G. Urena, Dmitrii Borisevich, Niels Grarup, J. Alfredo Martinez, Jean-Michel Oppert, Thorkild I. A. Sorensen, Torben Hansen, Ellen E. Blaak, Tuomas O. Kilpelainen
Summary: This study aimed to investigate the influences of higher abdominal compared with gluteofemoral fat on postprandial lipemia in individuals with obesity. Results suggested that higher abdominal fat deposition might be causally associated with elevated postprandial lipemia, independently of fasting lipid concentrations and BMI. Additionally, there were opposing effects of abdominal and gluteofemoral fat depots on postprandial lipemia.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2021)
Article
Endocrinology & Metabolism
Yanyun Zhao, Yue Zhou, Jingwei Chi, Kui Che, Yangang Wang, Wei Wang
Summary: This study aimed to compare the levels of serum pancreatic polypeptide (PP), insulin (INS), C-peptide (C-P), and glucagon (GCG) before and after glucose stimulation in type 2 diabetes mellitus (T2DM) patients with different body mass indexes (BMI). The results showed that overweight and obese subjects had impaired PP secretion after glucose stimulation compared to normal-weight subjects. Multiple linear regression analysis revealed that PP secretion was mainly affected by BMI and GCG. These findings contribute to understanding the role of PP in the development of obesity and diabetes.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Qunyan Xiang, Feng Tian, Jin Xu, Xiao Du, Shilan Zhang, Liling Guo, Liyuan Zhu, Yingying Xie, Xueyan Zang, Yajun Gui, Tie Wen, Ling Liu
Summary: In this study, the researchers found that postprandial triglyceride-rich lipoprotein (TRL) in association with insulin can promote the adipogenic differentiation of adipose-derived mesenchymal stem cells (AMSCs), which plays a crucial role in the development of obesity. The mechanism involves the activation of the PI3K/AKT1 signaling pathway mediated by the interaction between low-density lipoprotein-related protein 1 (LRP1) and caveolin-1 (Cav-1). These findings highlight the importance of postprandial TRL in the pathogenesis of hypertriglyceridemia and diet-induced obesity.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2023)
Article
Food Science & Technology
Hong Xu, Hang Gao, Feiyue Liu, Lingxiao Gong
Summary: This study found that red-skin extracts from lotus seeds can significantly improve obesity characteristics in high-fat-diet-fed mice by regulating lipoprotein lipase activity.
Article
Endocrinology & Metabolism
Boris Bajer, Zofia Radikova, Andrea Havranova, Ingrid Zitnanova, Miroslav Vlcek, Richard Imrich, Peter Sabaka, Matej Bendzala, Adela Penesova
OBESITY RESEARCH & CLINICAL PRACTICE
(2019)
Article
Physiology
P. Sabaka, A. Dukat, J. Gajdosik, M. Caprnda, M. Bendzala, F. Simko
PHYSIOLOGICAL RESEARCH
(2019)
Article
Infectious Diseases
M. Kachlikova, P. Sabaka, A. Koscalova, M. Bendzala, Z. Dovalova, I. Stankovic
BMC INFECTIOUS DISEASES
(2020)
Review
Medicine, Research & Experimental
Sandra Mersakova, Zora Lasabova, Jan Strnadel, Michal Kalman, Eva Gabonova, Peter Sabaka, Rachele Ciccocioppo, Luis Rodrigo, Peter Kruzliak, Peter Mikolajcik
Summary: Colorectal cancer (CRC) is a leading cancer in both genders, and the TNM staging system is commonly used for tumor classification and prognosis. Recent studies have shown that T-cell infiltration is not uniform and memory T-cells and CD8 cells may play a crucial role in predicting disease-free survival and overall survival in CRC patients. Factors such as immune cell-associated proteins and gene profiles, as well as immunotherapy, are important in determining the outcome of CRC patients.
CLINICAL AND EXPERIMENTAL MEDICINE
(2021)
Article
Infectious Diseases
P. Sabaka, A. Koscalova, I. Straka, J. Hodosy, R. Liptak, B. Kmotorkova, M. Kachlikova, A. Kusnirova
Summary: This study explored the role of interleukin 6 (IL-6) as a predictor for severe disease during a COVID-19 outbreak in a long-term care facility in Slovakia. The concentration of IL-6 > 24 pg/mL at initial assessment was found to predict the development of hypoxemia requiring hospitalization with excellent sensitivity and good specificity.
BMC INFECTIOUS DISEASES
(2021)
Review
Medicine, Research & Experimental
Alena Liskova, Marek Samec, Lenka Koklesova, Samson M. Samuel, Kevin Zhai, Raghad Khalid Al-Ishaq, Mariam Abotaleb, Vladimir Nosal, Karol Kajo, Milad Ashrafizadeh, Ali Zarrabi, Aranka Brockmueller, Mehdi Shakibaei, Peter Sabaka, Ioana Mozos, David Ullrich, Robert Prosecky, Giampiero La Rocca, Martin Caprnda, Dietrich Busselberg, Luis Rodrigo, Peter Kruzliak, Peter Kubatka
Summary: Flavonoids have the potential to modulate important signaling pathways crucial for COVID-19, particularly related to inflammation and immunity, by regulating inflammatory mediators, inhibiting endothelial activation, and impacting the activation of various factors like Nrf2 and ACE-2.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Infectious Diseases
Peter Mihalov, Eliska Krajcovicova, Helena Kacerova, Peter Sabaka
Summary: This case report presents a case of Lofgren syndrome developing in close temporal association with COVID-19, with notable clinical presentation, but most symptoms resolved following a course of oral prednisone.
Article
Multidisciplinary Sciences
Kristina Borsova, Evan D. Paul, Viera Kovacova, Monika Radvanszka, Roman Hajdu, Viktoria Cabanova, Monika Slavikova, Martina Lickova, L'ubomira Lukacikova, Andrej Belak, Lucia Roussier, Michaela Kosticova, Anna Liskova, Lucia Mad'arova, Maria Stefkovicova, Lenka Reizigova, Elena Novakova, Peter Sabaka, Alena Koscalova, Brona Brejova, Edita Staronova, Matej Misik, Tomas Vinar, Jozef Nosek, Pavol Cekan, Boris Klempa
Summary: The emergence of the novel SARS-CoV-2 B.1.1.7 variant raised global concerns, prompting the development of a new RT-qPCR test method to accurately differentiate B.1.1.7 from other variants, with promising results for rapid and accurate detection and tracking efforts.
SCIENTIFIC REPORTS
(2021)
Article
Infectious Diseases
P. Mihalov, J. Hodosy, A. Koscalova, M. Caprnda, M. Kachlikova, J. Jurenka, M. Bendzala, P. Sabaka
Summary: Prior exposure to ceftriaxone increases the risk of MDR-Ab infection in COVID-19 patients admitted to the ICU. Our findings suggest that antibiotic use in COVID-19 patients admitted to the ICU should be restricted to patients with documented bacterial superinfection.
CANADIAN JOURNAL OF INFECTIOUS DISEASES & MEDICAL MICROBIOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Dominik Hadzega, Klaudia Babisova, Michaela Hyblova, Nikola Janostiakova, Peter Sabaka, Pavol Janega, Gabriel Minarik
Summary: This study investigates the relationship between RT-qPCR Ct values and the success rate of SARS-CoV-2 genome assembly, describing it using metatranscriptomic sequencing data from human tissue without viral RNA isolation.
APPLIED SCIENCES-BASEL
(2023)
Article
Microbiology
Michaela Hyblova, Dominik Hadzega, Klaudia Babisova, Patrik Krumpolec, Andrej Gnip, Peter Sabaka, Stefan Lassan, Gabriel Minarik
Summary: The SARS-CoV-2 pandemic has led to accelerated research in various scientific areas, whose findings can help address future health challenges from emerging infectious agents. In this study, we conducted comprehensive shotgun analysis using culture-independent RNA sequencing to compare the microbial spectrum and viral presence in healthy individuals and those with varying degrees of COVID-19 severity. Our findings showed an increase in microbial species diversity among COVID-19 patients, regardless of disease severity. We also observed significant differences in the abundance of bacterial phyla between healthy individuals and those infected with COVID-19.
Article
Medicine, General & Internal
Roy H. Stevens, Hongming Zhang, Michal Kajsik, Rafal Ploski, Malgorzata Rydzanicz, Peter Sabaka, Stanislav Sutovsky
Summary: Chronic prostatitis (CP) is a common inflammatory condition of the prostate that affects 2%-10% of the world's male population. This study reports the successful use of a bacteriophage-derived muralytic enzyme to treat and resolve chronic bacterial prostatitis (CBP) in a 39 years-old patient.
FRONTIERS IN MEDICINE
(2023)
Article
Infectious Diseases
Jan Jurenka, Anna Nagyova, Mohammad Dababseh, Peter Mihalov, Igor Stankovic, Vladimir Boza, Marian Kravec, Michal Palkovic, Martin Caprnda, Peter Sabaka
Summary: The presence of negative anti-SARS-CoV-2 antibodies at the time of hospital admission is associated with higher in-hospital mortality and all-cause death during follow-up after discharge.
INFECTIOUS DISEASE REPORTS
(2022)
Article
Infectious Diseases
Peter Sabaka, Maria Kachlikova, Matej Bendzala, Igor Stankovic
Article
Infectious Diseases
Peter Sabaka, Maria Kachlikova, Matej Bendzala, Helena K Kacerova
