Article
Biochemistry & Molecular Biology
Xiangli Zhao, Sadaf Hasan, Benjamin Liou, Yi Lin, Ying Sun, Chuanju Liu
Summary: The study found that PGRN deficiency leads to neuron loss and activation of microglia and astrocytes in aged mice. Several characteristic neurodegenerative disease markers, including alpha-synuclein, TDP-43, Tau, and beta-amyloid, were accumulated in the brain tissue of PGRN-deficient mice. Moreover, higher aggregation of lipofuscin was observed in the brain tissue of PGRN-deficient mice, and autophagy was also defective.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Huixian Hou, Mai Horikawa, Yuki Narita, Hirofumi Jono, Yutaka Kakizoe, Yuichiro Izumi, Takashige Kuwabara, Masashi Mukoyama, Hideyuki Saito
Summary: Renal fibrosis, the final manifestation of chronic kidney disease (CKD), can be controlled and prevented by targeting the enzyme SULT1A1 to decrease the accumulation of indoxyl sulfate (IS). In a study with Sult1a1-KO mice, it was found that the exacerbation of inflammation and renal fibrosis in WT mice was significantly suppressed in Sult1a1-KO mice. Expression of CD206(+) was upregulated and β-catenin expression was downregulated in Sult1a1-KO mice. Additionally, the study confirmed the beneficial effect of erythropoietin (EPO) in attenuating renal fibrosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Patricia Schroeder, Marion Rivalan, Sami Zaqout, Christina Krueger, Jutta Schueler, Melissa Long, Andreas Meisel, York Winter, Angela M. Kaindl, Seija Lehnardt
Summary: The absence of MyD88 leads to morphological and cellular changes in the mouse brain, as well as alterations in specific behaviors. The data suggest a pathophysiological significance of MyD88 for mammalian CNS development, structure, and function.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Food Science & Technology
Yizhong Bao, Xihao Wang, Wei Mao, Xinyao Li, Jiangjie Lou, Weihua Jin, Genxiang Mao, Lijiang Tang, Yingzheng Weng
Summary: Atherosclerosis is the leading cause of cardiovascular diseases worldwide. This study investigated the anti-atherosclerosis activities of two types of oligosaccharides and found that sulfated glucuronomannan hexamer exhibited the best activity. It down-regulated the expression of LOX-1 and regulated multiple signaling pathways to reduce plaque progression and promote plaque stabilization.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Biochemistry & Molecular Biology
Ulrich Schweizer, Eva K. Wirth, Thomas Klopstock, Sabine M. Hoelter, Lore Becker, Jackob Moskovitz, Tilman Grune, Helmut Fuchs, Valerie Gailus-Durner, Martin Hrabe de Angelis, Josef Koehrle, Lutz Schomburg
Summary: Mice with disrupted Selenop gene exhibit neurological phenotypes that are highly dependent on selenium supply and timing of supplementation. Parvalbumin-expressing interneurons in the brain depend on dietary selenium availability. Selenium supplementation can prevent neurological abnormalities, but the timing and dosage of supplementation play a crucial role.
Article
Cell Biology
Maria Elvira Brocca, Arancha Mora-Rubio, Elena Alonso-Calvino, Elena Fernandez-Lopez, Natalia Diez-Revuelta, David Martos-Punal, Juan Aguilar, Alonso M. Higuero, Jose Abad-Rodriguez
Summary: Gal-4, a carbohydrate-binding protein, is believed to be a regulator of myelin patterning. However, the study on Gal-4-deficient mice shows that Gal-4 does not significantly affect cortical myelination. The composition, organization, and function of cortical myelin in Lgals4-KO mice are similar to the control group.
Article
Biochemistry & Molecular Biology
Ming-Yang Chang, Tsung-Inn Tsai, Li-Fang Chou, Shen-Hsing Hsu, Huang-Yu Yang, Cheng-Chieh Hung, Ya-Chung Tian, Albert C. M. Ong, Chih-Wei Yang
Summary: The study found that treatment with metformin in a mouse model with Pkd1 deficiency can increase disease severity and promote cyst growth. These results suggest that using metformin in the later stage of ADPKD may accelerate disease progression.
HUMAN MOLECULAR GENETICS
(2021)
Article
Biochemistry & Molecular Biology
Tiziana Genovese, Daniela Impellizzeri, Ramona D'Amico, Roberta Fusco, Alessio Filippo Peritore, Davide Di Paola, Livia Interdonato, Enrico Gugliandolo, Rosalia Crupi, Rosanna Di Paola, Salvatore Cuzzocrea, Marika Cordaro, Rosalba Siracusa
Summary: This study evaluated the effects of bevacizumab on ApoE(-/-) mice undergoing TBI, and found that bevacizumab improved motor deficits, reduced VEGF levels and brain edema, preserved BBB integrity, and mitigated neuroinflammation induced by TBI. Additionally, it was observed for the first time that bevacizumab prevented the acceleration of atherosclerosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Kessiri Kongmanas, Arpornrad Saewu, Wongsakorn Kiattiburut, Mark A. Baker, Kym F. Faull, Dylan Burger, Nongnuj Tanphaichitr
Summary: The study highlighted that increased ROS production after SGG accumulation in Sertoli cells was the mechanism behind decreased fertility.
Article
Neurosciences
Sachiko Noda, Shigeto Sato, Takahiro Fukuda, Shinichi Ueno, Norihiro Tada, Nobutaka Hattori
Summary: The study investigated the role of FBXO7 gene mutations in Parkinson's disease and found that these mutations lead to a decrease in dopaminergic neurons and the formation of protein aggregates. They also discovered mitochondrial fragmentation in neuronal cells, suggesting that dysfunction in proteolytic and mitochondrial degradation systems plays a crucial role in the development of Parkinson's disease.
Article
Chemistry, Multidisciplinary
Yang Song, Meixian Wu, Zhen Liu, Mengjiao Yu, Francesco Secundo, Xiangzhao Mao
Summary: Agar, extracted from red algae, is widely used in food, medicine, and biochemistry due to its gelling properties and stability. However, the sulfate groups in agar weaken its gel strength, necessitating sulfate removal for quality improvement. In this study, microorganisms were used for the first time to desulfate agar, providing an eco-friendly and effective method for improving agar quality.
Article
Clinical Neurology
Jinwei Pang, Yue Wu, Jianhua Peng, Ping Yang, Ligang Chen, Yong Jiang
Summary: The study found that microthrombosis is associated with pericytes loss, which promotes early brain injury after SAH. ApoE deficiency leads to more extensive microthrombosis, potentially worsening neurobehavioral deficits.
FRONTIERS IN NEUROLOGY
(2021)
Article
Cell Biology
Parameswaran Gangadharan Sreekumar, Feng Su, Christine Spee, Eduardo Araujo, Steven Nusinowitz, Srinivasa T. Reddy, Ram Kannan
Summary: Lipid peroxidation caused by oxidative stress is a major factor in age-related macular degeneration (AMD). This study aims to investigate the role of LDLR in the NaIO3-induced model of dry AMD. The results indicate that LDLR loss leads to lipid accumulation and impaired retinal function, which may contribute to the development of AMD.
Article
Immunology
Aya Osman, Nicholas L. Mervosh, Ana N. Strat, Tanner J. Euston, Gillian Zipursky, Rebecca M. Pollak, Katherine R. Meckel, Scott R. Tyler, Kenny L. Chan, Ariela Buxbaum Grice, Elodie Drapeau, Lev Litichevskiy, Jasleen Gill, Sharon M. Zeldin, Christoph A. Thaiss, Joseph. D. Buxbaum, Michael S. Breen, Drew D. Kiraly
Summary: This study highlights the key role of the gut microbiome and the neuroactive metabolite acetate in regulating ASD-like behaviors. In mice experiments, acetate supplementation reverses social deficits, while clinical data shows sex-specific correlations between acetate levels and hyperactivity scores. The findings suggest a potential therapeutic target for managing ASD symptoms.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Article
Neurosciences
Yi Zhang, Yaqiong Ren, Yueni Zhang, Ying Li, Chao Xu, Ziyue Peng, Ying Jia, Shupei Qiao, Zitong Zhang, Lei Shi
Summary: This study found that the number of T cells in the brain parenchyma was significantly increased in the early stage of brain calcification in Slc20a2-HO mice and was associated with the severity of calcification. CD3(+) CD4(-) and CD3(+) CD4(+) were the main subtypes of infiltrating T cells in the brain. Increased expression of endothelial cell adhesion molecules and decreased expression of tight and adherens junction proteins provided the molecular precondition for T cell migration into the brain. FTY720 showed potential in protecting against PFBC-related lesions by reducing T cell infiltration, modulating neuroinflammation and ossification process, and enhancing autophagy and phagocytosis of CNS-resident immune cells.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2023)
Article
Clinical Neurology
S. Haghighi, A. Lekman, S. Nilsson, M. Blomqvist, O. Andersen
ACTA NEUROLOGICA SCANDINAVICA
(2012)
Article
Behavioral Sciences
Vilborg Palsdottir, Jan-Eric Mansson, Maria Blomqvist, Emil Egecioglu, Bob Olsson
BEHAVIORAL NEUROSCIENCE
(2012)
Article
Immunology
Maria Blomqvist, Sara Rhost, Susann Teneberg, Linda Lofbom, Thomas Osterbye, Manfred Brigl, Jan-Eric Mansson, Susanna L. Cardell
EUROPEAN JOURNAL OF IMMUNOLOGY
(2009)
Article
Immunology
Sara Rhost, Linda Lofbom, Britt-Marie Rynmark, Bo Pei, Jan-Eric Mansson, Susann Teneberg, Maria Blomqvist, Susanna L. Cardell
EUROPEAN JOURNAL OF IMMUNOLOGY
(2012)
Review
Immunology
Nadir Kadri, Maria Blomqvist, Susanna L. Cardell
EXPERT REVIEW OF CLINICAL IMMUNOLOGY
(2008)
Article
Immunology
Jakub Kwiecinski, Sara Rhost, Linda Lofbom, Maria Blomqvist, Jan Eric Mansson, Susanna L. Cardell, Tao Jin
INFECTION AND IMMUNITY
(2013)
Article
Clinical Neurology
S. Haghighi, A. Lekman, S. Nilsson, M. Blomqvist, O. Andersen
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2013)
Article
Endocrinology & Metabolism
Niklas Mattsson, Maria Olsson, Mikael K. Gustavsson, Marko Kosicek, Martina Malnar, Jan-Eric Mansson, Maria Blomqvist, Johan Gobom, Ulf Andreasson, Gunnar Brinkmalm, Charles Vite, Silva Hecimovic, Caroline Hastings, Kaj Blennow, Henrik Zetterberg, Erik Portelius
METABOLIC BRAIN DISEASE
(2012)
Article
Medicine, Research & Experimental
Kalliopi Sofou, Kolja Meier, Leslie E. Sanderson, Debora Kaminski, Laia Montoliu-Gaya, Emma Samuelsson, Maria Blomqvist, Lotta Agholme, Jutta Gaertner, Chris Muehlhausen, Niklas Darin, Tahsin Stefan Barakat, Lars Schlotawa, Tjakko van Ham, Jorge Asin Cayuela, Fredrik H. Sterky
Summary: Patients with lysosomal storage disease-like symptoms were found to have homozygous mutations in VPS16, resulting in impaired cellular functions such as transferrin uptake and lysosomal accumulation, which were rescued by re-expression of VPS16. Disrupted vps16 expression in zebrafish led to developmental defects and similar lysosomal and autophagosomal accumulation in the brain. This expands the understanding of diseases resulting from mutations in HOPS/CORVET subunits.
EMBO MOLECULAR MEDICINE
(2021)
Article
Clinical Neurology
Lenka Novakova, Marcus Henricsson, Elias Bjornson, Markus Axelsson, Jan Boren, Igal Rosenstein, Jan Lycke, Susanna L. Cardell, Maria Blomqvist
Summary: The diagnostic utility of cerebrospinal fluid (CSF) sulfatide isoform levels in different courses or phenotypes of multiple sclerosis (MS) was investigated. The results showed that there was no difference in CSF total sulfatide concentrations and isoform distribution among the study groups, and the levels were independent of disease course/phenotype, disease duration, time to conversion to secondary progressive MS, age, and disability.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2023)
Article
Medicine, Research & Experimental
Maria Blomqvist, Marie Falkenberg Smeland, Julia Lindgren, Per Sikora, Hilde Monica Frostad Riise Stensland, Jorge Asin-Cayuela
COLD SPRING HARBOR MOLECULAR CASE STUDIES
(2019)
Article
Biochemistry & Molecular Biology
Maria Blomqvist, Thomas Osterbye, Jan-Eric Mansson, Karsten Buschard, Pam Fredman
LIPIDS IN HEALTH AND DISEASE
(2006)
Article
Endocrinology & Metabolism
Karsten Buschard, Maria Blomqvist, Jan-Eric Mansson, Pam Fredman, Kirstine Juhl, Jesper Gromada
Article
Endocrinology & Metabolism
M Blomqvist, M Carrier, T Andrews, K Pettersson, JE Månsson, BM Rynmark, P Fredman, K Buschard
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2005)