Article
Endocrinology & Metabolism
Ravindran Vini, Arumugam Rajavelu, Sreeja Sreeharshan
Summary: 27-HC, the first known endogenous selective estrogen receptor modulator, is closely associated with breast cancer. This study reveals that 27-HC may induce aberrant DNA methylation changes on gene promoters through modulating the ER-alpha and DNMT3B complexes, thereby affecting drug responses and breast cancer development.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Roberto Codella, Tiago C. Alves, Douglas E. Befroy, Cheol Soo Choi, Livio Luzi, Douglas L. Rothman, Richard G. Kibbey, Gerald Shulman
Summary: Uncoupling protein-3 (UCP3) is a highly expressed mitochondrial protein in muscle that regulates the efficiency of oxidative phosphorylation. Muscle-specific overexpression of UCP3 leads to increased mitochondrial inefficiency, resulting in a decrease in the ratio of ATP synthesis to mitochondrial oxidation.
Review
Cell Biology
Fabio Alessandro de Freitas, Debora Levy, Cadiele Oliana Reichert, Edecio Cunha-Neto, Jorge Kalil, Sergio Paulo Bydlowski
Summary: Oxysterols have diverse effects on the immune system and play a significant role in immune-related diseases. They can influence the function and migration of immune cells as well as immune responses. The main oxysterol receptors LXR and EBI2 also have important roles in the immune system.
Article
Biochemistry & Molecular Biology
Theodore L. Steck, Yvonne Lange
Summary: This review discusses the hypothesis that a small fraction of plasma membrane cholesterol, known as active cholesterol, regulates reverse cholesterol transport. Active cholesterol circulates among organelles, moves to plasma HDL via ABCA1, ABCG1, and SR-BI, and flows to cytoplasmic membranes. It serves as a feedback signal and substrate for homeostasis and mitochondrial 27-hydroxycholesterol synthesis. The binding of 27HC to LXR promotes the expression of transport proteins. Direct tests of this hypothesis are proposed.
JOURNAL OF LIPID RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Daniela Rojas, Serine Benachenhou, Asma Laroui, Amira Abdourahim Aden, Armita Abolghasemi, Luc Galarneau, Taratibu Janviere Irakoze, Rosalie Plantefeve, Sophie Bouhour, Amanda Toupin, Francois Corbin, Guy Fink, Pierre-Luc Mallet, Artuela Caku
Summary: Accurate quantification of 24(S)-hydroxycholesterol and 27-hydroxycholesterol is of significant biological importance due to their involvement in crucial cellular processes and their potential as disease biomarkers. By developing and validating a liquid chromatography coupled to tandem mass spectrometry method, we have successfully overcome the challenges of low concentrations and similarities in molecular structures, allowing consistent and reliable quantification of these oxysterols in human plasma.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Paola Gamba, Serena Giannelli, Erica Staurenghi, Gabriella Testa, Barbara Sottero, Fiorella Biasi, Giuseppe Poli, Gabriella Leonarduzzi
Summary: This review discusses the controversial role of 24-OHC in AD pathogenesis, including its levels in different AD biological samples and its detrimental or neuroprotective effects in the brain.
Article
Pharmacology & Pharmacy
Andrea Civra, Matteo Costantino, Roberta Cavalli, Marco Adami, Marco Volante, Giuseppe Poli, David Lembo
Summary: The study assessed the ability of two physiologic oxysterols and host-targeting antivirals to select resistant strains and found that 25OHC and 27OHC did not select oxysterol-resistant variants. The results also demonstrated the antiviral activity of 27OHC in inhibiting HRV and preventing virus-induced cilia damage in vitro. The promising potential of 27OHC as an antiviral drug candidate was highlighted.
ANTIVIRAL RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Xuesong Liu, Mengzhu Lv, Weimin Zhang, Qimin Zhan
Summary: Cholesterol homeostasis is implicated in the regulation of various diseases, including cancer. Abnormal cholesterol metabolism in cancer cells is closely related to malignant progression, and cancer-related signals also regulate cholesterol metabolism. Targeting cholesterol metabolism with anticancer drugs could be important for cancer treatment.
Review
Oceanography
Ilson C. A. da Silveira, Filipe Pereira, Glenn R. Flierl, Iury T. Simoes-Sousa, Andre Paloczy, Milton Borges-Silva, Cesar B. Rocha
Summary: The most conspicuous oceanographic features off Southeast Brazil are the quasi-stationary eddies formed off Capes Sao Tome (CSTE) and Frio (CFE) associated with the Brazil Current (BC). These eddies have an average growth rate of 0.06 day-1 and almost no propagation speeds. CFE tends to be more unstable and frequent than CSTE (3.5 vs. 2.3 events per year), with CSTE able to propagate north or south while CFE only propagating southward.
PROGRESS IN OCEANOGRAPHY
(2023)
Article
Biochemistry & Molecular Biology
Yanting Che, Jingzhi Yang, Fen Tang, Ziheng Wei, Yufan Chao, Na Li, Henghui Li, Si Wu, Xin Dong
Summary: Osteoporosis is a bone disease characterized by decreased bone strength, changes in bone tissues, and increased fracture risk. Cholesterol oxidation products play an important role in maintaining bone metabolism homeostasis and have effects on the differentiation of stem cells. This review aims to explore the biological roles of cholesterol oxidation products in osteoporosis development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nutrition & Dietetics
Lijing Wang, Cui Zhou, Huiyan Yu, Ling Hao, Mengwei Ju, Wenjing Feng, Zhiting Guo, Xuejing Sun, Qiushi Fan, Rong Xiao
Summary: This study aimed to investigate the effects of co-supplementation with vitamin D, folic acid, and vitamin B-12 on learning and memory ability in vitamin D-deficient mice. The results showed that the co-supplementation significantly improved the learning and memory impairment caused by vitamin D deficiency, possibly through the regulation of CYP27A1 expression and the metabolism of 27-OHC, 25(OH)D, and SAM.
Article
Veterinary Sciences
Peng-Fei Fu, Xuan Cheng, Bing-Qian Su, Li-Fang Duan, Cong-Rong Wang, Xin-Rui Niu, Jiang Wang, Guo-Yu Yang, Bei-Bei Chu
Summary: A double reporter PRV was constructed using gene editing technology for virology studies and antiviral agent evaluation, providing valuable insights for understanding the virulence enhancement of variant PRV and potential treatment options.
VETERINARY RESEARCH
(2021)
Article
Endocrinology & Metabolism
Liqian Ma, Hashni Epa Vidana Gamage, Srishti Tiwari, Chaeyeon Han, Madeline A. Henn, Natalia Krawczynska, Payam Dibaeinia, Graeme J. Koelwyn, Anasuya Das Gupta, Rafael Ovidio Bautista Rivas, Chris L. Wright, Fangxiu Xu, Kathryn J. Moore, Saurabh Sinha, Erik R. Nelson
Summary: Dysregulation of cholesterol homeostasis is associated with various diseases. Liver X receptors (LXRs), as major regulators of cholesterol homeostasis, can be selectively modulated by different ligands, influencing multiple biological systems. This study provides evidence of LXR selective modulation through gene expression analysis, laying the foundation for developing precision pharmacology LXR ligands.
Article
Agriculture, Dairy & Animal Science
Yuguo H. Tompkins, Shengchen Su, Sandra G. Velleman, Woo Kyun Kim
Summary: Research has shown that a lower concentration of 20S does not affect myogenesis in chicken muscle cells, but a high concentration of 1.0 mmol 20S may negatively impact proliferation and differentiation in chicken satellite cells.
Article
Endocrinology & Metabolism
Lucia Baila-Rueda, Ana Cenarro, Itziar Lamiquiz-Moneo, Victoria Marco-Benedi, Irene Gracia-Rubio, Maria Carmen Casamayor-Franco, Jose M. Arbones-Mainar, Fernando Civeira, Martin Laclaustra
Summary: This study found that cholesterol and oxidized metabolites in adipose tissue are associated with metabolic characteristics. Insulin is positively correlated with hydroxycholesterol, and leptin is also positively correlated with hydroxycholesterol. There is a positive correlation between tissue cholesterol and hydroxycholesterol.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Cell Biology
Yuan Z. Feng, Natasa Nikolic, Siril S. Bakke, Eili T. Kase, Kari Guderud, Joran Hjelmesaeth, Vigdis Aas, Arild C. Rustan, G. Hege Thoresen
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2015)
Review
Physiology
N. Nikolic, S. W. Goergens, G. H. Thoresen, V. Aas, J. Eckel, K. Eckardt
Article
Multidisciplinary Sciences
Jenny Lund, Vigdis Aas, Ragna H. Tingstad, Alfons Van Hees, Natasa Nikolic
SCIENTIFIC REPORTS
(2018)
Article
Biochemistry & Molecular Biology
Siril S. Bakke, Cedric Moro, Natasa Nikolic, Nina P. Hessvik, Pierre-Marie Badin, Line Lauvhaug, Katarina Fredriksson, Matthijs K. C. Hesselink, Mark V. Boekschoten, Sander Kersten, Michael Gaster, G. Hege Thoresen, Arild C. Rustan
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2012)
Meeting Abstract
Biochemistry & Molecular Biology
Siril S. Bakke, Natasa Nikolic, Cedric Moro, Line Lauvhaug, Nina P. Hessvik, G. Hege Thoresen, Arild C. Rustan
CHEMISTRY AND PHYSICS OF LIPIDS
(2011)
Article
Chemistry, Medicinal
Calin C. Ciocoiu, Natasa Nikolic, Huyen Hoa Nguyen, G. Hege Thoresen, Arne J. Aasen, Trond Vidar Hansen
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2010)
Article
Multidisciplinary Sciences
Natasa Nikolic, Siril Skaret Bakke, Eili Tranheim Kase, Ida Rudberg, Ingeborg Flo Halle, Arild C. Rustan, G. Hege Thoresen, Vigdis Aas
Article
Multidisciplinary Sciences
Eili Tranheim Kase, Natasa Nikolic, Siril Skaret Bakke, Kaja Kamilla Bogen, Vigdis Aas, G. Hege Thoresen, Arild Christian Rustan
Article
Multidisciplinary Sciences
Siril S. Bakke, Yuan Z. Feng, Natasa Nikolic, Eili T. Kase, Cedric Moro, Camilla Stensrud, Lisbeth Damlien, Marianne O. Ludahl, Rune Sandbu, Brita Marie Solheim, Arild C. Rustan, Joran Hjelmesaeth, G. Hege Thoresen, Vigdis Aas
Article
Biochemistry & Molecular Biology
Yuan Z. Feng, Natasa Nikolic, Siril S. Bakke, Mark V. Boekschoten, Sander Kersten, Eili T. Kase, Arild C. Rustan, G. Hege Thoresen
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
(2014)
Article
Biochemical Research Methods
Nata Sa Nikolic, Magdalena Rhedin, Arild C. Rustan, Len Storlien, G. Hege Thoresen, Maria Stroemstedt
BIOCHEMISTRY RESEARCH INTERNATIONAL
(2012)