Article
Food Science & Technology
Yanqiu Chen, Mei Wan, Yi Zhong, Tingfang Gao, Yuehan Zhang, Fen Yan, Da Huang, Yuanzi Wu, Zuquan Weng
Summary: The study found that PHGG can effectively prevent and alleviate depression in mice induced by chronic stress, possibly through regulating the gut microbiota structure, increasing short-chain fatty acid levels, and enhancing serotonin and dopamine levels.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Article
Food Science & Technology
Risako Kon, Nobutomo Ikarashi, Kazuhiro Onuma, Zenta Yasukawa, Makoto Ozeki, Hiroyasu Sakai, Junzo Kamei
Summary: In recent years, there has been progress in the development of functional foods for gastrointestinal disorders, including partially hydrolyzed guar gum (PHGG) which improves constipation. This study investigated the role of aquaporin-3 (AQP3) in the ameliorative effect of PHGG on constipation. It was found that PHGG decreased the expression of AQP3 in the colon, suppressing water transport and improving constipation.
FOOD SCIENCE & NUTRITION
(2023)
Article
Nutrition & Dietetics
Takuro Okamura, Masahide Hamaguchi, Jun Mori, Mihoko Yamaguchi, Katsura Mizushima, Aya Abe, Makoto Ozeki, Ryoichi Sasano, Yuji Naito, Michiaki Fukui
Summary: This study investigated the potential therapeutic effect of dietary supplementation with PHGG against sarcopenic obesity using Db/Db mice. The results showed that PHGG could increase grip strength and skeletal muscle weight, as well as increase the concentration of short-chain fatty acids in feces and sera. PHGG also exhibited anti-inflammatory effects in the small intestine, indicating its preventive role in sarcopenic obesity.
Article
Gastroenterology & Hepatology
Shun Takayama, Kazuhiro Katada, Tomohisa Takagi, Takaya Iida, Tomohiro Ueda, Katsura Mizushima, Yasuki Higashimura, Mayuko Morita, Tetsuya Okayama, Kazuhiro Kamada, Kazuhiko Uchiyama, Osamu Handa, Takeshi Ishikawa, Zenta Yasukawa, Tsutomu Okubo, Yoshito Itoh, Yuji Naito
Summary: The study found that PHGG partially prevented NAFLD development in mice by modulating microbiota and SCFA profiles.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Agriculture, Multidisciplinary
Dina Mustika Rini, Yoshinari Yamamoto, Takuya Suzuki
Summary: This study investigated the effects of partially hydrolyzed guar gum (PHGG) on the expression of HSP27 in intestinal Caco-2 cells and mouse intestines. The results showed that PHGG upregulated HSP27 expression through the mTOR and ERK signaling pathways, promoting intestinal epithelial integrity.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2023)
Article
Food Science & Technology
Mahendra P. Kapoor, Hiroaki Yamaguchi, Hitomi Ishida, Yoichi Mizutani, Derek Timm, Aya Abe
Summary: The dose-response study of prebiotic partially hydrolyzed guar gum (PHGG) dietary fiber supports the gut microbiome and improves gastrointestinal health, which is crucial for healthy skin. The ingestion of 6 and 12 g/day PHGG helps maintain constant moisture levels in the surface skin stratum corneum, preventing dryness and textural disorder to the skin. This study suggests a link between improved gut environment and increased hydration level of the skin, emphasizing the importance of consuming prebiotic PHGG dietary fiber.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Biochemistry & Molecular Biology
Tong Liu, Xuefei Hu, Peng Chen, Renlingzi Zhang, Shouqin Zhang, Wenjun Chang, Junjie Wang, Sheng Wang
Summary: This study investigated the effects of PHGG on gut flora composition and metabolic function in healthy mice. The results showed that long-term supplementation of PHGG had duration-dependent effects on the composition and function of intestinal flora. While it increased the abundance of some beneficial bacterial species and promoted beneficial phenotypes, it also resulted in increased body weight and decreased abundance and diversity of gut microorganisms. Further investigation is needed to understand the long-term use of PHGG as a nutritional product.
JOURNAL OF FOOD BIOCHEMISTRY
(2022)
Article
Nutrition & Dietetics
Takahiro Kato, Satoshi Kamiya, Soshi Narasaki, Ayako Sumii, Yasuo M. Tsutsumi, Kyoka Machida, Kanako Hara, Yuna Izumi-Mishima, Rie Tsutsumi, Hiroshi Sakaue
Summary: The consumption of partially hydrolyzed guar gum (PHGG) can improve the gut environment, alleviate the negative effects of H1N1 influenza virus infection, by promoting the production of short-chain fatty acids (SCFAs), inhibiting the increase of inflammatory cytokines, and enhancing natural killer cell activity and regulatory T-cell differentiation.
Article
Nutrition & Dietetics
Michele Massa, Carlotta Compari, Emilia Fisicaro
Summary: This study investigates the binding ability of soluble dietary fibers to bile salts and explores the mechanism of their cholesterol-lowering activity.
FRONTIERS IN NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Swagatika Behera, Manoj J. Dev, Rekha S. Singhal
Summary: In this study, immobilized β-mannanase M-CLEAs were successfully prepared, and the aggregation and cross-linking process were optimized to obtain M-CLEAs with higher pH stability, improved thermal and storage stability, and better reusability. Additionally, the prepared M-CLEAs showed higher activity and altered substrate affinity compared to free β-mannanase.
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Daisuke Sasaki, Kengo Sasaki, Aya Abe, Makoto Ozeki, Akihiko Kondo
Summary: This study evaluated the effects of two different molecular weight partially hydrolyzed guar gums (PHGGs) on human colonic microbiota and short-chain fatty acid (SCFA) production. The results showed that low molecular-weight PHGGs exerted similar prebiotic effects to high molecular-weight PHGGs, increasing SCFA production and the abundance of beneficial bacteria for human health.
JOURNAL OF BIOSCIENCE AND BIOENGINEERING
(2023)
Article
Geriatrics & Gerontology
T. C. Chan, V. M. W. Yu, J. K. H. Luk, L. W. Chu, J. K. Y. Yuen, F. H. W. Chan
Summary: This study aimed to assess the effectiveness of partially hydrolyzed guar gum (PHGG) in improving constipation and reducing the use of laxatives among long term care facility (LTCF) residents. The results showed that daily dietary fiber supplementation with PHGG for 4 weeks significantly reduced laxative use, suggesting it may be an effective way to reduce laxative dependence among older people living in LTCFs.
JOURNAL OF NUTRITION HEALTH & AGING
(2022)
Article
Chemistry, Applied
Xiaodan Fu, Zhemin Liu, Rong Li, Junyi Yin, Han Sun, Changliang Zhu, Qing Kong, Haijin Mou, Shaoping Nie
Summary: This study found that low molecular weight hydrolyzed guar gum has anti-obesity effects and improves hepatic metabolic processes. It achieves these effects by regulating lipid metabolism pathways, reducing disease biomarkers, and increasing the levels of certain metabolites.
CARBOHYDRATE POLYMERS
(2022)
Review
Food Science & Technology
Ana-Isabel Mulet-Cabero, Peter J. Wilde
Summary: This review explores the possible mechanisms of calcium in reducing cholesterol, including its interaction with fatty acids and bile acids, and provides clinical evidence. The interaction of calcium with blood lipid metabolism may depend on its multiple roles in lipid digestion in the small intestine and its influence on the solubilization and absorption of cholesterol through its interaction with fatty acids and bile.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Hua Xu, Lan Yang, Pengkai Xie, Qinying Zhou, Yuhang Chen, Emad Karrar, Huifang Qi, Ruixue Lin, Yun Zhu, Jun Jin, Qingzhe Jin, Xingguo Wang
Summary: The present study evaluated the effects of carrageenan and its blends with xanthan gum and guar gum on the stability of partially crystalline emulsions. The results showed that the gum blends significantly decreased the viscosity, particle size, and interfacial protein concentration of the emulsions, leading to improved stability.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Clinical Neurology
J. M. Menchon, J. Espadaler, M. Tuson, J. Saiz-Ruiz, J. Bobes, E. Vieta, E. Alvarez, V. Perez
JOURNAL OF NEURAL TRANSMISSION
(2019)
Review
Nutrition & Dietetics
Erola Asto, Iago Mendez, Sergi Audivert, Andreu Farran-Codina, Jordi Espadaler
Article
Nutrition & Dietetics
Erola Asto, Iago Mendez, Maria Rodriguez-Prado, Jordi Cune, Jordi Espadaler, Andreu Farran-Codina
Article
Pharmacology & Pharmacy
Silvia Vilches, Miguel Tuson, Eduard Vieta, Enric Alvarez, Jordi Espadaler
Meeting Abstract
Biochemistry & Molecular Biology
Marta Perez, Erola Asto, Pol Huedo, Cristina Alcantara, David Buj, Jordi Espadaler
Review
Immunology
Ashton Harper, Vineetha Vijayakumar, Arthur C. Ouwehand, Jessica ter Haar, David Obis, Jordi Espadaler, Sylvie Binda, Shrilakshmi Desiraju, Richard Day
Summary: Viral infections continue to pose significant global morbidity and mortality, with factors such as climate change, increased mobility of people and goods, and disruptions in the gastrointestinal microbiome all playing a role. Understanding the complex relationship between the microbiome, viral immunity, and host physiology is crucial for developing effective prevention and treatment strategies for viral diseases.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Microbiology
Tatiana Altadill, Jordi Espadaler-Mazo, Min-Tze Liong
Summary: The study re-analyzed the effects of Lactoplantibacillus plantarum DR7 probiotic on URTI symptoms and found a significant reduction in the duration of URTI and fever. The recent history of URTI appeared to modulate the efficacy of the probiotic. Additionally, the probiotic group showed a significantly lower average number of months with reported use of URTI-related medication compared to the placebo group.
Article
Nutrition & Dietetics
Rafael Guerrero-Bonmatty, Guadalupe Gil-Fernandez, Francisco Jose Rodriguez-Velasco, Jordi Espadaler-Mazo
Summary: This study showed that the combination of 10 mg of monacolin K and L. plantarum strains was effective in managing blood cholesterol, with statistically significant reductions in LDL-C and TC compared to placebo. The intervention was well tolerated with no adverse effects observed.
Article
Genetics & Heredity
Gerard Anmella, Silvia Vilches, Jordi Espadaler-Mazo, Andrea Murru, Isabella Pacchiarotti, Miquel Tuson, Marina Garriga, Eva Sole, Merce Brat, Giovanna Fico, Eduard Vieta
Summary: This study evaluated the impact of individual genes in the response to treatment in bipolar depression, finding that pharmacogenetic variables can predict patient response to medication and tolerability. These predictors could be useful for guiding pharmacological treatment in bipolar disorder, but further clinical studies are needed to confirm these findings.
Article
Microbiology
Erola Asto, Pol Huedo, Tatiana Altadill, Meritxell Aguilo Garcia, Maura Sticco, Marta Perez, Jordi Espadaler-Mazo
Summary: This study investigated the probiotic potential of Bifidobacterium longum KABP042 and Pediococcus pentosaceus KABP041 in treating infant FGIDs, confirming their safety and efficacy in in vitro experiments and a pilot study involving infants diagnosed with FGIDs. The strains showed great adhesion capacity to intestinal cells and the ability to antagonize bacterial pathogens alone and in combination, suggesting their potential as a treatment for pediatric FGIDs.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Gastroenterology & Hepatology
Pedro Gutierrez-Castrellon, Tania Gandara-Marti, Ana T. Abreu Y. Abreu, Cesar D. Nieto-Rufino, Eduardo Lopez-Orduna, Irma Jimenez-Escobar, Carlos Jimenez-Gutierrez, Gabriel Lopez-Velazquez, Jordi Espadaler-Mazo
Summary: This study suggests that probiotic supplementation can improve lung homeostasis by interacting with the host's immune system, thereby reducing symptoms and severity of COVID-19 infection.
Article
Gastroenterology & Hepatology
Ana D. Cano-Contreras, Isidro J. Minero Alfaro, Victor M. Medina Lopez, Mercedes Amieva Balmori, Jose M. Remes Troche, Jordi Espadaler Mazo, Nuria Perez Lopez
Summary: This study assessed the efficacy of probiotic i3.1 in improving symptoms of lactose intolerance. The results showed that the probiotic significantly reduced symptom scores, particularly for abdominal pain and flatulence. However, it did not have a significant effect on the lactose hydrogen breath test results.
JOURNAL OF CLINICAL GASTROENTEROLOGY
(2022)
Article
Microbiology
E. Ferres-Amat, J. Espadaler-Mazo, J. L. Calvo-Guirado, J. Mareque-Bueno, A. Salavert, M. Aguilo-Garcia, J. Moreno-Centeno, E. Ferres-Padro
BENEFICIAL MICROBES
(2020)
Article
Pharmacology & Pharmacy
Marta Ielmini, Nicola Poloni, Ivano Caselli, Jordi Espadaler, Miquel Tuson, Alessandro Grecchi, Camilla Callegari
PHARMACOGENOMICS & PERSONALIZED MEDICINE
(2018)
Meeting Abstract
Endocrinology & Metabolism
R. Pons Calabuig, E. Ferres Amat, J. Mareque Bueno, E. Navarro Tapia, E. Asto Sanchez-Lafuente, J. Espadaler Mazo, E. Ferres Padro
ANNALS OF NUTRITION AND METABOLISM
(2018)