Article
Immunology
Sarvatit Patel, Geoff Werstuck
Summary: The study found that deficiency in GSK3α affects the polarization and inflammatory response of M1 macrophages, while increasing cell migration; deficiency in GSK3β exacerbates the inflammatory response and lipid accumulation of M1 macrophages but decreases cell migration; double deficiency in GSK3α and GSK3β leads to increased cell viability, proliferation, and metabolism.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Lu Chen, Zhengdong Fang, Xiaotian Wang, Xiaojie Sun, Xinbao Ge, Can Cheng, Hejie Hu
Summary: This study suggests that activating GPR39 can alleviate ox-LDL-induced macrophage inflammation, lipid accumulation, and apoptosis in a manner dependent on A20.
Article
Hematology
Kaori Endo-Umeda, Eunyoung Kim, David G. Thomas, Wenli Liu, Huijuan Dou, Mustafa Yalcinkaya, Sandra Abramowicz, Tong Xiao, Per Antonson, Jan-Ake Gustafsson, Makoto Makishima, Muredach P. Reilly, Nan Wang, Alan R. Tall
Summary: Our study reveals the crucial role of macrophage LXRs in promoting the Trem2 gene expression program and suppressing inflammation in foam cells of atherosclerotic plaques.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Rafael Jaen, Adrian Povo-Retana, Cesar Rosales-Mendoza, Patricia Capillas-Herrero, Sergio Sanchez-Garcia, Paloma Martin-Sanz, Marina Mojena, Patricia Prieto, Lisardo Bosca
Summary: Atherosclerosis is a cardiovascular disease characterized by the formation of plaques and chronic inflammation. Proprotein convertase subtilisin/kexin type 9 (PCSK9) is an important protein involved in atherosclerosis. Through LDLR, human macrophages can take up circulating PCSK9, which activates the TLR4 pathway and leads to increased reactive oxygen species production, reduced lipid metabolism and cholesterol efflux gene expression, and enhanced pro-inflammatory cytokine production. This ultimately compromises macrophage viability and contributes to the progression of atherosclerosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Pharmacology & Pharmacy
Xiao He, Xuehui Fan, Bing Bai, Nanjuan Lu, Shuang Zhang, Liming Zhang
Summary: Pyroptosis is a form of programmed cell death triggered by various stimuli, and its association with oxidative stress, organelle dysfunction, and other mechanisms can accelerate atherosclerosis progression and plaque formation.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Jiarou Wang, Yifan Zhang, Xiaoteng Feng, Min Du, Sijin Li, Xindi Chang, Ping Liu
Summary: This study suggests that Tanshinone IIA (TIIA) may reduce lipid accumulation and treat atherosclerosis by enhancing macrophage efferocytosis.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Medicine, Research & Experimental
Lijun Zhao, Shifang Zhang, Qiaoli Su, Shuangqing Li
Summary: Lifestyle interventions and pharmacotherapy are commonly used non-invasive treatments for atherosclerosis, but the effect of diet on plaques is still unclear. This study found that withdrawing the atherogenic diet did not lead to regression of established lesions, but instead delayed progression and promoted plaque stabilization.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Juan Francisco Aranda, Ana Perez-Garcia, Marta Torrecilla-Parra, Mario Fernandez-de Frutos, Yolanda Martin-Martin, Pedro A. Mateos-Gomez, Virginia Pardo-Marques, Rebeca Busto, Cristina M. Ramirez
Summary: Hypoxia plays a crucial role in the maintenance of atherosclerotic lesions. miR-199a-5p and ABCA1 are inversely regulated by hypoxia and Ac-LDL, and their interaction can control macrophage cholesterol efflux during the onset of atherosclerosis.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Biotechnology & Applied Microbiology
Zhengyao Qian, Jianping Zhao
Summary: YY1 is involved in macrophage inflammation and lipid accumulation by activating PCSK9 and modulating LDLR expression.
JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Pi-Fen Tsui, Ching-Yuh Chern, Chih-Feng Lien, Feng-Yen Lin, Chien-Sung Tsai, Min-Chien Tsai, Chin-Sheng Lin
Summary: The octimibate derivative Oxa17 enhances ABCA1 expression and shows protective effects against atherosclerosis in an in vivo mouse model of high-fat diet-induced atherosclerosis, increasing plasma high-density lipoprotein (HDL) levels and reducing plaque formation, thus improving plaque stability.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Hematology
Abhijnan Chattopadhyay, Callie S. Kwartler, Kaveeta Kaw, Yanming Li, Anita Kaw, Jiyuan Chen, Scott A. LeMaire, Ying H. Shen, Dianna M. Milewicz
Summary: The study found that vascular smooth muscle cells undergo phenotypic switching and express macrophage and fibroblast markers under cholesterol exposure. This switching is associated with the activation of the endoplasmic reticulum unfolded protein response, and blocking this response prevents the phenotypic transition.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Lisa Willemsen, Hung-Jen Chen, Cindy P. A. A. van Roomen, Guillermo R. Griffith, Ricky Siebeler, Annette E. Neele, Jeffrey Kroon, Marten A. Hoeksema, Menno P. J. de Winther
Summary: This study discovered that lipid accumulation in macrophages suppresses the expression of interferon-stimulated genes (ISGs) and secretion of IFN-beta, which can be rescued by exogenous IFN-beta supplementation. Activation of the cholesterol-sensing nuclear liver X receptor (LXR) recapitulated the cholesterol-initiated interferon suppression. Similar interferon suppression was observed in monocytes of familial hypercholesterolemia patients. These findings provide new insights into controlling inflammation in hyperlipidemic conditions and support future therapeutic approaches targeting macrophage reprogramming to reduce atherosclerotic plaque progression and improve stability.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Hematology
Qian Li, Liwen Yu, Amy Gao, Ruiqing Ren, Jianlin Zhang, Lei Cao, Xiaohong Wang, Yapeng Liu, Wenqian Qi, Liangyu Cai, Wei Li, Weiwei Wang, Xiaobin Guo, Guohai Su, Xiao Yu, Jie Zhang, Bo Xi, Yun Zhang, Meng Zhang, Cheng Zhang
Summary: This study demonstrates that the expression of METTL3 in macrophages is associated with the progression of atherosclerosis. They found that myeloid cell-specific METTL3 deficiency can suppress hyperlipidemia-induced atherosclerotic plaque formation and the inflammatory response. The study also identified BRAF mRNA as a novel target of METTL3 in the activation of the ox-LDL-induced ERK pathway and inflammatory response in macrophages. Therefore, METTL3 may represent a potential target for the treatment of atherosclerosis.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Article
Medicine, Research & Experimental
Zhelong Li, Ping Zhao, Yajun Zhang, Jia Wang, Chen Wang, Yunnan Liu, Guodong Yang, Lijun Yuan
Summary: The study demonstrated that exosome-mediated delivery of Ldlr mRNA effectively restored receptor expression in Ldlr(-/-) mice, treating the disorders and reducing atherosclerotic plaque formation. Exo(Ldlr) treatment significantly decreased lipid deposition in the liver and lowered LDL-cholesterol levels in the treated mice, providing a new therapeutic approach for FH patients and managing atherosclerosis.
Article
Biochemistry & Molecular Biology
Ines Magro dos Reis, Tom Houben, Marion J. J. Gijbels, Dieter Luetjohann, Jogchum Plat, Ronit Shiri-Sverdlov
Summary: The study found that dietary plant stanol supplementation can reduce liver cholesterol accumulation and improve liver inflammation, especially in mice fed a high fat, high cholesterol diet. However, the effects of plant stanol supplementation on these parameters were less significant in mice fed a low cholesterol diet. Future research should investigate whether other models of metabolic inflammation exhibit similar stanol-related effects on inflammation.