期刊
LIPIDS
卷 44, 期 10, 页码 889-896出版社
WILEY
DOI: 10.1007/s11745-009-3347-x
关键词
Cyclooxygenase-2 (COX-2) expression; COX-2 activity; Arthritis; n-3 Polyunsaturated fatty acids
资金
- Arthritis Research Campaign
- Biotechnology and Biological Sciences Research Council [D16961]
Cyclooxygenase-2 (COX-2) is intimately involved in symptoms of arthritis while dietary n-3 polyunsaturated fatty acids (PUFA) are thought to be beneficial. In these experiments, using both bovine and human in vitro systems that mimic features of arthritis, we show that the n-3 PUFA eicosapentaenoic acid (EPA) is able to reduce mRNA and protein levels of COX-2. Activity, as assessed through prostaglandin E-2 formation, was also reduced in a dose-dependent manner. These effects of EPA contrasted noticeably with the n-6 PUFA, arachidonic acid. The data provide direct evidence for a molecular mechanism by which dietary n-3 PUFA, such as EPA, can reduce inflammation and, hence, associated symptoms in arthritis.
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