Article
Cell Biology
Azadeh Yeganeh, Faisal J. Alibhai, Stephanie W. Tobin, Fievel Lim, Jun Wu, Shuhong Li, Richard D. Weisel, Ren-Ke Li
Summary: Bone marrow mononuclear cell therapy improves cardiac repair after myocardial infarction by signaling to resident cardiac cells, but its efficacy decreases with age due to age-related changes in autophagy altering paracrine signaling between cells.
Article
Biochemistry & Molecular Biology
Cheng-Chang Lu, Cheng-Jung Ho, Hsuan-Ti Huang, Sung-Yen Lin, Shih-Hsiang Chou, Pei-Hsi Chou, Mei-Ling Ho, Yin-Chun Tien
Summary: Both bone marrow mononuclear cells (BMMNCs) and bone marrow stromal cells (BMSCs) have comparable effects on cell repopulation and interfacial allograft-bone healing after allograft anterior cruciate ligament reconstruction (ACLR). Intra-articular delivery of BM cells has limited benefits on graft cell repopulation and may cause higher inflammation in the early stage, with fibrocartilage formation in the tendon-bone interface.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell & Tissue Engineering
Li Ling, Han Shu, Yubin Huang, Jiying Hou, Yuanyuan Hua
Summary: This study aimed to investigate the effects of ginsenoside Rg1 (Rg1) on the biological behavior of human amnion-derived mesenchymal stem/stromal cells (hAD-MSCs). The results showed that Rg1 promoted cell cycle progression and increased cell proliferation rate. Rg1 also reduced cell senescence by regulating signaling pathways and inhibiting the expression of senescence markers.
STEM CELLS INTERNATIONAL
(2023)
Article
Biology
Wanqiu Chen, Chenguang Wang, Zhi-Xue Yang, Feng Zhang, Wei Wen, Christoph Schaniel, Xianqiang Mi, Matthew Bock, Xiao-Bing Zhang, Hongyu Qiu, Charles Wang
Summary: Researchers have developed a method to generate induced mesenchymal stromal cells (iMSCs) by directly reprogramming human peripheral blood mononuclear cells (PBMCs) using five factors. Omission of OCT4, one of the factors, significantly impairs the functionality of iMSCs and downregulates MSC-specific and mesoderm-regulating genes. The transient expression of OCT4 increases chromatin accessibility and promotes demethylation.
COMMUNICATIONS BIOLOGY
(2023)
Article
Immunology
Fulvio Massaro, Florent Corrillon, Basile Stamatopoulos, Nathan Dubois, Achille Ruer, Nathalie Meuleman, Dominique Bron, Laurence Lagneaux
Summary: Mesenchymal stromal cells (MSC) play a critical role in aging and inflammaging, and studying them is important for understanding the mechanisms of diseases in the elderly.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Plant Sciences
Jun-jie Zhang, Ke-cheng Chen, Yue Zhou, Heng Wei, Meng-han Qi, Zi Wang, Yi-nan Zheng, Ri-xin Chen, Shuang Liu, Wei Li
Summary: The study found that Rg2 could delay brain aging by increasing mitochondrial autophagy flux to maintain mitochondrial function, demonstrating good anti-aging activity.
Article
Cell & Tissue Engineering
Lingxian Yi, Yue Ju, Ying He, Xiushan Yin, Ye Xu, Tujun Weng
Summary: Desferal (R) significantly prevented age-related bone loss in aged rats by promoting BMSC growth potential, improving the balance of osteogenic and adipogenic differentiation, rejuvenating senescent BMSCs, and revising the expression of stemness/senescence-associated genes. The study demonstrated a novel role of Desferal (R) in rejuvenating aged BMSCs and preventing age-related bone loss.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Veterinary Sciences
Paula Silvestrini, Camila Beccaria, Maria S. Renna, Carolina Engler, Valeria Simonutti, Ivana Cellone, Luis F. Calvinho, Bibiana E. Dallard, Celina Baravalle
Summary: The aim of this study was to evaluate the immunomodulatory effect of ginsenoside Rg1 on mammary secretion and peripheral blood mononuclear cells (MSMC and PBMC, respectively). The study found that Rg1 treatment increased the mRNA expression of TLR2, TLR4, TNF-alpha, IL-1 beta, IL-6 and IL-8 in MSMC, and induced TLR2 and TLR4 protein expression in both MSMC and PBMC. Rg1 treatment also enhanced the phagocytic capacity, ROS production, and MHC-II expression in both MSMC and PBMC. However, Rg1 pre-treatment had no effect on cells co-cultured with S. aureus.
RESEARCH IN VETERINARY SCIENCE
(2023)
Review
Cell Biology
Kevin Woods, Borhane Guezguez
Summary: Mesenchymal stromal cells (MSCs) are a diverse cell population known for their nutrient-producing and immunomodulatory functions, crucial in regulating hematopoietic stem cells (HSC) in the bone marrow for blood production and immunity. MSCs contribute to bone integrity and hormone supply by differentiating into osteoblasts and adipocytes, playing a key role in the complex interactions of the HSC niche.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Cell Biology
Kevin Woods, Borhane Guezguez
Summary: MSCs are a heterogeneous cell population found in various tissues in the body, with important regulatory functions, especially in the bone marrow where they play a critical role in regulating HSCs. They contribute to maintaining bone integrity and hormonal nutrition supply, as well as regulating the homeostasis and differentiation of the HSC niche through differentiation into different cell types. Research on MSCs helps understand their role in regulating cell interactions and homeostasis in the body.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Siming Wang, Juhui Qiao, Chunyan Jiang, Daian Pan, Shiting Yu, Jingjing Chen, Shichao Liu, Peiguang Zhang, Daqing Zhao, Meichen Liu
Summary: Ginsenosides, active substances in ginseng, have been found to extend lifespan, ameliorate age-related damage, and limit functional decline. However, the specific components and molecular mechanisms of ginsenosides are not well understood. In this study, ginsenoside Rg1 was found to promote longevity in Saccharomyces cerevisiae by reducing aging-related surface wrinkling, enhancing stress resistance, decreasing reactive oxygen species' production and apoptosis, improving antioxidant enzyme activity, and slowing down the aging rate. Proteomic analysis revealed that Rg1 delays yeast senescence by regulating metabolic homeostasis, with CDC19 and SDH2 potentially being the effector proteins involved. Further experiments confirmed that Rg1 improves mitochondrial bioenergetics and glycolysis in yeast. These findings suggest that Rg1 could be used as a new treatment for slowing down the aging process.
Article
Biotechnology & Applied Microbiology
Dominik Hanetseder, Tina Levstek, Andreas Herbert Teuschl-Woller, Julia Katharina Frank, Barbara Schaedl, Heinz Redl, Darja Marolt Presen
Summary: This study used human-induced pluripotent stem cells to generate an engineered extracellular matrix (iECM) and tested its effects on the osteogenic capacity of human bone-marrow mesenchymal stromal cells (BMSCs). The results showed that BMSCs cultured on iECM exhibited increased proliferation, osteogenic marker expression, and mineralization. When cultured in 3D iECM/silk scaffolds, BMSCs also showed increased osteogenic gene expression levels and bone matrix deposition. These findings suggest that iECM can enhance the osteogenic activity of BMSCs, providing a bioactive and scalable biomaterial strategy for bone regeneration.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Biology
Zheting Liao, Yu Jin, Yuhao Chu, Hansen Wu, Xiaoyu Li, Zhonghao Deng, Shuhao Feng, Nachun Chen, Ziheng Luo, Xiaoyong Zheng, Liangxiao Bao, Yongqing Xu, Hongbo Tan, Liang Zhao
Summary: A study using single-cell RNA sequencing explored the transcriptomic landscape of alcohol-induced osteonecrosis of the femoral head (ONFH). The study revealed the relevance of stromal and endothelial cells to the pathogenesis of the disease and provided resources for developing cell type-specific therapeutic strategies.
COMMUNICATIONS BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jiying Hou, Ruoxiang Ma, Shisheng Zhu, Yaping Wang
Summary: This study investigated the therapeutic effects of Ginsenoside Rg1 on oxidative stress-related liver damage. The results showed that Rg1 treatment attenuated liver damage, reduced hepatic fat accumulation, promoted hepatic glycogen synthesis, and lowered serum lipid levels. Proteomic analysis suggested potential mechanisms of Rg1 in regulating hepatocyte metabolism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell & Tissue Engineering
Chao Ma, Juan Gao, Jun Liang, Weixiang Dai, Zhenfei Wang, Mengjiao Xia, Tao Chen, Sen Huang, Jian Na, Long Xu, Shiming Feng, Kerong Dai, Guangwang Liu
Summary: Senile osteoporosis is a common and severe disease affecting the elderly, characterized by increased risk of fractures due to bone fragility. Research focused on investigating the mechanisms underlying defective bone formation in age-related bone loss, particularly the role of histone acetylation. Inhibition of HDAC6 was found to improve osteogenic potential in aged mice, providing insights for potential therapies to treat senile osteoporosis.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Cell & Tissue Engineering
Shan Geng, Xin-Yi Mu, Xiong-Bin Chen, Ying Hou, Dao-Yong Jia, Chun-Yan Xu, Ya-Ping Wang
STEM CELLS INTERNATIONAL
(2015)
Article
Cell Biology
Ying Liu, Long Yi, Lu Wang, Linbo Chen, Xiongbin Chen, Yaping Wang
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2016)
Article
Biochemistry & Molecular Biology
Hanxianzhi Xiao, Lirong Xiong, Xiaoying Song, Pengwei Jin, Linbo Chen, Xiongbin Chen, Hui Yao, Yaping Wang, Lu Wang
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2017)
Article
Biochemistry & Molecular Biology
Linbo Chen, Hui Yao, Xiongbin Chen, Ziling Wang, Yue Xiang, Jieyu Xia, Ying Liu, Yaping Wang
NEUROCHEMICAL RESEARCH
(2018)
Article
Medicine, Research & Experimental
Zhaoying Dong, Mengxiong Xu, Jie Huang, Linbo Chen, Jieyu Xia, Xiongbin Chen, Rong Jiang, Lu Wang, Yaping Wang
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2017)
Article
Cell & Tissue Engineering
Xinyi Mu, Yanyan Zhang, Jing Li, Jieyu Xia, Xiongbin Chen, Pengwei Jing, Xiaoying Song, Lu Wang, Yaping Wang
STEM CELLS INTERNATIONAL
(2017)
Article
Oncology
Zi-Ling Wang, Lin-Bo Chen, Zhu Qiu, Xiong-Bin Chen, Ying Liu, Jing Li, Lu Wang, Ya-Ping Wang
MOLECULAR MEDICINE REPORTS
(2018)
Article
Medicine, Research & Experimental
Ming-He Xiao, Jie-Yu Xia, Zi-Ling Wang, Wen-Xu Hu, Yan-Ling Fan, Dao-Yong Jia, Jing Li, Peng-Wei Jing, Lu Wang, Ya-Ping Wang
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2018)
Article
Biochemistry & Molecular Biology
Jiying Hou, Ruoxiang Ma, Shisheng Zhu, Yaping Wang
Summary: This study investigated the therapeutic effects of Ginsenoside Rg1 on oxidative stress-related liver damage. The results showed that Rg1 treatment attenuated liver damage, reduced hepatic fat accumulation, promoted hepatic glycogen synthesis, and lowered serum lipid levels. Proteomic analysis suggested potential mechanisms of Rg1 in regulating hepatocyte metabolism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Yuwen Zhu, Yan Guo, Yujia Xue, Anqi Zhou, Ying Chen, Yifei Chen, Xiulian Miao, Fangqiao Lv
Summary: BRG1 plays an important role in HSC-myofibroblast transition and targeting it could be a reasonable strategy for liver fibrosis intervention.
Article
Medicine, Research & Experimental
Liu Ye, Beibei Liu, Jingling Huang, Xiaolin Zhao, Yuan Wang, Yungen Xu, Shuping Wang
Summary: Doublecortin-like kinase 1 (DCLK1) is a significant prooncogenic factor that is strongly associated with the malignant progression and clinical prognosis of various cancers. DCLK1 plays important roles in stem cell marker regulation, tumor cell reprogramming, and immune evasion. However, the exact biological functions of DCLK1, especially the disparities between its alpha- and beta-form transcripts in cancer progression, remain ambiguous.
Article
Medicine, Research & Experimental
Jiahui Yang, Xiaoyu Chen, Tianjing Liu, Yongyan Shi
Summary: This article reviews the role of bile acids in necrotizing enterocolitis (NEC) and their potential therapeutic value. The dysregulation of bile acids is associated with intestinal injury, and inflammatory factors in the liver also play a crucial role in regulating bile acid transport. The bile acid metabolic pathway is important for regulating intestinal microbiota, cell proliferation, and barrier protection.
Review
Medicine, Research & Experimental
Zhenzheng Zhu, Yuemiao Xu, Yuwei Xia, Xinru Jia, Yixin Chen, Yuyue Liu, Leyin Zhang, Hui Chai, Leitao Sun
Summary: Bile acid, as the final product of cholesterol breakdown, plays a complex regulatory and signaling role in human metabolism. Research suggests that it has the potential to enhance metabolism and regulate chronic metabolic diseases through various pathways. The interaction between bile acid and gut microbiota is also of great significance.
Article
Medicine, Research & Experimental
Xin He, Hong-Xu Zhou, Xian Fu, Kai-Di Ni, Ai-Zhi Lin, Ling-Tong Zhang, Hou-Hua Yin, Qing Jiang, Xue Zhou, Yi-Wen Meng, Jun-Yan Liu
Summary: DON exposure causes an increase in deoxycholic acid (DCA), which contributes to intestinal injury. DCA may be a potential therapeutic target for DON enterotoxicity.
Article
Medicine, Research & Experimental
Zhitao Wang, Heng Ma, Abdul Nasir, Sufang Liu, Zhisong Li, Feng Tao, Qian Bai
Summary: This study reveals the involvement of TET1-mediated epigenetic regulation in chronic TMJ pain through trigeminal TNF alpha signaling.
Article
Medicine, Research & Experimental
Lu Yu, Hao Ran, Yaru Lu, Qian Ma, Huan Huang, Weibin Liu
Summary: This study found that the HIF-1 alpha inhibitor BAY 87-2243 can alleviate the symptoms of the Experimental Autoimmune Myasthenia Gravis (EAMG) inflammation model. BAY 87-2243 can restore the balance of CD4(+)T cell subsets, reduce the production of pro-inflammatory cytokines, and act as both an immune imbalance regulator and anti-inflammatory.
Article
Medicine, Research & Experimental
Alex Peralvarez-Marin, Montse Sole, Judith Serrano, Alice Taddeucci, Belen Perez, Clara Penas, Gemma Manich, Marcel Jimenez, Pilar D'Ocon, Francesc Jimenez-Altayo
Summary: This study provides the first evidence that TRPV2 channels may modulate vascular tone by balancing opposing inputs from the endothelium and smooth muscle, leading to net vasodilation. The amplification of TRPV2 channel-induced activity by NO emphasizes the pathophysiological relevance of these findings.
Article
Medicine, Research & Experimental
Amin Ullah, Jing Zhao, Jiakun Li, Rajeev K. Singla, Bairong Shen
Summary: Gastric cancer is the fifth-most prevalent and second-most deadly cancer worldwide. Late onset of symptoms makes early detection important. CXC chemokines play an important role in the pathological process of gastric cancer, but their exact role in diagnosis and prognosis is not fully understood. Inhibiting CXC chemokines shows promise as a targeted therapy.
Article
Medicine, Research & Experimental
Menna S. Zeyada, Salma M. Eraky, Mamdouh M. El-Shishtawy
Summary: The current study demonstrates the prophylactic and antifibrotic effects of Trig against BLM-induced PF by targeting multiple signaling pathways. The combination of Trig and Pirf may be a promising approach to enhance Pirf's anti-fibrotic effect.