Article
Cell Biology
Hee Jung Kim, Dong-Hoon Kim, Sung Hee Um
Summary: YM976, a pyrimidine derivative, has anti-inflammatory and anti-asthmatic effects. It can reduce lipid accumulation and suppress adipocyte differentiation by increasing the phosphorylation of AMPK. Therefore, YM976 may be a potential compound for controlling lipid accumulation and formation of adipocytes in obesity.
Article
Ophthalmology
Yasushi Kitaoka, Kana Sase, Chihiro Tsukahara, Naoki Fujita, Ibuki Arizono, Jiro Kogo, Naoto Tokuda, Hitoshi Takagi
Summary: This study investigated the effect of netarsudil on TNF-induced axon loss and found that it increased autophagy and protected against axon degeneration.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Article
Medicine, Research & Experimental
Yeon Ju Kim, Sung Yun Park, Ju-Hee Lee
Summary: The study revealed that berteroin significantly inhibits lipid synthesis and lipid droplet formation, potentially mediated by AMPK activation.
Article
Biochemistry & Molecular Biology
Sam Cho, Seok Jin Hong, Sung Hun Kang, YongKeun Park, Sung Kyun Kim
Summary: This study investigated the impact of alpha-lipoic acid on ferroptosis and lipid droplets (LDs) in auditory hair cells damaged by cisplatin. It was found that alpha-lipoic acid inhibited 4-HNE expression, restored xCT and GPX4 expression, and normalized LD levels in the cells. The research provides biological evidence of ferroptosis and offers insights for investigating molecular pathways using 3D optical diffraction tomography (3D-ODT) of LDs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Veterinary Sciences
Franziska Dengler, Felix Sternberg, Marei Grages, Sabine B. R. Kaestner, Nicole Verhaar
Summary: This study investigated the adaptation mechanisms in equine small intestinal ischemia reperfusion injury (IRI) and found that HIF1 alpha and mitophagy are activated in response to IRI, indicating their potential therapeutic role in promoting cellular survival.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Ara Lee, Meng Li, Young Ho Ko, Sanghwang Park, Jongcheol Seo, Kyeng Min Park, Kimoon Kim
Summary: A rationally designed supramolecular FRET pair consisting of Cy3-CB[7] and BDP-AdA was used to visualize organelle-specific autophagy events. The intracellular accumulations of Cy3-CB[7] in lysosomes and BDP-AdA in lipid droplets, along with the formation of an intracellular host-guest complex resulting in FRET signals, allowed the visualization of the fusion of lipid droplets with lysosomes, namely, lipophagy. This study demonstrates the potential of supramolecular imaging based on bio-orthogonal host-guest interactions in investigating selective autophagy events.
CHEMICAL COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Guo-En Wang, Xiao-Ting Liu, Fan Yang, Ruo-Hong Wang, Xin-Yu Liu, Xi-Ting Lv, Xiao-Li Lin, Yan-Fen Chen
Summary: This study demonstrated the antihepatosteatosis effect of biochanin A (Bio-A) on oleate (OA)-treated hepatocytes by activating SIRT3/AMPK/ULK-1-mediated autophagy, providing a theoretical basis for the application of Bio-A to hepatic steatosis-related diseases.
JOURNAL OF FOOD BIOCHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Natalia Riera-Heredia, Esmail Lutfi, Sara Balbuena-Pecino, Emilio J. Velez, Karine Dias, Florian Beaumatin, Joaquim Gutierrez, Iban Seiliez, Encarnacion Capilla, Isabel Navarro
Summary: The study revealed the involvement of key adipogenic and autophagy-related genes in rainbow trout adipocyte differentiation, indicating a possible role of autophagy during adipogenesis. Additionally, the delay in adipogenesis process by incubating preadipocytes with lysosomal inhibitors suggests a relationship between autophagy and adipocyte differentiation.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY
(2022)
Article
Cell Biology
Nadav Kislev, Shira Eidelheit, Shaked Perlmutter, Dafna Benayahu
Summary: In this study, a novel machine learning-based method was developed for analyzing lipid droplets (LDs) by segmenting phase-contrast images. This method enables accurate and label-free quantification of LD-related parameters and analysis of LD dynamics. It can be applied in different metabolic conditions to study LD biogenesis and function.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Ling Yang, Linzi Li, Qian Lu, Lingfeng Li, Chun Xie, Fakun Jiang, Hongbing Li, Ai Zhao, Qian Wang, Wenyong Xiong
Summary: As a global epidemic disease, obesity leads to dysfunction of glucose and lipid metabolism, resulting in high morbidity and mortality. This study found that alisol B, a triterpene monomer from the Chinese medicine Alisma orientale, can suppress adipogenesis, reduce subcutaneous adipose tissue mass, and improve obesity-related metabolic disorders. The effects of alisol B on adipogenesis are mediated by the LKB1-AMPK signaling pathway. Overall, alisol B could be a potential lead compound for the treatment of obesity-related metabolic disorders.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Ida Florance, Seenivasan Ramasubbu
Summary: Lipid metabolism is crucial for various cellular functions and the survival of macrophages, but its role in macrophages varies depending on their location. Lipid-loaded macrophages have been linked to several diseases, and stress signals can regulate lipid metabolism differently. Understanding the biology of lipid accumulation in macrophages requires the development of potential modulators of lipid metabolism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Tao Yang, Xiaoye Qu, Xiao Wang, Dongwei Xu, Mingwei Sheng, Yuanbang Lin, Michael Ke, Ci Song, Qiang Xia, Longfeng Jiang, Jun Li, Douglas G. Farmer, Bibo Ke
Summary: This study found that the macrophage STING-YAP axis controls the development of hepatic steatosis by reprogramming lipid metabolism. These findings provide new insights into the regulatory mechanism of macrophage STING-driven YAP activity in lipid control.
Article
Biochemistry & Molecular Biology
Md. Ataur Rahman, Yoonjeong Cho, Ghilsoo Nam, Hyewhon Rhim
Summary: Oxyresveratrol affects the function of astrocytes by promoting autophagy signaling and inhibiting APP production. Co-treatment with chloroquine significantly enhances autophagic flux, and the regulation of autophagy substrates and pathways by Oxyresveratrol depends on the PI3 kinase pathway.
Article
Biochemistry & Molecular Biology
Norah Saeed Al-Zahrani, Mazin Abdulaziz Zamzami, Mohammed A. Baghdadi, Afnan H. El-Gowily, Ehab M. M. Ali
Summary: Combining metformin and paclitaxel shows promising outcomes in the treatment of liver cancer. It enhances treatment effectiveness, reduces side effects, induces cell cycle alterations and apoptosis, as well as modulates key cellular proteins involved in cancer growth.
Article
Nutrition & Dietetics
Changbao Sun, Ang Li, Huan Wang, Jiage Ma, Juncai Hou
Summary: Acetate is associated with adipocyte differentiation and lipid deposition. In a study on obese mice and mouse adipose mesenchymal stem cells, it was found that acetate significantly increased body weight, food intake, and fatty lesions, while decreasing anti-inflammatory factors levels and liver function. The mRNA expression levels of several genes in adipose tissue and stem cells were also significantly altered.
Article
Medicine, Research & Experimental
Yuwen Zhu, Yan Guo, Yujia Xue, Anqi Zhou, Ying Chen, Yifei Chen, Xiulian Miao, Fangqiao Lv
Summary: BRG1 plays an important role in HSC-myofibroblast transition and targeting it could be a reasonable strategy for liver fibrosis intervention.
Article
Medicine, Research & Experimental
Liu Ye, Beibei Liu, Jingling Huang, Xiaolin Zhao, Yuan Wang, Yungen Xu, Shuping Wang
Summary: Doublecortin-like kinase 1 (DCLK1) is a significant prooncogenic factor that is strongly associated with the malignant progression and clinical prognosis of various cancers. DCLK1 plays important roles in stem cell marker regulation, tumor cell reprogramming, and immune evasion. However, the exact biological functions of DCLK1, especially the disparities between its alpha- and beta-form transcripts in cancer progression, remain ambiguous.
Article
Medicine, Research & Experimental
Jiahui Yang, Xiaoyu Chen, Tianjing Liu, Yongyan Shi
Summary: This article reviews the role of bile acids in necrotizing enterocolitis (NEC) and their potential therapeutic value. The dysregulation of bile acids is associated with intestinal injury, and inflammatory factors in the liver also play a crucial role in regulating bile acid transport. The bile acid metabolic pathway is important for regulating intestinal microbiota, cell proliferation, and barrier protection.
Review
Medicine, Research & Experimental
Zhenzheng Zhu, Yuemiao Xu, Yuwei Xia, Xinru Jia, Yixin Chen, Yuyue Liu, Leyin Zhang, Hui Chai, Leitao Sun
Summary: Bile acid, as the final product of cholesterol breakdown, plays a complex regulatory and signaling role in human metabolism. Research suggests that it has the potential to enhance metabolism and regulate chronic metabolic diseases through various pathways. The interaction between bile acid and gut microbiota is also of great significance.
Article
Medicine, Research & Experimental
Xin He, Hong-Xu Zhou, Xian Fu, Kai-Di Ni, Ai-Zhi Lin, Ling-Tong Zhang, Hou-Hua Yin, Qing Jiang, Xue Zhou, Yi-Wen Meng, Jun-Yan Liu
Summary: DON exposure causes an increase in deoxycholic acid (DCA), which contributes to intestinal injury. DCA may be a potential therapeutic target for DON enterotoxicity.
Article
Medicine, Research & Experimental
Zhitao Wang, Heng Ma, Abdul Nasir, Sufang Liu, Zhisong Li, Feng Tao, Qian Bai
Summary: This study reveals the involvement of TET1-mediated epigenetic regulation in chronic TMJ pain through trigeminal TNF alpha signaling.
Article
Medicine, Research & Experimental
Lu Yu, Hao Ran, Yaru Lu, Qian Ma, Huan Huang, Weibin Liu
Summary: This study found that the HIF-1 alpha inhibitor BAY 87-2243 can alleviate the symptoms of the Experimental Autoimmune Myasthenia Gravis (EAMG) inflammation model. BAY 87-2243 can restore the balance of CD4(+)T cell subsets, reduce the production of pro-inflammatory cytokines, and act as both an immune imbalance regulator and anti-inflammatory.
Article
Medicine, Research & Experimental
Alex Peralvarez-Marin, Montse Sole, Judith Serrano, Alice Taddeucci, Belen Perez, Clara Penas, Gemma Manich, Marcel Jimenez, Pilar D'Ocon, Francesc Jimenez-Altayo
Summary: This study provides the first evidence that TRPV2 channels may modulate vascular tone by balancing opposing inputs from the endothelium and smooth muscle, leading to net vasodilation. The amplification of TRPV2 channel-induced activity by NO emphasizes the pathophysiological relevance of these findings.
Article
Medicine, Research & Experimental
Amin Ullah, Jing Zhao, Jiakun Li, Rajeev K. Singla, Bairong Shen
Summary: Gastric cancer is the fifth-most prevalent and second-most deadly cancer worldwide. Late onset of symptoms makes early detection important. CXC chemokines play an important role in the pathological process of gastric cancer, but their exact role in diagnosis and prognosis is not fully understood. Inhibiting CXC chemokines shows promise as a targeted therapy.
Article
Medicine, Research & Experimental
Menna S. Zeyada, Salma M. Eraky, Mamdouh M. El-Shishtawy
Summary: The current study demonstrates the prophylactic and antifibrotic effects of Trig against BLM-induced PF by targeting multiple signaling pathways. The combination of Trig and Pirf may be a promising approach to enhance Pirf's anti-fibrotic effect.