Article
Pharmacology & Pharmacy
Ruxue Huang, Lulu Ding, Ying Ye, Ke Wang, Wenjing Yu, Bingzhao Yan, Zongping Liu, Jicang Wang
Summary: Cadmium induces kidney injury and apoptosis, while Quercetin reduces kidney damage caused by Cadmium by decreasing oxidative stress and inhibiting apoptosis.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biology
Sajad Fakhri, Mohammad Mehdi Gravandi, Sadaf Abdian, Seyed Zachariah Moradi, Javier Echeverria
Summary: Spinal cord injury (SCI) is a complex disease with no FDA-approved treatment. Flavonoids, especially quercetin, found in plant secondary metabolites, have the potential to combat SCI and have been extensively studied.
Review
Clinical Neurology
Xichen Wang, Yuke Fu, Benson O. A. Botchway, Yufeng Zhang, Yong Zhang, Tian Jin, Xuehong Liu
Summary: The pathogenesis of spinal cord injury (SCI) is complex, and there is no effective treatment currently available. Quercetin, as a potential interventional agent, has therapeutic effects in SCI by modulating the mTOR signaling pathway to improve pathological alterations.
FRONTIERS IN NEUROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ning Wang, Hai Yu, Qian Song, Ping Mao, Kuo Li, Gang Bao
Summary: The study developed and characterized SM@SA-CS nanomicelles, showing potential therapeutic effects in oxidative stress in neural cells.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Geriatrics & Gerontology
Mingjie Xia, Qinyang Zhang, Yanan Zhang, Rulin Li, Tianyu Zhao, Lingxia Chen, Qiangxian Liu, Shengnai Zheng, Haijun Li, Zhanyang Qian, Lei Yang
Summary: Growth differentiation factor 15 (GDF15) plays an important role in neuronal ferroptosis following spinal cord injury (SCI). GDF15 inhibits neuronal ferroptosis through the p62-Keap1-Nrf2 signaling pathway and promotes locomotor recovery in SCI mice.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Tao Jiang, Tao Qin, Peng Gao, Zhiwen Tao, Xiaowei Wang, Mengyuan Wu, Jun Gu, Bo Chu, Ziyang Zheng, Jiang Yi, Tao Xu, Yifan Huang, Hao Liu, Shujie Zhao, Yongxin Ren, Jian Chen, Guoyong Yin
Summary: The expression of SIRT1 in spinal cord endothelial cells is decreased after spinal cord injury (SCI). SIRT1 has the ability to reduce endothelial reactive oxygen species production and protect endothelial barrier function, indicating its potential as a therapeutic target for promoting functional recovery against blood-spinal cord barrier (BSCB) disruption following SCI.
Article
Biochemistry & Molecular Biology
Alessia Filippone, Deborah Mannino, Laura Cucinotta, Irene Paterniti, Emanuela Esposito, Michela Campolo
Summary: This study aimed to investigate the role of PF06447475 as a pharmacological LRRK2 antagonist in counteracting the pathological consequences of spinal cord trauma. By using an in vivo model of SCI induced by extradural compression, it was found that treatment with PF-475 significantly reduced spinal cord tissue injury, glycogen accumulation, and demyelination of neurons associated with trauma. Additionally, LRRK2 antagonist treatment decreased oxidative stress and cytokine expression levels, suggesting that targeting LRRK2 activity could have direct effects on intervening in neuroinflammatory disorders.
Article
Biochemistry & Molecular Biology
Pauline Michel-Flutot, Laurie Efthimiadi, Lynda Djerbal, Therese B. Deramaudt, Marcel Bonay, Stephane Vinit
Summary: This study evaluated the antioxidant response in phrenic motoneurons following C2 spinal cord lateral hemi-section in rats, and found that the AMPK-Nrf2 signaling pathway plays a significant role in the oxidative stress response after high SCI. Harnessing this pathway could improve the antioxidant response and help in improving diaphragm activity in patients with high SCI.
Article
Neurosciences
Li-Na Xuan, Zhen-Xin Hu, Zhen-Fu Jiang, Cong Zhang, Xiao-Wan Sun, Wen-Hua Ming, Hui-Tao Liu, Rong-Fang Qiao, Lin-Jie Shen, Shao-Bo Liu, Guan-Yu Wang, Lin Wen, Zhi-Lin Luan, Jian Yin
Summary: In this study, it was found that pregnane X receptor (PXR) is involved in the recovery of motor function after spinal cord injury (SCI) by regulating the NRF2/HO-1 pathway. Activation of PXR suppressed the NRF2/HO-1 pathway, while PXR deficiency activated this pathway and improved motor function in mice after SCI.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Pharmacology & Pharmacy
Zhen Li, Zehui Li, Zhenyue Chen, He Sun, Zhagen Yuan, Xiaochao Wang, Jinqiang Wei, Xuewei Cao, Decai Zheng
Summary: Andro has shown neuroprotective effects against spinal cord injury (SCI) by reducing apoptosis, oxidative stress, and inflammation, promoting axonal regeneration and remyelination, leading to tissue repair and functional recovery.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Yang Yang, Lei Zhang, Meiyi Huang, Rubo Sui, Suliman Khan
Summary: The study demonstrates that ibuprofen-PEG/PLA nanomicelles significantly improve motor function restoration and alleviate inflammation and oxidative stress caused by SCI through the eNOS/Nrf2 signaling pathway.
ARABIAN JOURNAL OF CHEMISTRY
(2021)
Article
Neurosciences
Dachuan Li, Xiao Lu, Guangyu Xu, Siyang Liu, Zhaoyang Gong, Feizhou Lu, Xinlei Xia, Jianyuan Jiang, Hongli Wang, Fei Zou, Xiaosheng Ma
Summary: DHODH attenuates neuronal damage and inhibits ferroptosis in spinal cord injury by reducing lipid peroxide production and mitochondrial damage. In addition, DHODH inhibits ALOX15 expression by inhibiting P53. Therefore, DHODH may serve as a novel therapeutic target for the treatment of spinal cord injury.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Neurosciences
Zhengxin Jin, Lige Tian, Ying Zhang, Xiaodi Zhang, Jianning Kang, Hui Dong, Nana Huang, Liuzhu Pan, Bin Ning
Summary: This study investigated the effect of apigenin on fibrous scar formation after spinal cord injury (SCI) in mice. Results showed that apigenin inhibited fibrous scar formation and promoted motor function recovery. It achieved this by reducing the expression of fibrosis-related factors through the TGF beta/SMADs signaling pathway.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Biochemistry & Molecular Biology
Jun Lu, Yi Zhang, Huiyue Dong, Jingjing Sun, Ling Zhu, Pengyang Liu, Fuli Wen, Rong Lin
Summary: Triptolide activates the cGAS-STING signaling pathway in kidney tubular cells, leading to renal injury. Inhibiting over-activation of the cGAS-STING pathway may be a new strategy to alleviate triptolide-induced nephrotoxicity.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Immunology
Yonghui Hou, Jiyao Luan, Taida Huang, Tiancheng Deng, Xing Li, Zhifeng Xiao, Jiheng Zhan, Dan Luo, Yu Hou, Liangliang Xu, Dingkun Lin
Summary: In this study, TUDCA was shown to attenuate axon degeneration induced by oxidative stress in vitro and protect primary cortical neurons. In vivo, TUDCA treatment reduced tissue injury, oxidative stress, inflammation, and apoptosis, while promoting axon regeneration and remyelination in SCI mice. The functional recovery test also indicated that TUDCA treatment significantly improved limb function recovery after SCI.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Medicine, Research & Experimental
Yuwen Zhu, Yan Guo, Yujia Xue, Anqi Zhou, Ying Chen, Yifei Chen, Xiulian Miao, Fangqiao Lv
Summary: BRG1 plays an important role in HSC-myofibroblast transition and targeting it could be a reasonable strategy for liver fibrosis intervention.
Article
Medicine, Research & Experimental
Liu Ye, Beibei Liu, Jingling Huang, Xiaolin Zhao, Yuan Wang, Yungen Xu, Shuping Wang
Summary: Doublecortin-like kinase 1 (DCLK1) is a significant prooncogenic factor that is strongly associated with the malignant progression and clinical prognosis of various cancers. DCLK1 plays important roles in stem cell marker regulation, tumor cell reprogramming, and immune evasion. However, the exact biological functions of DCLK1, especially the disparities between its alpha- and beta-form transcripts in cancer progression, remain ambiguous.
Article
Medicine, Research & Experimental
Jiahui Yang, Xiaoyu Chen, Tianjing Liu, Yongyan Shi
Summary: This article reviews the role of bile acids in necrotizing enterocolitis (NEC) and their potential therapeutic value. The dysregulation of bile acids is associated with intestinal injury, and inflammatory factors in the liver also play a crucial role in regulating bile acid transport. The bile acid metabolic pathway is important for regulating intestinal microbiota, cell proliferation, and barrier protection.
Review
Medicine, Research & Experimental
Zhenzheng Zhu, Yuemiao Xu, Yuwei Xia, Xinru Jia, Yixin Chen, Yuyue Liu, Leyin Zhang, Hui Chai, Leitao Sun
Summary: Bile acid, as the final product of cholesterol breakdown, plays a complex regulatory and signaling role in human metabolism. Research suggests that it has the potential to enhance metabolism and regulate chronic metabolic diseases through various pathways. The interaction between bile acid and gut microbiota is also of great significance.
Article
Medicine, Research & Experimental
Xin He, Hong-Xu Zhou, Xian Fu, Kai-Di Ni, Ai-Zhi Lin, Ling-Tong Zhang, Hou-Hua Yin, Qing Jiang, Xue Zhou, Yi-Wen Meng, Jun-Yan Liu
Summary: DON exposure causes an increase in deoxycholic acid (DCA), which contributes to intestinal injury. DCA may be a potential therapeutic target for DON enterotoxicity.
Article
Medicine, Research & Experimental
Zhitao Wang, Heng Ma, Abdul Nasir, Sufang Liu, Zhisong Li, Feng Tao, Qian Bai
Summary: This study reveals the involvement of TET1-mediated epigenetic regulation in chronic TMJ pain through trigeminal TNF alpha signaling.
Article
Medicine, Research & Experimental
Lu Yu, Hao Ran, Yaru Lu, Qian Ma, Huan Huang, Weibin Liu
Summary: This study found that the HIF-1 alpha inhibitor BAY 87-2243 can alleviate the symptoms of the Experimental Autoimmune Myasthenia Gravis (EAMG) inflammation model. BAY 87-2243 can restore the balance of CD4(+)T cell subsets, reduce the production of pro-inflammatory cytokines, and act as both an immune imbalance regulator and anti-inflammatory.
Article
Medicine, Research & Experimental
Alex Peralvarez-Marin, Montse Sole, Judith Serrano, Alice Taddeucci, Belen Perez, Clara Penas, Gemma Manich, Marcel Jimenez, Pilar D'Ocon, Francesc Jimenez-Altayo
Summary: This study provides the first evidence that TRPV2 channels may modulate vascular tone by balancing opposing inputs from the endothelium and smooth muscle, leading to net vasodilation. The amplification of TRPV2 channel-induced activity by NO emphasizes the pathophysiological relevance of these findings.
Article
Medicine, Research & Experimental
Amin Ullah, Jing Zhao, Jiakun Li, Rajeev K. Singla, Bairong Shen
Summary: Gastric cancer is the fifth-most prevalent and second-most deadly cancer worldwide. Late onset of symptoms makes early detection important. CXC chemokines play an important role in the pathological process of gastric cancer, but their exact role in diagnosis and prognosis is not fully understood. Inhibiting CXC chemokines shows promise as a targeted therapy.
Article
Medicine, Research & Experimental
Menna S. Zeyada, Salma M. Eraky, Mamdouh M. El-Shishtawy
Summary: The current study demonstrates the prophylactic and antifibrotic effects of Trig against BLM-induced PF by targeting multiple signaling pathways. The combination of Trig and Pirf may be a promising approach to enhance Pirf's anti-fibrotic effect.