Article
Biochemistry & Molecular Biology
Tian Su, Zhengyi Zhang, Xiao Han, Fei Yang, Zhen Wang, Ying Cheng, Huadong Liu
Summary: This study reveals the interaction between SIRT1 and RanGap1, and its influence on intracellular ROS levels. The findings highlight the importance of this interaction in mitochondrial functions, cell proliferation, and transcription.
Article
Biochemistry & Molecular Biology
Lidia Ciccone, Eugenia Piragine, Simone Brogi, Caterina Camodeca, Raffaele Fucci, Vincenzo Calderone, Susanna Nencetti, Alma Martelli, Elisabetta Orlandini
Summary: The study found that the SIRT1 activator resveratrol can prevent vascular oxidative stress and endothelial dysfunction. However, its clinical use is limited due to low oral bioavailability. A computational protocol was used to identify promising derivatives from a chemical library, and the most effective derivative, compound 3d, exhibited good antioxidant effects in human umbilical vein endothelial cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Editorial Material
Nutrition & Dietetics
Arkadiusz Grzeczka, Pawel Kordowitzki
Summary: There is significant variability in the aging-related decline of oocytes among mammalian species. The evolutionary conservation of the aging mechanism and the need to develop antiaging strategies have attracted widespread interest. Resveratrol, an antioxidant, has shown antiaging properties and the ability to enhance Sirtuin 1 activity.
Article
Immunology
Hong Yang, Jianxia Chen, Yanghaoyu Chen, Yan Jiang, Baoxue Ge, Ling Hong
Summary: Sirt1 regulates apoptosis signaling in Mycobacterium tuberculosis infection, and its activation may serve as a potential candidate for the prevention and treatment of tuberculosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Review
Pharmacology & Pharmacy
Ramu Manjula, Kumari Anuja, Francisco J. Alcain
Summary: Sirtuins, a group of NAD(+) dependent histone deacetylases, play a crucial role in neuroprotection and cellular senescence. They regulate crucial proteins and can be targeted for therapeutic purposes in metabolic disorders. Their modulation shows promise in treating neurodegenerative diseases associated with aging and protein homeostasis.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Physiology
Zhenquan Zhou, Zhenhan Deng, Yuwei Liu, Yizi Zheng, Shiwei Yang, Wei Lu, Deming Xiao, Weimin Zhu
Summary: Resveratrol has shown potential therapeutic effects on osteoarthritis through activating the SIRT1 gene, inhibiting chondrocyte apoptosis, increasing trabecular bone number, and improving bone density. This highlights the importance of SIRT1 in maintaining articular cartilage health and provides a promising intervention for treating OA.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Xiao Le Tang, Xuan Wang, Gang Fang, Yi Lin Zhao, Jing Yan, Zhiqiang Zhou, Rao Sun, Ai Lin Luo, Shi Yong Li
Summary: Sevoflurane exposure leads to cognitive impairment in developing mice, which is ameliorated by resveratrol treatment through modulating the balance of microglia functions in the SIRT1 and NF-kappa B pathways.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2021)
Article
Immunology
Liyun Wu, Qiaozhen Chen, Bo Dong, Hancheng Geng, Yu Wang, Dong Han, Xiaoming Zhu, Haokun Liu, Zhimin Zhang, Yunxia Yang, Shouqi Xie, Junyan Jin
Summary: This study aimed to determine whether and how resveratrol (RES) can alleviate liver injury in lipopolysaccharide (LPS)-induced gibel carp. The results suggested that RES attenuated oxidative stress and inflammation by activating the Nrf2/Keap1 pathway and inhibiting the NF-kappa B pathway. Furthermore, RES cleared damaged mitochondria and enhanced mitochondrial biogenesis to mitigate reactive oxygen species (ROS) accumulation. Overall, RES alleviated LPS-induced oxidative stress and inflammation in gibel carp through mitochondria-related mechanisms.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Food Science & Technology
Lin Cong, Meng-Yu Lei, Zhi-Qi Liu, Zhuo-Fan Liu, Zhuo Ma, Kuan Liu, Jing Li, Yu Deng, Wei Liu, Bin Xu
Summary: The findings suggest that resveratrol alleviates manganese-induced oxidative stress and neuroinflammation in adult mice by activating SIRT1 signaling.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Environmental Sciences
Ruike Wang, Zuntao Wu, Lin Bai, Rundong Liu, Yue Ba, Huizhen Zhang, Xuemin Cheng, Guoyu Zhou, Hui Huang
Summary: The study confirmed the protective effects of resveratrol against hippocampal neurogenesis impairments induced by lead exposure in male rats, and demonstrated that resveratrol can alleviate cognitive damage and promote neurogenesis through regulation of the SIRT1 pathway.
ENVIRONMENTAL TOXICOLOGY
(2021)
Article
Cell Biology
Wei Zhang, Shaohuan Qian, Bi Tang, Pinfang Kang, Heng Zhang, Chao Shi
Summary: By activating the Sirt1/p53 pathway, resveratrol reduces the depletion of SLC7A11, inhibits ferroptosis, and improves cardiac function.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2023)
Article
Chemistry, Medicinal
Ruiting Wang, Weidong Yuan, Lu Li, Fei Lu, Lingling Zhang, Haifeng Gong, Xinzhong Huang
Summary: Chronic kidney disease (CKD) is often accompanied by muscle atrophy, and the application of resveratrol can improve renal function, reduce renal fibrosis, and alleviate muscle atrophy. SIRT1 plays a crucial role in linking renal disease and muscle atrophy, possibly through regulating FoxO1. Therefore, resveratrol and other SIRT1 agonists have great therapeutic potential for treating CKD and its related muscle atrophy.
PHYTOTHERAPY RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Shih-Bo Huang, Paul Rivas, Xiaoyu Yang, Zhao Lai, Yidong Chen, Keri L. Schadler, Ming Hu, Robert L. Reddick, Rita Ghosh, Addanki P. Kumar
Summary: Emerging evidence suggests that SIRT1 plays an important role in cancer development, progression, and therapeutic resistance, making it a potential therapeutic target. This study investigated the impact of resveratrol-mediated activation of SIRT1 on the progression of HGPIN lesions and prostate tumor development. The results showed that precise modulation of SIRT1 can benefit both cancer prevention and treatment. Activation of SIRT1 with resveratrol can prevent the development of HGPIN lesions in mice if administered early, but has little to no effect after the establishment of lesions or tumor cell implantation. Mechanistically, SIRT1 inhibition induces senescence under androgen deprivation conditions, and pharmacological inhibition of SIRT1 enhances the effects of clinical androgen receptor blockade agents and radiation. These findings provide an explanation for the contradictory role of SIRT1 in prostate tumorigenesis, highlighting the importance of precise SIRT1 modulation for cancer prevention and treatment.
MOLECULAR CARCINOGENESIS
(2022)
Review
Medicine, General & Internal
Zhenzhen Liu, Chengjie Wang, Jiangnan Pei, Mingqing Li, Weirong Gu
Summary: Pre-eclampsia is a severe complication of pregnancy characterized by insufficient trophoblast invasion, impaired uterine spiral artery remodeling, placental hypoxia and ischemia, and endothelial dysfunction. The role of SIRT1, a NAD+-dependent deacetylase, in pre-eclampsia and its mechanisms have been explored in recent studies. SIRT1 seems to affect placental development and trophoblast invasion, while protecting vascular endothelial cells from oxidative stress, inflammatory response, autophagy, and senescence. Activation of SIRT1 using compounds such as resveratrol has shown potential in attenuating symptoms of pre-eclampsia.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2022)
Article
Cell Biology
Lu Zhao, Dan Liu, Wei Ma, Hui Gu, Xiaowei Wei, Wenting Luo, Zhengwei Yuan
Summary: The study revealed that the Bhlhe40/Sirt1 axis regulated mitophagy plays a role in ATRA-induced SBA, providing new insights into the pathogenesis of NTDs and laying the foundation for potential therapeutic targets.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Medicine, Research & Experimental
Yuwen Zhu, Yan Guo, Yujia Xue, Anqi Zhou, Ying Chen, Yifei Chen, Xiulian Miao, Fangqiao Lv
Summary: BRG1 plays an important role in HSC-myofibroblast transition and targeting it could be a reasonable strategy for liver fibrosis intervention.
Article
Medicine, Research & Experimental
Liu Ye, Beibei Liu, Jingling Huang, Xiaolin Zhao, Yuan Wang, Yungen Xu, Shuping Wang
Summary: Doublecortin-like kinase 1 (DCLK1) is a significant prooncogenic factor that is strongly associated with the malignant progression and clinical prognosis of various cancers. DCLK1 plays important roles in stem cell marker regulation, tumor cell reprogramming, and immune evasion. However, the exact biological functions of DCLK1, especially the disparities between its alpha- and beta-form transcripts in cancer progression, remain ambiguous.
Article
Medicine, Research & Experimental
Jiahui Yang, Xiaoyu Chen, Tianjing Liu, Yongyan Shi
Summary: This article reviews the role of bile acids in necrotizing enterocolitis (NEC) and their potential therapeutic value. The dysregulation of bile acids is associated with intestinal injury, and inflammatory factors in the liver also play a crucial role in regulating bile acid transport. The bile acid metabolic pathway is important for regulating intestinal microbiota, cell proliferation, and barrier protection.
Review
Medicine, Research & Experimental
Zhenzheng Zhu, Yuemiao Xu, Yuwei Xia, Xinru Jia, Yixin Chen, Yuyue Liu, Leyin Zhang, Hui Chai, Leitao Sun
Summary: Bile acid, as the final product of cholesterol breakdown, plays a complex regulatory and signaling role in human metabolism. Research suggests that it has the potential to enhance metabolism and regulate chronic metabolic diseases through various pathways. The interaction between bile acid and gut microbiota is also of great significance.
Article
Medicine, Research & Experimental
Xin He, Hong-Xu Zhou, Xian Fu, Kai-Di Ni, Ai-Zhi Lin, Ling-Tong Zhang, Hou-Hua Yin, Qing Jiang, Xue Zhou, Yi-Wen Meng, Jun-Yan Liu
Summary: DON exposure causes an increase in deoxycholic acid (DCA), which contributes to intestinal injury. DCA may be a potential therapeutic target for DON enterotoxicity.
Article
Medicine, Research & Experimental
Zhitao Wang, Heng Ma, Abdul Nasir, Sufang Liu, Zhisong Li, Feng Tao, Qian Bai
Summary: This study reveals the involvement of TET1-mediated epigenetic regulation in chronic TMJ pain through trigeminal TNF alpha signaling.
Article
Medicine, Research & Experimental
Lu Yu, Hao Ran, Yaru Lu, Qian Ma, Huan Huang, Weibin Liu
Summary: This study found that the HIF-1 alpha inhibitor BAY 87-2243 can alleviate the symptoms of the Experimental Autoimmune Myasthenia Gravis (EAMG) inflammation model. BAY 87-2243 can restore the balance of CD4(+)T cell subsets, reduce the production of pro-inflammatory cytokines, and act as both an immune imbalance regulator and anti-inflammatory.
Article
Medicine, Research & Experimental
Alex Peralvarez-Marin, Montse Sole, Judith Serrano, Alice Taddeucci, Belen Perez, Clara Penas, Gemma Manich, Marcel Jimenez, Pilar D'Ocon, Francesc Jimenez-Altayo
Summary: This study provides the first evidence that TRPV2 channels may modulate vascular tone by balancing opposing inputs from the endothelium and smooth muscle, leading to net vasodilation. The amplification of TRPV2 channel-induced activity by NO emphasizes the pathophysiological relevance of these findings.
Article
Medicine, Research & Experimental
Amin Ullah, Jing Zhao, Jiakun Li, Rajeev K. Singla, Bairong Shen
Summary: Gastric cancer is the fifth-most prevalent and second-most deadly cancer worldwide. Late onset of symptoms makes early detection important. CXC chemokines play an important role in the pathological process of gastric cancer, but their exact role in diagnosis and prognosis is not fully understood. Inhibiting CXC chemokines shows promise as a targeted therapy.
Article
Medicine, Research & Experimental
Menna S. Zeyada, Salma M. Eraky, Mamdouh M. El-Shishtawy
Summary: The current study demonstrates the prophylactic and antifibrotic effects of Trig against BLM-induced PF by targeting multiple signaling pathways. The combination of Trig and Pirf may be a promising approach to enhance Pirf's anti-fibrotic effect.