Article
Biochemistry & Molecular Biology
Nellysha Namela Muhammad Abdul Kadar, Fairus Ahmad, Seong Lin Teoh, Mohamad Fairuz Yahaya
Summary: The supplementation of stingless bee honey (SBH) and pure antioxidant caffeic acid (CA) can reverse the hyperglycemic and hypertensive effects induced by high-carbohydrate high-fructose (HCHF) diet. SBH can significantly reduce brain TNF-alpha levels and increase brain neurotrophic factor BDNF levels.
Article
Physiology
Hongli Zeng, Xiangsheng Cai, Zhenyang Qiu, Yuchan Liang, Lu Huang
Summary: The study aimed to investigate the effects of quinoa on glucose and lipid metabolism, and the prognosis in people with impaired glucose tolerance. The results showed that adding quinoa to staple food intake significantly reduced postprandial blood glucose, improved lipid metabolism and insulin resistance, and delayed the progression of diabetes in people with impaired glucose tolerance.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Environmental Sciences
Qiang Ma, Houguo Xu, Samwel Mchele Limbu, Yuliang Wei, Mengqing Liang
Summary: In this study, the ability of fish to utilize carbohydrates was evaluated by intraperitoneal injection or oral administration of glucose or fructose to tiger puffer and turbot. The results showed that glucose and fructose stimulated insulin secretion and improved hypoxia tolerance in the two marine fishes.
FRONTIERS IN MARINE SCIENCE
(2023)
Article
Medicine, Research & Experimental
Alejandro Garcia-Beltran, Rosario Martinez, Jesus M. Porres, Francisco Arrebola, Inmaculada Ruiz Artero, Milagros Galisteo, Pilar Aranda, Garyfallia Kapravelou, Maria Lopez-Jurado
Summary: In this study, a rat model of diet-induced obesity was used to investigate the effects of aging on the gene expression of the liver transcriptome. The results showed that different lengths of diet-induced obesity resulted in significant differences in metabolic changes, including increased body weight, hepatic fat deposition, and abnormal fatty acid metabolism. The study suggests that the choice of obesity-induction length is crucial for controlling the obesity model in specific experimental designs.
Article
Biochemistry & Molecular Biology
Hidemi Hattori, Yuma Hanai, Yuto Oshima, Hiroaki Kataoka, Nozomu Eto
Summary: Excessive consumption of HFCS drinks, such as soft drinks, without a proper diet, induces nonobese IGT due to insulin-secretion defect. This study found that excess HFCS-water intake did not lead to obesity, but impaired glucose tolerance (IGT) due to insulin-secretion defect. The intake of HFCS-water affected glucose and fructose metabolism by decreasing the expression of certain enzymes in the pancreas.
Article
Agriculture, Dairy & Animal Science
Lijun Ning, Haotian Zhang, Xiaoying Chen, Jia Zhen, Shen Chen, Junfeng Guang, Chao Xu, Yuanyou Li
Summary: A 12-week trial showed that tilapia has higher tolerance to a high lipid diet than a high carbohydrate diet. Continuous feeding of the high carbohydrate diet impaired tilapia's appetite, weight gain rate, and immune response. Tilapia's distribution of fat may be a risk-avoidance strategy in response to a continuous high lipid diet.
Article
Endocrinology & Metabolism
Zili Lei, Huijuan Wu, Yanhong Yang, Qing Hu, Yuting Lei, Wanwan Liu, Ya Nie, Lanxiang Yang, Xueying Zhang, Changyuan Yang, Ting Lin, Fengxue Tong, Jiamin Zhu, Jiao Guo
Summary: The study revealed that hormones produced by ovaries play crucial roles in regulating hepatic glucose and lipid metabolism as well as communicating with the gut microbiota in females.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Nutrition & Dietetics
Gil Zandani, Sarit Anavi-Cohen, Tamar Yudelevich, Abraham Nyska, Nativ Dudai, Zecharia Madar, Jonathan Gorelick
Summary: This study found that supplementing high-fat diet with C. iphionoides can improve metabolic effects in a NAFLD model. Consumption of C. iphionoides can reduce weight gain, liver and adipose tissue weights, and improve liver function and lipid metabolism.
Article
Agriculture, Multidisciplinary
Tamara Dakic, Iva Lakic, Manja Zec, Marija Takic, Mojca Stojiljkovic, Tanja Jevdjovic
Summary: The study found that walnut intake restored the levels of GLUT1 and GLUT3 proteins affected by fructose-rich diet in the hypothalamus of rats, while showing distinct effects in the hippocampus.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2021)
Article
Medicine, Research & Experimental
Vanessa Barbosa Veronesi, Mariana Rodrigues Pioli, Dailson Nogueira de Souza, Caio Jordao Teixeira, Gilson Masahiro Murata, Junia Carolina Santos-Silva, Fernanda Ballerini Hecht, Julia Modesto Vicente, Silvana Bordin, Gabriel Forato Anhe
Summary: The study suggests that Agomelatine mimics the metabolic benefits of melatonin in fructose-treated rats, resulting in reduced body weight gain, improved liver lipid levels, and decreased circulating triglyceride levels. Additionally, Agomelatine also decreases hepatic fatty acid synthesis and intestinal lipoprotein production in fructose-treated rats.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Matthieu Dietz, Benoit Paulmier, Frederic Berthier, Filippo Civaia, Francois Mocquot, Benjamin Serrano, Valerie Nataf, Florent Hugonnet, Marc Faraggi
Summary: This study demonstrated that adding a lipid emulsion infusion to a high-fat, low-carbohydrate diet (HFLCD) can better suppress cardiac glucose metabolism than HFLCD alone, leading to improved clinical diagnostic performance of myocardial FDG PET/CT.
CLINICAL NUCLEAR MEDICINE
(2021)
Article
Gastroenterology & Hepatology
Maria J. Gonzalez-Rellan, Eva Novoa, Natalia da Silva Lima, Amaia Rodriguez, Christelle Veyrat-Durebex, Samuel Seoane, Begona Porteiro, Marcos F. Fondevila, Uxia Fernandez, Marta Varela-Rey, Ana Senra, Cristina Iglesias, Adriana Escudero, Miguel Fidalgo, Diana Guallar, Roman Perez-Fernandez, Vincent Prevot, Markus Schwaninger, Miguel Lopez, Carlos Dieguez, Roberto Coppari, Gema Fruhbeck, Ruben Nogueiras
Summary: The transcription factor p63 plays a key role in glucose metabolism by regulating SIRT1 and affecting blood glucose levels, thus influencing glucose homeostasis.
Review
Pharmacology & Pharmacy
Cecilia Gabriela Melendez-Salcido, Joel Ramirez-Emiliano, Victoriano Perez-Vazquez
Summary: Poor dietary habits, such as consuming high-fructose and high-fat diets, are associated with the development of metabolic abnormalities and conditions like obesity, diabetes, and dyslipidemia. The kidneys are particularly vulnerable to dyslipidemia, which can lead to lipid accumulation and impaired kidney function.
CURRENT PHARMACEUTICAL DESIGN
(2022)
Article
Plant Sciences
Federica Blando, Stefano Marchello, Gabriele Maiorano, Miriana Durante, Angelo Signore, Maura N. Laus, Mario Soccio, Giovanni Mita
Summary: Black and purple carrots, rich in anthocyanins, exhibit high antioxidant capacities and contain abundant polyphenolic compounds. In contrast, orange carrots lacking anthocyanins have lower nutritional value.
Article
Nutrition & Dietetics
Elisa Felix-Soriano, Alejandro Martinez-Gayo, Maria Jose Cobo, Adriana Perez-Chavez, Javier Ibanez-Santos, Natalia Palacios Samper, Inaki Goikoetxea Galarza, Marta Cuervo, Marisol Garcia-Unciti, Pedro Gonzalez-Muniesa, Silvia Lorente-Cebrian, Maria J. Moreno-Aliaga
Summary: Resistance training can improve body composition, bone mineral content, and glucose tolerance, while DHA-rich supplementation benefits cardiovascular health markers in overweight/obese postmenopausal women. However, there were no synergistic effects observed when combining DHA supplementation with the resistance training program.
Article
Cardiac & Cardiovascular Systems
Romina Becerra, Barbara Roman, Mariano N. Di Carlo, Juan Ignacio Mariangelo, Margarita Salas, Gina Sanchez, Paulina Donoso, Guillermo R. Schinella, Leticia Vittone, Xander H. Wehrens, Cecilia Mundina-Weilenmann, Matilde Said
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2016)
Article
Agriculture, Multidisciplinary
Luisa F. Gonzalez Arbelaez, Alejandro Ciocci Pardo, Juliana C. Fantinelli, Claudia Caldiz, Jose Luis Rios, Guillermo R. Schinella, Susana M. Mosca
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2016)
Article
Food Science & Technology
Juliana C. Fantinelli, Liceth N. Cuellar Alvarez, Luisa F. Gonzalez Arbelaez, Alejandro Ciocci Pardo, Paula L. Galeano Garcia, Guillermo R. Schinella, Susana M. Mosca
JOURNAL OF FUNCTIONAL FOODS
(2017)
Article
Medicine, Research & Experimental
Hernan Gonzalo Villagarcia, Maria Cecilia Castro, Luisa Gonzalez Arbelaez, Guillermo Schinella, Maria Laura Massa, Eduardo Spinedi, Flavio Francini
Article
Plant Sciences
Tatiana C. Gavilanez Bunay, German A. Colareda, Maria Ines Ragone, Milena Bonilla, Benjamin A. Rojano, Guillermo R. Schinella, Alicia E. Consolini
Review
Chemistry, Medicinal
Flavio Francini, Guillermo R. Schinella, Jose-Luis Rios
MINI-REVIEWS IN MEDICINAL CHEMISTRY
(2019)
Review
Plant Sciences
Jose-Luis Rios, Isabel Andujar, Guillermo R. Schinella, Flavio Francini
Article
Pharmacology & Pharmacy
Luisa F. Gonzalez Arbelaez, Alejandro Ciocci Pardo, Juliana C. Fantinelli, Benjamin Rojano, Guillermo R. Schinella, Susana M. Mosca
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2020)
Article
Plant Sciences
Maria Cecilia Castro, Hernan Villagarcia, Ada Nazar, Luisa Gonzalez Arbelaez, Maria Laura Massa, Hector Del Zotto, Jose Luis Rios, Guillermo R. Schinella, Flavio Francini
JOURNAL OF ETHNOPHARMACOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Gisela M. Gaddi, Romina A. Gisonno, Silvana A. Rosu, Lucrecia M. Curto, Eduardo D. Prieto, Guillermo R. Schinella, Gabriela S. Finarelli, M. Fernanda Cortez, Letizia Bauza, Esteban E. Elias, Nahuel A. Ramella, M. Alejandra Tricerri
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2020)
Article
Biochemistry & Molecular Biology
Romina A. Gisonno, Eduardo D. Prieto, Juan P. Gorgojo, Lucretia M. Curto, M. Eugenia Rodriguez, Silvana A. Rosu, Gisela M. Gaddi, Gabriela S. Finarelli, M. Fernanda Cortez, Guillermo R. Schinella, M. Alejandra Tricerri, Nahuel A. Ramella
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2020)
Review
Biochemistry & Molecular Biology
Jose M. Prieto, Guillermo R. Schinella
Summary: This experimental review explores the relationship between Traditional Chinese Medicine (TCM) herbal drugs and lipid peroxidation in the context of topical inflammation. The study finds that certain herbal drugs with bitter and cold properties inhibit both lipid peroxidation and eicosanoids production, while sweet drugs specifically inhibit eicosanoids production. The therapeutic value of other drugs may be based on their actions on the Qi. The study suggests potential translation between the two medical systems and provides insights for the treatment of skin conditions.
Article
Medicine, General & Internal
Maria Cecilia Castro, Hernan Gonzalo Villagarcia, Carolina Lisi Roman, Barbara Maiztegui, Luis Emilio Flores, Guillermo Raul Schinella, Maria Laura Massa, Flavio Francini
Summary: A study on normal rats found that a fructose-rich diet (FRD) triggered a series of events, including increased circulating triglycerides, liver fat deposit and metabolic disturbances, liver and pancreatic inflammation, pancreatic beta-cell dysfunction, and peripheral insulin resistance. These findings are helpful in preventing the progression from prediabetes to Type 2 diabetes (T2D) triggered by unhealthy diets.
MEDICINA-LITHUANIA
(2022)
Article
Medicine, General & Internal
C. Bergna, G. H. Marin, M. Maiz, H. Bruzzoni-Giovanelli, C. Ponzinibbio, G. Schinella, J. Errecalde, A. Rebollo
CEYLON MEDICAL JOURNAL
(2019)
Review
Biochemistry & Molecular Biology
Luisa F. Gonzalez Arbelaez, Alejandro Ciocci Pardo, Juliana C. Fantinelli, Guillermo R. Schinella, Susana M. Mosca, Jose-Luis Rios
Article
Medicine, Research & Experimental
Yuwen Zhu, Yan Guo, Yujia Xue, Anqi Zhou, Ying Chen, Yifei Chen, Xiulian Miao, Fangqiao Lv
Summary: BRG1 plays an important role in HSC-myofibroblast transition and targeting it could be a reasonable strategy for liver fibrosis intervention.
Article
Medicine, Research & Experimental
Liu Ye, Beibei Liu, Jingling Huang, Xiaolin Zhao, Yuan Wang, Yungen Xu, Shuping Wang
Summary: Doublecortin-like kinase 1 (DCLK1) is a significant prooncogenic factor that is strongly associated with the malignant progression and clinical prognosis of various cancers. DCLK1 plays important roles in stem cell marker regulation, tumor cell reprogramming, and immune evasion. However, the exact biological functions of DCLK1, especially the disparities between its alpha- and beta-form transcripts in cancer progression, remain ambiguous.
Article
Medicine, Research & Experimental
Jiahui Yang, Xiaoyu Chen, Tianjing Liu, Yongyan Shi
Summary: This article reviews the role of bile acids in necrotizing enterocolitis (NEC) and their potential therapeutic value. The dysregulation of bile acids is associated with intestinal injury, and inflammatory factors in the liver also play a crucial role in regulating bile acid transport. The bile acid metabolic pathway is important for regulating intestinal microbiota, cell proliferation, and barrier protection.
Review
Medicine, Research & Experimental
Zhenzheng Zhu, Yuemiao Xu, Yuwei Xia, Xinru Jia, Yixin Chen, Yuyue Liu, Leyin Zhang, Hui Chai, Leitao Sun
Summary: Bile acid, as the final product of cholesterol breakdown, plays a complex regulatory and signaling role in human metabolism. Research suggests that it has the potential to enhance metabolism and regulate chronic metabolic diseases through various pathways. The interaction between bile acid and gut microbiota is also of great significance.
Article
Medicine, Research & Experimental
Xin He, Hong-Xu Zhou, Xian Fu, Kai-Di Ni, Ai-Zhi Lin, Ling-Tong Zhang, Hou-Hua Yin, Qing Jiang, Xue Zhou, Yi-Wen Meng, Jun-Yan Liu
Summary: DON exposure causes an increase in deoxycholic acid (DCA), which contributes to intestinal injury. DCA may be a potential therapeutic target for DON enterotoxicity.
Article
Medicine, Research & Experimental
Zhitao Wang, Heng Ma, Abdul Nasir, Sufang Liu, Zhisong Li, Feng Tao, Qian Bai
Summary: This study reveals the involvement of TET1-mediated epigenetic regulation in chronic TMJ pain through trigeminal TNF alpha signaling.
Article
Medicine, Research & Experimental
Lu Yu, Hao Ran, Yaru Lu, Qian Ma, Huan Huang, Weibin Liu
Summary: This study found that the HIF-1 alpha inhibitor BAY 87-2243 can alleviate the symptoms of the Experimental Autoimmune Myasthenia Gravis (EAMG) inflammation model. BAY 87-2243 can restore the balance of CD4(+)T cell subsets, reduce the production of pro-inflammatory cytokines, and act as both an immune imbalance regulator and anti-inflammatory.
Article
Medicine, Research & Experimental
Alex Peralvarez-Marin, Montse Sole, Judith Serrano, Alice Taddeucci, Belen Perez, Clara Penas, Gemma Manich, Marcel Jimenez, Pilar D'Ocon, Francesc Jimenez-Altayo
Summary: This study provides the first evidence that TRPV2 channels may modulate vascular tone by balancing opposing inputs from the endothelium and smooth muscle, leading to net vasodilation. The amplification of TRPV2 channel-induced activity by NO emphasizes the pathophysiological relevance of these findings.
Article
Medicine, Research & Experimental
Amin Ullah, Jing Zhao, Jiakun Li, Rajeev K. Singla, Bairong Shen
Summary: Gastric cancer is the fifth-most prevalent and second-most deadly cancer worldwide. Late onset of symptoms makes early detection important. CXC chemokines play an important role in the pathological process of gastric cancer, but their exact role in diagnosis and prognosis is not fully understood. Inhibiting CXC chemokines shows promise as a targeted therapy.
Article
Medicine, Research & Experimental
Menna S. Zeyada, Salma M. Eraky, Mamdouh M. El-Shishtawy
Summary: The current study demonstrates the prophylactic and antifibrotic effects of Trig against BLM-induced PF by targeting multiple signaling pathways. The combination of Trig and Pirf may be a promising approach to enhance Pirf's anti-fibrotic effect.